{"id":"https://openalex.org/W1998900400","doi":"https://doi.org/10.1001/archpsyc.1997.01830180085011","title":"The Effects of a Selective D4 Dopamine Receptor Antagonist (L-745,870) in Acutely Psychotic Inpatients With Schizophrenia","display_name":"The Effects of a Selective D4 Dopamine Receptor Antagonist (L-745,870) in Acutely Psychotic Inpatients With Schizophrenia","publication_year":1997,"publication_date":"1997-06-01","ids":{"openalex":"https://openalex.org/W1998900400","doi":"https://doi.org/10.1001/archpsyc.1997.01830180085011","mag":"1998900400","pmid":"https://pubmed.ncbi.nlm.nih.gov/9193198"},"language":"en","primary_location":{"id":"doi:10.1001/archpsyc.1997.01830180085011","doi":"https://doi.org/10.1001/archpsyc.1997.01830180085011","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archpsyc.1997.01830180085011","pdf_url":null,"source":{"id":"https://openalex.org/S126359496","display_name":"Archives of General Psychiatry","issn_l":"0003-990X","issn":["0003-990X","1538-3636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of General Psychiatry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1998900400"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070746400","display_name":"Mark S. Kramer","orcid":"https://orcid.org/0000-0001-9272-8266","observed_orcids":["https://orcid.org/0000-0001-9272-8266"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark S. Kramer","raw_affiliation_strings":["Department of Clinical Neuroscience, Merch & Co Inc., West Point, Pa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Merch & Co Inc., West Point, Pa, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161676908","display_name":"B Last","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Last","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161638541","display_name":"A Getson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Getson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5161609064","display_name":"S A Reines","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Reines","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070746400"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":null,"apc_paid":null,"fwci":12.7066,"has_fulltext":false,"cited_by_count":201,"citation_normalized_percentile":{"value":0.99214847,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"54","issue":"6","first_page":"567","last_page":"567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12308","display_name":"Mental Health and Psychiatry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-745-870","display_name":"L-745,870","score":0.9909999966621399},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.8309999704360962},{"id":"https://openalex.org/keywords/acute-psychosis","display_name":"acute psychosis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/antipsychotic-efficacy","display_name":"antipsychotic efficacy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.4860000014305115},{"id":"https://openalex.org/keywords/brief-psychiatric-rating-scale","display_name":"Brief Psychiatric Rating Scale","score":0.9459999799728394},{"id":"https://openalex.org/keywords/clinical-global-impression-scale","display_name":"Clinical Global Impression Scale","score":0.7670000195503235},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7161771059036255},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6032657623291016},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5744847655296326},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4840949773788452},{"id":"https://openalex.org/C2781353949","wikidata":"https://www.wikidata.org/wiki/Q3271533","display_name":"Dopamine antagonist","level":4,"score":0.48315852880477905},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.47784921526908875},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.44097772240638733},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.44035810232162476},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35634845495224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35072949528694153},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33397844433784485},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21118098497390747},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.20514005422592163},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1798243224620819}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002697","descriptor_name":"Chloral Hydrate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008140","descriptor_name":"Lorazepam","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012565","descriptor_name":"Schizophrenic Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018492","descriptor_name":"Dopamine Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D050638","descriptor_name":"Receptors, Dopamine D4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/archpsyc.1997.01830180085011","doi":"https://doi.org/10.1001/archpsyc.1997.01830180085011","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archpsyc.1997.01830180085011","pdf_url":null,"source":{"id":"https://openalex.org/S126359496","display_name":"Archives of General Psychiatry","issn_l":"0003-990X","issn":["0003-990X","1538-3636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of General Psychiatry","raw_type":"journal-article"},{"id":"pmid:9193198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9193198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of general psychiatry","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1556416492","https://openalex.org/W1916318562","https://openalex.org/W1994065699","https://openalex.org/W2016583431","https://openalex.org/W2033928261","https://openalex.org/W2059230444","https://openalex.org/W2072069319","https://openalex.org/W2075028631","https://openalex.org/W2084919821","https://openalex.org/W2085360366","https://openalex.org/W2098144186","https://openalex.org/W2165379748","https://openalex.org/W2242438439","https://openalex.org/W2414817836"],"related_works":["https://openalex.org/W2008170648","https://openalex.org/W2073350805","https://openalex.org/W571817885","https://openalex.org/W2102642731","https://openalex.org/W1994773485","https://openalex.org/W2060156219","https://openalex.org/W58432556","https://openalex.org/W1963799008","https://openalex.org/W2883735540","https://openalex.org/W1989405057"],"abstract_inverted_index":{"BACKGROUND:":[0],"Based":[1],"mainly":[2],"on":[3,152,202,222,268],"the":[4,29,41,46,123,133,144,153,197,203,223,231,238,269,276,308],"selective":[5,22,296],"antagonism":[6],"of":[7,32,45,49,83,113,135,186,225,230,253,260,263,281,310],"clozapine":[8],"at":[9],"D4":[10,23,53,297],"compared":[11,117,289],"with":[12,34,61,76,87,118,266,290,314],"D2":[13],"dopamine":[14,24,54,298],"receptors,":[15],"hopes":[16],"have":[17],"run":[18],"high":[19],"that":[20],"a":[21,50,101,110],"receptor":[25,55,299],"antagonist":[26,56,300],"might":[27],"improve":[28],"pharmacological":[30],"treatment":[31,85,309],"patients":[33,60,114,119,254],"schizophrenia.":[35,63,316],"We":[36],"report,":[37],"to":[38,80,103,149],"our":[39],"knowledge,":[40],"first":[42],"multicenter":[43],"study":[44,124],"antipsychotic":[47,306],"potential":[48],"highly":[51],"specific":[52],"(ie,":[57],"L-745,870)":[58],"in":[59,184,188],"acute":[62,315],"METHODS:":[64],"Thirty-eight":[65],"acutely":[66],"psychotic":[67],"and":[68,216,236,275],"neuroleptic":[69,311],"responsive":[70,312],"(by":[71],"history)":[72],"newly":[73],"admitted":[74],"inpatients":[75,313],"schizophrenia":[77],"were":[78,194],"randomized":[79],"4":[81,136,151],"weeks":[82,137],"double-blind":[84],"(2:1)":[86],"either":[88],"L-745,870":[89,116,256,301],"(n":[90,97],"=":[91,98,180,244],"26),":[92],"15":[93],"mg/d,":[94],"or":[95],"placebo":[96,105,121,160,176,187],"12)":[99],"after":[100],"3-":[102],"5-day":[104],"run-in":[106],"period.":[107],"RESULTS:":[108],"Overall,":[109],"greater":[111,251],"percentage":[112,252],"receiving":[115,120,255,292],"discontinued":[122],"for":[125,175,196,212,237,307],"insufficient":[126],"therapeutic":[127],"response":[128],"(32%":[129],"vs":[130,168,177],"16%).":[131],"At":[132],"end":[134],"by":[138],"last":[139,217,246],"observation":[140,218,247],"carried":[141,199,214,219,248],"forward":[142,200,215,220],"analysis,":[143],"mean":[145,192],"change":[146,165,172],"from":[147,166,173,190],"baseline":[148,191],"week":[150],"total":[154,204,270],"Brief":[155,205,232,271],"Psychiatric":[156,206,233,272],"Rating":[157,207,234,273],"Scale":[158,208,274,283],"favored":[159],"(i.e.,":[161],"-8":[162],"points":[163],"[-15%":[164],"baseline]":[167,174],"-1":[169],"point":[170],"[-2%":[171],"L-745,870,":[178],"P":[179],".09).":[181],"Similar":[182],"differences":[183],"favor":[185],"changes":[189],"scores":[193,258],"observed":[195],"not":[198,213],"analysis":[201,242],"(P":[209,243],"<":[210],".03),":[211],"analyses":[221],"sum":[224],"selected":[226],"positive":[227,287],"symptom":[228],"items":[229],"Scale,":[235],"Clinical":[239,277],"Global":[240,278],"Impression":[241],".03,":[245],"forward).":[249],"A":[250],"had":[257],"indicative":[259],"some":[261],"level":[262],"worsening":[264],"(compared":[265],"baseline)":[267],"Impressions'":[279],"Severity":[280],"Illness":[282],"as":[284,286,304],"well":[285],"symptoms":[288],"those":[291],"placebo.":[293],"CONCLUSION:":[294],"The":[295],"was":[302],"ineffective":[303],"an":[305]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}