{"id":"https://openalex.org/W1998645801","doi":"https://doi.org/10.1007/bf00201105","title":"In vitro antibody response of human lymphocytes to the Haemophilus influenzae type b capsular polysaccharide","display_name":"In vitro antibody response of human lymphocytes to the Haemophilus influenzae type b capsular polysaccharide","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W1998645801","doi":"https://doi.org/10.1007/bf00201105","mag":"1998645801","pmid":"https://pubmed.ncbi.nlm.nih.gov/8256201"},"language":"en","primary_location":{"id":"doi:10.1007/bf00201105","doi":"https://doi.org/10.1007/bf00201105","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00201105","pdf_url":null,"source":{"id":"https://openalex.org/S22664439","display_name":"Springer Seminars in Immunopathology","issn_l":"0344-4325","issn":["0344-4325","1432-2196"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Springer Seminars in Immunopathology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109289834","display_name":"Carla C. A. M. Peeters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162850","display_name":"Wilhelmina Children's Hospital","ror":"https://ror.org/05fqypv61","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Carla C. A. M. Peeters","raw_affiliation_strings":["Department of Immunology, University Children's Hospital Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands","Department of Immunology, University Children's Hospital Het Wilhelmina Kinderziekenhuis, Nieuwe Gracht 137, NL-3512, LK Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University Children's Hospital Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]},{"raw_affiliation_string":"Department of Immunology, University Children's Hospital Het Wilhelmina Kinderziekenhuis, Nieuwe Gracht 137, NL-3512, LK Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111766655","display_name":"Anne-Marie J. Tenbergen-Meekes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162850","display_name":"Wilhelmina Children's Hospital","ror":"https://ror.org/05fqypv61","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anne-Marie J. Tenbergen-Meekes","raw_affiliation_strings":["Department of Immunology, University Children's Hospital Het Wilhelmina Kinderziekenhuis, Nieuwe Gracht 137, NL-3512, LK Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University Children's Hospital Het Wilhelmina Kinderziekenhuis, Nieuwe Gracht 137, NL-3512, LK Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038094499","display_name":"JAN T. POOLMAN","orcid":"https://orcid.org/0000-0002-9583-8126","observed_orcids":["https://orcid.org/0000-0002-9583-8126"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan T. Poolman","raw_affiliation_strings":["Unit for Bacterial Vaccine Development and Pathogenesis Research, National Institute of Public Health and Environmental Protection, Antonie van Leeuwenhoeklaan 9, NL-3720, BA Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit for Bacterial Vaccine Development and Pathogenesis Research, National Institute of Public Health and Environmental Protection, Antonie van Leeuwenhoeklaan 9, NL-3720, BA Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057241738","display_name":"BEN J. M. ZEGERS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162850","display_name":"Wilhelmina Children's Hospital","ror":"https://ror.org/05fqypv61","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ben J. M. Zegers","raw_affiliation_strings":["Department of Immunology, University Children's Hospital Het Wilhelmina Kinderziekenhuis, Nieuwe Gracht 137, NL-3512, LK Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University Children's Hospital Het Wilhelmina Kinderziekenhuis, Nieuwe Gracht 137, NL-3512, LK Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010046770","display_name":"Ger T. Rijkers","orcid":"https://orcid.org/0000-0001-6948-6123","observed_orcids":["https://orcid.org/0000-0001-6948-6123","https://orcid.org/0000-0002-5928-9545"]},"institutions":[{"id":"https://openalex.org/I4210162850","display_name":"Wilhelmina Children's Hospital","ror":"https://ror.org/05fqypv61","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ger T. Rijkers","raw_affiliation_strings":["Department of Immunology, University Children's Hospital Het Wilhelmina Kinderziekenhuis, Nieuwe Gracht 137, NL-3512, LK Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University Children's Hospital Het Wilhelmina Kinderziekenhuis, Nieuwe Gracht 137, NL-3512, LK Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"2-3","first_page":"247","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haemophilus-influenzae-type-b","display_name":"Haemophilus influenzae type b","score":0.9940000176429749},{"id":"https://openalex.org/keywords/capsular-polysaccharide","display_name":"capsular polysaccharide","score":0.9900000095367432},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.9240000247955322},{"id":"https://openalex.org/keywords/human-lymphocytes","display_name":"human lymphocytes","score":0.8289999961853027},{"id":"https://openalex.org/keywords/in-vitro-antibody-production","display_name":"in vitro antibody production","score":0.6740000247955322},{"id":"https://openalex.org/keywords/polysaccharide-immunization","display_name":"polysaccharide immunization","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7087643146514893},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.6912566423416138},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6422907114028931},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5740095973014832},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.5473686456680298},{"id":"https://openalex.org/C155292618","wikidata":"https://www.wikidata.org/wiki/Q1137328","display_name":"Bacterial capsule","level":4,"score":0.4970746338367462},{"id":"https://openalex.org/C2777154767","wikidata":"https://www.wikidata.org/wiki/Q142666","display_name":"Pasteurellaceae","level":4,"score":0.41549235582351685},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4020344018936157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3938291072845459},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3381253778934479},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.06990665197372437},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.06208491325378418},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008211","descriptor_name":"Lymphocyte Cooperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016667","descriptor_name":"Bacterial Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018073","descriptor_name":"Haemophilus Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/bf00201105","doi":"https://doi.org/10.1007/bf00201105","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00201105","pdf_url":null,"source":{"id":"https://openalex.org/S22664439","display_name":"Springer Seminars in Immunopathology","issn_l":"0344-4325","issn":["0344-4325","1432-2196"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Springer Seminars in Immunopathology","raw_type":"journal-article"},{"id":"pmid:8256201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8256201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Springer seminars in immunopathology","raw_type":"Journal Article"},{"id":"pmh:oai:rivm.openrepository.com:10029/634536","doi":null,"is_oa":false,"landing_page_url":"https://rivm.openrepository.com/handle/10029/634536","pdf_url":null,"source":{"id":"https://openalex.org/S4306401681","display_name":"Rivm (National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W43755114","https://openalex.org/W1506591149","https://openalex.org/W1562287970","https://openalex.org/W1576574960","https://openalex.org/W1586051883","https://openalex.org/W1592812354","https://openalex.org/W1886054339","https://openalex.org/W1918178498","https://openalex.org/W1918301721","https://openalex.org/W1922300296","https://openalex.org/W1956712871","https://openalex.org/W1965350881","https://openalex.org/W1965984940","https://openalex.org/W1969260731","https://openalex.org/W1973103992","https://openalex.org/W1975338010","https://openalex.org/W1984535689","https://openalex.org/W1993764487","https://openalex.org/W2002747699","https://openalex.org/W2012498949","https://openalex.org/W2025968178","https://openalex.org/W2026473877","https://openalex.org/W2030785840","https://openalex.org/W2037379789","https://openalex.org/W2046187595","https://openalex.org/W2070101126","https://openalex.org/W2074459264","https://openalex.org/W2086187308","https://openalex.org/W2110092258","https://openalex.org/W2118136385","https://openalex.org/W2118396981","https://openalex.org/W2147592449","https://openalex.org/W2156888419","https://openalex.org/W2330347921","https://openalex.org/W2412663033","https://openalex.org/W2728806434","https://openalex.org/W4247034050"],"related_works":["https://openalex.org/W2411491487","https://openalex.org/W2740810622","https://openalex.org/W1904684075","https://openalex.org/W2075980253","https://openalex.org/W2032035902","https://openalex.org/W2421207385","https://openalex.org/W2420239696","https://openalex.org/W4236874255","https://openalex.org/W2312268518","https://openalex.org/W2090759514"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}