{"id":"https://openalex.org/W1998707409","doi":"https://doi.org/10.1007/s10350-005-0175-9","title":"Gene Expression Profiling of Nonneoplastic Mucosa May Predict Clinical Outcome of Colon Cancer Patients","display_name":"Gene Expression Profiling of Nonneoplastic Mucosa May Predict Clinical Outcome of Colon Cancer Patients","publication_year":2005,"publication_date":"2005-10-13","ids":{"openalex":"https://openalex.org/W1998707409","doi":"https://doi.org/10.1007/s10350-005-0175-9","mag":"1998707409","pmid":"https://pubmed.ncbi.nlm.nih.gov/16228831"},"language":"en","primary_location":{"id":"doi:10.1007/s10350-005-0175-9","doi":"https://doi.org/10.1007/s10350-005-0175-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10350-005-0175-9","pdf_url":null,"source":{"id":"https://openalex.org/S170496595","display_name":"Diseases of the Colon & Rectum","issn_l":"0012-3706","issn":["0012-3706","1530-0358"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the Colon & Rectum","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://archive-ouverte.unige.ch/unige:47111","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049373118","display_name":"Alain J. Barrier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Barrier","raw_affiliation_strings":["Service de Chirurgie Digestive, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France. barrier@stat.berkeley.edu","Service de Chirurgie Digestive, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Chirurgie Digestive, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France. barrier@stat.berkeley.edu","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210166768","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"Service de Chirurgie Digestive, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210166768","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000035181","display_name":"Pierre\u2010Yves Bo\u00eblle","orcid":"https://orcid.org/0000-0002-5367-8232","observed_orcids":["https://orcid.org/0000-0002-5367-8232"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Pierre-Yves Boelle","raw_affiliation_strings":["Division of Biostatistics, School of Public Health, 140 Earl Warren Hall, Berkeley, California, 94720-7360, e-mail","INSERM U444, Facult\u00e9 de M\u00e9decine Saint-Antoine, Universit\u00e9 Pierre et Marie Curie, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, School of Public Health, 140 Earl Warren Hall, Berkeley, California, 94720-7360, e-mail","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"INSERM U444, Facult\u00e9 de M\u00e9decine Saint-Antoine, Universit\u00e9 Pierre et Marie Curie, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087747021","display_name":"Antoinette Lemoine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoinette Lemoine","raw_affiliation_strings":["INSERM U602, H\u00f4pital Paul Brousse, Universit\u00e9 Paris XI, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U602, H\u00f4pital Paul Brousse, Universit\u00e9 Paris XI, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210164847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057506145","display_name":"Chantal Ts\u00e9","orcid":"https://orcid.org/0000-0003-1212-4441","observed_orcids":["https://orcid.org/0000-0003-1212-4441"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chantal Tse","raw_affiliation_strings":["Service de Biochimie, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Biochimie, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210166768","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020208808","display_name":"Didier Brault","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Brault","raw_affiliation_strings":["Service de Biochimie, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Biochimie, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210166768","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083707745","display_name":"Franck Chiappini","orcid":"https://orcid.org/0000-0002-2684-1241","observed_orcids":["https://orcid.org/0000-0002-2684-1241"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Chiappini","raw_affiliation_strings":["INSERM U602, H\u00f4pital Paul Brousse, Universit\u00e9 Paris XI, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U602, H\u00f4pital Paul Brousse, Universit\u00e9 Paris XI, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210164847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024153667","display_name":"FRAN\u00c7OIS LACAINE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Lacaine","raw_affiliation_strings":["Service de Chirurgie Digestive, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Chirurgie Digestive, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210166768","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064602870","display_name":"Sidney Houry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sidney Houry","raw_affiliation_strings":["Service de Chirurgie Digestive, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Chirurgie Digestive, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210166768","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110267930","display_name":"Michel Huguier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Huguier","raw_affiliation_strings":["Service de Chirurgie Digestive, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Chirurgie Digestive, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie, Assistance Publique, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210166768","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077750825","display_name":"Antoine Flahault","orcid":"https://orcid.org/0000-0002-6957-2977","observed_orcids":["https://orcid.org/0000-0002-6957-2977"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoine Flahault","raw_affiliation_strings":["INSERM U444, Facult\u00e9 de M\u00e9decine Saint-Antoine, Universit\u00e9 Pierre et Marie Curie, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U444, Facult\u00e9 de M\u00e9decine Saint-Antoine, Universit\u00e9 Pierre et Marie Curie, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405264447"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018207168","display_name":"Sandrine Dudoit","orcid":"https://orcid.org/0000-0002-6069-8629","observed_orcids":["https://orcid.org/0000-0002-6069-8629"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandrine Dudoit","raw_affiliation_strings":["Division of Biostatistics, School of Public Health, University of California, Berkeley, California, France","Division of Biostatistics, School of Public Health, University of California, Berkeley, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, School of Public Health, University of California, Berkeley, California, France","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Division of Biostatistics, School of Public Health, University of California, Berkeley, France","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5059,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.79526862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"48","issue":"12","first_page":"2238","last_page":"2248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/prognosis-prediction","display_name":"outcome prediction","score":0.6349999904632568},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8159999847412109},{"id":"https://openalex.org/keywords/adjacent-normal-tissue","display_name":"adjacent normal tissue","score":0.6959999799728394},{"id":"https://openalex.org/keywords/metachronous-metastases","display_name":"metachronous metastasis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/stage-ii-colon-cancer","display_name":"stage II colon cancer","score":0.7950000166893005},{"id":"https://openalex.org/keywords/stage-iii-colon-cancer","display_name":"stage III colon cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7210000157356262},{"id":"https://openalex.org/keywords/k-nearest-neighbors","display_name":"k-nearest neighbors","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8921130895614624},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6931470632553101},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.6623619198799133},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5927457809448242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4774892032146454},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4596007466316223},{"id":"https://openalex.org/C523026621","wikidata":"https://www.wikidata.org/wiki/Q1413084","display_name":"Colorectal surgery","level":3,"score":0.43245846033096313},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4216920733451843},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3688247799873352},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2816341817378998},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23917368054389954},{"id":"https://openalex.org/C2780120127","wikidata":"https://www.wikidata.org/wiki/Q743664","display_name":"Abdominal surgery","level":2,"score":0.1802160143852234},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07537788152694702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005188","descriptor_name":"False Negative Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s10350-005-0175-9","doi":"https://doi.org/10.1007/s10350-005-0175-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10350-005-0175-9","pdf_url":null,"source":{"id":"https://openalex.org/S170496595","display_name":"Diseases of the Colon & Rectum","issn_l":"0012-3706","issn":["0012-3706","1530-0358"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the Colon & Rectum","raw_type":"journal-article"},{"id":"pmid:16228831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16228831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the colon and rectum","raw_type":"Evaluation Study"},{"id":"pmh:oai:unige.ch:unige:47111","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:47111","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 0012-3706","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:aou:unige:47111","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:47111","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0012-3706","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:unige.ch:aou:unige:47111","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:47111","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0012-3706","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W118074277","https://openalex.org/W1539282978","https://openalex.org/W1575714113","https://openalex.org/W1777887542","https://openalex.org/W1795564265","https://openalex.org/W1845706120","https://openalex.org/W1935492807","https://openalex.org/W1955295242","https://openalex.org/W1958418663","https://openalex.org/W1962875322","https://openalex.org/W1965138864","https://openalex.org/W1965327752","https://openalex.org/W1976564639","https://openalex.org/W1980645806","https://openalex.org/W2000317813","https://openalex.org/W2000435171","https://openalex.org/W2000771269","https://openalex.org/W2018009295","https://openalex.org/W2024090397","https://openalex.org/W2031300004","https://openalex.org/W2041413731","https://openalex.org/W2058347339","https://openalex.org/W2064208261","https://openalex.org/W2073738917","https://openalex.org/W2074279306","https://openalex.org/W2074336818","https://openalex.org/W2078502914","https://openalex.org/W2081463764","https://openalex.org/W2087684630","https://openalex.org/W2096353669","https://openalex.org/W2096478492","https://openalex.org/W2097413644","https://openalex.org/W2098373165","https://openalex.org/W2105436057","https://openalex.org/W2107956883","https://openalex.org/W2108047366","https://openalex.org/W2113745932","https://openalex.org/W2114149902","https://openalex.org/W2120574072","https://openalex.org/W2120865735","https://openalex.org/W2121708973","https://openalex.org/W2128985829","https://openalex.org/W2130177771","https://openalex.org/W2130184067","https://openalex.org/W2139393303","https://openalex.org/W2153206163","https://openalex.org/W2154648888","https://openalex.org/W2160450758","https://openalex.org/W2160933524","https://openalex.org/W2161867610","https://openalex.org/W2163149540","https://openalex.org/W2163564081","https://openalex.org/W2168561598","https://openalex.org/W2170989872","https://openalex.org/W2171232394","https://openalex.org/W2313857605","https://openalex.org/W2327245331","https://openalex.org/W2469345929","https://openalex.org/W2502134830","https://openalex.org/W2600195475","https://openalex.org/W2796856748","https://openalex.org/W4250091029","https://openalex.org/W6986938095"],"related_works":["https://openalex.org/W7024070018","https://openalex.org/W2064231891","https://openalex.org/W2070605698","https://openalex.org/W1490338373","https://openalex.org/W2138137742","https://openalex.org/W2587815472","https://openalex.org/W2285567736","https://openalex.org/W956682484","https://openalex.org/W7030321115","https://openalex.org/W6788358"],"abstract_inverted_index":{"PURPOSE:":[0],"This":[1,213],"study":[2,214],"assessed":[3],"the":[4,40,53,69,84,87,100,119,142,152,197,239],"possibility":[5],"to":[6,117,171],"build":[7,219],"a":[8,49,220],"prognosis":[9,221],"predictor,":[10],"based":[11,124,231],"on":[12,108,125,232],"microarray":[13,233],"gene":[14,70,88,234],"expression":[15,71,89,235],"measures,":[16,236],"in":[17,73,77,190,196,206],"Stage":[18,224],"II":[19,225],"and":[20,27,83,97,99,111,130,147,154,159,180,184,199,203,209,226,237],"III":[21,227],"colon":[22,34,228],"cancer":[23,35,229],"patients.":[24],"METHODS:":[25],"Tumor":[26],"nonneoplastic":[28,79,243],"mucosa":[29,80,244],"mRNA":[30],"samples":[31,75,81],"from":[32],"12":[33,46],"patients":[36,47],"were":[37,65,106,137,165],"profiled":[38],"using":[39],"Affymetrix":[41],"HGU133A":[42],"GeneChip.":[43],"Six":[44],"of":[45,86,95,122,128,173,178,242],"experienced":[48],"metachronous":[50],"metastasis,":[51],"whereas":[52],"6":[54],"others":[55],"remained":[56],"disease-free":[57],"for":[58,223,245],"more":[59,166],"than":[60,182],"five":[61],"years.":[62],"Three":[63],"datasets":[64],"constituted,":[66],"including,":[67],"respectively,":[68],"measures":[72,90],"tumor":[74],"(T),":[76],"adjacent":[78],"(A),":[82],"log-ratio":[85],"(L).":[91],"The":[92,133],"step-down":[93],"procedure":[94],"Westfall":[96],"Young":[98],"k-nearest":[101],"neighbor":[102],"class":[103],"prediction":[104,140],"method":[105],"applied":[107],"T,":[109],"A,":[110],"L.":[112],"Leave-one-out":[113],"cross-validation":[114],"was":[115],"used":[116],"estimate":[118],"generalization":[120],"error":[121],"predictors":[123,144,157,164,192],"different":[126],"numbers":[127,177],"genes":[129,179,189,194,204],"neighbors.":[131],"RESULTS:":[132],"most":[134],"frequent":[135],"results":[136],"one":[138,217],"false":[139,149],"with":[141,151],"A-based":[143,163,191],"(95":[145],"percent)":[146],"two":[148],"predictions":[150],"T-":[153,183],"L:":[155,185],"-based":[156,186],"(65":[158],"60":[160],"percent,":[161],"respectively).":[162],"stable":[167],"(i.e.,":[168],"less":[169],"sensitive":[170],"changes":[172],"parameters,":[174],"such":[175],"as":[176],"neighbors)":[181],"predictors.":[187],"Informative":[188],"included":[193],"involved":[195,205],"oxidative":[198],"phosphorylative":[200],"mitochondrial":[201],"metabolism":[202],"cell-signaling":[207],"pathways":[208],"their":[210],"receptors.":[211],"CONCLUSIONS:":[212],"suggests":[215,238],"that":[216],"can":[218],"predictor":[222],"patients,":[230],"potential":[240],"usefulness":[241],"this":[246],"purpose.":[247]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}