{"id":"https://openalex.org/W1998839760","doi":"https://doi.org/10.1111/j.1537-2995.2004.03274.x","title":"Low\u2010dose lenograstim to enhance engraftment after autologous stem cell transplantation: a prospective randomized evaluation of two different fixed doses","display_name":"Low\u2010dose lenograstim to enhance engraftment after autologous stem cell transplantation: a prospective randomized evaluation of two different fixed doses","publication_year":2004,"publication_date":"2004-03-24","ids":{"openalex":"https://openalex.org/W1998839760","doi":"https://doi.org/10.1111/j.1537-2995.2004.03274.x","mag":"1998839760","pmid":"https://pubmed.ncbi.nlm.nih.gov/15043569"},"language":"en","primary_location":{"id":"doi:10.1111/j.1537-2995.2004.03274.x","doi":"https://doi.org/10.1111/j.1537-2995.2004.03274.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1537-2995.2004.03274.x","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044958787","display_name":"Cheolwon Suh","orcid":"https://orcid.org/0000-0002-9178-4431","observed_orcids":["https://orcid.org/0000-0002-9178-4431"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Cheolwon Suh","raw_affiliation_strings":["Department of Internal Medicine, ASAN Medical Center, University of Ulsan College of Medicine, Seoul, Korea. csuh@amc.seoul.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, ASAN Medical Center, University of Ulsan College of Medicine, Seoul, Korea. csuh@amc.seoul.kr","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674931","display_name":"Hyo\u2010Jung Kim","orcid":"https://orcid.org/0000-0002-2027-6341","observed_orcids":["https://orcid.org/0000-0002-2027-6341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyo\u2010Jung Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103494288","display_name":"Sang\u2010Hee Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sang\u2010Hee Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075714089","display_name":"Shin Kim","orcid":"https://orcid.org/0000-0002-1099-5027","observed_orcids":["https://orcid.org/0000-0002-1099-5027","https://orcid.org/0000-0002-9796-8266","https://orcid.org/0000-0001-6276-3693"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shin Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106070760","display_name":"Soon\u2010Jong Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soon\u2010Jong Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035731843","display_name":"Yoonshin Lee","orcid":"https://orcid.org/0000-0002-9017-9758","observed_orcids":["https://orcid.org/0000-0002-9017-9758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoon\u2010Shin Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100673990","display_name":"Eun\u2010Kyoung Kim","orcid":"https://orcid.org/0000-0002-0631-3660","observed_orcids":["https://orcid.org/0000-0002-0631-3660"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eun\u2010Kyoung Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026459010","display_name":"Sung\u2010Bae Kim","orcid":"https://orcid.org/0000-0001-5588-8332","observed_orcids":["https://orcid.org/0000-0001-5588-8332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sung\u2010Bae Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111612871","display_name":"Jung\u2010Sin Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jung\u2010Sin Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068422918","display_name":"Michael W. Kim","orcid":"https://orcid.org/0000-0002-1272-1062","observed_orcids":["https://orcid.org/0000-0002-1272-1062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael W. Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100353399","display_name":"Kihyun K\u0131m","orcid":"https://orcid.org/0000-0002-5878-8895","observed_orcids":["https://orcid.org/0000-0002-5878-8895"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kihyun Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113556058","display_name":"And Sung\u2010Soo Yoon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"And Sung\u2010Soo Yoon","raw_affiliation_strings":["SNUCM Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SNUCM Internal Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044958787"],"corresponding_institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":1.2797,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.79426109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"4","first_page":"533","last_page":"538"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lenograstim","display_name":"lenograstim","score":0.9990000128746033},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.675000011920929},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hematopoietic-engraftment","display_name":"hematopoietic engraftment","score":0.8809999823570251},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.6200000047683716},{"id":"https://openalex.org/keywords/neutrophil-engraftment","display_name":"neutrophil engraftment","score":0.8309999704360962},{"id":"https://openalex.org/keywords/platelet-engraftment","display_name":"platelet engraftment","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cost-reduction","display_name":"cost reduction","score":0.5450000166893005},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8847330808639526},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5759176015853882},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5497541427612305},{"id":"https://openalex.org/C2779050716","wikidata":"https://www.wikidata.org/wiki/Q4826373","display_name":"Autologous stem-cell transplantation","level":3,"score":0.5067554116249084},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.4955383539199829},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.48855409026145935},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.45475637912750244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41026031970977783},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.36642810702323914}],"mesh":[{"descriptor_ui":"D000078224","descriptor_name":"Lenograstim","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007902","descriptor_name":"Length of Stay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1537-2995.2004.03274.x","doi":"https://doi.org/10.1111/j.1537-2995.2004.03274.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1537-2995.2004.03274.x","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},{"id":"pmid:15043569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15043569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1757326868","https://openalex.org/W1847164289","https://openalex.org/W1877440965","https://openalex.org/W1964062130","https://openalex.org/W1968401252","https://openalex.org/W1986990246","https://openalex.org/W1997353354","https://openalex.org/W2009003130","https://openalex.org/W2010071686","https://openalex.org/W2029730670","https://openalex.org/W2062026233","https://openalex.org/W2064280837","https://openalex.org/W2078150969","https://openalex.org/W2082520315","https://openalex.org/W2127143739","https://openalex.org/W2180046020","https://openalex.org/W2226490553","https://openalex.org/W2266904127","https://openalex.org/W2329859906","https://openalex.org/W2444236372"],"related_works":["https://openalex.org/W2148333631","https://openalex.org/W3014729529","https://openalex.org/W1986990246","https://openalex.org/W2089180192","https://openalex.org/W2100871440","https://openalex.org/W2982184014","https://openalex.org/W2035081309","https://openalex.org/W2790632746","https://openalex.org/W2051708180","https://openalex.org/W2038876038"],"abstract_inverted_index":{"BACKGROUND:":[0],"G-CSF":[1,19,40],"is":[2,31,41,60],"used":[3,46,223],"to":[4,63,131,140,250],"enhance":[5],"hematopoietic":[6,258],"recovery":[7,259],"after":[8,260],"autologous":[9],"stem":[10],"cell":[11],"transplantation":[12],"(ASCT),":[13],"but":[14],"the":[15,42,107,157,169,195,205,231,264],"optimal":[16],"dose":[17,57,213,266],"of":[18,29,58,110,116,147,184,189,221,239,244,263],"during":[20,224],"engraftment":[21,133,142],"has":[22],"not":[23],"been":[24],"established.":[25],"The":[26],"medical":[27],"cost":[28],"ASCT":[30,225],"a":[32,53,64,113],"serious":[33],"financial":[34],"burden":[35],"in":[36,47,156,168,180,230],"developing":[37],"countries,":[38],"and":[39,137,163,201,218,274],"most":[43],"costly":[44],"drug":[45],"this":[48],"procedure.":[49],"We":[50],"evaluated":[51],"whether":[52],"lower,":[54],"vial-size":[55],"fitted":[56],"lenograstim":[59,103,127,212,222,245,255,272],"clinically":[61,148],"equivalent":[62],"higher":[65],"fixed":[66],"dose.":[67],"STUDY":[68],"DESIGN":[69],"AND":[70],"METHODS:":[71],"A":[72],"prospective":[73],"randomized":[74],"study":[75],"was":[76,134,143,191,267],"performed":[77],"on":[78,106],"33":[79],"patients":[80],"(11":[81],"non-Hodgkin's":[82],"lymphoma,":[83],"8":[84],"multiple":[85],"myeloma,":[86],"14":[87],"breast":[88],"cancer)":[89],"undergoing":[90],"ASCT.":[91,261],"Patients":[92],"were":[93,151,176,226],"randomly":[94],"administered":[95],"100":[96,158,196,232,240],"micro":[97,101],"g":[98,102],"or":[99,186],"250":[100,170,206,251],"daily":[104],"starting":[105],"next":[108],"day":[109,161,173,199,209,235,243,254],"ASCT,":[111],"with":[112,269],"minimum":[114],"infusion":[115],"3":[117],"x":[118],"10(6)":[119],"CD34+":[120],"cells":[121],"per":[122,153,160,165,172,198,208,214,234,242,253],"kg.":[123],"RESULTS:":[124],"For":[125],"both":[126,227],"doses,":[128],"median":[129,138],"time":[130,139],"neutrophil":[132],"9":[135],"days":[136,193,203],"PLT":[141],"11":[144],"days.":[145],"Episodes":[146],"documented":[149],"infections":[150],"10":[152,164],"379":[154],"patient-days":[155,167],"microg":[159,171,197,207,233,241,252],"group":[162,200],"320":[166],"group.":[174,210,236],"There":[175],"no":[177],"between-group":[178],"differences":[179],"requirements":[181],"for":[182,194,204,256],"transfusion":[183],"RBCs":[185],"PLTs.":[187],"Duration":[188],"hospitalization":[190],"16":[192],"17":[202],"Daily":[211],"patient's":[215],"body":[216],"weight":[217],"total":[219],"amount":[220],"significantly":[228],"lower":[229,265,270,275],"CONCLUSION:":[237],"Administration":[238],"showed":[246],"comparable":[247],"clinical":[248],"efficacy":[249],"immediate":[257],"Use":[262],"associated":[268],"overall":[271],"usage":[273],"cost.":[276]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}