{"id":"https://openalex.org/W199915670","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1020-b","title":"Abstract 5871: Chronic Organic Mitral Regurgitation Results in Myofibrillar Degeneration and Oxidative Stress with Post-Surgical Left Ventricular Impairment Despite Pre-Surgical Left Ventricular Ejection Fraction > 60%","display_name":"Abstract 5871: Chronic Organic Mitral Regurgitation Results in Myofibrillar Degeneration and Oxidative Stress with Post-Surgical Left Ventricular Impairment Despite Pre-Surgical Left Ventricular Ejection Fraction > 60%","publication_year":2008,"publication_date":"2008-10-28","ids":{"openalex":"https://openalex.org/W199915670","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1020-b","mag":"199915670"},"language":"en","primary_location":{"id":"doi:10.1161/circ.118.suppl_18.s_1020-b","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1020-b","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1020-b","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103085312","display_name":"Mustafa I. Ahmed","orcid":"https://orcid.org/0009-0008-6842-6151","observed_orcids":["https://orcid.org/0009-0008-6842-6151"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mustafa I Ahmed","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047667800","display_name":"James D. Gladden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D Gladden","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040168425","display_name":"Steven G. Lloyd","orcid":"https://orcid.org/0000-0001-6843-0224","observed_orcids":["https://orcid.org/0000-0001-6843-0224"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven G Lloyd","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087241955","display_name":"Silvio Hector Litovsky","orcid":"https://orcid.org/0000-0002-3174-2192","observed_orcids":["https://orcid.org/0000-0002-3174-2192"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvio H Litovsky","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102007223","display_name":"Himanshu Gupta","orcid":"https://orcid.org/0000-0001-9428-4988","observed_orcids":["https://orcid.org/0000-0001-9428-4988"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Himanshu Gupta","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110452463","display_name":"Seidu Inusah","orcid":"https://orcid.org/0009-0005-2137-2713","observed_orcids":["https://orcid.org/0009-0005-2137-2713"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seidu Inusah","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022480407","display_name":"Thomas S. Denney","orcid":"https://orcid.org/0000-0002-6695-4777","observed_orcids":["https://orcid.org/0000-0002-6695-4777"]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Denney","raw_affiliation_strings":["Auburn Univ, Auburn, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auburn Univ, Auburn, AL","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039698601","display_name":"David C. McGiffin","orcid":"https://orcid.org/0000-0003-4894-2518","observed_orcids":["https://orcid.org/0000-0003-4894-2518"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C McGiffin","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053149684","display_name":"Louis J. Dell\u2019Italia","orcid":"https://orcid.org/0000-0001-6654-0665","observed_orcids":["https://orcid.org/0000-0001-6654-0665"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis J Dell\u2019Italia","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"suppl_18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitral-valve-repair","display_name":"mitral valve repair","score":0.9869999885559082},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction-decline","display_name":"left ventricular ejection fraction decline","score":0.75},{"id":"https://openalex.org/keywords/myofibrillar-degeneration","display_name":"myofibrillar degeneration","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cardiomyocyte-injury","display_name":"cardiomyocyte injury","score":0.8899999856948853},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9380000233650208},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lipofuscin-deposition","display_name":"lipofuscin deposition","score":0.9020000100135803},{"id":"https://openalex.org/keywords/left-ventricular-strain","display_name":"left ventricular strain","score":0.6830000281333923},{"id":"https://openalex.org/keywords/left-ventricular-end-diastolic-volume","display_name":"left ventricular end-diastolic volume","score":0.7459999918937683},{"id":"https://openalex.org/keywords/left-ventricular-remodeling","display_name":"left ventricular remodeling","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8943197727203369},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.824575662612915},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6779934763908386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6236739158630371},{"id":"https://openalex.org/C2993373945","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Mitral regurgitation","level":2,"score":0.5986124277114868},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.5929840207099915},{"id":"https://openalex.org/C2780679668","wikidata":"https://www.wikidata.org/wiki/Q6882374","display_name":"Mitral valve repair","level":3,"score":0.5432348251342773},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4995565414428711},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.49093297123908997},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.43430641293525696},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3891322910785675},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.118.suppl_18.s_1020-b","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1020-b","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1020-b","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2148544366","https://openalex.org/W2758839779","https://openalex.org/W2465220326","https://openalex.org/W1963525050","https://openalex.org/W2034053756","https://openalex.org/W2029485336","https://openalex.org/W4416690898","https://openalex.org/W4253537062","https://openalex.org/W2954622960","https://openalex.org/W3194806219"],"abstract_inverted_index":{"Background:":[0],"Current":[1],"guidelines":[2],"recommend":[3],"valve":[4,74,152],"repair":[5,244,287],"for":[6,93,216,323],"chronic":[7,293],"organic":[8],"mitral":[9,73,151],"regurgitation":[10],"(MR)":[11],"if":[12],"LVEF":[13,27,125,298],"drops":[14],"below":[15,162],"60%":[16],"to":[17,33,36,49,68,91,129,141,248],"preserve":[18],"LV":[19,76,135,155,189,194,280,340],"function":[20],"and":[21,30,69,101,103,115,134,157,172,187,308,331],"maximize":[22],"outcome.":[23],"Post-operative":[24],"drop":[25],"in":[26,38,63,184,226,263,292,336,343],"is":[28,301],"typical,":[29],"widely":[31],"believed":[32],"be":[34],"due":[35],"alteration":[37],"loading":[39],"conditions.":[40],"Here":[41],"we":[42],"address":[43],"whether":[44],"cardiomyocyte":[45,198,305],"damage":[46,310,335],"may":[47],"contribute":[48],"postoperative":[50],"dysfunction.":[51],"Methods:":[52],"Three-dimensional":[53],"magnetic":[54],"resonance":[55],"imaging":[56],"(3D-MRI)":[57],"with":[58],"tissue":[59],"tagging":[60],"was":[61,78,89,224,261],"performed":[62,90],"23":[64],"MR":[65,82,120,227,266,294],"patients,":[66],"prior":[67],"six":[70,116,148],"months":[71,117,149,284],"following":[72],"repair.":[75,154],"biopsy":[77],"obtained":[79],"from":[80],"all":[81],"patients":[83,121,295],"at":[84,311],"time":[85,313],"of":[86,95,105,258,265,314,321,339],"surgery.":[87,315],"Immunohistochemistry":[88],"assess":[92],"signs":[94],"oxidative":[96,222,259,309,332],"stress,":[97,260],"specifically":[98],"lipofuscin":[99],"deposition,":[100,255],"presence":[102],"quantity":[104],"xanthine":[106,217],"oxidase":[107,218],"(XO).":[108],"Plasma":[109],"XO":[110,241,330],"levels":[111],"were":[112],"measured":[113],"before,":[114],"post-surgery.":[118],"Results:":[119],"(n=23)":[122],"demonstrated":[123,196],"decreased":[124,161,242],"(62":[126],"\u00b1":[127,131,139,143,165,169,174,178,204,208,231,235,246,250,270,274],"1":[128],"54":[130],"2%":[132],"p=0.0002)":[133],"end-diastolic":[136],"volume":[137],"(116":[138],"5":[140,144],"79":[142],"ml/m":[145],"2":[146],"p<0.0001)":[147],"after":[150],"(MV)":[153],"circumferential":[156],"longitudinal":[158],"strain":[159,281],"rates":[160,282],"normal":[163],"(6.54":[164],"0.21":[166],"vs.":[167,176,201,206,228,233,267,272],"5.24":[168],"0.24":[170],"p=0.0001,":[171],"6.56":[173],"0.26":[175],"5.41":[177],"0.27":[179],"p=0.0084)":[180],"despite":[181,296],"no":[182],"change":[183],"blood":[185],"pressure":[186],"3-dimensional":[188],"end-systolic":[190],"radius/wall":[191],"thickness":[192],"ratios.":[193],"biopsies":[195],"marked":[197,304],"myofibrillar":[199,306],"degeneration":[200,212,307],"normals":[202,229,268],"(2.32":[203],"1.09":[205],"1.25":[207],"0.45,":[209],"p=0.0016,":[210],"mean":[211],"grade":[213],"[1\u20134]).":[214],"Immunostaining":[215],"(XO),":[219],"a":[220,256],"prominent":[221],"enzyme,":[223],"increased":[225,262],"(88":[230],"7":[232],"33":[234],"4%,":[236],"p":[237,276],"<0.01),":[238],"as":[239],"plasma":[240],"post-MV":[243],"(2.12":[245],"0.46":[247],"0.49":[249],"0.25":[251],"\u03bcU/mL,":[252],"p=0.008).":[253],"Lipofuscin":[254],"product":[257],"cardiomyocytes":[264],"(0.62":[269],"0.04":[271],"0.33":[273],"0.04%,":[275],"<0.01).":[277],"Conclusions:":[278],"Decreased":[279],"6":[283],"post":[285],"MV":[286],"indicate":[288],"myocyte":[289,334],"contractile":[290,341],"dysfunction":[291,342],"pre-surgical":[297],">60%.":[299],"This":[300],"supported":[302],"by":[303],"the":[312,337],"While":[316],"raising":[317],"questions":[318],"regarding":[319],"timing":[320],"surgery":[322],"MR,":[324],"these":[325],"findings":[326],"generate":[327],"hypothesis":[328],"concerning":[329],"stress-related":[333],"pathophysiology":[338],"MR.":[344]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
