{"id":"https://openalex.org/W1999075455","doi":"https://doi.org/10.1007/bf00189409","title":"Inhibition (in vitro) of replication and of the cytopathic effect of human immunodeficiency virus by an extract of the culture medium of Lentinus edodes mycelia","display_name":"Inhibition (in vitro) of replication and of the cytopathic effect of human immunodeficiency virus by an extract of the culture medium of Lentinus edodes mycelia","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W1999075455","doi":"https://doi.org/10.1007/bf00189409","mag":"1999075455","pmid":"https://pubmed.ncbi.nlm.nih.gov/3173237"},"language":"en","primary_location":{"id":"doi:10.1007/bf00189409","doi":"https://doi.org/10.1007/bf00189409","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00189409","pdf_url":null,"source":{"id":"https://openalex.org/S182878189","display_name":"Medical Microbiology and Immunology","issn_l":"0044-3077","issn":["0044-3077","0300-8584","1432-1831"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Microbiology and Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111536573","display_name":"Tadafumi S. Tochikura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T.S. Tochikura","raw_affiliation_strings":["Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056038063","display_name":"Hiroshi Nakashima","orcid":"https://orcid.org/0000-0001-8096-6398","observed_orcids":["https://orcid.org/0000-0001-8096-6398"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Nakashima","raw_affiliation_strings":["Department of Virology and Parasitology, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, 755, Yamaguchi, Japan","Department of Virology and Parasitology, Yamaguchi University School of Medicine, Yamaguchi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology and Parasitology, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, 755, Yamaguchi, Japan","institution_ids":["https://openalex.org/I173915773"]},{"raw_affiliation_string":"Department of Virology and Parasitology, Yamaguchi University School of Medicine, Yamaguchi, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101567909","display_name":"Yoshifumi Ohashi","orcid":"https://orcid.org/0000-0002-7521-6928","observed_orcids":["https://orcid.org/0000-0002-7521-6928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Ohashi","raw_affiliation_strings":["Noda Shokukin Kogyo Co. Ltd., 121 Shimizu, Noda, 278, Chiba, Japan","Noda Shokukin Kogyo Co. Ltd., Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Noda Shokukin Kogyo Co. Ltd., 121 Shimizu, Noda, 278, Chiba, Japan","institution_ids":[]},{"raw_affiliation_string":"Noda Shokukin Kogyo Co. Ltd., Chiba, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006845416","display_name":"Naoki Yamamoto","orcid":"https://orcid.org/0009-0001-7364-9543","observed_orcids":["https://orcid.org/0009-0001-7364-9543","https://orcid.org/0009-0004-8616-175X"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Yamamoto","raw_affiliation_strings":["Department of Virology and Parasitology, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, 755, Yamaguchi, Japan","Department of Virology and Parasitology, Yamaguchi University School of Medicine, Yamaguchi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology and Parasitology, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, 755, Yamaguchi, Japan","institution_ids":["https://openalex.org/I173915773"]},{"raw_affiliation_string":"Department of Virology and Parasitology, Yamaguchi University School of Medicine, Yamaguchi, Japan","institution_ids":["https://openalex.org/I173915773"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":null,"fwci":0.7556,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.6666022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"177","issue":"5","first_page":"235","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.11509999632835388,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lentinula-edodes","display_name":"shiitake mushroom","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hiv-replication-inhibition","display_name":"HIV replication inhibition","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cytopathic-effect","display_name":"cytopathic effect","score":0.9539999961853027},{"id":"https://openalex.org/keywords/multinucleated-giant-cells","display_name":"multinucleated giant cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mt-4-cells","display_name":"MT-4 cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/molt-4-cells","display_name":"MOLT-4 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2775996393","wikidata":"https://www.wikidata.org/wiki/Q1149147","display_name":"Cytopathic effect","level":3,"score":0.8040614724159241},{"id":"https://openalex.org/C2779220235","wikidata":"https://www.wikidata.org/wiki/Q2033960","display_name":"Lentinus","level":3,"score":0.7263370752334595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6416403651237488},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.633647620677948},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5944875478744507},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.593639612197876},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5674633383750916},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.46298399567604065},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.45353883504867554},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4155750274658203},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37831059098243713},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15740156173706055},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1355563998222351},{"id":"https://openalex.org/C2776474821","wikidata":"https://www.wikidata.org/wiki/Q83093","display_name":"Mushroom","level":2,"score":0.09030020236968994},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001487","descriptor_name":"Basidiomycota","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003588","descriptor_name":"Cytopathogenic Effect, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009189","descriptor_name":"Avian Myeloblastosis Virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011124","descriptor_name":"Polyporaceae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D011124","descriptor_name":"Polyporaceae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015490","descriptor_name":"HTLV-I Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015490","descriptor_name":"HTLV-I Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00189409","doi":"https://doi.org/10.1007/bf00189409","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00189409","pdf_url":null,"source":{"id":"https://openalex.org/S182878189","display_name":"Medical Microbiology and Immunology","issn_l":"0044-3077","issn":["0044-3077","0300-8584","1432-1831"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Microbiology and Immunology","raw_type":"journal-article"},{"id":"pmid:3173237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3173237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical microbiology and immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1593836724","https://openalex.org/W1969604023","https://openalex.org/W1977282539","https://openalex.org/W1979328848","https://openalex.org/W1991670386","https://openalex.org/W1997685222","https://openalex.org/W2004796290","https://openalex.org/W2008791719","https://openalex.org/W2015326137","https://openalex.org/W2015386472","https://openalex.org/W2060116991","https://openalex.org/W2060558597","https://openalex.org/W2060613726","https://openalex.org/W2065985904","https://openalex.org/W2067170143","https://openalex.org/W2087130744","https://openalex.org/W2104815294","https://openalex.org/W2110917275","https://openalex.org/W2117149353","https://openalex.org/W2124479482","https://openalex.org/W2129248774","https://openalex.org/W2133764756","https://openalex.org/W2137267461","https://openalex.org/W2141152969","https://openalex.org/W2148013683","https://openalex.org/W2154464018","https://openalex.org/W2322885282","https://openalex.org/W2492970920","https://openalex.org/W4299712811"],"related_works":["https://openalex.org/W2009575408","https://openalex.org/W4234619225","https://openalex.org/W2008469082","https://openalex.org/W2039127838","https://openalex.org/W2187813958","https://openalex.org/W2801275484","https://openalex.org/W2080709282","https://openalex.org/W2045175773","https://openalex.org/W2131526152","https://openalex.org/W2075131321"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}