{"id":"https://openalex.org/W1998779365","doi":"https://doi.org/10.1021/np050351x","title":"Cytotoxic and Other Compounds from Didymochlaena truncatula from the Madagascar Rain Forest","display_name":"Cytotoxic and Other Compounds from Didymochlaena truncatula from the Madagascar Rain Forest","publication_year":2006,"publication_date":"2006-01-21","ids":{"openalex":"https://openalex.org/W1998779365","doi":"https://doi.org/10.1021/np050351x","mag":"1998779365","pmid":"https://pubmed.ncbi.nlm.nih.gov/16499333","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2442717"},"language":"en","primary_location":{"id":"doi:10.1021/np050351x","doi":"https://doi.org/10.1021/np050351x","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np050351x","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2442717","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080155749","display_name":"Shugeng Cao","orcid":"https://orcid.org/0000-0001-6684-8221","observed_orcids":["https://orcid.org/0000-0001-6684-8221"]},"institutions":[{"id":"https://openalex.org/I2802431724","display_name":"Missouri Botanical Garden","ror":"https://ror.org/04tzy5g14","country_code":"US","type":"archive","lineage":["https://openalex.org/I2802431724"]},{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["MG","US"],"is_corresponding":false,"raw_author_name":"Shugeng Cao","raw_affiliation_strings":["Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar","institution_ids":["https://openalex.org/I2802431724","https://openalex.org/I4210121583","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035057631","display_name":"Mohamed M. Radwan","orcid":"https://orcid.org/0000-0002-7393-8601","observed_orcids":["https://orcid.org/0000-0002-7393-8601"]},"institutions":[{"id":"https://openalex.org/I2802431724","display_name":"Missouri Botanical Garden","ror":"https://ror.org/04tzy5g14","country_code":"US","type":"archive","lineage":["https://openalex.org/I2802431724"]},{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["MG","US"],"is_corresponding":false,"raw_author_name":"Mohamed M. Radwan","raw_affiliation_strings":["Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar","institution_ids":["https://openalex.org/I2802431724","https://openalex.org/I4210121583","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076485694","display_name":"Andrew S. Norris","orcid":"https://orcid.org/0000-0002-0121-5922","observed_orcids":["https://orcid.org/0000-0002-0121-5922"]},"institutions":[{"id":"https://openalex.org/I2802431724","display_name":"Missouri Botanical Garden","ror":"https://ror.org/04tzy5g14","country_code":"US","type":"archive","lineage":["https://openalex.org/I2802431724"]},{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["MG","US"],"is_corresponding":false,"raw_author_name":"Andrew Norris","raw_affiliation_strings":["Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar","institution_ids":["https://openalex.org/I2802431724","https://openalex.org/I4210121583","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084949171","display_name":"James S. Miller","orcid":"https://orcid.org/0000-0002-9987-479X","observed_orcids":["https://orcid.org/0000-0002-9987-479X"]},"institutions":[{"id":"https://openalex.org/I2802431724","display_name":"Missouri Botanical Garden","ror":"https://ror.org/04tzy5g14","country_code":"US","type":"archive","lineage":["https://openalex.org/I2802431724"]},{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["MG","US"],"is_corresponding":false,"raw_author_name":"James S. Miller","raw_affiliation_strings":["Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar","institution_ids":["https://openalex.org/I2802431724","https://openalex.org/I4210121583","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113602083","display_name":"Fidy Ratovoson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802431724","display_name":"Missouri Botanical Garden","ror":"https://ror.org/04tzy5g14","country_code":"US","type":"archive","lineage":["https://openalex.org/I2802431724"]},{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["MG","US"],"is_corresponding":false,"raw_author_name":"Fidy Ratovoson","raw_affiliation_strings":["Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar","institution_ids":["https://openalex.org/I2802431724","https://openalex.org/I4210121583","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052710012","display_name":"Mamisoa N. Andrianjafy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802431724","display_name":"Missouri Botanical Garden","ror":"https://ror.org/04tzy5g14","country_code":"US","type":"archive","lineage":["https://openalex.org/I2802431724"]},{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["MG","US"],"is_corresponding":false,"raw_author_name":"Andrianjafy Mamisoa","raw_affiliation_strings":["Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar","institution_ids":["https://openalex.org/I2802431724","https://openalex.org/I4210121583","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078402723","display_name":"Rabodo Andriantsiferana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802431724","display_name":"Missouri Botanical Garden","ror":"https://ror.org/04tzy5g14","country_code":"US","type":"archive","lineage":["https://openalex.org/I2802431724"]},{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["MG","US"],"is_corresponding":false,"raw_author_name":"Rabodo Andriantsiferana","raw_affiliation_strings":["Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar","institution_ids":["https://openalex.org/I2802431724","https://openalex.org/I4210121583","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113215236","display_name":"Vincent Emile Rasamison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802431724","display_name":"Missouri Botanical Garden","ror":"https://ror.org/04tzy5g14","country_code":"US","type":"archive","lineage":["https://openalex.org/I2802431724"]},{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["MG","US"],"is_corresponding":false,"raw_author_name":"Vincent E. Rasamison","raw_affiliation_strings":["Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar","institution_ids":["https://openalex.org/I2802431724","https://openalex.org/I4210121583","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112891166","display_name":"Stephan Richard Rakotonandrasana","orcid":"https://orcid.org/0000-0002-2950-2739","observed_orcids":["https://orcid.org/0000-0002-2950-2739"]},"institutions":[{"id":"https://openalex.org/I2802431724","display_name":"Missouri Botanical Garden","ror":"https://ror.org/04tzy5g14","country_code":"US","type":"archive","lineage":["https://openalex.org/I2802431724"]},{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["MG","US"],"is_corresponding":false,"raw_author_name":"Stephan Rakotonandrasana","raw_affiliation_strings":["Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar","institution_ids":["https://openalex.org/I2802431724","https://openalex.org/I4210121583","https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035334062","display_name":"David G. I. Kingston","orcid":"https://orcid.org/0000-0001-8944-246X","observed_orcids":["https://orcid.org/0000-0001-8944-246X"]},"institutions":[{"id":"https://openalex.org/I2802431724","display_name":"Missouri Botanical Garden","ror":"https://ror.org/04tzy5g14","country_code":"US","type":"archive","lineage":["https://openalex.org/I2802431724"]},{"id":"https://openalex.org/I4210121583","display_name":"National Centre for the Application of Pharmaceutical Research","ror":"https://ror.org/02y7h5c73","country_code":"MG","type":"facility","lineage":["https://openalex.org/I4210121583"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["MG","US"],"is_corresponding":true,"raw_author_name":"David G. I. Kingston","raw_affiliation_strings":["Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar","institution_ids":["https://openalex.org/I2802431724","https://openalex.org/I4210121583","https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035334062"],"corresponding_institution_ids":["https://openalex.org/I2802431724","https://openalex.org/I4210121583","https://openalex.org/I859038795"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.9315,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.69323652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"69","issue":"2","first_page":"284","last_page":"286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.4918999969959259,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.4918999969959259,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.0997999981045723,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.060100000351667404,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/didymochlaena-truncatula","display_name":"Didymochlaena truncatula","score":1.0},{"id":"https://openalex.org/keywords/cytotoxic-alkaloids","display_name":"cytotoxic alkaloids","score":0.9169999957084656},{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.996999979019165},{"id":"https://openalex.org/keywords/lignans","display_name":"lignans","score":0.7110000252723694},{"id":"https://openalex.org/keywords/stilbenes","display_name":"stilbenes","score":0.8479999899864197},{"id":"https://openalex.org/keywords/stigmasterol-derivatives","display_name":"stigmasterol derivatives","score":0.9620000123977661},{"id":"https://openalex.org/keywords/stigmast-4-en-3-one","display_name":"stigmast-4-en-3-one","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bioassay-guided-fractionation","display_name":"bioassay-guided fractionation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C2619416","wikidata":"https://www.wikidata.org/wiki/Q9444","display_name":"Rainforest","level":2,"score":0.4805731773376465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3479790687561035},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34264588356018066},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.34254512190818787},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2945646047592163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2826443910598755}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008270","descriptor_name":"Madagascar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032491","descriptor_name":"Dryopteridaceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/np050351x","doi":"https://doi.org/10.1021/np050351x","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np050351x","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:16499333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16499333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1930382","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2442717","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2442717","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2442717/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Nat Prod","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1930382","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2442717","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1240151649","display_name":"BIODIVERSITY CONSERVATION AND DRUG DISCOVERY IN MADAGASCAR","funder_award_id":"U01TW000313","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"}],"funders":[{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1499822007","https://openalex.org/W1536538430","https://openalex.org/W1574186453","https://openalex.org/W1969303467","https://openalex.org/W1970964188","https://openalex.org/W1988233851","https://openalex.org/W1988782508","https://openalex.org/W2001074177","https://openalex.org/W2007790651","https://openalex.org/W2021449906","https://openalex.org/W2030959425","https://openalex.org/W2056477652","https://openalex.org/W2159921901","https://openalex.org/W2330639134","https://openalex.org/W2950688107","https://openalex.org/W4297920058"],"related_works":["https://openalex.org/W4226086367","https://openalex.org/W2091598145","https://openalex.org/W2014275855","https://openalex.org/W2075606469","https://openalex.org/W76238874","https://openalex.org/W2004145547","https://openalex.org/W1970039521","https://openalex.org/W2411586634","https://openalex.org/W2000074889","https://openalex.org/W2035446774"],"abstract_inverted_index":{"Bioassay-guided":[0],"fractionation":[1],"of":[2,18,67,73,85,88],"the":[3,16,68,74,83],"EtOH":[4],"extracts":[5],"obtained":[6],"from":[7],"a":[8,59,64],"plant":[9,27],"identified":[10],"as":[11],"Didymochlaena":[12],"truncatula":[13],"led":[14,62],"to":[15,63],"isolation":[17],"two":[19,45],"cytotoxic":[20],"alkaloids,":[21],"camptothecin":[22],"and":[23,39,44,49,54,78,90],"9-methoxycamptothecin.":[24],"A":[25,34],"second":[26],"collection":[28],"yielded":[29],"three":[30],"lignan":[31],"derivatives,":[32,47],"didymochlaenone":[33,36],"(1),":[35],"B":[37],"(2),":[38],"(-)-wikstromol,":[40],"one":[41],"stilbene,":[42],"(E)-3-methoxy-5-hydroxystilbene,":[43],"stigmasterol":[46],"stigmast-4-en-3beta-ol":[48],"stigmast-4-en-3-one,":[50],"but":[51],"no":[52],"camptothecins,":[53],"it":[55],"is":[56],"probable":[57],"that":[58],"coding":[60],"error":[61],"mistaken":[65],"identification":[66],"original":[69],"extract.":[70],"The":[71],"structures":[72],"new":[75],"compounds":[76],"1":[77],"2":[79],"were":[80],"established":[81],"on":[82],"basis":[84],"extensive":[86],"interpretation":[87],"one-":[89],"two-dimensional":[91],"NMR":[92],"spectroscopic":[93],"data.":[94]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}