{"id":"https://openalex.org/W1998662767","doi":"https://doi.org/10.1111/j.1365-3156.2005.01506.x","title":"Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Senegal","display_name":"Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Senegal","publication_year":2005,"publication_date":"2005-10-26","ids":{"openalex":"https://openalex.org/W1998662767","doi":"https://doi.org/10.1111/j.1365-3156.2005.01506.x","mag":"1998662767","pmid":"https://pubmed.ncbi.nlm.nih.gov/16262743","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2582373"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-3156.2005.01506.x","doi":"https://doi.org/10.1111/j.1365-3156.2005.01506.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-3156.2005.01506.x","pdf_url":null,"source":{"id":"https://openalex.org/S148484591","display_name":"Tropical Medicine & International Health","issn_l":"1360-2276","issn":["1360-2276","1365-3156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Medicine &amp; International Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2582373","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113963931","display_name":"Daouda Ndiaye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":true,"raw_author_name":"D. Ndiaye","raw_affiliation_strings":["Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021687785","display_name":"Johanna Patricia Daily","orcid":"https://orcid.org/0000-0003-2506-1072","observed_orcids":["https://orcid.org/0000-0003-2506-1072"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. P. Daily","raw_affiliation_strings":["Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA, USA","Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113017747","display_name":"O. Sarr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106377","display_name":"H\u00f4pital Aristide Le Dantec","ror":"https://ror.org/01n1j0f20","country_code":"SN","type":"healthcare","lineage":["https://openalex.org/I4210106377"]}],"countries":["SN"],"is_corresponding":true,"raw_author_name":"O. Sarr","raw_affiliation_strings":["Laboratory of Bacteriology and Virology, Dantec Hospital, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bacteriology and Virology, Dantec Hospital, Dakar, Senegal","institution_ids":["https://openalex.org/I4210106377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110124600","display_name":"Omar Ndir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":true,"raw_author_name":"O. Ndir","raw_affiliation_strings":["Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016074838","display_name":"Oumar Gaye","orcid":"https://orcid.org/0000-0002-8186-5924","observed_orcids":["https://orcid.org/0000-0002-8186-5924"]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":true,"raw_author_name":"O. Gaye","raw_affiliation_strings":["Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087123292","display_name":"Souleymane Mboup","orcid":"https://orcid.org/0000-0002-7968-3320","observed_orcids":["https://orcid.org/0000-0002-7968-3320"]},"institutions":[{"id":"https://openalex.org/I4210106377","display_name":"H\u00f4pital Aristide Le Dantec","ror":"https://ror.org/01n1j0f20","country_code":"SN","type":"healthcare","lineage":["https://openalex.org/I4210106377"]}],"countries":["SN"],"is_corresponding":true,"raw_author_name":"S. Mboup","raw_affiliation_strings":["Laboratory of Bacteriology and Virology, Dantec Hospital, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bacteriology and Virology, Dantec Hospital, Dakar, Senegal","institution_ids":["https://openalex.org/I4210106377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011964221","display_name":"Dyann F. Wirth","orcid":"https://orcid.org/0000-0002-8604-4455","observed_orcids":["https://orcid.org/0000-0002-8604-4455"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. F. Wirth","raw_affiliation_strings":["Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA, USA","Dept. of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Dept. of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011964221","https://openalex.org/A5016074838","https://openalex.org/A5021687785","https://openalex.org/A5087123292","https://openalex.org/A5110124600","https://openalex.org/A5113017747","https://openalex.org/A5113963931"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210106377","https://openalex.org/I96840727"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":3.4811,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.91445321,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"11","first_page":"1176","last_page":"1179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":1.0},{"id":"https://openalex.org/keywords/dihydrofolate-reductase","display_name":"dihydrofolate reductase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dihydropteroate-synthase","display_name":"dihydropteroate synthase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sulfadoxine-pyrimethamine-resistance","display_name":"sulfadoxine-pyrimethamine resistance","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pyrimethamine-resistance","display_name":"pyrimethamine resistance","score":0.9129999876022339},{"id":"https://openalex.org/keywords/chloroquine-resistance","display_name":"chloroquine resistance","score":0.7889999747276306},{"id":"https://openalex.org/keywords/antimalarial-drug-resistance","display_name":"antimalarial drug resistance","score":0.8349999785423279},{"id":"https://openalex.org/keywords/geographic-variation-in-resistance","display_name":"regional variation in resistance","score":0.7850000262260437},{"id":"https://openalex.org/keywords/senegal","display_name":"Senegal","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2777234095","wikidata":"https://www.wikidata.org/wiki/Q5276443","display_name":"Dihydropteroate synthase","level":5,"score":0.9582031965255737},{"id":"https://openalex.org/C2780866276","wikidata":"https://www.wikidata.org/wiki/Q7761386","display_name":"DHPS","level":4,"score":0.918653130531311},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.7376461029052734},{"id":"https://openalex.org/C2780441369","wikidata":"https://www.wikidata.org/wiki/Q421072","display_name":"Sulfadoxine/pyrimethamine","level":5,"score":0.6042910814285278},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.5765936374664307},{"id":"https://openalex.org/C2781320022","wikidata":"https://www.wikidata.org/wiki/Q417149","display_name":"Dihydrofolate reductase","level":3,"score":0.5716713070869446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5420215725898743},{"id":"https://openalex.org/C2778301690","wikidata":"https://www.wikidata.org/wiki/Q411557","display_name":"Sulfadoxine","level":5,"score":0.5264424085617065},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.510772705078125},{"id":"https://openalex.org/C2777035104","wikidata":"https://www.wikidata.org/wiki/Q421072","display_name":"Pyrimethamine","level":4,"score":0.5018641948699951},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4684208631515503},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.4218369722366333},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41544902324676514},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4113597869873047},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26212698221206665},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15646892786026}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004094","descriptor_name":"Dihydropteroate Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012675","descriptor_name":"Senegal","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013762","descriptor_name":"Tetrahydrofolate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017125","descriptor_name":"Genes, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-3156.2005.01506.x","doi":"https://doi.org/10.1111/j.1365-3156.2005.01506.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-3156.2005.01506.x","pdf_url":null,"source":{"id":"https://openalex.org/S148484591","display_name":"Tropical Medicine & International Health","issn_l":"1360-2276","issn":["1360-2276","1365-3156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Medicine &amp; International Health","raw_type":"journal-article"},{"id":"pmid:16262743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16262743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical medicine & international health : TM & IH","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2582373","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2582373","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trop Med Int Health","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2582373","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2582373","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trop Med Int Health","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1381791872","display_name":null,"funder_award_id":"D43 TW01503","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G1661578524","display_name":"Drug resistance in Plasmodium falciparum","funder_award_id":"K23AI054518","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4769250486","display_name":"Training in Malaria Pathogenesis and Diversity in Africa","funder_award_id":"5d43tw001503-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G615423686","display_name":null,"funder_award_id":"(D43TW001503","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1838568970","https://openalex.org/W1984669077","https://openalex.org/W1989290058","https://openalex.org/W2051443327","https://openalex.org/W2064855181","https://openalex.org/W2076702075","https://openalex.org/W2079451231","https://openalex.org/W2081729133","https://openalex.org/W2096511206","https://openalex.org/W2099198335","https://openalex.org/W2129174519","https://openalex.org/W2131867921","https://openalex.org/W2134524753","https://openalex.org/W2135192999","https://openalex.org/W2136308226","https://openalex.org/W2136624366","https://openalex.org/W2139971426","https://openalex.org/W2158232847","https://openalex.org/W2167523978","https://openalex.org/W2170936619","https://openalex.org/W2407042394","https://openalex.org/W2525107976"],"related_works":["https://openalex.org/W1986794785","https://openalex.org/W2124270158","https://openalex.org/W2136464551","https://openalex.org/W7220421064","https://openalex.org/W3041460430","https://openalex.org/W3208394208","https://openalex.org/W2100014799","https://openalex.org/W2139099242","https://openalex.org/W2527516004","https://openalex.org/W2056578549"],"abstract_inverted_index":{"Senegal":[0],"recently":[1],"(2004)":[2],"switched":[3],"to":[4,17,26,40,183],"sulfadoxine-pyrimethamine":[5],"(SP)":[6],"with":[7,78,137],"amodiaquine":[8],"as":[9,28,166],"first":[10],"line":[11],"therapy":[12],"for":[13],"malaria":[14,80],"in":[15,34,48,54,94,107,112,124,147,163,170,176,205,208],"response":[16],"increasing":[18],"chloroquine":[19],"resistance.":[20],"In":[21,190],"anticipation":[22],"of":[23,31,45,66,98,130,199],"emerging":[24],"resistance":[25,140,201],"SP":[27,200],"a":[29,96,195],"result":[30],"this":[32,192],"change":[33],"drug":[35],"pressure,":[36],"we":[37],"set":[38],"out":[39,106],"define":[41],"the":[42,49,131,177],"baseline":[43],"prevalence":[44,111,129,145,175,198],"SP-associated":[46],"mutations":[47,202],"dhfr":[50],"and":[51,60,92,117,122,151,155,179],"dhps":[52],"genes":[53,181],"Plasmodium":[55],"falciparum":[56,207],"using":[57],"geographically":[58],"diverse":[59,101],"longitudinally":[61],"collected":[62,89],"samples.":[63],"A":[64],"total":[65],"153":[67],"blood":[68],"samples":[69,87,167,184],"were":[70,88],"analysed":[71],"from":[72,168,185],"patients":[73],"(5":[74],"years":[75],"or":[76],"older)":[77],"mild":[79],"after":[81],"informed":[82],"consent":[83],"was":[84,104],"obtained.":[85],"Longitudinal":[86],"between":[90],"2000":[91],"2003":[93,171],"Pikine,":[95,125],"suburb":[97],"Dakar.":[99],"Geographically":[100],"site":[102],"sampling":[103],"carried":[105],"2003.":[108,126],"The":[109,127,143],"mutation":[110,133,144,174],"DHFR":[113],"codons":[114,149],"51,":[115],"59":[116],"108":[118],"is":[119,135,141,153,159],"65%,":[120],"61%":[121],"78%":[123],"overall":[128],"triple":[132],"that":[134],"associated":[136],"high-level":[138],"pyrimethamine":[139],"61%.":[142],"rate":[146],"DHPS":[148],"436":[150],"437":[152],"21%":[154],"40%,":[156],"respectively.":[157],"There":[158],"significant":[160],"geographic":[161],"variation":[162],"genotypic":[164],"resistance,":[165],"Pikine":[169],"had":[172],"higher":[173],"pfdhfr":[178],"pfdhps":[180],"compared":[182],"Tambacounda":[186],"(P":[187],"<":[188],"0.015).":[189],"summary,":[191],"study":[193],"demonstrates":[194],"high":[196],"background":[197],"already":[203],"present":[204],"P.":[206],"Senegal.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
