{"id":"https://openalex.org/W1998987725","doi":"https://doi.org/10.1021/bp00018a009","title":"Dextran Retention in the Rat Brain Following Release from a Polymer Implant","display_name":"Dextran Retention in the Rat Brain Following Release from a Polymer Implant","publication_year":1992,"publication_date":"1992-11-01","ids":{"openalex":"https://openalex.org/W1998987725","doi":"https://doi.org/10.1021/bp00018a009","mag":"1998987725","pmid":"https://pubmed.ncbi.nlm.nih.gov/1282018"},"language":"en","primary_location":{"id":"doi:10.1021/bp00018a009","doi":"https://doi.org/10.1021/bp00018a009","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bp00018a009","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wenbin Dang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenbin Dang","raw_affiliation_strings":["Department of Chemical Engineering, Johns Hopkins University, Baltimore, Maryland 21218","Departments of Chemical Engineering and Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Departments of Chemical Engineering and Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012106344","display_name":"W. Mark Saltzman","orcid":"https://orcid.org/0000-0002-2163-549X","observed_orcids":["https://orcid.org/0000-0002-2163-549X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. Mark Saltzman","raw_affiliation_strings":["Departments of Chemical Engineering and Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012106344"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":1.514,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.76669086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"8","issue":"6","first_page":"527","last_page":"532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.04129999876022339,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracranial-drug-delivery","display_name":"intracranial drug delivery","score":0.7300000190734863},{"id":"https://openalex.org/keywords/controlled-release-polymers","display_name":"controlled release polymers","score":0.8840000033378601},{"id":"https://openalex.org/keywords/sebacic-acid","display_name":"sebacic acid","score":0.7139999866485596},{"id":"https://openalex.org/keywords/fatty-acid-dimers","display_name":"fatty acid dimers","score":0.9229999780654907},{"id":"https://openalex.org/keywords/molecular-weight-dependence","display_name":"molecular weight dependence","score":0.7409999966621399},{"id":"https://openalex.org/keywords/brain-extracellular-space","display_name":"brain extracellular space","score":0.7639999985694885},{"id":"https://openalex.org/keywords/tracer-diffusion","display_name":"tracer diffusion","score":0.5690000057220459},{"id":"https://openalex.org/keywords/elimination-rate","display_name":"elimination rate","score":0.5630000233650208},{"id":"https://openalex.org/keywords/fitc-dextran","display_name":"FITC-dextran","score":0.8640000224113464},{"id":"https://openalex.org/keywords/fluorescein","display_name":"fluorescein","score":0.9300000071525574},{"id":"https://openalex.org/keywords/neural-implants","display_name":"neural implants","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.9191634058952332},{"id":"https://openalex.org/C2778015030","wikidata":"https://www.wikidata.org/wiki/Q410922","display_name":"Fluorescein","level":3,"score":0.8833149671554565},{"id":"https://openalex.org/C2777019933","wikidata":"https://www.wikidata.org/wiki/Q853845","display_name":"Fluorescein isothiocyanate","level":3,"score":0.708156406879425},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6554238796234131},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3983559310436249},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3913196325302124},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.3485143780708313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3295276165008545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10347869992256165},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016650","descriptor_name":"Fluorescein-5-isothiocyanate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D016650","descriptor_name":"Fluorescein-5-isothiocyanate","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bp00018a009","doi":"https://doi.org/10.1021/bp00018a009","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bp00018a009","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},{"id":"pmid:1282018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1282018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology progress","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2857335507","display_name":"POLYMERIC CONTROLLED RELEASE --NEUROLOGICAL APPLICATION","funder_award_id":"1r01ns027961-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7529318193","display_name":null,"funder_award_id":"NS-27961","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G864520458","display_name":null,"funder_award_id":"CA52857","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W591403642","https://openalex.org/W1581170315","https://openalex.org/W1954279215","https://openalex.org/W1983007289","https://openalex.org/W1994252309","https://openalex.org/W1995258879","https://openalex.org/W2006328841","https://openalex.org/W2024889831","https://openalex.org/W2025940959","https://openalex.org/W2033595979","https://openalex.org/W2061060077","https://openalex.org/W2063066300","https://openalex.org/W2069277230","https://openalex.org/W2071675260","https://openalex.org/W2079539618","https://openalex.org/W2082032025","https://openalex.org/W2083280522","https://openalex.org/W2085977293","https://openalex.org/W2086470645","https://openalex.org/W2092226976","https://openalex.org/W2099435753","https://openalex.org/W2149145595","https://openalex.org/W2326565381","https://openalex.org/W2398919304","https://openalex.org/W2415480725","https://openalex.org/W2415517196"],"related_works":["https://openalex.org/W2083280522","https://openalex.org/W2033595979","https://openalex.org/W2626443850","https://openalex.org/W205461530","https://openalex.org/W2738545266","https://openalex.org/W2506113361","https://openalex.org/W2033398961","https://openalex.org/W2005182433","https://openalex.org/W1992987500","https://openalex.org/W3135252607"],"abstract_inverted_index":{"Intracranial":[0],"controlled":[1],"release":[2,52],"polymers":[3],"may":[4],"improve":[5],"drug":[6,31],"administration":[7],"to":[8,17,24],"the":[9,18,28,48,127,160,171,180,210,225],"brain,":[10],"where":[11],"therapy":[12],"is":[13],"frequently":[14],"limited":[15],"due":[16],"low":[19],"permeability":[20],"of":[21,30,63,68,95,120,144,162,203,206],"brain":[22,49,172,181,211,226],"capillaries":[23],"therapeutic":[25],"agents.":[26],"On":[27],"basis":[29],"transport":[32],"and":[33,105,136],"elimination":[34],"rates,":[35],"we":[36],"proposed":[37],"that":[38],"high":[39],"molecular":[40,65,82,187,233],"weight,":[41],"water-soluble":[42],"molecules":[43],"would":[44],"be":[45],"retained":[46],"in":[47,93,108,115,224],"space":[50],"following":[51],"from":[53,100,126,209],"an":[54],"intracranial":[55],"implant.":[56],"To":[57],"test":[58],"this":[59],"hypothesis,":[60],"solid":[61],"particles":[62],"different":[64],"weight":[66,83,188,234],"fractions":[67,119],"fluorescein":[69,89,137,158],"isothiocyanate":[70],"labeled":[71],"dextran":[72],"(FITC-dextran;":[73],"4":[74,132,153,195,237],"x":[75],"10(3)":[76],"Da":[77],"(4":[78],"kDa)":[79,87],"<":[80,85],"weight-averaged":[81],"(Mw)":[84],"150":[86],"or":[88,157],"were":[90,124,138,167,182],"uniformly":[91],"dispersed":[92],"matrices":[94,146],"a":[96,101,109,219],"polyanhydride":[97],"copolymer":[98],"synthesized":[99],"fatty":[102],"acid":[103,107],"dimer":[104],"sebacic":[106],"50:50":[110],"ratio,":[111],"P(FAD:SA).":[112],"When":[113],"incubated":[114],"buffered":[116],"saline,":[117],"FITC-dextran":[118,135,193,198,240],"70":[121,149,242],"kDa":[122,133,150,154,191,196,238,243],"Mw":[123,134,151,155,192,197,239,244],"released":[125,139,169],"polymer":[128],"within":[129,179],"48":[130],"h;":[131],"more":[140],"slowly.":[141],"Following":[142],"implantation":[143],"P(FAD:SA)":[145],"containing":[147],"either":[148],"FITC-dextran,":[152,156],"into":[159,170],"brains":[161],"normal":[163],"rats,":[164],"fluorescent":[165],"tracers":[166,189],"continuously":[168],"tissue":[173],"for":[174,185],"30":[175],"days.":[176],"Tracer":[177],"concentrations":[178],"significantly":[183],"higher":[184],"large":[186],"(70":[190],">>":[194],">":[199,236,241],"fluorescein).":[200],"The":[201],"rate":[202],"elimination,":[204],"kapp,":[205],"each":[207],"tracer":[208,222],"was":[212],"determined":[213],"by":[214],"comparing":[215],"experimental":[216],"data":[217],"with":[218,231],"model":[220],"describing":[221],"diffusion/elimination":[223],"extracellular":[227],"space;":[228],"kapp":[229],"decreased":[230],"increasing":[232],"(fluorescein":[235],"FITC-dextran).":[245]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}