{"id":"https://openalex.org/W1998660799","doi":"https://doi.org/10.1016/s0140-6736(00)02854-3","title":"Adverse effects of antiretroviral therapy","display_name":"Adverse effects of antiretroviral therapy","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W1998660799","doi":"https://doi.org/10.1016/s0140-6736(00)02854-3","mag":"1998660799","pmid":"https://pubmed.ncbi.nlm.nih.gov/11052597"},"language":"en","primary_location":{"id":"doi:10.1016/s0140-6736(00)02854-3","doi":"https://doi.org/10.1016/s0140-6736(00)02854-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(00)02854-3","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1998660799"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112161317","display_name":"Andrew D Carr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Andrew Carr","raw_affiliation_strings":["HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, New South Wales, Australia. acarr@stvincents.com.au","HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, New South Wales, Australia. acarr@stvincents.com.au","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210087284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111965256","display_name":"David A. Cooper","orcid":"https://orcid.org/0000-0002-1345-2546","observed_orcids":["https://orcid.org/0000-0002-1345-2546"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David A Cooper","raw_affiliation_strings":["HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia","National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112161317"],"corresponding_institution_ids":["https://openalex.org/I4210087284"],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":14.4699,"has_fulltext":false,"cited_by_count":1078,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"356","issue":"9239","first_page":"1423","last_page":"1430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.06019999831914902,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mitochondrial-toxicity","display_name":"mitochondrial toxicity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hypersensitivity","display_name":"hypersensitivity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/lipodystrophy","display_name":"lipodystrophy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C2777071529","wikidata":"https://www.wikidata.org/wiki/Q12796879","display_name":"Mitochondrial toxicity","level":3,"score":0.8013290166854858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7770984172821045},{"id":"https://openalex.org/C2780941825","wikidata":"https://www.wikidata.org/wiki/Q1538213","display_name":"Lipodystrophy","level":5,"score":0.7572320699691772},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7255496978759766},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.5440293550491333},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5280716419219971},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5155410766601562},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46743929386138916},{"id":"https://openalex.org/C2992092908","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug toxicity","level":3,"score":0.4628552496433258},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46021759510040283},{"id":"https://openalex.org/C3018457394","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral drug","level":5,"score":0.4587441384792328},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.39590439200401306},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35447102785110474},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2464989721775055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21566981077194214},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.1658482551574707}],"mesh":[{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008060","descriptor_name":"Lipodystrophy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008060","descriptor_name":"Lipodystrophy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0140-6736(00)02854-3","doi":"https://doi.org/10.1016/s0140-6736(00)02854-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(00)02854-3","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:11052597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11052597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W1136084675","https://openalex.org/W1482522011","https://openalex.org/W1497870368","https://openalex.org/W1525015059","https://openalex.org/W1965295314","https://openalex.org/W1967813026","https://openalex.org/W1978444406","https://openalex.org/W1978724449","https://openalex.org/W1978902758","https://openalex.org/W1980363740","https://openalex.org/W1983060180","https://openalex.org/W1985101204","https://openalex.org/W1989206970","https://openalex.org/W1989669356","https://openalex.org/W1990720570","https://openalex.org/W1996729408","https://openalex.org/W1998237849","https://openalex.org/W2000239378","https://openalex.org/W2001662117","https://openalex.org/W2003403009","https://openalex.org/W2005458536","https://openalex.org/W2006869604","https://openalex.org/W2014898575","https://openalex.org/W2023242450","https://openalex.org/W2025649131","https://openalex.org/W2028643246","https://openalex.org/W2030127456","https://openalex.org/W2031302357","https://openalex.org/W2031577449","https://openalex.org/W2033978941","https://openalex.org/W2034660792","https://openalex.org/W2036003161","https://openalex.org/W2038074971","https://openalex.org/W2040661694","https://openalex.org/W2040974298","https://openalex.org/W2041841997","https://openalex.org/W2042467292","https://openalex.org/W2043077254","https://openalex.org/W2044139946","https://openalex.org/W2051820511","https://openalex.org/W2052152835","https://openalex.org/W2052486964","https://openalex.org/W2053753842","https://openalex.org/W2060210361","https://openalex.org/W2066329291","https://openalex.org/W2075699405","https://openalex.org/W2076562284","https://openalex.org/W2076989459","https://openalex.org/W2078978810","https://openalex.org/W2079571840","https://openalex.org/W2083600593","https://openalex.org/W2084332399","https://openalex.org/W2085560533","https://openalex.org/W2086040638","https://openalex.org/W2088128506","https://openalex.org/W2090646713","https://openalex.org/W2097916721","https://openalex.org/W2101354046","https://openalex.org/W2102213279","https://openalex.org/W2102705913","https://openalex.org/W2117858206","https://openalex.org/W2119844486","https://openalex.org/W2122204312","https://openalex.org/W2123227598","https://openalex.org/W2137516211","https://openalex.org/W2141136035","https://openalex.org/W2142144836","https://openalex.org/W2144560690","https://openalex.org/W2149129111","https://openalex.org/W2153683121","https://openalex.org/W2155449170","https://openalex.org/W2159944585","https://openalex.org/W2162997734","https://openalex.org/W2163492123","https://openalex.org/W2163617802","https://openalex.org/W2170947401","https://openalex.org/W2171030070","https://openalex.org/W2314831911","https://openalex.org/W2316911370","https://openalex.org/W2317192882","https://openalex.org/W2317624504","https://openalex.org/W2324224482","https://openalex.org/W2324473093","https://openalex.org/W2325369502","https://openalex.org/W2327070670","https://openalex.org/W2330885867","https://openalex.org/W2336894756","https://openalex.org/W2339057709","https://openalex.org/W2343382300","https://openalex.org/W2407361564","https://openalex.org/W2414793413","https://openalex.org/W2464331243","https://openalex.org/W4250396005"],"related_works":["https://openalex.org/W2547811374","https://openalex.org/W2310958365","https://openalex.org/W2148083950","https://openalex.org/W2127847317","https://openalex.org/W2131376512","https://openalex.org/W3166449914","https://openalex.org/W7130822346","https://openalex.org/W2096919656","https://openalex.org/W1980525584","https://openalex.org/W2019425059"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":30},{"year":2017,"cited_by_count":30},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":39},{"year":2014,"cited_by_count":49},{"year":2013,"cited_by_count":49},{"year":2012,"cited_by_count":43}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}