{"id":"https://openalex.org/W1999258798","doi":"https://doi.org/10.1016/s0022-2836(77)80162-9","title":"Preliminary X-ray study of leucine aminopeptidase (bovine lens), an oligomeric metalloenzyme","display_name":"Preliminary X-ray study of leucine aminopeptidase (bovine lens), an oligomeric metalloenzyme","publication_year":1977,"publication_date":"1977-05-01","ids":{"openalex":"https://openalex.org/W1999258798","doi":"https://doi.org/10.1016/s0022-2836(77)80162-9","mag":"1999258798","pmid":"https://pubmed.ncbi.nlm.nih.gov/881727"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2836(77)80162-9","doi":"https://doi.org/10.1016/s0022-2836(77)80162-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-2836(77)80162-9","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056886846","display_name":"FRANCES A. JURNAK","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Frances Jurnak","raw_affiliation_strings":["Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103066840","display_name":"Alexander Rich","orcid":"https://orcid.org/0000-0002-1951-1180","observed_orcids":["https://orcid.org/0000-0002-1951-1180"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Alexander Rich","raw_affiliation_strings":["Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072871530","display_name":"Lucy van Loon-Klaassen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Lucy van Loon-Klaassen","raw_affiliation_strings":["Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067559427","display_name":"Hans BLOEMENDAL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Hans Bloemendal","raw_affiliation_strings":["Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Allen Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Allen Taylor","raw_affiliation_strings":["Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113642106","display_name":"Frederick H. Carpenter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Frederick H. Carpenter","raw_affiliation_strings":["Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nijmegen University Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"Department of Biochemistry, University of California, Berkeley, Calif. 94720, U.S.A","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge Mass. 02139, U.S.A","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":1.4445,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.77449027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"112","issue":"1","first_page":"149","last_page":"153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10464","display_name":"Crystal structures of chemical compounds","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leucyl-aminopeptidase","display_name":"leucine aminopeptidase","score":1.0},{"id":"https://openalex.org/keywords/bovine-lens","display_name":"bovine lens","score":0.9879999756813049},{"id":"https://openalex.org/keywords/metalloenzymes","display_name":"metalloenzymes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/oligomeric-enzymes","display_name":"oligomeric enzymes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hexameric-enzyme","display_name":"hexameric enzyme","score":0.6290000081062317},{"id":"https://openalex.org/keywords/enzyme-crystal-structure","display_name":"enzyme crystal structure","score":0.7549999952316284},{"id":"https://openalex.org/keywords/dyad-symmetry","display_name":"dyad symmetry","score":0.7900000214576721},{"id":"https://openalex.org/keywords/point-group-symmetry","display_name":"point group symmetry","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2780985610","wikidata":"https://www.wikidata.org/wiki/Q419527","display_name":"Aminopeptidase","level":4,"score":0.8341739177703857},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.6181291937828064},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5359097123146057},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46437540650367737},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44907528162002563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3694359362125397},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2147430181503296}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007931","descriptor_name":"Leucyl Aminopeptidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-2836(77)80162-9","doi":"https://doi.org/10.1016/s0022-2836(77)80162-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-2836(77)80162-9","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:881727","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/881727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1518183134","https://openalex.org/W1552083732","https://openalex.org/W1603139379","https://openalex.org/W1989858176","https://openalex.org/W1990018758","https://openalex.org/W2014694459","https://openalex.org/W2069043406","https://openalex.org/W2314335159","https://openalex.org/W2326087692","https://openalex.org/W2332783662"],"related_works":["https://openalex.org/W1566040104","https://openalex.org/W2993060870","https://openalex.org/W561200465","https://openalex.org/W174492136","https://openalex.org/W2993408989","https://openalex.org/W2089292410","https://openalex.org/W2073131234","https://openalex.org/W2422883621","https://openalex.org/W2783667174","https://openalex.org/W2003107936"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}