{"id":"https://openalex.org/W1998645387","doi":"https://doi.org/10.1089/jmf.2011.1716","title":"Molecular Characteristics and Immunomodulatory Activities of Water-Soluble Sulfated Polysaccharides from Ulva pertusa","display_name":"Molecular Characteristics and Immunomodulatory Activities of Water-Soluble Sulfated Polysaccharides from Ulva pertusa","publication_year":2011,"publication_date":"2011-12-22","ids":{"openalex":"https://openalex.org/W1998645387","doi":"https://doi.org/10.1089/jmf.2011.1716","mag":"1998645387","pmid":"https://pubmed.ncbi.nlm.nih.gov/22191629"},"language":"en","primary_location":{"id":"doi:10.1089/jmf.2011.1716","doi":"https://doi.org/10.1089/jmf.2011.1716","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jmf.2011.1716","pdf_url":null,"source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039154387","display_name":"Mehdi Tabarsa","orcid":"https://orcid.org/0000-0001-5683-2138","observed_orcids":["https://orcid.org/0000-0001-5683-2138","https://orcid.org/0009-0000-4533-5291"]},"institutions":[{"id":"https://openalex.org/I133533813","display_name":"Gangneung\u2013Wonju National University","ror":"https://ror.org/0461cvh40","country_code":"KR","type":"education","lineage":["https://openalex.org/I133533813"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mehdi Tabarsa","raw_affiliation_strings":["Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Gangwon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Gangwon, Korea","institution_ids":["https://openalex.org/I133533813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109109286","display_name":"Jung Hee Han","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jung H. Han","raw_affiliation_strings":["PepsiCo Advanced Research, Plano, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PepsiCo Advanced Research, Plano, Texas, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001686682","display_name":"Chul Young Kim","orcid":"https://orcid.org/0000-0002-6988-1059","observed_orcids":["https://orcid.org/0000-0002-6988-1059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chul Young Kim","raw_affiliation_strings":["Gangneung Techno Valley, Gangneung, Gangwon-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gangneung Techno Valley, Gangneung, Gangwon-do, Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111952986","display_name":"Sang Guan You","orcid":"https://orcid.org/0000-0002-8785-7167","observed_orcids":["https://orcid.org/0000-0002-8785-7167"]},"institutions":[{"id":"https://openalex.org/I133533813","display_name":"Gangneung\u2013Wonju National University","ror":"https://ror.org/0461cvh40","country_code":"KR","type":"education","lineage":["https://openalex.org/I133533813"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang Guan You","raw_affiliation_strings":["Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Gangwon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Gangwon, Korea","institution_ids":["https://openalex.org/I133533813"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111952986"],"corresponding_institution_ids":["https://openalex.org/I133533813"],"apc_list":null,"apc_paid":null,"fwci":3.3137,"has_fulltext":false,"cited_by_count":115,"citation_normalized_percentile":{"value":0.90980102,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"15","issue":"2","first_page":"135","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulva-pertusa","display_name":"Ulva pertusa","score":0.9599999785423279},{"id":"https://openalex.org/keywords/sulfated-polysaccharides","display_name":"sulfated polysaccharides","score":0.9589999914169312},{"id":"https://openalex.org/keywords/seaweed-polysaccharides","display_name":"seaweed polysaccharides","score":0.9700000286102295},{"id":"https://openalex.org/keywords/uronic-acid","display_name":"uronic acid","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rhamnose","display_name":"rhamnose","score":0.9819999933242798},{"id":"https://openalex.org/keywords/polysaccharide-monosaccharide-composition","display_name":"polysaccharide monosaccharide composition","score":0.8169999718666077},{"id":"https://openalex.org/keywords/molecular-weight-distribution","display_name":"molecular weight distribution","score":0.781000018119812},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/immunostimulation","display_name":"immunostimulation","score":0.628000020980835},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.824999988079071},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.953000009059906},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9129999876022339},{"id":"https://openalex.org/keywords/green-macroalgae","display_name":"green macroalgae","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.9347274303436279},{"id":"https://openalex.org/C2778284416","wikidata":"https://www.wikidata.org/wiki/Q412056","display_name":"Uronic acid","level":3,"score":0.7829434275627136},{"id":"https://openalex.org/C118859902","wikidata":"https://www.wikidata.org/wiki/Q133516","display_name":"Monosaccharide","level":2,"score":0.766330361366272},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7006224393844604},{"id":"https://openalex.org/C2780294150","wikidata":"https://www.wikidata.org/wiki/Q66589603","display_name":"Xylose","level":3,"score":0.6881862878799438},{"id":"https://openalex.org/C2779213145","wikidata":"https://www.wikidata.org/wiki/Q414109","display_name":"Rhamnose","level":3,"score":0.5921597480773926},{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.5886014103889465},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5000190734863281},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4830234944820404},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.4797298014163971},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.4000185430049896},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33166682720184326},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.20306044816970825},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012624","descriptor_name":"Seaweed","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D044445","descriptor_name":"Ulva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/jmf.2011.1716","doi":"https://doi.org/10.1089/jmf.2011.1716","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jmf.2011.1716","pdf_url":null,"source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},{"id":"pmid:22191629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22191629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal food","raw_type":"Journal Article"},{"id":"pmh:oai:repository.hanyang.ac.kr:20.500.11754/94845","doi":null,"is_oa":false,"landing_page_url":"http://repository.hanyang.ac.kr/handle/20.500.11754/94845","pdf_url":null,"source":{"id":"https://openalex.org/S4306401328","display_name":"The Royal Society of Chemistry\u2019s Journals, Books and Databases (The Royal Society of Chemistry)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2751430930","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/I2751430930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W28630372","https://openalex.org/W318852683","https://openalex.org/W1968834637","https://openalex.org/W1982323023","https://openalex.org/W1986574293","https://openalex.org/W1990802251","https://openalex.org/W1991944541","https://openalex.org/W1992670830","https://openalex.org/W1995356642","https://openalex.org/W2000860870","https://openalex.org/W2003669320","https://openalex.org/W2004187431","https://openalex.org/W2006691616","https://openalex.org/W2007589758","https://openalex.org/W2011600141","https://openalex.org/W2022603507","https://openalex.org/W2025326818","https://openalex.org/W2033837674","https://openalex.org/W2038946558","https://openalex.org/W2039471616","https://openalex.org/W2044335811","https://openalex.org/W2068373927","https://openalex.org/W2069610733","https://openalex.org/W2070336354","https://openalex.org/W2076865326","https://openalex.org/W2084326027","https://openalex.org/W2101301801","https://openalex.org/W2122296266","https://openalex.org/W2156258819","https://openalex.org/W2161807370","https://openalex.org/W4238402194","https://openalex.org/W4241238773"],"related_works":["https://openalex.org/W2748639469","https://openalex.org/W2146527086","https://openalex.org/W2404564457","https://openalex.org/W1975287835","https://openalex.org/W3094987674","https://openalex.org/W4400217280","https://openalex.org/W4413101911","https://openalex.org/W4210900992","https://openalex.org/W7220466106","https://openalex.org/W1995356642"],"abstract_inverted_index":{"Sulfated":[0],"polysaccharides":[1,24,67,93,113],"isolated":[2],"from":[3,79],"Ulva":[4],"pertusa":[5],"and":[6,18,22,27,37,63,125],"fractionated":[7,23],"using":[8],"anion-exchange":[9],"chromatography":[10],"were":[11,29],"investigated":[12],"to":[13,81],"determine":[14],"their":[15],"molecular":[16,76],"characteristics":[17],"bioactivities.":[19],"The":[20,66,84],"crude":[21],"(F(1),":[25],"F(2),":[26],"F(3))":[28],"mainly":[30],"composed":[31],"of":[32,44,54,60,91,122],"carbohydrates":[33],"(59.9-65.9%),":[34],"sulfates":[35],"(11.6-15.3%),":[36],"uronic":[38],"acid":[39],"(7.30-16.4%)":[40],"with":[41,57,74],"small":[42],"amounts":[43,121],"proteins":[45],"(1.40-4.80%).":[46],"Rhamnose":[47],"(62.5-80.7%)":[48],"was":[49],"the":[50,92,102,109,112],"major":[51,72],"monosaccharide":[52],"unit":[53],"these":[55],"polysaccharides,":[56],"different":[58],"levels":[59],"glucose":[61],"(13.5-27.4%)":[62],"xylose":[64],"(2.74-11.5%).":[65],"contained":[68],"one":[69],"or":[70],"two":[71],"subfractions":[73],"weight-average":[75],"mass":[77],"ranging":[78],"51.1\u00d710(3)":[80],"1,690\u00d710(3)":[82],"g/mol.":[83],"relatively":[85],"low":[86],"in":[87],"vitro":[88],"anticancer":[89],"activity":[90],"(22.3-42.4%)":[94],"suggested":[95,130],"that":[96,131],"they":[97,132],"had":[98],"little":[99],"cytotoxicity":[100],"against":[101],"cancer":[103],"cell":[104],"line":[105],"used":[106],"(AGS).":[107],"On":[108],"other":[110],"hand,":[111],"significantly":[114],"stimulated":[115],"Raw":[116],"264.7":[117],"cells,":[118],"inducing":[119],"considerable":[120],"nitric":[123],"oxide":[124],"various":[126],"cytokines":[127],"production,":[128],"which":[129],"could":[133],"be":[134],"strong":[135],"immunostimulators.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}