{"id":"https://openalex.org/W1999088776","doi":"https://doi.org/10.1111/j.1365-3024.2007.00977.x","title":"Determinants of memory in experimental filarial infections in mice","display_name":"Determinants of memory in experimental filarial infections in mice","publication_year":2007,"publication_date":"2007-10-17","ids":{"openalex":"https://openalex.org/W1999088776","doi":"https://doi.org/10.1111/j.1365-3024.2007.00977.x","mag":"1999088776","pmid":"https://pubmed.ncbi.nlm.nih.gov/17944746"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-3024.2007.00977.x","doi":"https://doi.org/10.1111/j.1365-3024.2007.00977.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-3024.2007.00977.x","pdf_url":null,"source":{"id":"https://openalex.org/S80886111","display_name":"Parasite Immunology","issn_l":"0141-9838","issn":["0141-9838","1365-3024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasite Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024020730","display_name":"Yashodhara Dash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. DASH","raw_affiliation_strings":["Department of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA","Department of Immunology; University of Connecticut Health Center; Farmington CT USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"Department of Immunology; University of Connecticut Health Center; Farmington CT USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. RAMESH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. RAMESH","raw_affiliation_strings":["Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA,","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022634163","display_name":"Dale L. Greiner","orcid":"https://orcid.org/0000-0002-5923-339X","observed_orcids":["https://orcid.org/0000-0002-5923-339X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. GREINER","raw_affiliation_strings":["Department of Medicine; University of Massachusetts Medical Center; Worcester, MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine; University of Massachusetts Medical Center; Worcester, MA USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036394378","display_name":"Leonard D. Shultz","orcid":"https://orcid.org/0000-0002-4868-1031","observed_orcids":["https://orcid.org/0000-0002-4868-1031"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. D. SHULTZ","raw_affiliation_strings":["Jackson Laboratory, Bar Harbor, ME, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jackson Laboratory, Bar Harbor, ME, USA,","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059017136","display_name":"Thomas R. Klei","orcid":"https://orcid.org/0000-0002-2864-4073","observed_orcids":["https://orcid.org/0000-0002-2864-4073"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. R. KLEI","raw_affiliation_strings":["Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108693496","display_name":"Thiruchandurai V. Rajan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"T. V. RAJAN","raw_affiliation_strings":["Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA,","institution_ids":["https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5108693496"],"corresponding_institution_ids":["https://openalex.org/I75929689"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":0.21,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.60825749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"29","issue":"11","first_page":"567","last_page":"574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brugia-pahangi","display_name":"Brugia pahangi","score":0.9070000052452087},{"id":"https://openalex.org/keywords/filariasis","display_name":"filariasis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.527999997138977},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/t-cell-deficient-mice","display_name":"T cell-deficient mice","score":0.8080000281333923},{"id":"https://openalex.org/keywords/intraperitoneal-infection","display_name":"peritoneal infection","score":0.6510000228881836},{"id":"https://openalex.org/keywords/balb-cbyj-mice","display_name":"BALB/cByJ mice","score":0.746999979019165},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.9200000166893005},{"id":"https://openalex.org/keywords/recall-response","display_name":"recall response","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C2776573122","wikidata":"https://www.wikidata.org/wiki/Q4978677","display_name":"Brugia pahangi","level":3,"score":0.7686799168586731},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.736087441444397},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.6634206771850586},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6405659914016724},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.6117498874664307},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5660466551780701},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4516911506652832},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4209347665309906},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.41280800104141235},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3374604284763336},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12613606452941895},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.09006008505821228},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005368","descriptor_name":"Filariasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005368","descriptor_name":"Filariasis","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D005368","descriptor_name":"Filariasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017179","descriptor_name":"Brugia pahangi","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-3024.2007.00977.x","doi":"https://doi.org/10.1111/j.1365-3024.2007.00977.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-3024.2007.00977.x","pdf_url":null,"source":{"id":"https://openalex.org/S80886111","display_name":"Parasite Immunology","issn_l":"0141-9838","issn":["0141-9838","1365-3024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasite Immunology","raw_type":"journal-article"},{"id":"pmid:17944746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17944746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasite immunology","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:stfb2000_2009-2651","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb2000_2009/1652","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2000 - 2009","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W26122267","https://openalex.org/W1557436211","https://openalex.org/W1612135387","https://openalex.org/W1997075392","https://openalex.org/W1997320239","https://openalex.org/W2044961935","https://openalex.org/W2101154896","https://openalex.org/W2120473296","https://openalex.org/W2121576952","https://openalex.org/W2150866075","https://openalex.org/W2165782913","https://openalex.org/W2322449347","https://openalex.org/W6948344298"],"related_works":["https://openalex.org/W2102319031","https://openalex.org/W2108022900","https://openalex.org/W2165782913","https://openalex.org/W3112325921","https://openalex.org/W2150866075","https://openalex.org/W2124999100","https://openalex.org/W2054648552","https://openalex.org/W2117356632","https://openalex.org/W2398894357","https://openalex.org/W2004408321"],"abstract_inverted_index":{"In":[0],"this":[1],"communication,":[2],"we":[3,84,155],"examine":[4],"the":[5,26,32,74,81,149,152,184,200],"determinants":[6],"and":[7,186,194],"duration":[8],"of":[9,20,28,137,151,159,177,189],"memory":[10,33,82,153,201],"responses":[11,202],"against":[12,35],"filarial":[13],"parasites":[14],"using":[15],"an":[16,69,143],"intraperitoneal":[17,63],"mouse":[18],"model":[19],"Brugia":[21],"pahangi":[22,37,179],"infection.":[23],"We":[24,53,197],"assessed":[25],"role":[27],"T":[29,42,60,87,92,96,129],"cells":[30,43,61,88,93,97,130],"in":[31,68,203,212],"response":[34],"B.":[36,178],"larvae":[38,67,190],"by":[39],"transferring":[40],"splenic":[41],"from":[44,98],"wild-type":[45,160],"mice":[46,56,100,161,169,205,214],"primed":[47,59,101,156],"with":[48,58,65,105,173],"L3":[49,106],"into":[50,107],"T-cell-deficient":[51,108],"mice.":[52,111],"found":[54,198],"that":[55,76,123,199],"reconstituted":[57],"cleared":[62],"infections":[64],"infective":[66],"accelerated":[70],"manner.":[71],"To":[72,147],"determine":[73],"components":[75],"may":[77],"be":[78],"responsible":[79],"for":[80,142],"response,":[83,154],"transferred":[85],"unfractionated":[86],"or":[89,94,127],"purified":[90],"CD4+":[91,126],"CD8+":[95,128],"BALB/cByJ":[99,204],"a":[102,166,174,208],"month":[103],"earlier":[104],"BALB/c":[109],"TCRbeta-/-":[110],"Recipients":[112],"were":[113,170],"challenged":[114,172],"10":[115],"days":[116],"after":[117],"adoptive":[118],"transfer.":[119],"Our":[120],"data":[121],"demonstrated":[122],"while":[124],"either":[125],"are":[131,140],"able":[132],"to":[133],"confer":[134],"some":[135],"level":[136],"protection,":[138],"both":[139],"required":[141],"optimal":[144],"recall":[145],"response.":[146],"evaluate":[148],"longevity":[150],"several":[157],"groups":[158],"at":[162],"different":[163],"times":[164],"over":[165,207],"year.":[167],"These":[168],"then":[171],"single":[175],"injection":[176],"L3.":[180],"The":[181],"gap":[182],"between":[183,192],"priming":[185],"second":[187],"injections":[188],"ranged":[191],"4":[193],"60":[195],"weeks.":[196],"lasted":[206],"year":[209],"whereas":[210],"those":[211],"C57BL/6":[213],"waned":[215],"more":[216],"rapidly.":[217]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}