{"id":"https://openalex.org/W1998866038","doi":"https://doi.org/10.1021/tx0255929","title":"Detection and Characterization of a Glutathione Conjugate of Ochratoxin A","display_name":"Detection and Characterization of a Glutathione Conjugate of Ochratoxin A","publication_year":2002,"publication_date":"2002-11-09","ids":{"openalex":"https://openalex.org/W1998866038","doi":"https://doi.org/10.1021/tx0255929","mag":"1998866038","pmid":"https://pubmed.ncbi.nlm.nih.gov/12482240"},"language":"en","primary_location":{"id":"doi:10.1021/tx0255929","doi":"https://doi.org/10.1021/tx0255929","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx0255929","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110119395","display_name":"Jian Dai","orcid":"https://orcid.org/0009-0002-1508-8140","observed_orcids":["https://orcid.org/0009-0002-1508-8140"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Dai","raw_affiliation_strings":["Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049902756","display_name":"Gyungse Park","orcid":"https://orcid.org/0000-0003-1614-3818","observed_orcids":["https://orcid.org/0000-0003-1614-3818"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gyungse Park","raw_affiliation_strings":["Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110246514","display_name":"Marcus W. Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus W. Wright","raw_affiliation_strings":["Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064990615","display_name":"M. L. Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marissa Adams","raw_affiliation_strings":["Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004437433","display_name":"Steven A. Akman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven A. Akman","raw_affiliation_strings":["Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038862912","display_name":"Richard A. Manderville","orcid":"https://orcid.org/0000-0003-4035-8093","observed_orcids":["https://orcid.org/0000-0003-4035-8093"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Manderville","raw_affiliation_strings":["Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064990615"],"corresponding_institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.4191,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.93893076,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"12","first_page":"1581","last_page":"1588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ochratoxin-a","display_name":"ochratoxin A","score":1.0},{"id":"https://openalex.org/keywords/glutathione-conjugates","display_name":"glutathione conjugates","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mycotoxin-biotransformation","display_name":"mycotoxin biotransformation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/glutathione-conjugation","display_name":"glutathione conjugation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/hydroquinone","display_name":"hydroquinone","score":0.6710000038146973},{"id":"https://openalex.org/keywords/horseradish-peroxidase","display_name":"horseradish peroxidase","score":0.8230000138282776},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.9190000295639038},{"id":"https://openalex.org/keywords/iron-ii-oxidation","display_name":"iron(II) oxidation","score":0.5879999995231628},{"id":"https://openalex.org/keywords/carcinogenic-mycotoxins","display_name":"carcinogenic mycotoxins","score":0.75},{"id":"https://openalex.org/keywords/covalent-attachment","display_name":"covalent binding","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.8830241560935974},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8585199117660522},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7677994966506958},{"id":"https://openalex.org/C2776008721","wikidata":"https://www.wikidata.org/wiki/Q1885038","display_name":"Ochratoxin A","level":3,"score":0.704670250415802},{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.698387086391449},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6099539995193481},{"id":"https://openalex.org/C2777550763","wikidata":"https://www.wikidata.org/wiki/Q419164","display_name":"Hydroquinone","level":2,"score":0.5310229063034058},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.5110341310501099},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.45818769931793213},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4330214858055115},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.4300777018070221},{"id":"https://openalex.org/C2778113725","wikidata":"https://www.wikidata.org/wiki/Q414439","display_name":"Cumene hydroperoxide","level":3,"score":0.4137563407421112},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3510637879371643},{"id":"https://openalex.org/C84699730","wikidata":"https://www.wikidata.org/wiki/Q422449","display_name":"Mycotoxin","level":2,"score":0.3342243432998657},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26867449283599854},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15537357330322266},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005296","descriptor_name":"Ferrous Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006735","descriptor_name":"Horseradish Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006873","descriptor_name":"Hydroquinones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009183","descriptor_name":"Mycotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009793","descriptor_name":"Ochratoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009793","descriptor_name":"Ochratoxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010777","descriptor_name":"Photochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/tx0255929","doi":"https://doi.org/10.1021/tx0255929","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx0255929","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},{"id":"pmid:12482240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12482240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical research in toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6485834527","display_name":"DNA DAMAGE AND MUTAGENICITY OF OCHRATOXIN A","funder_award_id":"R01CA080787","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1534789482","https://openalex.org/W2004075793","https://openalex.org/W2004779786","https://openalex.org/W2006833294","https://openalex.org/W2016713201","https://openalex.org/W2018910745","https://openalex.org/W2023761574","https://openalex.org/W2032064787","https://openalex.org/W2038242129","https://openalex.org/W2044908741","https://openalex.org/W2092569387","https://openalex.org/W2109769559","https://openalex.org/W2323057147","https://openalex.org/W2927471196","https://openalex.org/W3005301111"],"related_works":["https://openalex.org/W2080460528","https://openalex.org/W2119827328","https://openalex.org/W2801013746","https://openalex.org/W3093060447","https://openalex.org/W2195683980","https://openalex.org/W116084821","https://openalex.org/W2069928790","https://openalex.org/W2020484676","https://openalex.org/W2004075793","https://openalex.org/W1978119321"],"abstract_inverted_index":{"The":[0,219],"ability":[1],"of":[2,26,43,47,61,68,87,102,110,133,156,161,184,190,222,225],"the":[3,24,27,34,44,69,84,95,108,137,148,157,162,168,172,177,195,216,223],"carcinogenic":[4],"mycotoxin":[5],"ochratoxin":[6],"A":[7],"(OTA)":[8],"to":[9,63,165,197,203,214],"react":[10],"with":[11,57,119,212],"reduced":[12,45],"glutathione":[13],"(GSH)":[14],"has":[15],"been":[16],"assessed":[17],"using":[18],"electrospray":[19],"ionization":[20],"(ES)-MS":[21],"techniques.":[22],"On":[23],"basis":[25],"assumption":[28],"that":[29,72,94,166,176,199,209],"OTA":[30,105,150,200,226],"undergoes":[31,201],"biotransformation":[32,202],"into":[33],"reactive":[35,205],"quinone":[36],"species":[37],"OTQ":[38,48],"(6),":[39,49],"a":[40,182,204],"synthetic":[41],"sample":[42,67,86],"form":[46],"hydroquinone":[50],"OTHQ":[51],"(5),":[52],"was":[53,73,92,140,179],"prepared":[54],"and":[55,81,147],"photoreacted":[56],"6":[58],"M":[59],"equiv":[60],"GSH":[62,113,213,228],"yield":[64,146,215],"an":[65],"authentic":[66,85],"conjugate":[70,97,138,163,178,217],"8":[71,88,139,164],"definitively":[74],"identified":[75],"by":[76],"mass":[77],"spectrometry,":[78],"UV-vis":[79],"spectroscopy":[80],"NMR.":[82],"With":[83],"in":[89,107,142],"hand,":[90],"it":[91],"demonstrated":[93],"same":[96],"is":[98,152],"produced":[99,180],"from":[100,171],"reaction":[101],"100":[103],"microM":[104],"(1)":[106],"presence":[109],"5":[111],"mM":[112],"following":[114],"incubation":[115],"for":[116,167],"1":[117],"h":[118],"either":[120],"horseradish":[121],"peroxidase":[122],"(HRP)/H(2)O(2),":[123],"rat":[124],"liver":[125],"microsomes":[126],"(RLM)/NADPH":[127],"or":[128],"free":[129],"Fe(II).":[130],"In":[131],"each":[132],"these":[134],"oxidative":[135],"systems":[136],"generated":[141],"less":[143],"than":[144],"1%":[145],"parent":[149],"molecule":[151],"poorly":[153],"metabolized.":[154],"Comparison":[155],"peak":[158],"area":[159],"ratio":[160],"hydroxyOTA":[169],"metabolite":[170],"RLM/NADPH":[173],"system":[174],"implied":[175],"at":[181],"rate":[183],"approximately":[185],"1-3":[186],"pmol":[187],"min(-)(1)":[188],"(mg":[189],"protein)(-)(1).":[191],"These":[192],"studies":[193],"are":[194,229],"first":[196],"demonstrate":[198],"intermediate":[206],"[OTQ":[207],"(6)]":[208],"covalently":[210],"reacts":[211],"8.":[218],"biological":[220],"implications":[221],"reactivity":[224],"toward":[227],"discussed.":[230]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}