{"id":"https://openalex.org/W1998765910","doi":"https://doi.org/10.1021/jm058026u","title":"New \u03b2-Alanine Derivatives Are Orally Available Glucagon Receptor Antagonists","display_name":"New \u03b2-Alanine Derivatives Are Orally Available Glucagon Receptor Antagonists","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1998765910","doi":"https://doi.org/10.1021/jm058026u","mag":"1998765910","pmid":"https://pubmed.ncbi.nlm.nih.gov/17201415"},"language":"en","primary_location":{"id":"doi:10.1021/jm058026u","doi":"https://doi.org/10.1021/jm058026u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm058026u","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.7270/q26m36gk","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034154367","display_name":"Jesper F. Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Jesper Lau","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103752752","display_name":"Carsten Behrens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Carsten Behrens","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037124292","display_name":"Ulla Grove Sidelmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Ulla G. Sidelmann","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088627727","display_name":"Lotte Bjerre Knudsen","orcid":"https://orcid.org/0000-0002-2439-7116","observed_orcids":["https://orcid.org/0000-0002-2439-7116"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Lotte B. Knudsen","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111846767","display_name":"Behrend F. Lundt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Behrend Lundt","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061751693","display_name":"Christian K. Sams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Christian Sams","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051883836","display_name":"Lars Ynddal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Lars Ynddal","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013301991","display_name":"Christian Lehn Brand","orcid":"https://orcid.org/0000-0002-7355-4448","observed_orcids":["https://orcid.org/0000-0002-7355-4448"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Christian L. Brand","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051742014","display_name":"Lone Pridal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Lone Pridal","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071128028","display_name":"Anthony L Ling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Anthony Ling","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041537360","display_name":"Dan Kiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Dan Kiel","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040815750","display_name":"Michael B. Plewe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Michael Plewe","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089982355","display_name":"Shengua Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Shengua Shi","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104635952","display_name":"Peter Madsen","orcid":"https://orcid.org/0000-0003-0398-7309","observed_orcids":["https://orcid.org/0000-0003-0398-7309"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Peter Madsen","raw_affiliation_strings":["Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Engineering, Discovery Biology Management, Medicinal Chemistry, Insulin Engineering, Drug Metabolism, Pharmacology Research, and Screening & Assay Technology, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 M\u00e5l\u00f8v, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121","institution_ids":["https://openalex.org/I180857899","https://openalex.org/I189090001"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.1863,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.87039267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"50","issue":"1","first_page":"113","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-receptor-antagonists","display_name":"glucagon receptor antagonists","score":0.8600000143051147},{"id":"https://openalex.org/keywords/beta-alanine-derivatives","display_name":"\u03b2-alanine derivatives","score":0.9440000057220459},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pharmacokinetic-optimization","display_name":"pharmacokinetic optimization","score":0.7260000109672546},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.7350000143051147},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/metabolic-stability","display_name":"metabolic stability","score":0.7080000042915344},{"id":"https://openalex.org/keywords/plasma-half-life","display_name":"plasma half-life","score":0.6669999957084656},{"id":"https://openalex.org/keywords/blood-glucose-reduction","display_name":"blood glucose reduction","score":0.6690000295639038},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.609000027179718},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C2778542361","wikidata":"https://www.wikidata.org/wiki/Q14904911","display_name":"Glucagon receptor","level":4,"score":0.8797787427902222},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.8445677757263184},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.779316782951355},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.761480987071991},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.621745228767395},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5624776482582092},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.49831271171569824},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.49482864141464233},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4377700090408325},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.434217631816864},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39664408564567566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3538326025009155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3174017071723938},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3148144781589508},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29921117424964905},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.12117001414299011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08053359389305115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07988694310188293}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015091","descriptor_name":"beta-Alanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/jm058026u","doi":"https://doi.org/10.1021/jm058026u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm058026u","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:17201415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17201415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"doi:10.7270/q26m36gk","doi":"https://doi.org/10.7270/q26m36gk","is_oa":true,"landing_page_url":"https://doi.org/10.7270/q26m36gk","pdf_url":null,"source":{"id":"https://openalex.org/S7407050887","display_name":"UC San Diego","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36258959","host_organization_name":"University of California San Diego","host_organization_lineage":["https://openalex.org/I36258959"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.7270/q26m36gk","doi":"https://doi.org/10.7270/q26m36gk","is_oa":true,"landing_page_url":"https://doi.org/10.7270/q26m36gk","pdf_url":null,"source":{"id":"https://openalex.org/S7407050887","display_name":"UC San Diego","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36258959","host_organization_name":"University of California San Diego","host_organization_lineage":["https://openalex.org/I36258959"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9077000021934509,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1970197446","https://openalex.org/W1971916173","https://openalex.org/W1995475257","https://openalex.org/W2020860451","https://openalex.org/W2046912474","https://openalex.org/W2053234614","https://openalex.org/W2057537453","https://openalex.org/W2069607377","https://openalex.org/W2074027399","https://openalex.org/W2093559498","https://openalex.org/W2102597208","https://openalex.org/W2116862105","https://openalex.org/W2127258982","https://openalex.org/W2148501195","https://openalex.org/W2157723257","https://openalex.org/W2174116315","https://openalex.org/W2175889513","https://openalex.org/W2328089478","https://openalex.org/W2469222964","https://openalex.org/W4249267146"],"related_works":["https://openalex.org/W2065770644","https://openalex.org/W2955219150","https://openalex.org/W2061888378","https://openalex.org/W4309135006","https://openalex.org/W4382182595","https://openalex.org/W4312184764","https://openalex.org/W2096420012","https://openalex.org/W2948991480","https://openalex.org/W1993170262","https://openalex.org/W4385835379"],"abstract_inverted_index":{"A":[0,71],"weak":[1],"human":[2,76,77],"glucagon":[3,43,78,123],"receptor":[4,44,57,79],"antagonist":[5,73,124],"with":[6,48,89,111],"an":[7],"IC50":[8],"of":[9,17,25,35,74,93,99],"7":[10],"microM":[11],"was":[12,80,126,134],"initially":[13],"found":[14],"by":[15],"screening":[16],"libraries":[18],"originally":[19],"targeted":[20],"to":[21,31,46,56,63,106,113,120],"mimic":[22],"the":[23,26,42,51,65,75],"binding":[24,39],"glucagon-like":[27],"peptide":[28],"(GLP-1)":[29],"hormone":[30],"its":[32],"receptor.":[33],"Optimization":[34],"this":[36,100,109],"hit":[37],"for":[38,41],"affinity":[40,49],"led":[45,119],"ligands":[47],"in":[50,87,129,136,141],"nanomolar":[52],"range.":[53],"In":[54],"addition":[55],"binding,":[58],"optimization":[59,118],"efforts":[60],"were":[61,102],"made":[62],"stabilize":[64],"molecules":[66],"against":[67],"fast":[68],"metabolic":[69],"turnover.":[70],"potent":[72,122],"obtained":[81],"that":[82,125],"had":[83],"17%":[84],"oral":[85],"availability":[86],"rats":[88,130],"a":[90,121,142],"plasma":[91],"half-life":[92],"90":[94],"min.":[95],"The":[96],"major":[97],"metabolites":[98],"lead":[101],"identified":[103],"and":[104,131,133],"used":[105],"further":[107],"optimize":[108],"series":[110],"respect":[112],"pharmacokinetic":[114],"properties.":[115],"This":[116],"final":[117],"orally":[127],"available":[128],"dogs":[132],"efficacious":[135],"lowering":[137],"blood":[138],"glucose":[139],"levels":[140],"diabetic":[143],"animal":[144],"model.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}