{"id":"https://openalex.org/W1998670002","doi":"https://doi.org/10.1089/aid.1997.13.383","title":"Recognition of a Small Number of Diverse Epitopes Dominates the Cytotoxic T Lymphocyte Response to HIV Type 1 in an Infected Individual","display_name":"Recognition of a Small Number of Diverse Epitopes Dominates the Cytotoxic T Lymphocyte Response to HIV Type 1 in an Infected Individual","publication_year":1997,"publication_date":"1997-03-20","ids":{"openalex":"https://openalex.org/W1998670002","doi":"https://doi.org/10.1089/aid.1997.13.383","mag":"1998670002","pmid":"https://pubmed.ncbi.nlm.nih.gov/9075479"},"language":"en","primary_location":{"id":"doi:10.1089/aid.1997.13.383","doi":"https://doi.org/10.1089/aid.1997.13.383","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.1997.13.383","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003060618","display_name":"Judy Lieberman","orcid":"https://orcid.org/0000-0002-6200-4715","observed_orcids":["https://orcid.org/0000-0002-6200-4715"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JUDY LIEBERMAN","raw_affiliation_strings":["Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02111, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017157686","display_name":"Jessica A. Fabry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JESSICA A. FABRY","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055465229","display_name":"DONNA MEI FONG","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DONNA MEI FONG","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113549928","display_name":"George R. Parkerson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"GEORGE R. PARKERSON","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2022,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.78983957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"13","issue":"5","first_page":"383","last_page":"392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.906000018119812},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ctl-epitopes","display_name":"CTL epitopes","score":0.8349999785423279},{"id":"https://openalex.org/keywords/immunodominant-epitopes","display_name":"immunodominant epitopes","score":0.9330000281333923},{"id":"https://openalex.org/keywords/gag","display_name":"Gag","score":0.4729999899864197},{"id":"https://openalex.org/keywords/nef","display_name":"NEF","score":0.9580000042915344},{"id":"https://openalex.org/keywords/env","display_name":"Env","score":0.703000009059906},{"id":"https://openalex.org/keywords/mhc-diversity","display_name":"MHC diversity","score":0.675000011920929},{"id":"https://openalex.org/keywords/gp160","display_name":"gp160","score":0.6660000085830688},{"id":"https://openalex.org/keywords/hiv-seropositive-individuals","display_name":"HIV seropositive individuals","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.9755973815917969},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.9242417812347412},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7196303606033325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6950933337211609},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6703482270240784},{"id":"https://openalex.org/C2781356689","wikidata":"https://www.wikidata.org/wiki/Q1986297","display_name":"Vaccinia","level":4,"score":0.6030374765396118},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.455618679523468},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.44032636284828186},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.42650726437568665},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.32502222061157227},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.320731520652771},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2939435839653015},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22331783175468445},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10858488082885742},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.09574589133262634},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0865325927734375}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016056","descriptor_name":"Immunodominant Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016056","descriptor_name":"Immunodominant Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016056","descriptor_name":"Immunodominant Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/aid.1997.13.383","doi":"https://doi.org/10.1089/aid.1997.13.383","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.1997.13.383","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},{"id":"pmid:9075479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9075479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS research and human retroviruses","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3669738430","display_name":null,"funder_award_id":"N01-AI-15123","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5837764299","display_name":null,"funder_award_id":"K08-CA01449","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5870121149","display_name":null,"funder_award_id":"R01-AI30926","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1484135921","https://openalex.org/W1498853706","https://openalex.org/W1500975308","https://openalex.org/W1504631955","https://openalex.org/W1519407700","https://openalex.org/W1523002822","https://openalex.org/W1525840776","https://openalex.org/W1646416275","https://openalex.org/W1655510925","https://openalex.org/W1978941920","https://openalex.org/W1997953585","https://openalex.org/W2001267374","https://openalex.org/W2004518821","https://openalex.org/W2006597943","https://openalex.org/W2014311539","https://openalex.org/W2019993505","https://openalex.org/W2022989578","https://openalex.org/W2026078176","https://openalex.org/W2026893977","https://openalex.org/W2030017358","https://openalex.org/W2030641724","https://openalex.org/W2039725698","https://openalex.org/W2047269867","https://openalex.org/W2048053093","https://openalex.org/W2048999843","https://openalex.org/W2049932413","https://openalex.org/W2056525353","https://openalex.org/W2066493864","https://openalex.org/W2071459721","https://openalex.org/W2082814103","https://openalex.org/W2083177852","https://openalex.org/W2101305284","https://openalex.org/W2102973326","https://openalex.org/W2103182811","https://openalex.org/W2120573262","https://openalex.org/W2125796652","https://openalex.org/W2144956326","https://openalex.org/W2150756957","https://openalex.org/W2163972742"],"related_works":["https://openalex.org/W2052483994","https://openalex.org/W2087643987","https://openalex.org/W2165391137","https://openalex.org/W3023021292","https://openalex.org/W2160740620","https://openalex.org/W1674854702","https://openalex.org/W2109434501","https://openalex.org/W1589818703","https://openalex.org/W1976062079","https://openalex.org/W2001342405"],"abstract_inverted_index":{"Mitogen-activated":[0],"T":[1,93,104,136],"cell":[2,94,105,137,191],"lines":[3,95,106],"may":[4],"be":[5],"reproducibly":[6],"used":[7],"to":[8],"identify":[9],"relatively":[10,58,173],"conserved":[11,59,174],"HIV-1":[12,43,229],"epitopes":[13,61,123,169,211,231],"that":[14,36],"dominate":[15],"CTL":[16,60,88,122,165,202,230],"recognition":[17,203],"of":[18,24,27,41,46,77,96,98,100,133,145,152,155,164,176,181,210,218,225,241],"HIV-infected":[19],"cells.":[20],"Using":[21],"a":[22,186],"combination":[23],"nested":[25],"truncations":[26],"HIV-vaccinia":[28,112],"recombinants":[29],"encoding":[30],"HIV-1LAI":[31],"Env":[32],"and":[33,51,72,74,142,148,158,220,244],"overlapping":[34],"peptides":[35,183],"span":[37],"the":[38,42,56,92,101,103,149,162,215,239],"coding":[39],"regions":[40,175,224],"SF2":[44],"subclone":[45],"env,":[47],"gag,":[48],"nef,":[49],"rev,":[50],"tat,":[52],"we":[53],"have":[54],"mapped":[55],"immunodominant,":[57],"recognized":[62,90,111],"by":[63,91,128,131,140],"25":[64,99,134,146],"HIV-seropositive":[65],"individuals":[66],"with":[67],"CD4":[68],"counts":[69],"between":[70],"100":[71],"500/mm3":[73],"no":[75,116,198],"history":[76],"AIDS":[78],"opportunistic":[79],"infection.":[80],"We":[81],"could":[82],"characterize":[83],"at":[84,185],"least":[85],"1":[86],"peptide":[87,118,200],"epitope":[89,119],"18":[97],"subjects;":[102],"from":[107],"2":[108],"additional":[109],"subjects":[110],"presenting":[113],"targets,":[114],"but":[115],"dominant":[117,228],"was":[120,193],"identified.":[121],"were":[124,160,212,235],"most":[125],"frequently":[126],"encoded":[127],"gag":[129],"(recognized":[130],"16":[132],"patient":[135],"lines),":[138],"followed":[139],"nef":[141],"env":[143],"(11":[144],"each),":[147],"RT":[150],"region":[151,217],"pol":[153],"(9":[154],"25).":[156],"Tat":[157],"Rev":[159],"rarely":[161],"sites":[163],"epitopes.":[166],"The":[167,178,227],"identified":[168,184],"occurred":[170],"predominantly":[171],"in":[172,204,214,221,232,247],"HIV-1.":[177],"mean":[179],"number":[180],"HIV":[182],"single":[187,199],"time":[188],"for":[189],"each":[190],"line":[192],"2.7":[194],"+/-":[195],"1.7.":[196],"Although":[197],"dominated":[201],"more":[205],"than":[206],"four":[207],"individuals,":[208],"clusters":[209],"found":[213],"N-terminal":[216],"gp160":[219],"two":[222],"central":[223],"Nef.":[226],"infected":[233],"patients":[234],"not":[236],"predictable":[237],"on":[238],"basis":[240],"MHC":[242],"expression":[243],"varied":[245],"widely":[246],"an":[248],"MHC-diverse":[249],"population.":[250]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}