{"id":"https://openalex.org/W1998714974","doi":"https://doi.org/10.1097/mph.0000000000000160","title":"Practice Patterns of Stroke Screening and Hydroxyurea Use in Children With Sickle Cell Disease","display_name":"Practice Patterns of Stroke Screening and Hydroxyurea Use in Children With Sickle Cell Disease","publication_year":2014,"publication_date":"2014-04-07","ids":{"openalex":"https://openalex.org/W1998714974","doi":"https://doi.org/10.1097/mph.0000000000000160","mag":"1998714974","pmid":"https://pubmed.ncbi.nlm.nih.gov/24714503"},"language":"en","primary_location":{"id":"doi:10.1097/mph.0000000000000160","doi":"https://doi.org/10.1097/mph.0000000000000160","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0000000000000160","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082449593","display_name":"Nicholas Andrew Madden","orcid":"https://orcid.org/0000-0002-3287-9422","observed_orcids":["https://orcid.org/0000-0002-3287-9422"]},"institutions":[{"id":"https://openalex.org/I1328594524","display_name":"Children's Mercy Hospital","ror":"https://ror.org/04zfmcq84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328594524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas A. Madden","raw_affiliation_strings":["Children's Mercy Hospitals and Clinics, Kansas City, MO","Accepted March 5, 2014","Received July 28, 2013","Reprints: Nicholas A. Madden, MD, 209 E. 36th St. Unit #3, Kansas City, MO 64111 (e-mail: [email\u00a0protected])","The authors declare no conflict of interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Mercy Hospitals and Clinics, Kansas City, MO","institution_ids":["https://openalex.org/I1328594524"]},{"raw_affiliation_string":"Accepted March 5, 2014","institution_ids":[]},{"raw_affiliation_string":"Received July 28, 2013","institution_ids":[]},{"raw_affiliation_string":"Reprints: Nicholas A. Madden, MD, 209 E. 36th St. Unit #3, Kansas City, MO 64111 (e-mail: [email\u00a0protected])","institution_ids":[]},{"raw_affiliation_string":"The authors declare no conflict of interest","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064134029","display_name":"G. Jones","orcid":"https://orcid.org/0000-0002-4761-5729","observed_orcids":["https://orcid.org/0000-0002-4761-5729"]},"institutions":[{"id":"https://openalex.org/I1328594524","display_name":"Children's Mercy Hospital","ror":"https://ror.org/04zfmcq84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328594524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary L. Jones","raw_affiliation_strings":["Accepted March 5, 2014","Children\u2019s Mercy Hospitals and Clinics, Kansas City, MO","Received July 28, 2013","Reprints: Nicholas A. Madden, MD, 209 E. 36th St. Unit #3, Kansas City, MO 64111 (e-mail: [email\u00a0protected])","The authors declare no conflict of interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Accepted March 5, 2014","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Mercy Hospitals and Clinics, Kansas City, MO","institution_ids":["https://openalex.org/I1328594524"]},{"raw_affiliation_string":"Received July 28, 2013","institution_ids":[]},{"raw_affiliation_string":"Reprints: Nicholas A. Madden, MD, 209 E. 36th St. Unit #3, Kansas City, MO 64111 (e-mail: [email\u00a0protected])","institution_ids":[]},{"raw_affiliation_string":"The authors declare no conflict of interest","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087767536","display_name":"Ram V. Kalpatthi","orcid":"https://orcid.org/0000-0002-2135-2801","observed_orcids":["https://orcid.org/0000-0002-2135-2801"]},"institutions":[{"id":"https://openalex.org/I1328594524","display_name":"Children's Mercy Hospital","ror":"https://ror.org/04zfmcq84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328594524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ram Kalpatthi","raw_affiliation_strings":["Accepted March 5, 2014","Children\u2019s Mercy Hospitals and Clinics, Kansas City, MO","Received July 28, 2013","Reprints: Nicholas A. Madden, MD, 209 E. 36th St. Unit #3, Kansas City, MO 64111 (e-mail: [email\u00a0protected])","The authors declare no conflict of interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Accepted March 5, 2014","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Mercy Hospitals and Clinics, Kansas City, MO","institution_ids":["https://openalex.org/I1328594524"]},{"raw_affiliation_string":"Received July 28, 2013","institution_ids":[]},{"raw_affiliation_string":"Reprints: Nicholas A. Madden, MD, 209 E. 36th St. Unit #3, Kansas City, MO 64111 (e-mail: [email\u00a0protected])","institution_ids":[]},{"raw_affiliation_string":"The authors declare no conflict of interest","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110507157","display_name":"Gerald M. Woods","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1328594524","display_name":"Children's Mercy Hospital","ror":"https://ror.org/04zfmcq84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328594524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald Woods","raw_affiliation_strings":["Accepted March 5, 2014","Children\u2019s Mercy Hospitals and Clinics, Kansas City, MO","Received July 28, 2013","Reprints: Nicholas A. Madden, MD, 209 E. 36th St. Unit #3, Kansas City, MO 64111 (e-mail: [email\u00a0protected])","The authors declare no conflict of interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Accepted March 5, 2014","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Mercy Hospitals and Clinics, Kansas City, MO","institution_ids":["https://openalex.org/I1328594524"]},{"raw_affiliation_string":"Received July 28, 2013","institution_ids":[]},{"raw_affiliation_string":"Reprints: Nicholas A. Madden, MD, 209 E. 36th St. Unit #3, Kansas City, MO 64111 (e-mail: [email\u00a0protected])","institution_ids":[]},{"raw_affiliation_string":"The authors declare no conflict of interest","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1328594524"],"apc_list":null,"apc_paid":null,"fwci":0.9381,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.73583974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"36","issue":"6","first_page":"e382","last_page":"e386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/stroke-screening","display_name":"stroke screening","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.8529999852180481},{"id":"https://openalex.org/keywords/silent-cerebral-infarction","display_name":"silent cerebral infarction","score":0.8960000276565552},{"id":"https://openalex.org/keywords/transcranial-doppler","display_name":"transcranial Doppler","score":0.968999981880188},{"id":"https://openalex.org/keywords/mri-screening","display_name":"MRI screening","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.5680000185966492},{"id":"https://openalex.org/keywords/variation-in-clinical-practice","display_name":"clinical practice variation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/chronic-transfusion-therapy","display_name":"chronic transfusion","score":0.7089999914169312},{"id":"https://openalex.org/keywords/acute-chest-syndrome","display_name":"acute chest syndrome","score":0.6420000195503235},{"id":"https://openalex.org/keywords/geographic-variation-in-prescribing","display_name":"geographic variation in prescribing","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9683217406272888},{"id":"https://openalex.org/C191616109","wikidata":"https://www.wikidata.org/wiki/Q3512319","display_name":"Transcranial Doppler","level":2,"score":0.8343064785003662},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.7502932548522949},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.606765866279602},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5820785760879517},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5060445666313171},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4865809679031372},{"id":"https://openalex.org/C2779668550","wikidata":"https://www.wikidata.org/wiki/Q1642147","display_name":"Hemoglobinopathy","level":3,"score":0.46714967489242554},{"id":"https://openalex.org/C2779546523","wikidata":"https://www.wikidata.org/wiki/Q17143511","display_name":"Pediatric stroke","level":4,"score":0.4623848497867584},{"id":"https://openalex.org/C2780976302","wikidata":"https://www.wikidata.org/wiki/Q4677915","display_name":"Acute chest syndrome","level":4,"score":0.45170509815216064},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.4004892408847809},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.37759020924568176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31842678785324097},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.22233781218528748},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.19671767950057983},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.12883532047271729},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000986","descriptor_name":"Antisickling Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D006451","descriptor_name":"Hemoglobin, Sickle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009017","descriptor_name":"Morbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010818","descriptor_name":"Practice Patterns, Physicians'","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019538","descriptor_name":"Health Care Surveys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019983","descriptor_name":"Guideline Adherence","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D056586","descriptor_name":"Acute Chest Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D056586","descriptor_name":"Acute Chest Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/mph.0000000000000160","doi":"https://doi.org/10.1097/mph.0000000000000160","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0000000000000160","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},{"id":"pmid:24714503","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24714503","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric hematology/oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2000957858","https://openalex.org/W2053431904"],"related_works":["https://openalex.org/W4317545813","https://openalex.org/W2609957964","https://openalex.org/W2560764302","https://openalex.org/W4389248765","https://openalex.org/W4396663975","https://openalex.org/W2010433766","https://openalex.org/W2914296878","https://openalex.org/W2808078884","https://openalex.org/W2922063927","https://openalex.org/W4407691110"],"abstract_inverted_index":{"Incidence":[0],"of":[1,13,60,81,104,117,125,138,157,183,198],"stroke":[2,122,172],"in":[3,28,47,77,161,171],"sickle":[4],"cell":[5],"disease":[6],"(SCD)":[7],"has":[8,92],"declined":[9],"with":[10,79,98,179],"the":[11,58,115],"use":[12,27,97,116,124,149,176],"transcranial":[14,118],"Doppler":[15,119],"ultrasound":[16,120],"and":[17,33,50,85,130,145,147,174,186],"chronic":[18],"transfusion":[19],"therapy.":[20],"There":[21,189],"is":[22,52,73],"little":[23],"information":[24],"regarding":[25,67],"their":[26],"genotypes":[29,141],"other":[30,99,142],"than":[31,143],"HbSS":[32,144],"HbS\u03b2.":[34],"Silent":[35],"cerebral":[36],"infarcts":[37],"(SCIs)":[38],"have":[39,165],"been":[40,94],"identified":[41],"by":[42],"magnetic":[43],"resonance":[44],"imaging":[45],"(MRI)":[46],"SCD":[48],"patients":[49,78],"it":[51],"believed":[53],"that":[54],"these":[55,199],"may":[56],"increase":[57],"risk":[59],"overt":[61],"stroke.":[62],"No":[63],"evidence-based":[64,193],"guidelines":[65,194],"exist":[66],"MRI":[68,127,150],"screening":[69,126,173],"for":[70,96,121,128,133,153],"SCIs.":[71,154,166],"Hydroxyurea":[72],"a":[74,108],"standard":[75],"therapy":[76],"history":[80],"acute":[82],"chest":[83],"syndrome":[84],"severe,":[86],"recurrent,":[87],"SCD-associated":[88],"pain":[89],"episodes,":[90],"but":[91],"not":[93],"established":[95],"sickle-associated":[100],"morbidities.":[101],"A":[102],"total":[103],"102":[105],"institutions":[106,139,158],"received":[107],"survey":[109],"(with":[110],"62":[111],"responses)":[112],"to":[113,151,164,195],"assess":[114],"screening,":[123],"SCIs,":[129],"institutional":[131],"patterns":[132],"prescribing":[134],"hydroxyurea.":[135],"Nineteen":[136],"percent":[137,156],"screen":[140,152],"HbS\u03b2,":[146],"24%":[148],"Twenty-six":[155],"prescribed":[159],"hydroxyurea":[160,175],"patient":[162],"found":[163],"Results":[167],"indicate":[168],"significant":[169],"variation":[170],"often":[177],"correlating":[178],"clinic":[180],"size,":[181],"number":[182],"physician":[184],"providers,":[185],"geographic":[187],"location.":[188],"are":[190],"currently":[191],"no":[192],"support":[196],"many":[197],"practices.":[200]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}