{"id":"https://openalex.org/W1998754748","doi":"https://doi.org/10.1042/bj20030985","title":"A proximal tissue-specific module and a distal negative regulatory module control apolipoprotein(a) gene transcription","display_name":"A proximal tissue-specific module and a distal negative regulatory module control apolipoprotein(a) gene transcription","publication_year":2004,"publication_date":"2004-04-01","ids":{"openalex":"https://openalex.org/W1998754748","doi":"https://doi.org/10.1042/bj20030985","mag":"1998754748","pmid":"https://pubmed.ncbi.nlm.nih.gov/14680477","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1224047"},"language":"en","primary_location":{"id":"doi:10.1042/bj20030985","doi":"https://doi.org/10.1042/bj20030985","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20030985","pdf_url":"https://portlandpress.com/biochemj/article-pdf/379/1/151/713124/bj3790151.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/379/1/151/713124/bj3790151.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sarita NEGI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sarita NEGI","raw_affiliation_strings":["Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India","institution_ids":["https://openalex.org/I152429107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100657132","display_name":"Saurabh Kumar Singh","orcid":"https://orcid.org/0000-0001-5081-5249","observed_orcids":["https://orcid.org/0000-0001-5081-5249"]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saurabh K. SINGH","raw_affiliation_strings":["Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India","institution_ids":["https://openalex.org/I152429107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113572762","display_name":"Nirupma Trehan Pati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nirupma PATI","raw_affiliation_strings":["Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India","institution_ids":["https://openalex.org/I152429107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040018378","display_name":"Vikas Handa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vikas HANDA","raw_affiliation_strings":["Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India","institution_ids":["https://openalex.org/I152429107"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ruchi CHAUHAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ruchi CHAUHAN","raw_affiliation_strings":["Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India","institution_ids":["https://openalex.org/I152429107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077963886","display_name":"Uttam Pati","orcid":"https://orcid.org/0000-0002-2115-9219","observed_orcids":["https://orcid.org/0000-0002-2115-9219"]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Uttam PATI","raw_affiliation_strings":["Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India","institution_ids":["https://openalex.org/I152429107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I152429107"],"apc_list":null,"apc_paid":null,"fwci":0.0962,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.34674685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"379","issue":"1","first_page":"151","last_page":"159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.25290000438690186,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.06679999828338623,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/promoter","display_name":"promoter","score":0.5419999957084656},{"id":"https://openalex.org/keywords/tissue-specific-gene-regulation","display_name":"tissue-specific gene regulation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6119999885559082},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.7319999933242798},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/atherosclerosis-risk","display_name":"atherosclerosis risk","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5931980609893799},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5514142513275146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.533402681350708},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5215675234794617},{"id":"https://openalex.org/C190796033","wikidata":"https://www.wikidata.org/wiki/Q1093165","display_name":"Cis-regulatory module","level":5,"score":0.43507158756256104},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43483787775039673},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.416675865650177},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39250510931015015},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.1808813512325287},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001054","descriptor_name":"Apolipoproteins A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001054","descriptor_name":"Apolipoproteins A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj20030985","doi":"https://doi.org/10.1042/bj20030985","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20030985","pdf_url":"https://portlandpress.com/biochemj/article-pdf/379/1/151/713124/bj3790151.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:14680477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14680477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:1224047","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1224047/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1042/bj20030985","doi":"https://doi.org/10.1042/bj20030985","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20030985","pdf_url":"https://portlandpress.com/biochemj/article-pdf/379/1/151/713124/bj3790151.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998754748.pdf","grobid_xml":"https://content.openalex.org/works/W1998754748.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W140894674","https://openalex.org/W1499141978","https://openalex.org/W1507474576","https://openalex.org/W1519773895","https://openalex.org/W1552524080","https://openalex.org/W1570166102","https://openalex.org/W1577509897","https://openalex.org/W1784996751","https://openalex.org/W1974497491","https://openalex.org/W1975739280","https://openalex.org/W1985004365","https://openalex.org/W1987462225","https://openalex.org/W1993282231","https://openalex.org/W2002102021","https://openalex.org/W2002146594","https://openalex.org/W2007609332","https://openalex.org/W2012405150","https://openalex.org/W2025982106","https://openalex.org/W2035913301","https://openalex.org/W2037186278","https://openalex.org/W2043593473","https://openalex.org/W2045297835","https://openalex.org/W2046031772","https://openalex.org/W2053111090","https://openalex.org/W2054518067","https://openalex.org/W2059128672","https://openalex.org/W2060297699","https://openalex.org/W2063816440","https://openalex.org/W2064586774","https://openalex.org/W2066126216","https://openalex.org/W2070815694","https://openalex.org/W2077639429","https://openalex.org/W2079456814","https://openalex.org/W2079569490","https://openalex.org/W2081572625","https://openalex.org/W2084442122","https://openalex.org/W2093039351","https://openalex.org/W2095138452","https://openalex.org/W2108161900","https://openalex.org/W2110320405","https://openalex.org/W2143308743","https://openalex.org/W2162507144","https://openalex.org/W2171302228","https://openalex.org/W2175278878","https://openalex.org/W2267250638","https://openalex.org/W2417512642","https://openalex.org/W2993032494"],"related_works":["https://openalex.org/W1499141978","https://openalex.org/W2087397328","https://openalex.org/W1971012418","https://openalex.org/W2002102021","https://openalex.org/W1597231611","https://openalex.org/W206244674","https://openalex.org/W3023473932","https://openalex.org/W1489708200","https://openalex.org/W1484600553","https://openalex.org/W2085695328"],"abstract_inverted_index":{"The":[0,24,75,108,142],"apo(a)":[1,25,51,168,189,199,223],"[apolipoprotein(a)]":[2],"gene":[3,140,169,190,200,224],"is":[4,163,196],"responsible":[5,164],"for":[6,19,165,198],"variations":[7],"in":[8,33,38,117,157,170,204],"plasma":[9],"lipoprotein(a),":[10],"high":[11],"levels":[12],"of":[13,30,211,222],"which":[14,97,162],"are":[15],"a":[16,58,68,118,176,205],"risk":[17],"factor":[18,128],"atherosclerosis":[20],"and":[21,67,91,130,160,202,214],"myocardial":[22],"infarction.":[23],"promoter":[26,52],"stimulates":[27],"the":[28,42,48,99,122,167,193,208,212,219],"expression":[29],"reporter":[31],"genes":[32],"HepG2":[34,158],"cells,":[35,159],"but":[36],"not":[37],"HeLa":[39,171],"cells.":[40,172],"In":[41],"present":[43],"study,":[44],"we":[45],"demonstrate":[46],"that":[47,154],"1.4":[49],"kb":[50],"comprises":[53],"two":[54,81,147],"composite":[55],"regulatory":[56,61,78,84,94,101,105,148,181],"regions:":[57],"distal":[59,76,213],"negative":[60,77,83],"module":[62,71,79,145,195],"(positions":[63],"-1432":[64],"to":[65,73,112,114,136,138,175,186],"-716)":[66],"proximal":[69,143,215],"tissue-specific":[70,119,144,194,206],"(-716":[72],"-616).":[74],"contains":[80,146],"strong":[82],"regions":[85],"[polymorphic":[86],"PNR":[87,109],"(pentanucleotide":[88],"repeat":[89],"region)":[90],"NREbeta":[92,137],"(negative":[93],"element":[95,106],"beta)],":[96],"sandwich":[98],"postive":[100],"region":[102,152],"PREbeta":[103],"(positive":[104],"beta).":[107],"was":[110],"shown":[111],"bind":[113],"transcription":[115,124,156],"factors":[116,125],"manner,":[120,207],"whereas":[121],"ubiquitous":[123],"hepatocyte":[126],"nuclear":[127],"3alpha":[129],"GATA":[131],"binding":[132],"protein":[133],"4":[134],"bound":[135],"repress":[139],"transcription.":[141],"elements:":[149],"an":[150],"activating":[151],"(PREalpha)":[153],"activates":[155],"NREalpha,":[161],"repressing":[166],"NREalpha":[173],"binds":[174],"HeLa-specific":[177],"repressor.":[178],"These":[179],"multiple":[180],"elements":[182],"might":[183,217],"work":[184],"co-operatively":[185],"finely":[187],"regulate":[188],"expression.":[191],"Although":[192],"required":[197],"activation":[201],"repression":[203],"combinatorial":[209],"interplay":[210],"regulators":[216],"define":[218],"complex":[220],"pathway(s)":[221],"regulation.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
