{"id":"https://openalex.org/W1998996148","doi":"https://doi.org/10.1097/sap.0b013e31817762fd","title":"Topical Negative Pressure Stimulates Endothelial Migration and Proliferation","display_name":"Topical Negative Pressure Stimulates Endothelial Migration and Proliferation","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1998996148","doi":"https://doi.org/10.1097/sap.0b013e31817762fd","mag":"1998996148","pmid":"https://pubmed.ncbi.nlm.nih.gov/19131729"},"language":"en","primary_location":{"id":"doi:10.1097/sap.0b013e31817762fd","doi":"https://doi.org/10.1097/sap.0b013e31817762fd","is_oa":false,"landing_page_url":"https://doi.org/10.1097/sap.0b013e31817762fd","pdf_url":null,"source":{"id":"https://openalex.org/S11131942","display_name":"Annals of Plastic Surgery","issn_l":"0148-7043","issn":["0148-7043","1536-3708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Plastic Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Christopher Baldwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]},{"id":"https://openalex.org/I4210136503","display_name":"RAFT","ror":"https://ror.org/03n4ayy20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210136503"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher Baldwin","raw_affiliation_strings":["RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood, UK","RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood, UK","institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I4210136503"]},{"raw_affiliation_string":"RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood","institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I4210136503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109115687","display_name":"Matthew Potter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]},{"id":"https://openalex.org/I4210136503","display_name":"RAFT","ror":"https://ror.org/03n4ayy20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210136503"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Matthew Potter","raw_affiliation_strings":["RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood","institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I4210136503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108429593","display_name":"Elizabeth Clayton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]},{"id":"https://openalex.org/I4210136503","display_name":"RAFT","ror":"https://ror.org/03n4ayy20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210136503"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Elizabeth Clayton","raw_affiliation_strings":["RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood","institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I4210136503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113767142","display_name":"Laurie Montgomery Irvine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801227293","display_name":"Watford General Hospital","ror":"https://ror.org/01v13p275","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800621266","https://openalex.org/I2801227293"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laurie Irvine","raw_affiliation_strings":["Watford General Hospital, Watford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Watford General Hospital, Watford, UK","institution_ids":["https://openalex.org/I2801227293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075675089","display_name":"Julian F. Dye","orcid":"https://orcid.org/0000-0001-7634-2822","observed_orcids":["https://orcid.org/0000-0001-7634-2822"]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]},{"id":"https://openalex.org/I4210136503","display_name":"RAFT","ror":"https://ror.org/03n4ayy20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210136503"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Julian Dye","raw_affiliation_strings":["RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood","institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I4210136503"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075675089","https://openalex.org/A5108429593","https://openalex.org/A5109115687"],"corresponding_institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I4210136503"],"apc_list":null,"apc_paid":null,"fwci":5.5234,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.95456491,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"62","issue":"1","first_page":"92","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topical-negative-pressure","display_name":"topical negative pressure","score":0.9480000138282776},{"id":"https://openalex.org/keywords/negative-pressure-wound-therapy","display_name":"negative pressure wound therapy","score":0.7509999871253967},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.9610000252723694},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/microvascular-endothelial-cells","display_name":"microvascular endothelial cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.9639999866485596},{"id":"https://openalex.org/keywords/integra","display_name":"Integra","score":0.8730000257492065},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7567906379699707},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7369384169578552},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6728267073631287},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6336790323257446},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6147202253341675},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5347724556922913},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4611110985279083},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4154786765575409},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38718175888061523},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3241470456123352},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2873583137989044},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.21308022737503052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14748895168304443},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.09448346495628357},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06014949083328247}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002809","descriptor_name":"Chondroitin Sulfates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054843","descriptor_name":"Negative-Pressure Wound Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/sap.0b013e31817762fd","doi":"https://doi.org/10.1097/sap.0b013e31817762fd","is_oa":false,"landing_page_url":"https://doi.org/10.1097/sap.0b013e31817762fd","pdf_url":null,"source":{"id":"https://openalex.org/S11131942","display_name":"Annals of Plastic Surgery","issn_l":"0148-7043","issn":["0148-7043","1536-3708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Plastic Surgery","raw_type":"journal-article"},{"id":"pmid:19131729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19131729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of plastic surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1957106","https://openalex.org/W46374681","https://openalex.org/W1569577235","https://openalex.org/W1963630554","https://openalex.org/W1970318846","https://openalex.org/W1981060398","https://openalex.org/W1982105288","https://openalex.org/W1983090554","https://openalex.org/W1984626484","https://openalex.org/W1984669542","https://openalex.org/W1993140461","https://openalex.org/W2010546098","https://openalex.org/W2017519300","https://openalex.org/W2026640136","https://openalex.org/W2028359498","https://openalex.org/W2028609922","https://openalex.org/W2037413874","https://openalex.org/W2065930566","https://openalex.org/W2067508176","https://openalex.org/W2069888703","https://openalex.org/W2082925748","https://openalex.org/W2084477726","https://openalex.org/W2088765890","https://openalex.org/W2114761298","https://openalex.org/W2118161860","https://openalex.org/W2125240138","https://openalex.org/W2137305295","https://openalex.org/W2151350356","https://openalex.org/W2169898283","https://openalex.org/W2472167186","https://openalex.org/W4233068027","https://openalex.org/W4292425573"],"related_works":["https://openalex.org/W2155841592","https://openalex.org/W4310135751","https://openalex.org/W2139303015","https://openalex.org/W3169378273","https://openalex.org/W3029544576","https://openalex.org/W3169257302","https://openalex.org/W3033734156","https://openalex.org/W7138039775","https://openalex.org/W2279110546","https://openalex.org/W7124464348"],"abstract_inverted_index":{"Topical":[0],"negative":[1,32,56,124,145],"pressure":[2,33,106,146],"is":[3,117],"an":[4,23,137],"effective":[5],"technique":[6],"to":[7,27,52,94,110],"promote":[8],"wound":[9,148],"healing":[10],"and":[11,17,50,69,79,92,113],"the":[12,29,65,100],"integration":[13],"of":[14,31,61],"skin":[15],"graft":[16],"synthetic":[18],"dermal":[19,131],"equivalents.":[20],"We":[21],"describe":[22],"in":[24],"vitro":[25],"model":[26],"investigate":[28],"effect":[30,129],"on":[34,48,130],"angiogenesis,":[35],"a":[36,90,111],"pivotal":[37],"step.":[38],"Dermal":[39],"fibroblasts":[40,97],"or":[41,54],"human":[42],"microvascular":[43],"endothelial":[44,87,108],"cells":[45,88],"were":[46],"cultured":[47],"Integra":[49,66,101],"subjected":[51],"intermittent":[53,120],"continuous":[55,123],"pressure.":[57,125],"At":[58],"fixed":[59,68],"intervals":[60],"over":[62],"120":[63],"hours,":[64],"was":[67],"assessed":[70],"for":[71],"cell":[72,75,80,109],"migration":[73],"(microscopy),":[74],"viability":[76],"(MTS":[77],"assay),":[78],"proliferation":[81],"(Ki67":[82],"immunostaining).":[83],"Under":[84],"control":[85],"conditions,":[86],"formed":[89],"monolayer":[91],"failed":[93],"ingress,":[95],"whereas":[96],"migrated":[98],"throughout":[99],"within":[102],"24":[103],"hours.":[104],"Negative":[105],"switches":[107],"migratory":[112],"proliferative":[114],"phenotype.":[115],"Ingress":[116],"greatest":[118],"with":[119],"rather":[121],"than":[122],"It":[126],"has":[127],"no":[128],"fibroblast":[132],"function.":[133],"This":[134],"study":[135],"identifies":[136],"important,":[138],"potential":[139],"pro-angiogenic":[140],"mechanism":[141],"by":[142],"which":[143],"topical":[144],"promotes":[147],"healing.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}