{"id":"https://openalex.org/W1998929301","doi":"https://doi.org/10.1104/pp.70.3.833","title":"Enzymological Basis for Herbicidal Action of Glyphosate","display_name":"Enzymological Basis for Herbicidal Action of Glyphosate","publication_year":1982,"publication_date":"1982-09-01","ids":{"openalex":"https://openalex.org/W1998929301","doi":"https://doi.org/10.1104/pp.70.3.833","mag":"1998929301","pmid":"https://pubmed.ncbi.nlm.nih.gov/16662584","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1065779"},"language":"en","primary_location":{"id":"doi:10.1104/pp.70.3.833","doi":"https://doi.org/10.1104/pp.70.3.833","is_oa":true,"landing_page_url":"https://doi.org/10.1104/pp.70.3.833","pdf_url":"https://academic.oup.com/plphys/article-pdf/70/3/833/35602730/plphys_v70_3_833.pdf","source":{"id":"https://openalex.org/S42294715","display_name":"PLANT PHYSIOLOGY","issn_l":"0032-0889","issn":["0032-0889","1532-2548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/plphys/article-pdf/70/3/833/35602730/plphys_v70_3_833.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019546021","display_name":"Judith L. Rubin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith L. Rubin","raw_affiliation_strings":["Center for Somatic-Cell Genetics and Biochemistry, State University of New York at Binghamton, Binghamton, New York 13901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Somatic-Cell Genetics and Biochemistry, State University of New York at Binghamton, Binghamton, New York 13901","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023197970","display_name":"Charles G. Gaines","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles G. Gaines","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024030506","display_name":"Roy A. Jensen","orcid":"https://orcid.org/0000-0003-4430-2281","observed_orcids":["https://orcid.org/0000-0003-4430-2281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roy A. Jensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3851,"currency":"USD","value_usd":3851},"apc_paid":null,"fwci":10.7379,"has_fulltext":true,"cited_by_count":104,"citation_normalized_percentile":{"value":0.98605557,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"70","issue":"3","first_page":"833","last_page":"839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10774","display_name":"Weed Control and Herbicide Applications","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10774","display_name":"Weed Control and Herbicide Applications","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11180","display_name":"Pesticide and Herbicide Environmental Studies","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12058","display_name":"Allelopathy and phytotoxic interactions","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glyphosate","display_name":"glyphosate","score":0.9959999918937683},{"id":"https://openalex.org/keywords/aromatic-amino-acid-biosynthesis","display_name":"aromatic amino acid biosynthesis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/shikimate-pathway","display_name":"shikimate pathway","score":0.7889999747276306},{"id":"https://openalex.org/keywords/dahp-synthase","display_name":"DAHP synthase","score":0.9089999794960022},{"id":"https://openalex.org/keywords/chorismate-mutase","display_name":"chorismate mutase","score":0.9079999923706055},{"id":"https://openalex.org/keywords/shikimate-dehydrogenase","display_name":"shikimate dehydrogenase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/aromatic-aminotransferase","display_name":"aromatic aminotransferase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/prephenate-dehydrogenase","display_name":"prephenate dehydrogenase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/isoenzymes","display_name":"isozymes","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mungbean","display_name":"mungbean","score":0.9520000219345093},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.6480000019073486},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.5920000076293945},{"id":"https://openalex.org/keywords/cobalt-activation","display_name":"cobalt activation","score":0.4749999940395355},{"id":"https://openalex.org/keywords/manganese-activation","display_name":"manganese activation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/shikimate-accumulation","display_name":"shikimate accumulation","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C2777992278","wikidata":"https://www.wikidata.org/wiki/Q705605","display_name":"Aromatic amino acids","level":3,"score":0.8050695657730103},{"id":"https://openalex.org/C2778255928","wikidata":"https://www.wikidata.org/wiki/Q858525","display_name":"Shikimate pathway","level":4,"score":0.7872298359870911},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.7001557350158691},{"id":"https://openalex.org/C2781440633","wikidata":"https://www.wikidata.org/wiki/Q410830","display_name":"Shikimic acid","level":2,"score":0.5982338190078735},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.5864118337631226},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5136718153953552},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.4746152460575104},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.4473945200443268},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.4387945830821991},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40855371952056885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38374394178390503}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1104/pp.70.3.833","doi":"https://doi.org/10.1104/pp.70.3.833","is_oa":true,"landing_page_url":"https://doi.org/10.1104/pp.70.3.833","pdf_url":"https://academic.oup.com/plphys/article-pdf/70/3/833/35602730/plphys_v70_3_833.pdf","source":{"id":"https://openalex.org/S42294715","display_name":"PLANT PHYSIOLOGY","issn_l":"0032-0889","issn":["0032-0889","1532-2548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1065779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1065779","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1065779/pdf/plntphys00552-0209.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiol","raw_type":"Text"},{"id":"pmid:16662584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16662584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1104/pp.70.3.833","doi":"https://doi.org/10.1104/pp.70.3.833","is_oa":true,"landing_page_url":"https://doi.org/10.1104/pp.70.3.833","pdf_url":"https://academic.oup.com/plphys/article-pdf/70/3/833/35602730/plphys_v70_3_833.pdf","source":{"id":"https://openalex.org/S42294715","display_name":"PLANT PHYSIOLOGY","issn_l":"0032-0889","issn":["0032-0889","1532-2548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5365999937057495,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998929301.pdf","grobid_xml":"https://content.openalex.org/works/W1998929301.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2994423374"],"related_works":["https://openalex.org/W2111617986","https://openalex.org/W2062314481","https://openalex.org/W7098724495","https://openalex.org/W15622665","https://openalex.org/W2036359859","https://openalex.org/W2476135618","https://openalex.org/W2127972744","https://openalex.org/W1967297529","https://openalex.org/W2066350002","https://openalex.org/W2056349628"],"abstract_inverted_index":{"The":[0,54,146,196],"effects":[1],"of":[2,10,12,35,56,71,93,110,118,148,160,168,187,193,221],"1":[3],"millimolar":[4],"glyphosate":[5,131,201],"(N-[phosphonomethyl]glycine)":[6],"upon":[7,90],"the":[8,86,91,116,169,219,222],"activities":[9,55],"enzymes":[11],"aromatic":[13,41],"amino":[14,175],"acid":[15,163],"biosynthesis,":[16],"partially":[17],"purified":[18],"by":[19,52,81,135],"ion-exchange":[20],"chromatography":[21],"from":[22],"mung":[23,194],"bean":[24],"seedings":[25],"(Vigna":[26],"radiata":[27],"[L.]":[28],"Wilczek),":[29],"were":[30,43,47,62,76],"examined.":[31],"Multiple":[32],"isozyme":[33],"species":[34,70],"shikimate":[36,149],"dehydrogenase,":[37],"chorismate":[38],"mutase,":[39],"and":[40,45,59,85,166],"aminotransferase":[42],"separated,":[44],"these":[46],"all":[48],"insensitive":[49],"to":[50,66,104,128,144],"inhibition":[51,109,139,159,189],"glyphosate.":[53,119],"prephenate":[57],"dehydrogenase":[58,61],"arogenate":[60],"also":[63],"not":[64],"sensitive":[65],"inhibition.":[67],"Two":[68],"molecular":[69],"3-deoxy-d-arabino-heptulosonate":[72],"7-phosphate":[73],"(DAHP)":[74],"synthase":[75,165,172],"resolved,":[77],"one":[78,167],"stimulated":[79],"several-fold":[80],"Mn(2+)":[82],"(DAHP":[83,97],"synthase-Mn),":[84],"other":[87],"absolutely":[88],"dependent":[89],"presence":[92,117],"Co(2+)":[94,121,136],"for":[95],"activity":[96],"synthase-Co).":[98],"Whereas":[99],"DAHP":[100,111,171],"synthase-Mn":[101],"was":[102,113],"invulnerable":[103],"glyphosate,":[105],"greater":[106],"than":[107],"95%":[108],"synthase-Co":[112],"found":[114,150],"in":[115,151,157,179,190,208,218],"Since":[120],"is":[122,140,154],"a":[123,183,209],"V(max)":[124],"activator":[125],"with":[126,142,156],"respect":[127,143],"both":[129,161],"substrates,":[130],"cannot":[132],"act":[133,203],"simply":[134],"chelation":[137],"because":[138],"competitive":[141],"erythrose-4-phosphate.":[145],"accumulation":[147],"glyphosate-treated":[152],"seedlings":[153,192],"consistent":[155],"vivo":[158],"5-enolpyruvylshikimic":[162],"3-phosphate":[164],"two":[170],"isozymes.":[173],"Aromatic":[174],"acids,":[176],"singly":[177],"or":[178,212],"combination,":[180],"only":[181],"showed":[182],"trend":[184],"towards":[185],"reversal":[186],"growth":[188],"7-day":[191],"bean.":[195],"possibilities":[197],"are":[198],"raised":[199],"that":[200,213],"may":[202,216],"at":[204],"multiple":[205],"enzyme":[206,224],"targets":[207],"given":[210],"organism":[211],"different":[214],"plants":[215],"vary":[217],"identity":[220],"prime":[223],"target.":[225]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}