{"id":"https://openalex.org/W1998712005","doi":"https://doi.org/10.1097/cej.0b013e3281108101","title":"The relation of soy intake and isoflavone levels in nipple aspirate fluid","display_name":"The relation of soy intake and isoflavone levels in nipple aspirate fluid","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W1998712005","doi":"https://doi.org/10.1097/cej.0b013e3281108101","mag":"1998712005","pmid":"https://pubmed.ncbi.nlm.nih.gov/18090913"},"language":"en","primary_location":{"id":"doi:10.1097/cej.0b013e3281108101","doi":"https://doi.org/10.1097/cej.0b013e3281108101","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cej.0b013e3281108101","pdf_url":null,"source":{"id":"https://openalex.org/S35423025","display_name":"European Journal of Cancer Prevention","issn_l":"0959-8278","issn":["0959-8278","1473-5709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer Prevention","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022456575","display_name":"Gertraud Maskarinec","orcid":"https://orcid.org/0000-0002-8129-958X","observed_orcids":["https://orcid.org/0000-0002-8129-958X"]},"institutions":[{"id":"https://openalex.org/I4210093646","display_name":"Cancer Center of Hawaii","ror":"https://ror.org/0065jhh26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093646"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gertraud Maskarinec","raw_affiliation_strings":["Cancer Research Center of Hawaii, Honolulu, Hawaii 96813, USA. gertraud@crch.hawaii.edu","Cancer Research Center of Hawaii, Honolulu, Hawaii, USA","to Gertraud Maskarinec, MD, PhD, Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center of Hawaii, Honolulu, Hawaii 96813, USA. gertraud@crch.hawaii.edu","institution_ids":[]},{"raw_affiliation_string":"Cancer Research Center of Hawaii, Honolulu, Hawaii, USA","institution_ids":[]},{"raw_affiliation_string":"to Gertraud Maskarinec, MD, PhD, Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I4210093646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026857532","display_name":"Sandra M. Hebshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Hebshi","raw_affiliation_strings":["Cancer Research Center of Hawaii, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center of Hawaii, Honolulu, Hawaii, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019126987","display_name":"Laurie J. Custer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurie Custer","raw_affiliation_strings":["Cancer Research Center of Hawaii, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center of Hawaii, Honolulu, Hawaii, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077982482","display_name":"Adrian A. Franke","orcid":"https://orcid.org/0000-0002-1911-1662","observed_orcids":["https://orcid.org/0000-0002-1911-1662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adrian A. Franke","raw_affiliation_strings":["Cancer Research Center of Hawaii, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center of Hawaii, Honolulu, Hawaii, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022456575"],"corresponding_institution_ids":["https://openalex.org/I4210093646"],"apc_list":null,"apc_paid":null,"fwci":2.9487,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.90093336,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"1","first_page":"67","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.9319999814033508},{"id":"https://openalex.org/keywords/soy-consumption","display_name":"soy consumption","score":0.7799999713897705},{"id":"https://openalex.org/keywords/nipple-aspirate-fluid","display_name":"nipple aspirate fluid","score":0.8790000081062317},{"id":"https://openalex.org/keywords/breast-cancer-prevention","display_name":"breast cancer prevention","score":0.6980000138282776},{"id":"https://openalex.org/keywords/soy-milk","display_name":"soy milk","score":0.7400000095367432},{"id":"https://openalex.org/keywords/breast-tissue","display_name":"breast tissue","score":0.6660000085830688},{"id":"https://openalex.org/keywords/estrogenic-compounds","display_name":"estrogenic compounds","score":0.5350000262260437},{"id":"https://openalex.org/keywords/dietary-soy","display_name":"dietary soy","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C2910376424","wikidata":"https://www.wikidata.org/wiki/Q11006","display_name":"SOY ISOFLAVONES","level":3,"score":0.5628735423088074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5443214774131775},{"id":"https://openalex.org/C2993983287","wikidata":"https://www.wikidata.org/wiki/Q192199","display_name":"Soy milk","level":2,"score":0.46666401624679565},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.41685253381729126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28159138560295105},{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.20816603302955627},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1491476595401764}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009558","descriptor_name":"Nipples","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009558","descriptor_name":"Nipples","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009558","descriptor_name":"Nipples","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009558","descriptor_name":"Nipples","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009558","descriptor_name":"Nipples","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009558","descriptor_name":"Nipples","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045730","descriptor_name":"Soy Foods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045730","descriptor_name":"Soy Foods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045730","descriptor_name":"Soy Foods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/cej.0b013e3281108101","doi":"https://doi.org/10.1097/cej.0b013e3281108101","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cej.0b013e3281108101","pdf_url":null,"source":{"id":"https://openalex.org/S35423025","display_name":"European Journal of Cancer Prevention","issn_l":"0959-8278","issn":["0959-8278","1473-5709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer Prevention","raw_type":"journal-article"},{"id":"pmid:18090913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18090913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6499999761581421}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G4497407828","display_name":"Liquid Chromatography Mass Spectrometry system","funder_award_id":"1s10rr020890-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6448502959","display_name":null,"funder_award_id":"RR020890","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1892142783","https://openalex.org/W1926166914","https://openalex.org/W1939905704","https://openalex.org/W1963853968","https://openalex.org/W1969374932","https://openalex.org/W1981266085","https://openalex.org/W1992890529","https://openalex.org/W2001515046","https://openalex.org/W2006379730","https://openalex.org/W2010547780","https://openalex.org/W2050847082","https://openalex.org/W2080595487","https://openalex.org/W2081889687","https://openalex.org/W2089775638","https://openalex.org/W2092258778","https://openalex.org/W2096219527","https://openalex.org/W2108355221","https://openalex.org/W2115638437","https://openalex.org/W2127737387","https://openalex.org/W2142297484","https://openalex.org/W2148926849","https://openalex.org/W2164260731","https://openalex.org/W2262102326","https://openalex.org/W2324825551","https://openalex.org/W4247188945"],"related_works":["https://openalex.org/W835048466","https://openalex.org/W781346807","https://openalex.org/W1988562990","https://openalex.org/W2305030950","https://openalex.org/W1526348889","https://openalex.org/W2378239227","https://openalex.org/W747897157","https://openalex.org/W4311960574","https://openalex.org/W848135557","https://openalex.org/W2006219613"],"abstract_inverted_index":{"Given":[0],"the":[1,26,85,149,178,198],"possible":[2],"breast":[3,245,252],"cancer":[4],"preventive":[5],"effects":[6],"of":[7,19,30,63,67,92,200,231],"isoflavones,":[8],"substances":[9],"with":[10,46,102,197,205],"an":[11,103],"estrogen-like":[12],"structure":[13],"occurring":[14],"in":[15,25,38,116,170,182,187,214,223,233,244],"soybeans,":[16],"it":[17],"is":[18],"interest":[20],"to":[21,35,229],"assess":[22],"levels":[23,169,230],"directly":[24,250],"breast.":[27],"The":[28],"objective":[29],"this":[31],"pilot":[32,44,209],"study":[33,45,210],"was":[34,100],"measure":[36],"isoflavones":[37],"nipple":[39,49,78,117,154,171,188,215],"aspirate":[40,50,79,98,118,155,172,189,216],"fluid.":[41],"In":[42,71],"a":[43,72],"11":[47],"women,":[48],"fluid":[51,99,156,173,217,246],"and":[52,59,82,109,121,167,192,204,225,235,247],"urine":[53,83,122,193,234],"samples":[54,180],"were":[55,123,194],"collected":[56,101,181],"at":[57,111],"baseline":[58],"after":[60,88,126],"1":[61,106],"month":[62],"consuming":[64,89],"two":[65],"servings":[66,203],"soymilk":[68],"per":[69],"day.":[70],"parallel":[73],"investigation,":[74],"one":[75,183],"woman":[76],"donated":[77],"fluid,":[80,119,190],"blood,":[81],"on":[84,251],"same":[86],"day":[87],"different":[90],"amounts":[91],"soy":[93,151,202],"for":[94],"9":[95],"days.":[96],"Nipple":[97],"aspirator,":[104],"diluted":[105],":":[107],"11,":[108],"stored":[110],"-20":[112],"degrees":[113],"C.":[114],"Isoflavonoids":[115],"serum,":[120],"liquid-liquid":[124],"extracted":[125],"enzymatic":[127],"hydrolysis":[128],"followed":[129],"by":[130],"liquid":[131],"chromatography":[132],"electrospray":[133],"ionization":[134],"high":[135],"resolution":[136],"tandem":[137],"mass":[138],"spectrometry":[139],"analysis":[140],"using":[141],"triply":[142],"C":[143],"labeled":[144],"internal":[145],"isoflavonoid":[146,164,168],"standards.":[147],"After":[148],"30-day":[150],"intervention,":[152],"median":[153],"yield":[157],"changed":[158],"very":[159],"little":[160],"(P=0.47),":[161],"whereas":[162],"urinary":[163],"excretion":[165],"(P=0.04)":[166],"(P=0.12)":[174],"increased":[175],"substantially.":[176],"For":[177],"nine":[179],"participant,":[184],"isoflavonoids":[185,213,232,241],"measured":[186],"plasma,":[191],"highly":[195],"correlated":[196],"number":[199],"daily":[201],"each":[206],"other.":[207],"This":[208],"indicates":[211],"that":[212,240],"are":[218,226,242],"10":[219],"times":[220],"lower":[221],"than":[222],"plasma":[224],"closely":[227],"related":[228],"plasma.":[236],"These":[237],"findings":[238],"show":[239],"present":[243],"may":[248],"act":[249],"tissue.":[253]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}