{"id":"https://openalex.org/W199916356","doi":null,"title":"Mort cellulaire induite par des radiations ionisantes dans des tumeurs humaines radior\u00e9sistantes : \u00e9tude, in vitro et in vivo, des m\u00e9canismes impliqu\u00e9s dans son induction par diff\u00e9rents types de rayonnements et modulation pharmacologique","display_name":"Mort cellulaire induite par des radiations ionisantes dans des tumeurs humaines radior\u00e9sistantes : \u00e9tude, in vitro et in vivo, des m\u00e9canismes impliqu\u00e9s dans son induction par diff\u00e9rents types de rayonnements et modulation pharmacologique","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W199916356","mag":"199916356"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/859069","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/859069","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008211599","display_name":"Ana\u00efs Altmeyer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ana\u00efs Altmeyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008211599"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.07490000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-induced-cell-death","display_name":"radiation-induced cell death","score":0.8059999942779541},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.843999981880188},{"id":"https://openalex.org/keywords/radiosensitizers","display_name":"radiosensitizers","score":0.8100000023841858},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6269999742507935},{"id":"https://openalex.org/keywords/high-let-radiation","display_name":"high-LET radiation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/fast-neutrons","display_name":"fast neutrons","score":0.8140000104904175},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/sk-hep-1-cells","display_name":"SK-Hep-1 cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/orthotopic-nude-mouse-model","display_name":"orthotopic nude mouse model","score":0.7829999923706055},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.765999972820282},{"id":"https://openalex.org/keywords/particle-therapy","display_name":"particle therapy","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6082121133804321},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.38339847326278687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35469627380371094},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.32202276587486267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3116260766983032}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/859069","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/859069","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:EPrintsUneraTest01:2112","doi":null,"is_oa":false,"landing_page_url":"http://scd-theses.u-strasbg.fr/2112/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400486","display_name":"Serveur des th\u00e8ses de l'Universit\u00e9 de Strasbourg (University of Strasbourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I68947357","host_organization_name":"Universit\u00e9 de Strasbourg","host_organization_lineage":["https://openalex.org/I68947357"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Th\u00e8se de doctorat"},{"id":"mag:199916356","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/2010STRA6229","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W970969496","https://openalex.org/W1538279946","https://openalex.org/W1547364212","https://openalex.org/W1557310888","https://openalex.org/W1571118411","https://openalex.org/W1584328564","https://openalex.org/W1661600867","https://openalex.org/W1794995646","https://openalex.org/W1814249860","https://openalex.org/W1963524125","https://openalex.org/W1964482555","https://openalex.org/W1965478720","https://openalex.org/W1975869552","https://openalex.org/W1976385056","https://openalex.org/W1978039127","https://openalex.org/W1978506033","https://openalex.org/W1982095943","https://openalex.org/W1997331071","https://openalex.org/W1998959684","https://openalex.org/W2001711640","https://openalex.org/W2007377687","https://openalex.org/W2012276721","https://openalex.org/W2013537373","https://openalex.org/W2023374425","https://openalex.org/W2023895580","https://openalex.org/W2028040595","https://openalex.org/W2039575792","https://openalex.org/W2043776284","https://openalex.org/W2043972688","https://openalex.org/W2047242201","https://openalex.org/W2048289333","https://openalex.org/W2051875036","https://openalex.org/W2052701304","https://openalex.org/W2054537564","https://openalex.org/W2058184154","https://openalex.org/W2059716720","https://openalex.org/W2062612181","https://openalex.org/W2063156737","https://openalex.org/W2063391304","https://openalex.org/W2066264051","https://openalex.org/W2074433596","https://openalex.org/W2077372900","https://openalex.org/W2077569993","https://openalex.org/W2078374613","https://openalex.org/W2078881221","https://openalex.org/W2080884633","https://openalex.org/W2085419794","https://openalex.org/W2089417788","https://openalex.org/W2092507799","https://openalex.org/W2098012859","https://openalex.org/W2101308683","https://openalex.org/W2101988823","https://openalex.org/W2107112594","https://openalex.org/W2115427429","https://openalex.org/W2117479168","https://openalex.org/W2119551137","https://openalex.org/W2128186312","https://openalex.org/W2129191085","https://openalex.org/W2130266193","https://openalex.org/W2134009187","https://openalex.org/W2135411719","https://openalex.org/W2135658143","https://openalex.org/W2136907822","https://openalex.org/W2137124072","https://openalex.org/W2137413565","https://openalex.org/W2141511099","https://openalex.org/W2143278431","https://openalex.org/W2144707486","https://openalex.org/W2144851947","https://openalex.org/W2154027835","https://openalex.org/W2155142215","https://openalex.org/W2155384808","https://openalex.org/W2155784435","https://openalex.org/W2156311525","https://openalex.org/W2161437969","https://openalex.org/W2163549410","https://openalex.org/W2165091409","https://openalex.org/W2166630278","https://openalex.org/W2168199397","https://openalex.org/W2170498206","https://openalex.org/W2171261006","https://openalex.org/W2212405398","https://openalex.org/W2408889139","https://openalex.org/W2416730013"],"related_works":["https://openalex.org/W7008500926","https://openalex.org/W627783902","https://openalex.org/W7047631064","https://openalex.org/W2227794756","https://openalex.org/W2744118019","https://openalex.org/W2029550378","https://openalex.org/W2129663524","https://openalex.org/W2568066363","https://openalex.org/W2077556440","https://openalex.org/W1995582211"],"abstract_inverted_index":{"A":[0],"l":[1,79,139,212,217,241],"heure":[2],"actuelle,":[3],"les":[4,95,165,195],"protocoles":[5,245],"de":[6,26,34,39,49,81,89,98,138,148,179,231,243,250],"chimio-radioth\u00e9rapie":[7],"concomitante":[8],"font":[9],"preuve":[10],"d":[11,62,77,114,143,154,169],"une":[12,129,170,208,227],"grande":[13],"efficacit\u00e9":[14],"dans":[15,158,223,247],"la":[16,110,203],"prise":[17],"en":[18,32],"charge":[19],"des":[20,57,84,102,183],"tumeurs.":[21,225],"En":[22],"revanche,":[23],"le":[24,54,141,248],"traitement":[25,127],"certaines":[27,224],"tumeurs":[28],"reste":[29],"parfois":[30],"limit\u00e9":[31],"raison":[33],"leur":[35,40,69,82],"localisation":[36],"critique":[37],"ou":[38,66],"faible":[41,157],"radiosensibilit\u00e9":[42],"aux":[43],"radiations":[44,58],"conventionnelles":[45],".":[46],"Une":[47],"mani\u00e8re":[48,149],"contourner":[50],"ce":[51,232],"probl\u00e8me":[52],"est":[53],"recours":[55],"\u00e0":[56,59,131,200,237,240],"transfert":[60],"lin\u00e9ique":[61],"\u00e9nergie":[63],"(TLE)":[64],"\u00e9lev\u00e9":[65,133],"hadronth\u00e9rapie.":[67],"Cependant,":[68],"utilisation":[70],"seule":[71],"peut":[72],"encore":[73],"s":[74],"av\u00e9rer":[75],"insuffisante,":[76],"o\u00f9":[78],"int\u00e9r\u00eat":[80],"associer":[83],"agents":[85],"radiosensibilisateurs.":[86],"Au":[87],"cours":[88],"cette":[90],"th\u00e8se,":[91],"nous":[92,191],"avons":[93,120,162,192],"\u00e9valu\u00e9":[94],"effets":[96,166],"radiosensibilisateurs":[97],"diff\u00e9rentes":[99,189],"mol\u00e9cules":[100],"sur":[101,175,182],"lign\u00e9es":[103],"tumorales":[104],"humaines":[105],"radior\u00e9sistantes,":[106],"et":[107,137],"plus":[108],"particuli\u00e8rement":[109],"lign\u00e9e":[111],"SK-Hep1,":[112],"issue":[113],"un":[115,126,176],"carcinome":[116],"h\u00e9patocellulaire":[117],"(CHC).":[118],"Nous":[119,161],"ainsi":[121],"pu":[122,193],"montrer":[123],"qu":[124],"apr\u00e8s":[125,207],"combinant":[128],"irradiation":[130,171,210],"TLE":[132],"par":[134,172,188],"neutrons":[135,173],"rapides":[136,174],"oxaliplatine,":[140],"pourcentage":[142],"autophagie":[144],"in":[145,167,198],"vitro":[146],"augmentait":[147],"consid\u00e9rable,":[150],"contrairement":[151],"au":[152],"taux":[153],"apoptose,":[155],"tr\u00e8s":[156],"ces":[159,234],"cellules.":[160],"ensuite":[163],"\u00e9tudi\u00e9":[164],"vivo":[168],"mod\u00e8le":[177],"orthotopique":[178],"CHC":[180],"greff\u00e9":[181],"souris":[184],"nude.":[185],"Apr\u00e8s":[186,226],"analyse":[187,228],"techniques,":[190],"confirmer":[194],"observations":[196],"faites":[197],"vitro,":[199],"savoir":[201],"que":[202],"mort":[204],"cellulaire":[205],"pr\u00e9dominante":[206],"telle":[209],"\u00e9tait":[211],"autophagie.":[213],"Ces":[214],"r\u00e9sultats":[215],"r\u00e9v\u00e8lent":[216],"importance":[218],"du":[219],"ph\u00e9nom\u00e8ne":[220],"autophagique":[221],"radio-induit":[222],"m\u00e9canistique":[229],"approfondie":[230],"ph\u00e9nom\u00e8ne,":[233],"recherches":[235],"pourraient":[236],"terme":[238],"contribuer":[239],"\u00e9laboration":[242],"nouveaux":[244],"th\u00e9rapeutiques":[246],"cas":[249],"cancers":[251],"radior\u00e9sistants.":[252]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
