{"id":"https://openalex.org/W1998683098","doi":"https://doi.org/10.2174/1874382601003010017","title":"Diabetes, Ghrelin And Related Peptides: From Pathophysiology To Vasculopathy","display_name":"Diabetes, Ghrelin And Related Peptides: From Pathophysiology To Vasculopathy","publication_year":2012,"publication_date":"2012-03-14","ids":{"openalex":"https://openalex.org/W1998683098","doi":"https://doi.org/10.2174/1874382601003010017","mag":"1998683098"},"language":"en","primary_location":{"id":"doi:10.2174/1874382601003010017","doi":"https://doi.org/10.2174/1874382601003010017","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874382601003010017","pdf_url":"http://benthamopen.com/contents/pdf/TOCVJ/TOCVJ-3-17.pdf","source":{"id":"https://openalex.org/S81246582","display_name":"The Open Circulation & Vascular Journal","issn_l":"1877-3826","issn":["1877-3826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Circulation & Vascular Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://benthamopen.com/contents/pdf/TOCVJ/TOCVJ-3-17.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052061979","display_name":"Am\u00e2ndio Rocha\u2010Sousa","orcid":"https://orcid.org/0000-0001-8374-0298","observed_orcids":["https://orcid.org/0000-0001-8374-0298"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Amandio Rocha-Sousa","raw_affiliation_strings":["Department of Physiology 1 and Ophthalmology 2 , Faculty of Medicine , University of Porto , Porto , Portugal","University of Porto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology 1 and Ophthalmology 2 , Faculty of Medicine , University of Porto , Porto , Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"University of Porto","institution_ids":["https://openalex.org/I182534213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052061979"],"corresponding_institution_ids":["https://openalex.org/I182534213"],"apc_list":null,"apc_paid":null,"fwci":0.2817,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.54155844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"1","first_page":"17","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":1.0},{"id":"https://openalex.org/keywords/obestatin","display_name":"obestatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8899999856948853},{"id":"https://openalex.org/keywords/pathophysiology-of-diabetes","display_name":"diabetes pathophysiology","score":0.875},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/metabolism","display_name":"metabolism","score":0.7820000052452087},{"id":"https://openalex.org/keywords/growth-hormone-secretagogue-receptor","display_name":"growth hormone secretagogue receptor","score":0.8930000066757202},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/diabetic-vascular-disease","display_name":"diabetic vascular disease","score":0.6909999847412109},{"id":"https://openalex.org/keywords/diabetic-vascular-complications","display_name":"diabetic vascular complications","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.9885646104812622},{"id":"https://openalex.org/C2781146222","wikidata":"https://www.wikidata.org/wiki/Q905680","display_name":"Obestatin","level":4,"score":0.9770693778991699},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.7145084142684937},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6476974487304688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5726203322410583},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5476759672164917},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5422568917274475},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5157835483551025},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5061354041099548},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.46456634998321533},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43572354316711426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32840681076049805},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.18129464983940125}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/1874382601003010017","doi":"https://doi.org/10.2174/1874382601003010017","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874382601003010017","pdf_url":"http://benthamopen.com/contents/pdf/TOCVJ/TOCVJ-3-17.pdf","source":{"id":"https://openalex.org/S81246582","display_name":"The Open Circulation & Vascular Journal","issn_l":"1877-3826","issn":["1877-3826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Circulation & Vascular Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2174/1874382601003010017","doi":"https://doi.org/10.2174/1874382601003010017","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874382601003010017","pdf_url":"http://benthamopen.com/contents/pdf/TOCVJ/TOCVJ-3-17.pdf","source":{"id":"https://openalex.org/S81246582","display_name":"The Open Circulation & Vascular Journal","issn_l":"1877-3826","issn":["1877-3826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Circulation & Vascular Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1781721788","display_name":"Modula\u00e7\u00e3o das propriedades diast\u00f3licas do mioc\u00e1rdio pela endotelina-1 e angiotensina II - Implica\u00e7\u00f5es fisiopatol\u00f3gicas e terap\u00eauticas na insufici\u00eancia card\u00edaca","funder_award_id":"POCI/SAU-FCF/60803/2004","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998683098.pdf","grobid_xml":"https://content.openalex.org/works/W1998683098.grobid-xml"},"referenced_works_count":174,"referenced_works":["https://openalex.org/W235602998","https://openalex.org/W1487667267","https://openalex.org/W1511410209","https://openalex.org/W1616806865","https://openalex.org/W1631334501","https://openalex.org/W1637971961","https://openalex.org/W1868063534","https://openalex.org/W1963930004","https://openalex.org/W1970938572","https://openalex.org/W1973256343","https://openalex.org/W1973600888","https://openalex.org/W1973894166","https://openalex.org/W1977879939","https://openalex.org/W1979098275","https://openalex.org/W1979588112","https://openalex.org/W1980986856","https://openalex.org/W1981052653","https://openalex.org/W1986168431","https://openalex.org/W1986700733","https://openalex.org/W1988022480","https://openalex.org/W1988143227","https://openalex.org/W1989130418","https://openalex.org/W1994176470","https://openalex.org/W1995734405","https://openalex.org/W1996284417","https://openalex.org/W1998289958","https://openalex.org/W2000663727","https://openalex.org/W2001044066","https://openalex.org/W2001161494","https://openalex.org/W2003577251","https://openalex.org/W2004396240","https://openalex.org/W2005380415","https://openalex.org/W2005525019","https://openalex.org/W2006920408","https://openalex.org/W2008646871","https://openalex.org/W2011240459","https://openalex.org/W2012455440","https://openalex.org/W2014159666","https://openalex.org/W2014256858","https://openalex.org/W2017858542","https://openalex.org/W2018492121","https://openalex.org/W2019190598","https://openalex.org/W2022384558","https://openalex.org/W2022832486","https://openalex.org/W2024601252","https://openalex.org/W2027108665","https://openalex.org/W2029958630","https://openalex.org/W2030195369","https://openalex.org/W2031481579","https://openalex.org/W2032659853","https://openalex.org/W2033468788","https://openalex.org/W2034623773","https://openalex.org/W2035600501","https://openalex.org/W2035643732","https://openalex.org/W2036022419","https://openalex.org/W2036861042","https://openalex.org/W2037328290","https://openalex.org/W2037889163","https://openalex.org/W2039814536","https://openalex.org/W2040478405","https://openalex.org/W2045040707","https://openalex.org/W2045397984","https://openalex.org/W2046402357","https://openalex.org/W2046735971","https://openalex.org/W2047258533","https://openalex.org/W2048053645","https://openalex.org/W2048151838","https://openalex.org/W2048194663","https://openalex.org/W2048314567","https://openalex.org/W2050931629","https://openalex.org/W2051410725","https://openalex.org/W2051753034","https://openalex.org/W2056635534","https://openalex.org/W2057644525","https://openalex.org/W2058023072","https://openalex.org/W2060936747","https://openalex.org/W2060982742","https://openalex.org/W2061776382","https://openalex.org/W2062048887","https://openalex.org/W2063052824","https://openalex.org/W2063816197","https://openalex.org/W2065136507","https://openalex.org/W2069505068","https://openalex.org/W2069552504","https://openalex.org/W2070849419","https://openalex.org/W2072911841","https://openalex.org/W2073118840","https://openalex.org/W2073360655","https://openalex.org/W2076987540","https://openalex.org/W2077982572","https://openalex.org/W2078086997","https://openalex.org/W2079011273","https://openalex.org/W2081535097","https://openalex.org/W2082214107","https://openalex.org/W2087357268","https://openalex.org/W2089517606","https://openalex.org/W2090286106","https://openalex.org/W2090389952","https://openalex.org/W2092800106","https://openalex.org/W2094486174","https://openalex.org/W2095318565","https://openalex.org/W2096690310","https://openalex.org/W2096743396","https://openalex.org/W2097643786","https://openalex.org/W2097743939","https://openalex.org/W2097997433","https://openalex.org/W2100398881","https://openalex.org/W2100619916","https://openalex.org/W2103010974","https://openalex.org/W2104122589","https://openalex.org/W2104673560","https://openalex.org/W2105573142","https://openalex.org/W2107194844","https://openalex.org/W2107914421","https://openalex.org/W2109287668","https://openalex.org/W2110305454","https://openalex.org/W2111349333","https://openalex.org/W2112202133","https://openalex.org/W2113970487","https://openalex.org/W2114234975","https://openalex.org/W2117094310","https://openalex.org/W2118617555","https://openalex.org/W2119300545","https://openalex.org/W2119580431","https://openalex.org/W2120228339","https://openalex.org/W2120576941","https://openalex.org/W2121815272","https://openalex.org/W2122603818","https://openalex.org/W2124549557","https://openalex.org/W2124903886","https://openalex.org/W2127182681","https://openalex.org/W2127212851","https://openalex.org/W2128535483","https://openalex.org/W2128594838","https://openalex.org/W2129389766","https://openalex.org/W2131160537","https://openalex.org/W2134304063","https://openalex.org/W2138358001","https://openalex.org/W2139789471","https://openalex.org/W2142674699","https://openalex.org/W2144575734","https://openalex.org/W2144623624","https://openalex.org/W2144648093","https://openalex.org/W2146456530","https://openalex.org/W2147503312","https://openalex.org/W2149074941","https://openalex.org/W2151472458","https://openalex.org/W2153184502","https://openalex.org/W2153745306","https://openalex.org/W2153808458","https://openalex.org/W2156492806","https://openalex.org/W2158823127","https://openalex.org/W2158864582","https://openalex.org/W2159279278","https://openalex.org/W2161371876","https://openalex.org/W2162102234","https://openalex.org/W2162900287","https://openalex.org/W2163314855","https://openalex.org/W2163419120","https://openalex.org/W2163865122","https://openalex.org/W2169715697","https://openalex.org/W2171376440","https://openalex.org/W2171421283","https://openalex.org/W2172086940","https://openalex.org/W2226803319","https://openalex.org/W3134431802","https://openalex.org/W4230431472","https://openalex.org/W4239467172","https://openalex.org/W4240938174","https://openalex.org/W4242398111","https://openalex.org/W4249419262","https://openalex.org/W4251537032","https://openalex.org/W4252489788","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2013163420","https://openalex.org/W2052324668","https://openalex.org/W2035643732","https://openalex.org/W2343685375","https://openalex.org/W1755482721","https://openalex.org/W1485850144","https://openalex.org/W2031532396","https://openalex.org/W1751231261","https://openalex.org/W2054174374","https://openalex.org/W1976084606"],"abstract_inverted_index":{"Ghrelin":[0],"and":[1,33,51,59,63,74,85,92],"obestatin":[2,52,60,86],"are":[3,24],"two":[4,22],"different":[5],"peptides":[6,23],"originated":[7],"from":[8],"the":[9,14,45,55,70,81,98],"same":[10],"gene":[11],"isolated":[12],"in":[13,26,49,61,69,77,87,97],"stomach.Numerous":[15],"actions":[16],"have":[17],"been":[18],"described":[19],"where":[20],"these":[21],"implicated":[25,48],"metabolism,":[27],"appetite":[28,64],"regulation,":[29,32],"glucose":[30,71],"levels":[31],"a":[34],"wide":[35],"range":[36],"of":[37,57,83,89,100],"systemic":[38],"effects.In":[39],"this":[40],"article,":[41],"we":[42],"summarize":[43],"(1)":[44],"cellular":[46],"receptors":[47],"ghrelin":[50,58,84],"effects;":[53],"(2)":[54],"role":[56,68,96],"metabolism":[62],"regulation;":[65],"(3)":[66],"their":[67,94],"homeostasis":[72],"regulation":[73,88,99],"its":[75],"implication":[76],"diabetes":[78],"patho-physiology;":[79],"(5)":[80],"effects":[82],"normal":[90],"angiogenesis":[91],"(6)":[93],"possible":[95],"diabetes-induced":[101],"pathologic":[102],"angiogenesis.":[103]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}