{"id":"https://openalex.org/W1999211404","doi":"https://doi.org/10.1097/00004872-199715090-00010","title":"Influence of the angiotensin converting enzyme I/D gene polymorphisms on left ventricular diastolic filling in patients with essential hypertension","display_name":"Influence of the angiotensin converting enzyme I/D gene polymorphisms on left ventricular diastolic filling in patients with essential hypertension","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W1999211404","doi":"https://doi.org/10.1097/00004872-199715090-00010","mag":"1999211404","pmid":"https://pubmed.ncbi.nlm.nih.gov/9321747"},"language":"en","primary_location":{"id":"doi:10.1097/00004872-199715090-00010","doi":"https://doi.org/10.1097/00004872-199715090-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-199715090-00010","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110035738","display_name":"PETER B. M. CLARKSON","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peter B.M. Clarkson","raw_affiliation_strings":["Cardiology Department, Walsgrave Hospital, Coventry, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, Walsgrave Hospital, Coventry, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025450757","display_name":"Neeraj Prasad","orcid":"https://orcid.org/0000-0003-3971-2040","observed_orcids":["https://orcid.org/0000-0003-3971-2040"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neeraj Prasad","raw_affiliation_strings":["The University Department of Clinical Pharmacology, Ninewells Hospital & Medical School, Dundee, Scotland, UK","Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University Department of Clinical Pharmacology, Ninewells Hospital & Medical School, Dundee, Scotland, UK","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]},{"raw_affiliation_string":"Ninewells Hospital","institution_ids":["https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Catherine MacLeod","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catherine MacLeod","raw_affiliation_strings":["The University Department of Clinical Pharmacology, Ninewells Hospital & Medical School, Dundee, Scotland, UK","Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University Department of Clinical Pharmacology, Ninewells Hospital & Medical School, Dundee, Scotland, UK","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]},{"raw_affiliation_string":"Ninewells Hospital","institution_ids":["https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067829318","display_name":"Brian Burchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian Burchell","raw_affiliation_strings":["The University Department of Biochemistry, Ninewells Hospital & Medical School, Dundee, Scotland, UK","Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University Department of Biochemistry, Ninewells Hospital & Medical School, Dundee, Scotland, UK","institution_ids":["https://openalex.org/I2802526638"]},{"raw_affiliation_string":"Ninewells Hospital","institution_ids":["https://openalex.org/I2802526638"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072989992","display_name":"Thomas MacLennan MacDonald","orcid":"https://orcid.org/0000-0001-5189-6669","observed_orcids":["https://orcid.org/0000-0001-5189-6669"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas M. MacDonald","raw_affiliation_strings":["The University Department of Clinical Pharmacology, Ninewells Hospital & Medical School, Dundee, Scotland, UK","Ninewells Hospital","University of Dundee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University Department of Clinical Pharmacology, Ninewells Hospital & Medical School, Dundee, Scotland, UK","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]},{"raw_affiliation_string":"Ninewells Hospital","institution_ids":["https://openalex.org/I2802526638"]},{"raw_affiliation_string":"University of Dundee","institution_ids":["https://openalex.org/I177639307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110035738"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7646,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.72315819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"15","issue":"9","first_page":"995","last_page":"1000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.04910000041127205,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ace-insertion-deletion-polymorphism","display_name":"ACE I/D polymorphism","score":0.9160000085830688},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9440000057220459},{"id":"https://openalex.org/keywords/left-ventricular-diastolic-function","display_name":"left ventricular diastolic function","score":0.9129999876022339},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.8700000047683716},{"id":"https://openalex.org/keywords/diastolic-filling","display_name":"diastolic filling","score":0.6819999814033508},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8610000014305115},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7889999747276306},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.5170000195503235},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8327963352203369},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8211734294891357},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6846026182174683},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.6693861484527588},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.5968611836433411},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5814405083656311},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.5751979351043701},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5517489910125732},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.4446634352207184},{"id":"https://openalex.org/C76252995","wikidata":"https://www.wikidata.org/wiki/Q3395645","display_name":"Gene polymorphism","level":4,"score":0.41687849164009094},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3458630442619324},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0928545594215393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.043699443340301514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018619","descriptor_name":"Echocardiography, Doppler, Pulsed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00004872-199715090-00010","doi":"https://doi.org/10.1097/00004872-199715090-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-199715090-00010","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:9321747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9321747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension","raw_type":"Journal Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire_cris_publications/df008a3a-45c2-4040-aa3f-9d3611d2080b","doi":null,"is_oa":false,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/df008a3a-45c2-4040-aa3f-9d3611d2080b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clarkson, P B M, Prasad, N, MacLeoc, C, Burchell, B & MacDonald, T M 1997, 'Influence of the angiotensin converting enzyme I/D gene polymorphisms on left ventricular diastolic filling in patients with essential hypertension', Journal of Hypertension, vol. 15, no. 9, pp. 995-1000. https://doi.org/10.1097/00004872-199715090-00010","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W48031782","https://openalex.org/W1582334575","https://openalex.org/W1972792954","https://openalex.org/W1976692128","https://openalex.org/W1977152294","https://openalex.org/W1978327007","https://openalex.org/W1978513789","https://openalex.org/W1979022842","https://openalex.org/W1981152291","https://openalex.org/W1981643267","https://openalex.org/W1995934832","https://openalex.org/W2000294775","https://openalex.org/W2013709047","https://openalex.org/W2037679059","https://openalex.org/W2043600435","https://openalex.org/W2051322687","https://openalex.org/W2066467739","https://openalex.org/W2077353347","https://openalex.org/W2081485152","https://openalex.org/W2084465304","https://openalex.org/W2095634234","https://openalex.org/W2097532633","https://openalex.org/W2125957043","https://openalex.org/W2129925176","https://openalex.org/W2136036216","https://openalex.org/W2138479426","https://openalex.org/W2141989424","https://openalex.org/W2149196816","https://openalex.org/W2153138032","https://openalex.org/W2156796053","https://openalex.org/W2255335348","https://openalex.org/W2338539226","https://openalex.org/W2411550897","https://openalex.org/W4233429344"],"related_works":["https://openalex.org/W1990604791","https://openalex.org/W2408790682","https://openalex.org/W6991800849","https://openalex.org/W2012395611","https://openalex.org/W2410634586","https://openalex.org/W2012287896","https://openalex.org/W2080765156","https://openalex.org/W2428995333","https://openalex.org/W2406362228","https://openalex.org/W2368750809"],"abstract_inverted_index":{"BACKGROUND:":[0],"An":[1],"insertion/deletion":[2],"(I/D)":[3],"polymorphism":[4,232],"in":[5,18,67,115,251],"the":[6,16,26,51,57,61,104,144,164,189,192,195,207,230,234,238],"angiotensin":[7,29],"converting":[8],"enzyme":[9],"(ACE)":[10],"gene":[11,59,236],"accounts":[12],"for":[13,25,129,135,194,206],"50%":[14],"of":[15,28,53,63,81,126,131,233],"variance":[17],"serum":[19],"ACE":[20,22,58,105,158,178,235],"activity.":[21],"is":[23],"responsible":[24],"generation":[27],"II,":[30],"which":[31],"not":[32,205],"only":[33],"has":[34],"pressor":[35],"and":[36,90,99,102,120,140,157,177,191,215,244],"mitogenic":[37],"activities":[38],"but":[39,204],"also":[40],"exerts":[41],"effects":[42],"on":[43],"left":[44,77,93,241,246],"ventricular":[45,78,94,242,247],"diastolic":[46,64,95,132,248],"performance.":[47],"OBJECTIVE:":[48],"To":[49],"investigate":[50],"contribution":[52],"genetic":[54],"polymorphisms":[55],"at":[56],"to":[60],"development":[62],"functional":[65],"abnormalities":[66,250],"100":[68],"patients":[69,252],"with":[70,147,167,253],"essential":[71,254],"hypertension.":[72,255],"METHODS":[73],"AND":[74],"RESULTS:":[75],"The":[76],"mass":[79,243],"(LVMI)":[80],"each":[82],"patient":[83],"was":[84,111,184],"assessed":[85],"echocardiographically.":[86],"We":[87],"calculated":[88],"peak":[89],"integral":[91],"early:late":[92],"filling":[96,249],"ratios":[97],"(E:AP,":[98],"E:AI,":[100],"respectively)":[101],"determined":[103],"genotype":[106,123,159,179],"from":[107],"leukocyte":[108],"DNA.":[109],"There":[110,183],"no":[112],"significant":[113],"difference":[114],"age,":[116,136],"sex,":[117,137],"blood":[118],"pressure":[119],"LVMI":[121,193],"among":[122],"groups.":[124,223],"Analysis":[125],"covariance":[127],"modelled":[128],"indices":[130],"function,":[133],"adjusted":[134],"heart":[138,152,172],"rate":[139,153,173],"LVMI,":[141],"demonstrated":[142],"that":[143,228,229],"E:AP":[145,190],"interacted":[146,166],"age":[148,168],"(P":[149,154,160,169,174,180],"<":[150,155,170,202],"0.0001),":[151],"0.001)":[156],"=":[161,175,181,199,210,213,218,221],"0.018).":[162],"Similarly,":[163],"E:AI":[165],"0.001),":[171],"0.025)":[176],"0.047).":[182],"a":[185],"strong":[186],"correlation":[187],"between":[188,240],"DD":[196],"group":[197],"(r":[198,209,217],"-0.81,":[200],"P":[201,212,220],"0.0001)":[203],"ID":[208],"-0.03,":[211],"0.83)":[214],"II":[216],"-0.23,":[219],"0.23)":[222],"CONCLUSIONS:":[224],"These":[225],"findings":[226],"suggest":[227],"I/D":[231],"influences":[237],"relationship":[239],"echocardiographic":[245]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}