{"id":"https://openalex.org/W1998910657","doi":"https://doi.org/10.2307/3579427","title":"Late Response to Whole-Lung Irradiation Alone and with Whole-Body Hyperthermia in Dogs","display_name":"Late Response to Whole-Lung Irradiation Alone and with Whole-Body Hyperthermia in Dogs","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W1998910657","doi":"https://doi.org/10.2307/3579427","mag":"1998910657","pmid":"https://pubmed.ncbi.nlm.nih.gov/9008218"},"language":"en","primary_location":{"id":"doi:10.2307/3579427","doi":"https://doi.org/10.2307/3579427","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3579427","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046030076","display_name":"S.M. Gillette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. Gillette","raw_affiliation_strings":["Department of Radiological Health Sciences, Colorado State University, Fort Collins 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Health Sciences, Colorado State University, Fort Collins 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110410358","display_name":"CHRISTOPHER A. DAWSON","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. A. Dawson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016316512","display_name":"David A. Rickaby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. A. Rickaby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109054887","display_name":"Michael R. Johnston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. R. Johnston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060625343","display_name":"Edward L. Gillette","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. L. Gillette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7743,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.7107501,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"147","issue":"2","first_page":"257","last_page":"257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/whole-lung-irradiation","display_name":"whole lung irradiation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/whole-body-hyperthermia","display_name":"whole-body hyperthermia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/late-radiation-effects","display_name":"late radiation effects","score":0.9129999876022339},{"id":"https://openalex.org/keywords/radiation-induced-lung-injury","display_name":"radiation-induced lung injury","score":0.6579999923706055},{"id":"https://openalex.org/keywords/pleural-fibrosis","display_name":"pleural fibrosis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/peribronchial-fibrosis","display_name":"peribronchial fibrosis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/perivascular-fibrosis","display_name":"perivascular fibrosis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.5370000004768372},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7739999890327454},{"id":"https://openalex.org/keywords/dynamic-compliance","display_name":"dynamic compliance","score":0.5680000185966492},{"id":"https://openalex.org/keywords/serotonin-uptake","display_name":"serotonin uptake","score":0.9309999942779541},{"id":"https://openalex.org/keywords/lung-lavage","display_name":"lung lavage","score":0.6470000147819519},{"id":"https://openalex.org/keywords/beagle","display_name":"beagle dogs","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2776820430","wikidata":"https://www.wikidata.org/wiki/Q21102","display_name":"Beagle","level":2,"score":0.895778238773346},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.8894921541213989},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.7080416679382324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6604962348937988},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5431569814682007},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48719948530197144},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.46962976455688477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21214118599891663}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D001834","descriptor_name":"Body Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008170","descriptor_name":"Lung Compliance","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017785","descriptor_name":"Photons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2307/3579427","doi":"https://doi.org/10.2307/3579427","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3579427","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},{"id":"pmid:9008218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9008218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G105831409","display_name":"TARGETED THERAPY FOR LUNG CANCER","funder_award_id":"U01CA046088","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3946504295","display_name":null,"funder_award_id":"HL-24349","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4096902951","display_name":null,"funder_award_id":"P01 CA 13899","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G794394314","display_name":"Lung Metabolism: Multiple Indicator Dilution","funder_award_id":"R01HL024349","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W19969599","https://openalex.org/W1970680970","https://openalex.org/W1971204639","https://openalex.org/W1993082783","https://openalex.org/W2012063674","https://openalex.org/W2019822838","https://openalex.org/W2048176426","https://openalex.org/W2057955197","https://openalex.org/W2085556593","https://openalex.org/W2106320153","https://openalex.org/W2133312485","https://openalex.org/W2140502183","https://openalex.org/W2330388350","https://openalex.org/W2342190178","https://openalex.org/W2429832800"],"related_works":["https://openalex.org/W1971204639","https://openalex.org/W2506797792","https://openalex.org/W2002126056","https://openalex.org/W1992033880","https://openalex.org/W2161799839","https://openalex.org/W2507995978","https://openalex.org/W2037921395","https://openalex.org/W2103026850","https://openalex.org/W2063611496","https://openalex.org/W2005469630"],"abstract_inverted_index":{"The":[0,16],"late":[1,145],"effects":[2],"of":[3,45,108,124,144],"whole-lung":[4],"irradiation":[5],"with":[6,53],"and":[7,59,76,87,101,127,135,137],"without":[8],"whole-body":[9],"hyperthermia":[10,33,54,150],"were":[11,62,95,98,122],"studied":[12],"in":[13,26,36,68,84,90,104,114,152],"beagle":[14],"dogs.":[15],"reference":[17],"doses":[18,107],"ranged":[19],"from":[20],"18":[21],"to":[22,40,147],"49.5":[23],"Gy":[24,110],"given":[25,35,51,113],"1.5-Gy":[27,115],"fractions":[28,116],"over":[29,117],"6":[30,118],"weeks.":[31,119],"Whole-body":[32],"was":[34,50,141],"three":[37],"2-h":[38],"treatments":[39],"a":[41],"deep":[42],"rectal":[43],"temperature":[44],"42.0":[46],"degrees":[47],"C.":[48],"Radiation":[49],"simultaneously":[52],"on":[55],"those":[56],"days.":[57],"Physiological":[58,64],"histopathological":[60],"responses":[61],"evaluated.":[63],"changes":[65,80,94,121],"included":[66,81,128],"decreases":[67],"cardiac":[69],"output,":[70],"systemic":[71],"blood":[72],"pressure,":[73],"dynamic":[74],"compliance":[75],"serotonin":[77],"uptake.":[78],"Early":[79],"an":[82],"increase":[83],"extravascular":[85],"water":[86],"total":[88],"protein":[89],"the":[91],"lavage.":[92],"These":[93],"considered":[96],"mild,":[97],"compensated":[99],"for":[100],"occurred":[102],"only":[103],"dogs":[105],"receiving":[106],"40.5":[109],"or":[111],"greater":[112],"Histopathological":[120],"typical":[123],"irradiated":[125],"lung":[126,148],"pleural":[129],"fibrosis,":[130,132],"interstitial":[131],"fibrotic":[133],"foci,":[134],"peribronchial":[136],"perivascular":[138],"fibrosis.":[139],"There":[140],"no":[142],"enhancement":[143],"injury":[146],"by":[149],"seen":[151],"this":[153],"study.":[154]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}