{"id":"https://openalex.org/W1998936348","doi":"https://doi.org/10.1128/jb.01327-13","title":"An Archaeal Glutamate Decarboxylase Homolog Functions as an Aspartate Decarboxylase and Is Involved in \u03b2-Alanine and Coenzyme A Biosynthesis","display_name":"An Archaeal Glutamate Decarboxylase Homolog Functions as an Aspartate Decarboxylase and Is Involved in \u03b2-Alanine and Coenzyme A Biosynthesis","publication_year":2014,"publication_date":"2014-01-11","ids":{"openalex":"https://openalex.org/W1998936348","doi":"https://doi.org/10.1128/jb.01327-13","mag":"1998936348","pmid":"https://pubmed.ncbi.nlm.nih.gov/24415726","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3957723"},"language":"en","primary_location":{"id":"doi:10.1128/jb.01327-13","doi":"https://doi.org/10.1128/jb.01327-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.01327-13","pdf_url":"https://jb.asm.org/content/jb/196/6/1222.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jb.asm.org/content/jb/196/6/1222.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039772684","display_name":"Hiroya Tomita","orcid":"https://orcid.org/0000-0001-7967-921X","observed_orcids":["https://orcid.org/0000-0001-7967-921X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroya Tomita","raw_affiliation_strings":["Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040950344","display_name":"Yuusuke Yokooji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuusuke Yokooji","raw_affiliation_strings":["Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takuya Ishibashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Ishibashi","raw_affiliation_strings":["Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102071497","display_name":"Tadayuki Imanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135768898","display_name":"Ritsumeikan University","ror":"https://ror.org/0197nmd03","country_code":"JP","type":"education","lineage":["https://openalex.org/I135768898","https://openalex.org/I4390039241"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadayuki Imanaka","raw_affiliation_strings":["Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu, Japan","JST, CREST, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu, Japan","institution_ids":["https://openalex.org/I135768898"]},{"raw_affiliation_string":"JST, CREST, Tokyo, Japan","institution_ids":["https://openalex.org/I4210086780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062941634","display_name":"Haruyuki Atomi","orcid":"https://orcid.org/0000-0001-9687-6426","observed_orcids":["https://orcid.org/0000-0001-9687-6426"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruyuki Atomi","raw_affiliation_strings":["Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan","JST, CREST, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"JST, CREST, Tokyo, Japan","institution_ids":["https://openalex.org/I4210086780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.503,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.78148649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"196","issue":"6","first_page":"1222","last_page":"1230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.29589998722076416,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.29589998722076416,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.2786000072956085,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.1339000016450882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspartate-decarboxylase","display_name":"aspartate decarboxylase","score":0.8999999761581421},{"id":"https://openalex.org/keywords/coenzyme-a-biosynthesis","display_name":"coenzyme A biosynthesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thermococcus-kodakarensis","display_name":"Thermococcus kodakarensis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hyperthermophilic-archaea","display_name":"hyperthermophilic archaea","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pyridoxal-5-phosphate-cofactor","display_name":"pyridoxal 5'-phosphate cofactor","score":0.8930000066757202},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.45899999141693115},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.7749714851379395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7501125335693359},{"id":"https://openalex.org/C2780595602","wikidata":"https://www.wikidata.org/wiki/Q898436","display_name":"Decarboxylation","level":3,"score":0.7368614673614502},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.6511635780334473},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5602173805236816},{"id":"https://openalex.org/C550995028","wikidata":"https://www.wikidata.org/wiki/Q10872","display_name":"Archaea","level":3,"score":0.5545951128005981},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.55159592628479},{"id":"https://openalex.org/C2780627266","wikidata":"https://www.wikidata.org/wiki/Q417781","display_name":"Carboxy-lyases","level":3,"score":0.5457285642623901},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.5256879329681396},{"id":"https://openalex.org/C2779123261","wikidata":"https://www.wikidata.org/wiki/Q407635","display_name":"Coenzyme A","level":4,"score":0.4449740946292877},{"id":"https://openalex.org/C2778899470","wikidata":"https://www.wikidata.org/wiki/Q2710532","display_name":"Thermococcus","level":4,"score":0.44126948714256287},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3860202431678772},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18782824277877808},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.07017332315444946},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003065","descriptor_name":"Coenzyme A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011732","descriptor_name":"Pyridoxal Phosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019712","descriptor_name":"Thermococcus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D019712","descriptor_name":"Thermococcus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019712","descriptor_name":"Thermococcus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D019843","descriptor_name":"Archaeal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jb.01327-13","doi":"https://doi.org/10.1128/jb.01327-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.01327-13","pdf_url":"https://jb.asm.org/content/jb/196/6/1222.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmid:24415726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24415726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3957723","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3957723/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.884.9143","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.884.9143","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jb.asm.org/content/196/6/1222.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1128/jb.01327-13","doi":"https://doi.org/10.1128/jb.01327-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.01327-13","pdf_url":"https://jb.asm.org/content/jb/196/6/1222.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998936348.pdf"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W102253821","https://openalex.org/W129435480","https://openalex.org/W1494994900","https://openalex.org/W1505743758","https://openalex.org/W1507468227","https://openalex.org/W1563355822","https://openalex.org/W1597470737","https://openalex.org/W1605797683","https://openalex.org/W1880504515","https://openalex.org/W1968215707","https://openalex.org/W1982847785","https://openalex.org/W1989427529","https://openalex.org/W1990105826","https://openalex.org/W1990693599","https://openalex.org/W1998209012","https://openalex.org/W2005002861","https://openalex.org/W2013947063","https://openalex.org/W2019879105","https://openalex.org/W2022966294","https://openalex.org/W2024299510","https://openalex.org/W2024328209","https://openalex.org/W2041760333","https://openalex.org/W2053993498","https://openalex.org/W2054830619","https://openalex.org/W2062462021","https://openalex.org/W2062690710","https://openalex.org/W2070266683","https://openalex.org/W2075323978","https://openalex.org/W2083294419","https://openalex.org/W2097706568","https://openalex.org/W2100737694","https://openalex.org/W2108836154","https://openalex.org/W2113677520","https://openalex.org/W2121404986","https://openalex.org/W2125309314","https://openalex.org/W2127128472","https://openalex.org/W2130292311","https://openalex.org/W2131105371","https://openalex.org/W2137983526","https://openalex.org/W2141995133","https://openalex.org/W2147008397","https://openalex.org/W2147418844","https://openalex.org/W2147670977","https://openalex.org/W2158419708","https://openalex.org/W2165331908","https://openalex.org/W2169942612","https://openalex.org/W6999277025"],"related_works":["https://openalex.org/W7096541672","https://openalex.org/W2160845504","https://openalex.org/W2983746707","https://openalex.org/W2165331908","https://openalex.org/W2125309314","https://openalex.org/W5738589","https://openalex.org/W2210033408","https://openalex.org/W2024299510","https://openalex.org/W2012256457","https://openalex.org/W2552154453"],"abstract_inverted_index":{"\u03b2-Alanine":[0,22],"is":[1,10,23,213],"a":[2,11,73,79,128,147,159,232],"precursor":[3],"for":[4,13,200,216,241],"coenzyme":[5],"A":[6],"(CoA)":[7],"biosynthesis":[8,67,243],"and":[9,18,30,75,237],"substrate":[12,141],"the":[14,33,42,47,63,88,104,134,175,197,208,221],"bacterial/eukaryotic":[15],"pantothenate":[16],"synthetase":[17],"archaeal":[19],"phosphopantothenate":[20],"synthetase.":[21],"synthesized":[24],"through":[25],"various":[26],"enzymes/pathways":[27],"in":[28,52,96,150,158,165,193,224,231,244],"bacteria":[29],"eukaryotes,":[31],"including":[32],"direct":[34],"decarboxylation":[35,105],"of":[36,44,49,56,65,100,106,155,169,211,235],"Asp":[37,138],"by":[38,85],"aspartate":[39],"1-decarboxylase":[40],"(ADC),":[41],"degradation":[43],"pyrimidine,":[45],"or":[46,172],"oxidation":[48],"polyamines.":[50],"However,":[51],"most":[53],"archaea,":[54],"homologs":[55,228],"these":[57,245],"enzymes":[58],"are":[59,94,229],"not":[60,116,163,214],"present;":[61],"thus,":[62],"mechanisms":[64],"\u03b2-alanine":[66,198,242],"remain":[68],"unclear.":[69],"Here,":[70],"we":[71],"performed":[72],"biochemical":[74],"genetic":[76,185],"study":[77],"on":[78],"glutamate":[80],"decarboxylase":[81],"(GAD)":[82],"homolog":[83],"encoded":[84],"TK1814":[86,113,135,156,188,212,227],"from":[87],"hyperthermophilic":[89],"archaeon":[90],"Thermococcus":[91],"kodakarensis.":[92],"GADs":[93],"distributed":[95,230],"all":[97],"three":[98],"domains":[99],"life,":[101],"generally":[102],"catalyzing":[103],"Glu":[107],"to":[108],"\u03b3-aminobutyrate":[109],"(GABA).":[110],"The":[111,203],"recombinant":[112],"protein":[114,136],"displayed":[115],"only":[117],"GAD":[118,209],"activity":[119,123,210],"but":[120],"also":[121,205],"ADC":[122,192],"using":[124],"pyridoxal":[125],"5'-phosphate":[126],"as":[127,139,190],"cofactor.":[129],"Kinetic":[130],"studies":[131],"revealed":[132],"that":[133,161,187,207],"prefers":[137],"its":[140],"rather":[142],"than":[143],"Glu,":[144],"with":[145],"nearly":[146],"20-fold":[148],"difference":[149],"catalytic":[151],"efficiency.":[152],"Gene":[153],"disruption":[154],"resulted":[157],"strain":[160],"could":[162,180],"grow":[164],"standard":[166],"medium.":[167],"Addition":[168],"\u03b2-alanine,":[170],"4'-phosphopantothenate,":[171],"CoA":[173,201],"complemented":[174],"growth":[176],"defect,":[177],"whereas":[178],"GABA":[179],"not.":[181],"Our":[182],"results":[183,204],"provide":[184],"evidence":[186],"functions":[189],"an":[191],"T.":[194],"kodakarensis,":[195],"providing":[196],"necessary":[199,215],"biosynthesis.":[202],"suggest":[206],"growth,":[217],"at":[218],"least":[219],"under":[220],"conditions":[222],"applied":[223],"this":[225],"study.":[226],"wide":[233],"range":[234],"archaea":[236],"may":[238],"be":[239],"responsible":[240],"organisms.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}