{"id":"https://openalex.org/W1999217897","doi":"https://doi.org/10.1158/0008-5472.can-10-0412","title":"Transplanting Normal Vascular Proangiogenic Cells to Tumor-Bearing Mice Triggers Vascular Remodeling and Reduces Hypoxia in Tumors","display_name":"Transplanting Normal Vascular Proangiogenic Cells to Tumor-Bearing Mice Triggers Vascular Remodeling and Reduces Hypoxia in Tumors","publication_year":2010,"publication_date":"2010-07-14","ids":{"openalex":"https://openalex.org/W1999217897","doi":"https://doi.org/10.1158/0008-5472.can-10-0412","mag":"1999217897","pmid":"https://pubmed.ncbi.nlm.nih.gov/20631070","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3063898"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-10-0412","doi":"https://doi.org/10.1158/0008-5472.can-10-0412","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-10-0412","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3063898","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056544156","display_name":"Junpei Sasajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Junpei Sasajima","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025471308","display_name":"Yusuke Mizukami","orcid":"https://orcid.org/0000-0002-1068-7024","observed_orcids":["https://orcid.org/0000-0002-1068-7024"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Yusuke Mizukami","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111730317","display_name":"Yoshiaki Sugiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yoshiaki Sugiyama","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102868041","display_name":"Kazumasa Nakamura","orcid":"https://orcid.org/0000-0001-5451-7716","observed_orcids":["https://orcid.org/0000-0001-5451-7716"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Kazumasa Nakamura","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110392176","display_name":"Toru Kawamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Toru Kawamoto","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030996670","display_name":"Kazuya Koizumi","orcid":"https://orcid.org/0000-0002-3677-5030","observed_orcids":["https://orcid.org/0000-0002-3677-5030"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Kazuya Koizumi","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112487790","display_name":"Rie Fujii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Rie Fujii","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013878244","display_name":"Wataru Motomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Wataru Motomura","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044690140","display_name":"Kazuya Sato","orcid":"https://orcid.org/0000-0002-7893-3615","observed_orcids":["https://orcid.org/0000-0002-7893-3615"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Kazuya Sato","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111703146","display_name":"Yasuaki Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yasuaki Suzuki","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966911","display_name":"Satoshi Tanno","orcid":"https://orcid.org/0009-0008-0593-1273","observed_orcids":["https://orcid.org/0009-0008-0593-1273"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Satoshi Tanno","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108411575","display_name":"Mikihiro Fujiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Mikihiro Fujiya","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103460794","display_name":"Katsunori Sasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Katsunori Sasaki","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067240745","display_name":"Norihiko Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Norihiko Shimizu","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051945468","display_name":"Hidenori Karasaki","orcid":"https://orcid.org/0000-0003-4285-6379","observed_orcids":["https://orcid.org/0000-0003-4285-6379"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hidenori Karasaki","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110174354","display_name":"Toru Kono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Toru Kono","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089905179","display_name":"Jun-ichi Kawabe","orcid":"https://orcid.org/0000-0002-4837-6598","observed_orcids":["https://orcid.org/0000-0002-4837-6598"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Jun-ichi Kawabe","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064744050","display_name":"Masaaki Ii","orcid":"https://orcid.org/0000-0002-0464-8758","observed_orcids":["https://orcid.org/0000-0002-0464-8758"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Masaaki Ii","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083081166","display_name":"Hiroki Yoshiara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hiroki Yoshiara","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045449747","display_name":"Naohisa Kamiyama","orcid":"https://orcid.org/0000-0002-1477-8150","observed_orcids":["https://orcid.org/0000-0002-1477-8150"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Naohisa Kamiyama","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051637203","display_name":"Toshifumi Ashida","orcid":"https://orcid.org/0000-0003-4553-7664","observed_orcids":["https://orcid.org/0000-0003-4553-7664"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Toshifumi Ashida","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108207076","display_name":"Nabeel M. Bardeesy","orcid":"https://orcid.org/0000-0003-3867-0416","observed_orcids":["https://orcid.org/0000-0003-3867-0416"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Nabeel Bardeesy","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel C. Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Daniel C. Chung","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069703142","display_name":"Yutaka Kohgo","orcid":"https://orcid.org/0000-0001-7076-2842","observed_orcids":["https://orcid.org/0000-0001-7076-2842"]},"institutions":[{"id":"https://openalex.org/I127036137","display_name":"Asahikawa Medical College Hospital","ror":"https://ror.org/00ftrxq20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I127036137"]},{"id":"https://openalex.org/I1292669757","display_name":"Toshiba (Japan)","ror":"https://ror.org/0326v3z14","country_code":"JP","type":"company","lineage":["https://openalex.org/I1292669757"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]},{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yutaka Kohgo","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Department of Pharmacology, Osaka Medical College, Osaka, Japan","Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Toshiba Medical Systems Corp., Otawara, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Gastroenterology and Hematology/Oncology, Department of Medicine, 2Department of Animal Facility, 3Division of Gastroenterological and General Surgery, Department of Surgery, and 4Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical College, Asahikawa, Hokkaido, Japan; 5Department of Pharmacology, Osaka Medical College, Osaka, Japan; 6Toshiba Medical Systems Corp., Otawara, Tochigi, Japan; 7Center for IBD, Sapporo Higashi Tokusyukai Hospital, Sapporo, Hokkaido, Japan; and 8Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I127036137","https://openalex.org/I147809708"]},{"raw_affiliation_string":"Department of Pharmacology, Osaka Medical College, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Toshiba Medical Systems Corp., Otawara, Tochigi, Japan","institution_ids":["https://openalex.org/I1292669757"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5025471308"],"corresponding_institution_ids":["https://openalex.org/I127036137","https://openalex.org/I1292669757","https://openalex.org/I136199984","https://openalex.org/I147809708","https://openalex.org/I205143321","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":1.6923,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.82557808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"70","issue":"15","first_page":"6283","last_page":"6292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-mononuclear-cells","display_name":"bone marrow mononuclear cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-vasculature-normalization","display_name":"tumor vasculature normalization","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.7369999885559082},{"id":"https://openalex.org/keywords/pericyte-coverage","display_name":"pericyte coverage","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pancreatic-cancer-xenografts","display_name":"pancreatic cancer xenografts","score":0.9210000038146973},{"id":"https://openalex.org/keywords/drug-delivery-to-tumors","display_name":"drug delivery to tumors","score":0.5770000219345093},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.847000002861023},{"id":"https://openalex.org/keywords/contrast-enhanced-ultrasound","display_name":"contrast-enhanced ultrasound","score":0.4350000023841858},{"id":"https://openalex.org/keywords/sonazoid","display_name":"Sonazoid","score":0.652999997138977},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C2780427682","wikidata":"https://www.wikidata.org/wiki/Q500446","display_name":"Pericyte","level":4,"score":0.5635984539985657},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.562131404876709},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5486479997634888},{"id":"https://openalex.org/C2779081379","wikidata":"https://www.wikidata.org/wiki/Q7852677","display_name":"Tumor hypoxia","level":3,"score":0.4652142822742462},{"id":"https://openalex.org/C60781801","wikidata":"https://www.wikidata.org/wiki/Q1424593","display_name":"Vasculogenesis","level":4,"score":0.46351301670074463},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.463010311126709},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.46282774209976196},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4524473249912262},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4389810562133789},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.43585532903671265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39638757705688477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38122519850730896},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.36697959899902344},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31572407484054565},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.31507107615470886},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.24489238858222961},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.20863237977027893},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18039312958717346},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15383955836296082},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09916287660598755},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039481","descriptor_name":"CD11b Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D042501","descriptor_name":"Angiogenic Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1158/0008-5472.can-10-0412","doi":"https://doi.org/10.1158/0008-5472.can-10-0412","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-10-0412","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:20631070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20631070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2073919","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3063898","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3063898","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3063898","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:01468:0006142008","doi":null,"is_oa":true,"landing_page_url":"https://asahikawa-med.repo.nii.ac.jp/records/3905","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u5b66\u4f4d\u8ad6\u6587\u5185\u5bb9\u306e\u8981\u65e8\u53ca\u3073\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8","raw_type":"other"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2073919","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3063898","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2424020900","display_name":"Genetic Regulation of Angiogenesis in Colonic Polyps","funder_award_id":"R01CA092594","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4467422808","display_name":"Role of bone marrow-derived cells during pancreatic tumorigenesis","funder_award_id":"22590754","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320321625","display_name":"Daiichi-Sankyo","ror":"https://ror.org/027y26122"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W59556011","https://openalex.org/W1493048246","https://openalex.org/W1573363574","https://openalex.org/W1578283200","https://openalex.org/W1583600832","https://openalex.org/W1592390749","https://openalex.org/W1931508686","https://openalex.org/W1963655153","https://openalex.org/W1972295121","https://openalex.org/W1973541913","https://openalex.org/W1980152243","https://openalex.org/W1985698425","https://openalex.org/W1999736897","https://openalex.org/W1999966467","https://openalex.org/W2008269431","https://openalex.org/W2013818100","https://openalex.org/W2019541940","https://openalex.org/W2031795384","https://openalex.org/W2034461318","https://openalex.org/W2042644232","https://openalex.org/W2043609102","https://openalex.org/W2045359719","https://openalex.org/W2046001207","https://openalex.org/W2061184351","https://openalex.org/W2061797905","https://openalex.org/W2063415707","https://openalex.org/W2065176645","https://openalex.org/W2072148454","https://openalex.org/W2080196370","https://openalex.org/W2084239507","https://openalex.org/W2102416115","https://openalex.org/W2105925116","https://openalex.org/W2112813549","https://openalex.org/W2119793842","https://openalex.org/W2120992176","https://openalex.org/W2124863710","https://openalex.org/W2128553876","https://openalex.org/W2130549804","https://openalex.org/W2138091232","https://openalex.org/W2140088548","https://openalex.org/W2140165420","https://openalex.org/W2144262617","https://openalex.org/W2145835533","https://openalex.org/W2147259052","https://openalex.org/W2148679920","https://openalex.org/W2152100793","https://openalex.org/W2155703416","https://openalex.org/W2157769714","https://openalex.org/W2160741229","https://openalex.org/W2164506013","https://openalex.org/W2339361819","https://openalex.org/W4252851641","https://openalex.org/W4285719527","https://openalex.org/W6679216324","https://openalex.org/W6683003170"],"related_works":["https://openalex.org/W2590953976","https://openalex.org/W2408926762","https://openalex.org/W3171756805","https://openalex.org/W2026356653","https://openalex.org/W2063568609","https://openalex.org/W2304873987","https://openalex.org/W3197133949","https://openalex.org/W244073174","https://openalex.org/W2001009247","https://openalex.org/W2074991531"],"abstract_inverted_index":{"Blood":[0],"vessels":[1,135],"deliver":[2],"oxygen":[3],"and":[4,8,30,38,110,190,215],"nutrients":[5,37],"to":[6,14,47,54,65,203,211,220],"tissues,":[7],"vascular":[9,99],"networks":[10],"are":[11],"spatially":[12],"organized":[13],"meet":[15],"the":[16,24,71,82,167,176,209,213],"metabolic":[17],"needs":[18],"for":[19],"maintaining":[20],"homeostasis.":[21],"In":[22,170],"contrast,":[23],"vasculature":[25,131],"of":[26,36,85,96,123,156,166,192,217],"tumors":[27],"is":[28],"immature":[29],"leaky,":[31],"resulting":[32,130],"in":[33,44,70,76,81,141,175,183,187],"insufficient":[34],"delivery":[35,214],"oxygen.":[39],"Vasculogenic":[40],"processes":[41],"occur":[42],"normally":[43],"adult":[45],"tissues":[46],"repair":[48],"\"injured\"":[49],"blood":[50],"vessels,":[51,207],"leading":[52],"us":[53],"hypothesize":[55],"that":[56,115],"bone":[57],"marrow":[58],"mononuclear":[59],"cells":[60,88,101],"(BMMNC)":[61],"may":[62],"be":[63],"able":[64],"restore":[66],"appropriate":[67],"vessel":[68],"function":[69],"tumor":[72,127,168,206],"vasculature.":[73,169],"Culturing":[74],"BMMNCs":[75],"endothelial":[77],"growth":[78],"medium":[79],"resulted":[80],"early":[83],"outgrowth":[84],"spindle-shaped":[86],"attached":[87],"expressing":[89],"CD11b/Flt1/Tie2/c-Kit/CXCR4":[90],"with":[91,136,149],"proangiogenic":[92,100],"activity.":[93],"Intravenous":[94],"administration":[95],"these":[97],"cultured":[98],"(VPC)":[102],"into":[103],"nude":[104],"mice":[105,114],"bearing":[106],"pancreatic":[107,117],"cancer":[108,193],"xenografts":[109,146,178],"Pdx1-Cre;LSL-Kras(G12D);p53(lox/+)":[111],"genetically":[112],"engineered":[113],"develop":[116],"ductal":[118],"adenocarcinoma":[119],"significantly":[120],"reduced":[121],"areas":[122,143],"hypoxia":[124],"without":[125],"enhancing":[126],"growth.":[128],"The":[129],"structurally":[132],"mimicked":[133],"normal":[134],"intensive":[137],"pericyte":[138],"coverage.":[139],"Increases":[140],"vascularized":[142],"within":[144],"VPC-injected":[145],"were":[147],"visualized":[148],"an":[150],"ultrasound":[151],"diagnostic":[152],"system":[153],"during":[154],"injection":[155],"a":[157,163,180,199],"microbubble-based":[158],"contrast":[159],"agent":[160],"(Sonazoid),":[161],"indicating":[162],"functional":[164],"\"normalization\"":[165],"addition,":[171],"gene":[172],"expression":[173],"profiles":[174],"VPC-transplanted":[177],"revealed":[179],"marked":[181],"reduction":[182],"major":[184],"factors":[185],"involved":[186],"drug":[188],"resistance":[189],"\"stemness\"":[191],"cells.":[194],"Together,":[195],"our":[196],"findings":[197],"identify":[198],"novel":[200],"alternate":[201],"approach":[202],"regulate":[204],"abnormal":[205],"offering":[208],"potential":[210],"improve":[212],"efficacy":[216],"anticancer":[218],"drugs":[219],"hypoxic":[221],"tumors.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}