{"id":"https://openalex.org/W1998819811","doi":"https://doi.org/10.3109/01677069509083458","title":"Increased Neuronal Excitability Conferred by a Mutation in theDrosophila BemusedGene","display_name":"Increased Neuronal Excitability Conferred by a Mutation in theDrosophila BemusedGene","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W1998819811","doi":"https://doi.org/10.3109/01677069509083458","mag":"1998819811","pmid":"https://pubmed.ncbi.nlm.nih.gov/8592271"},"language":"en","primary_location":{"id":"doi:10.3109/01677069509083458","doi":"https://doi.org/10.3109/01677069509083458","is_oa":false,"landing_page_url":"https://doi.org/10.3109/01677069509083458","pdf_url":null,"source":{"id":"https://openalex.org/S64145856","display_name":"Journal of Neurogenetics","issn_l":"0167-7063","issn":["0167-7063","1026-8057","1563-5260"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurogenetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michael Stern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Stern","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251, USA","Dept. of Biochemistry and Cell Biology, Rice University, Houston, TX 77251"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251, USA","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Dept. of Biochemistry and Cell Biology, Rice University, Houston, TX 77251","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017121721","display_name":"Nicquet M.J. Blake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicquet Blake","raw_affiliation_strings":["Division of Biology and Biomedical Science, Washington University, St Louis, Missouri, 63143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology and Biomedical Science, Washington University, St Louis, Missouri, 63143","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072255412","display_name":"Neal Joseph Zondlo","orcid":"https://orcid.org/0000-0002-7417-8085","observed_orcids":["https://orcid.org/0000-0002-7417-8085"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal Zondlo","raw_affiliation_strings":["Department of Chemistry, Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055717471","display_name":"Karina Joanne Walters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karina Walters","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Rice University, Houston, TX, 77251","Dept. of Biochemistry and Cell Biology, Rice University, Houston, TX 77251"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Rice University, Houston, TX, 77251","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Dept. of Biochemistry and Cell Biology, Rice University, Houston, TX 77251","institution_ids":["https://openalex.org/I74775410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2481,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.4720766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":"2","first_page":"103","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.24779999256134033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.1234000027179718,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.9369999766349792},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7990000247955322},{"id":"https://openalex.org/keywords/p-element-insertion","display_name":"P-element insertion","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.8320000171661377},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.9359999895095825},{"id":"https://openalex.org/keywords/augmentation","display_name":"augmentation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/quinidine","display_name":"quinidine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.6060000061988831},{"id":"https://openalex.org/keywords/flight-behavior","display_name":"flight behavior","score":0.48500001430511475},{"id":"https://openalex.org/keywords/coordination","display_name":"coordination","score":0.5979999899864197},{"id":"https://openalex.org/keywords/fertility","display_name":"fertility","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6992202997207642},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6348254680633545},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5643653273582458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5637987852096558},{"id":"https://openalex.org/C2777240379","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Neuromuscular junction","level":2,"score":0.5443335175514221},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.47483760118484497},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4431384205818176},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.43750688433647156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4043675661087036},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3254077136516571},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.18433794379234314}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011802","descriptor_name":"Quinidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011802","descriptor_name":"Quinidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011802","descriptor_name":"Quinidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/01677069509083458","doi":"https://doi.org/10.3109/01677069509083458","is_oa":false,"landing_page_url":"https://doi.org/10.3109/01677069509083458","pdf_url":null,"source":{"id":"https://openalex.org/S64145856","display_name":"Journal of Neurogenetics","issn_l":"0167-7063","issn":["0167-7063","1026-8057","1563-5260"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurogenetics","raw_type":"journal-article"},{"id":"pmid:8592271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8592271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurogenetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2623722456","display_name":null,"funder_award_id":"GM-46566","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7116215280","display_name":"IN VIVO ROLES OF A DROSOPHILA TRANSMITTER TRANSPORTER","funder_award_id":"5r01gm046566-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W69783081","https://openalex.org/W1524359382","https://openalex.org/W1561725912","https://openalex.org/W1602374960","https://openalex.org/W1605923556","https://openalex.org/W1636334135","https://openalex.org/W1653259249","https://openalex.org/W1892860364","https://openalex.org/W1966631841","https://openalex.org/W1966939918","https://openalex.org/W1970706920","https://openalex.org/W1977912923","https://openalex.org/W1987689933","https://openalex.org/W1991587314","https://openalex.org/W1993288432","https://openalex.org/W1993506650","https://openalex.org/W1995312770","https://openalex.org/W1995528444","https://openalex.org/W2002957477","https://openalex.org/W2012604591","https://openalex.org/W2012799858","https://openalex.org/W2018435113","https://openalex.org/W2024495842","https://openalex.org/W2029725761","https://openalex.org/W2032601606","https://openalex.org/W2033117412","https://openalex.org/W2039568017","https://openalex.org/W2044750341","https://openalex.org/W2045441572","https://openalex.org/W2050357864","https://openalex.org/W2054371611","https://openalex.org/W2063840208","https://openalex.org/W2068684319","https://openalex.org/W2100548210","https://openalex.org/W2102036006","https://openalex.org/W2103292455","https://openalex.org/W2112551261","https://openalex.org/W2114640601","https://openalex.org/W2121118011","https://openalex.org/W2131898914","https://openalex.org/W2137628065","https://openalex.org/W2143079238","https://openalex.org/W2144691484","https://openalex.org/W2149742460","https://openalex.org/W2155970893","https://openalex.org/W2175877739","https://openalex.org/W2411865887","https://openalex.org/W2418048212"],"related_works":["https://openalex.org/W2018435113","https://openalex.org/W1600020968","https://openalex.org/W1993288432","https://openalex.org/W2126219323","https://openalex.org/W2133612017","https://openalex.org/W1966939918","https://openalex.org/W2128946071","https://openalex.org/W2044750341","https://openalex.org/W4233633967","https://openalex.org/W2411865887"],"abstract_inverted_index":{"We":[0,113],"have":[1],"identified":[2],"a":[3,12,30,67,124,127],"new":[4],"gene":[5],"in":[6,93,109,129],"Drosophila":[7],"on":[8],"the":[9,27,58,81,103,110,116],"basis":[10],"of":[11,29,71,105,126],"mutation":[13,52,118],"that":[14,91,115],"affects":[15,54],"both":[16],"behavior":[17],"and":[18,48],"neuronal":[19,120],"excitability.":[20],"This":[21,76],"mutation,":[22],"called":[23],"bemused":[24],"(bem)":[25],"is":[26,78,100],"result":[28,125],"P":[31],"element":[32],"insertion":[33],"at":[34,40,57],"cytological":[35],"position":[36],"85D.":[37],"Flies":[38],"defective":[39],"bem":[41,51,64,94,117],"display":[42,66],"greatly":[43],"reduced":[44],"coordination,":[45],"flight":[46],"ability":[47],"fertility.":[49],"The":[50,87],"also":[53],"synaptic":[55],"transmission":[56],"larval":[59],"neuromuscular":[60],"junction.":[61],"In":[62],"particular,":[63],"larvae":[65],"more":[68],"rapid":[69],"onset":[70],"augmentation":[72],"than":[73],"bem+":[74],"larvae.":[75],"effect":[77],"potentiated":[79],"by":[80,102],"potassium":[82],"channel":[83,132],"blocking":[84],"drug":[85],"quinidine.":[86],"increased":[88],"transmitter":[89],"release":[90],"occurs":[92],"mutants":[95],"following":[96],"repetitive":[97],"nerve":[98],"stimulation":[99],"accompanied":[101],"appearance":[104],"extra":[106],"action":[107],"potentials":[108],"motor":[111],"neuron.":[112],"conclude":[114],"increases":[119],"excitability,":[121],"possibly":[122],"as":[123],"defect":[128],"an":[130],"ion":[131],"structural":[133],"or":[134],"regulatory":[135],"gene.":[136]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}