{"id":"https://openalex.org/W1998654752","doi":"https://doi.org/10.1034/j.1600-0773.2003.920304.x","title":"Nicotine\u2010Induced Inflammatory Decreasing Effect on Passive Skin Arthus Reaction in Paraventricular Nucleus\u2010Lesioned Wistar Rats","display_name":"Nicotine\u2010Induced Inflammatory Decreasing Effect on Passive Skin Arthus Reaction in Paraventricular Nucleus\u2010Lesioned Wistar Rats","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W1998654752","doi":"https://doi.org/10.1034/j.1600-0773.2003.920304.x","mag":"1998654752","pmid":"https://pubmed.ncbi.nlm.nih.gov/12753427"},"language":"en","primary_location":{"id":"doi:10.1034/j.1600-0773.2003.920304.x","doi":"https://doi.org/10.1034/j.1600-0773.2003.920304.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-0773.2003.920304.x","pdf_url":null,"source":{"id":"https://openalex.org/S62051601","display_name":"Pharmacology & Toxicology","issn_l":"0901-9928","issn":["0901-9928","1600-0773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111708923","display_name":"Kaoru Kubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kaoru Kubo","raw_affiliation_strings":["Laboratory Animal Research Center, Nara Medical University, Kashihara, Nara, Japan. k-kubo@naramed-u.ac.jp","Laboratory Animal Research Center, Nara Medical University, Kashihara, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Animal Research Center, Nara Medical University, Kashihara, Nara, Japan. k-kubo@naramed-u.ac.jp","institution_ids":["https://openalex.org/I64926303"]},{"raw_affiliation_string":"Laboratory Animal Research Center, Nara Medical University, Kashihara, Nara, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111623209","display_name":"Taizo Kita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taizo Kita","raw_affiliation_strings":["Department of Pharmacology, Nara Medical University, Kashihara, Nara 634-8521"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Nara Medical University, Kashihara, Nara 634-8521","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057648824","display_name":"Itaru Narushima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Itaru Narushima","raw_affiliation_strings":["Department of Pharmacology, Nara Medical University, Kashihara, Nara 634-8521"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Nara Medical University, Kashihara, Nara 634-8521","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103255023","display_name":"Takeshi Tanaka","orcid":"https://orcid.org/0000-0003-0490-3453","observed_orcids":["https://orcid.org/0000-0003-0490-3453"]},"institutions":[{"id":"https://openalex.org/I4210166991","display_name":"Nara Prefectural Institute of Public Health Research Center","ror":"https://ror.org/005ns7397","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210166991"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Tanaka","raw_affiliation_strings":["Department of Pharmacology, Nara Medical University, Kashihara, Nara 634-8521","Nara Prefectural Institute of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Nara Medical University, Kashihara, Nara 634-8521","institution_ids":["https://openalex.org/I64926303"]},{"raw_affiliation_string":"Nara Prefectural Institute of Public Health","institution_ids":["https://openalex.org/I4210166991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108396086","display_name":"Toshiaki Nakatani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48126063","display_name":"Tenri University","ror":"https://ror.org/00d440w27","country_code":"JP","type":"education","lineage":["https://openalex.org/I48126063"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Nakatani","raw_affiliation_strings":["Department of Pharmacology, Nara Medical University, Kashihara, Nara 634-8521","Human Performance and Exercise Prescription Laboratory, Tenri University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Nara Medical University, Kashihara, Nara 634-8521","institution_ids":["https://openalex.org/I64926303"]},{"raw_affiliation_string":"Human Performance and Exercise Prescription Laboratory, Tenri University, Japan","institution_ids":["https://openalex.org/I48126063"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113922333","display_name":"Toshikatsu Nakashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshikatsu Nakashima","raw_affiliation_strings":["Department of Pharmacology, Nara Medical University, Kashihara, Nara 634-8521"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Nara Medical University, Kashihara, Nara 634-8521","institution_ids":["https://openalex.org/I64926303"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111708923"],"corresponding_institution_ids":["https://openalex.org/I64926303"],"apc_list":null,"apc_paid":null,"fwci":0.2498,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.42820946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"92","issue":"3","first_page":"125","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.41990000009536743,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.41990000009536743,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.4009000062942505,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0729999989271164,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.8690000176429749},{"id":"https://openalex.org/keywords/paraventricular-nucleus","display_name":"paraventricular nucleus","score":0.9700000286102295},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hypothalamic-lesions","display_name":"hypothalamic lesions","score":0.6970000267028809},{"id":"https://openalex.org/keywords/mecamylamine","display_name":"mecamylamine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mifepristone","display_name":"mifepristone","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.9129999876022339},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.6359999775886536},{"id":"https://openalex.org/keywords/plasma-extravasation","display_name":"plasma extravasation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C2776880047","wikidata":"https://www.wikidata.org/wiki/Q3332124","display_name":"Mecamylamine","level":4,"score":0.8291025161743164},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.7437000870704651},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.6565544009208679},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6517618894577026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6027872562408447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5178687572479248},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.5044976472854614},{"id":"https://openalex.org/C2779142470","wikidata":"https://www.wikidata.org/wiki/Q712320","display_name":"Arthus reaction","level":3,"score":0.5034841895103455},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4678780734539032},{"id":"https://openalex.org/C2776390293","wikidata":"https://www.wikidata.org/wiki/Q2035485","display_name":"Subcutaneous injection","level":2,"score":0.46784600615501404},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46587133407592773},{"id":"https://openalex.org/C2775893369","wikidata":"https://www.wikidata.org/wiki/Q410557","display_name":"Hexamethonium","level":3,"score":0.4256637692451477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4005151093006134},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3005996346473694},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.059802085161209106}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001183","descriptor_name":"Arthus Reaction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001183","descriptor_name":"Arthus Reaction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008464","descriptor_name":"Mecamylamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010286","descriptor_name":"Paraventricular Hypothalamic Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015735","descriptor_name":"Mifepristone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018733","descriptor_name":"Nicotinic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018738","descriptor_name":"Hexamethonium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1034/j.1600-0773.2003.920304.x","doi":"https://doi.org/10.1034/j.1600-0773.2003.920304.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-0773.2003.920304.x","pdf_url":null,"source":{"id":"https://openalex.org/S62051601","display_name":"Pharmacology & Toxicology","issn_l":"0901-9928","issn":["0901-9928","1600-0773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Toxicology","raw_type":"journal-article"},{"id":"pmid:12753427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12753427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & toxicology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322555","display_name":"Smoking Research Foundation","ror":"https://ror.org/04q4hbm31"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1954195443","https://openalex.org/W1967172735","https://openalex.org/W1971037960","https://openalex.org/W1975165762","https://openalex.org/W1985024152","https://openalex.org/W1985342506","https://openalex.org/W1990296242","https://openalex.org/W1993133636","https://openalex.org/W2002288044","https://openalex.org/W2006948114","https://openalex.org/W2016867400","https://openalex.org/W2018680730","https://openalex.org/W2029140436","https://openalex.org/W2030407376","https://openalex.org/W2034178928","https://openalex.org/W2036066421","https://openalex.org/W2040559972","https://openalex.org/W2075155139","https://openalex.org/W2079912778","https://openalex.org/W2080476258","https://openalex.org/W2082486415","https://openalex.org/W2083737326","https://openalex.org/W2084719283","https://openalex.org/W2091108193","https://openalex.org/W2097683886","https://openalex.org/W2140365866","https://openalex.org/W2148120848","https://openalex.org/W2163815564","https://openalex.org/W2171584675","https://openalex.org/W2283070556","https://openalex.org/W2292088268","https://openalex.org/W2426446234"],"related_works":["https://openalex.org/W1993555170","https://openalex.org/W2109819929","https://openalex.org/W2170228498","https://openalex.org/W2104789360","https://openalex.org/W2044695502","https://openalex.org/W1973799661","https://openalex.org/W2044483119","https://openalex.org/W1981236707","https://openalex.org/W1985024152","https://openalex.org/W1990798086"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"the":[2,11,19,58,89,103,108,115,128,152,199,207,211,221,241,245],"relationship":[3],"between":[4],"nicotine":[5,14,45,76,139,203],"and":[6,32,72,85,114,210],"immunological":[7,63,112,129,226],"inflammation,":[8],"we":[9,93],"investigated":[10],"effects":[12,132],"of":[13,18,44,102,111,133,138,202,213,240],"on":[15,206,225],"plasma":[16],"extravasation":[17],"passive":[20,59],"skin":[21,29,60],"Arthus":[22,61],"reaction,":[23],"elicited":[24],"4":[25],"hr":[26],"after":[27,75,88,99],"sensitizing":[28],"with":[30,39,81,147,163,176,189],"antiserum,":[31],"serum":[33,117,233],"corticosterone":[34,66,118,215,234],"levels":[35,67,119,235],"in":[36,122],"rats.":[37],"Pretreatment":[38],"a":[40,82,134,167,180,193],"single":[41,135],"subcutaneous":[42,136,161],"injection":[43,137],"(0.4":[46,140,204],"or":[47,51],"0.8":[48],"mg/kg)":[49,141,205],"30":[50,71],"60":[52,73],"min.":[53,74],"before":[54],"antigen":[55],"challenge":[56],"attenuated":[57,121],"reaction":[62],"inflammation.":[64],"Serum":[65],"were":[68,120,142],"dose-dependently":[69],"increased":[70,116],"administration.":[77],"Both":[78],"markers":[79],"co-varied":[80],"similar":[83],"dose-response":[84],"time":[86],"course":[87],"nicotine-treatment.":[90],"In":[91],"addition,":[92],"also":[94],"examined":[95],"these":[96],"nicotine-induced":[97,109,222],"responses":[98],"bilateral":[100,123],"lesions":[101],"hypothalamic":[104],"paraventricular":[105,124,242],"nucleus;":[106],"both":[107,198],"suppression":[110],"inflammation":[113],"nucleus-lesioned":[125],"animals.":[126],"Moreover,":[127],"inflammatory":[130,227],"decreasing":[131,223],"antagonized":[143],"by":[144,160,173,237],"intraperitoneal":[145,174,187],"preinjection":[146,162,175,188],"mecamylamine":[148],"(1.0":[149],"mg/kg;":[150,166,179],"blocking":[151],"brain":[153,246],"nicotinic":[154,182,247],"acetylcholine":[155,183,248],"receptors)":[156],"as":[157,159],"well":[158],"mifepristone":[164],"(30":[165],"glucocorticoid":[168],"receptor":[169],"antagonist)":[170],"but":[171],"not":[172],"hexamethonium":[177],"(2.0":[178],"peripheral":[181],"receptors":[184],"antagonist).":[185],"Finally,":[186],"cycloheximide":[190],"(2":[191],"mg/kg),":[192],"protein":[194],"synthesis":[195],"inhibitor,":[196],"abolished":[197],"inhibitory":[200],"effect":[201,224],"dye":[208],"leakage":[209],"elevation":[212],"blood":[214],"levels.":[216],"These":[217],"findings":[218],"indicate":[219],"that":[220],"response":[228],"may":[229],"be":[230],"related":[231],"to":[232],"elevated":[236],"an":[238],"activation":[239],"nucleus":[243],"through":[244],"receptors.":[249]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}