{"id":"https://openalex.org/W1998624792","doi":"https://doi.org/10.3389/fimmu.2013.00188","title":"Composite Tissue Allotransplantation and Dysregulation in Tissue Repair and Regeneration: A Role for Mesenchymal Stem Cells","display_name":"Composite Tissue Allotransplantation and Dysregulation in Tissue Repair and Regeneration: A Role for Mesenchymal Stem Cells","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1998624792","doi":"https://doi.org/10.3389/fimmu.2013.00188","mag":"1998624792","pmid":"https://pubmed.ncbi.nlm.nih.gov/23847625","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3705198"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2013.00188","doi":"https://doi.org/10.3389/fimmu.2013.00188","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2013.00188","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2013.00188/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2013.00188/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074667589","display_name":"Anuja K. Antony","orcid":"https://orcid.org/0009-0002-7074-7727","observed_orcids":["https://orcid.org/0009-0002-7074-7727"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anuja K. Antony","raw_affiliation_strings":["Department of Surgery, Division of Plastic, Reconstructive and Cosmetic Surgery, University of Illinois at Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Plastic, Reconstructive and Cosmetic Surgery, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018774137","display_name":"Katherine A. Rodby","orcid":"https://orcid.org/0000-0002-1518-1065","observed_orcids":["https://orcid.org/0000-0002-1518-1065"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210125096","display_name":"University of Illinois Hospital & Health Sciences System","ror":"https://ror.org/03jhe7195","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210125096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Rodby","raw_affiliation_strings":["University of Illinois at Chicago Hospital and Health Sciences System, Division of Plastic, Reconstructive and Cosmetic Surgery, 820 South Wood Street, CSN 515, Chicago, IL, 60612, United States","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago Hospital and Health Sciences System, Division of Plastic, Reconstructive and Cosmetic Surgery, 820 South Wood Street, CSN 515, Chicago, IL, 60612, United States","institution_ids":["https://openalex.org/I4210125096"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006064938","display_name":"Matthew Kyle Tobin","orcid":"https://orcid.org/0000-0001-5717-5133","observed_orcids":["https://orcid.org/0000-0001-5717-5133"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210125096","display_name":"University of Illinois Hospital & Health Sciences System","ror":"https://ror.org/03jhe7195","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210125096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew K. Tobin","raw_affiliation_strings":["University of Illinois at Chicago Hospital and Health Sciences System, Division of Translational Research, 840 South Wood Street, Suite #402, MC 958, Chicago, 60612, IL, United States","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago Hospital and Health Sciences System, Division of Translational Research, 840 South Wood Street, Suite #402, MC 958, Chicago, 60612, IL, United States","institution_ids":["https://openalex.org/I4210125096"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Megan I. O\u2019Connor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan I. O\u2019Connor","raw_affiliation_strings":["Department of Surgery, Division of Transplant Surgery, University of Illinois at Chicago, Chicago, IL, USA","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Transplant Surgery, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048413738","display_name":"Russell K. Pearl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell K. Pearl","raw_affiliation_strings":["University of Illinois at Chicago, Division of Biomedical Visualization, Chicago, 606012, IL, United States","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Division of Biomedical Visualization, Chicago, 606012, IL, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001159362","display_name":"Luisa Ann DiPietro","orcid":"https://orcid.org/0000-0002-4842-1547","observed_orcids":["https://orcid.org/0000-0002-4842-1547"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luisa A. DiPietro","raw_affiliation_strings":["University of Illinois at Chicago, College of Dentistry, 801 S. Paulina Street, Chicago, 60612, IL, United States","Periodontics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, College of Dentistry, 801 S. Paulina Street, Chicago, 60612, IL, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Periodontics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084434544","display_name":"Warren C. Breidenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren C. Breidenbach","raw_affiliation_strings":["University of Arizona, Division of Plastic and Reconstructive Surgery, 1501 N. Campbell Ave, 5334B, Tucson, 85724-5062, AZ, United States","University of Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona, Division of Plastic and Reconstructive Surgery, 1501 N. Campbell Ave, 5334B, Tucson, 85724-5062, AZ, United States","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112803953","display_name":"Amelia M. Bartholomew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amelia M. Bartholomew","raw_affiliation_strings":["Department of Surgery , Division of Transplant Surgery , University of Illinois at Chicago , Chicago , IL , USA","Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery , Division of Transplant Surgery , University of Illinois at Chicago , Chicago , IL , USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Surgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074667589"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.7302,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.68590187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":null,"first_page":"188","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.6610000133514404},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.9950000047683716},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.902999997138977},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9100000262260437},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.7179999947547913},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.8019999861717224},{"id":"https://openalex.org/keywords/neuropathy","display_name":"neuropathy","score":0.800000011920929},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5149999856948853},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hand-transplantation","display_name":"hand transplantation","score":0.3149999976158142},{"id":"https://openalex.org/keywords/plastic-surgery","display_name":"plastic surgery","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7797874212265015},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.7063154578208923},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.6841455101966858},{"id":"https://openalex.org/C2777561873","wikidata":"https://www.wikidata.org/wiki/Q1773075","display_name":"Allotransplantation","level":3,"score":0.628519594669342},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5698671340942383},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.5555564761161804},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5049198269844055},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.44477978348731995},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4119873642921448},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.39426884055137634},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2098824381828308},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20695039629936218},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18720495700836182},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17431679368019104},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.12914228439331055}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fimmu.2013.00188","doi":"https://doi.org/10.3389/fimmu.2013.00188","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2013.00188","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2013.00188/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2703455","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3705198","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3705198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3705198","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:23847625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23847625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f90544ed97e941458b5df7ebd3c6e635","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f90544ed97e941458b5df7ebd3c6e635","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 4 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/10762445","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Composite_tissue_allotransplantation_and_dysregulation_in_tissue_repair_and_regeneration_a_role_for_mesenchymal_stem_cells/10762445","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2013.00188","doi":"https://doi.org/10.3389/fimmu.2013.00188","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2013.00188","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2013.00188/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2558679506","display_name":"Angiogenesis in Wound Repair","funder_award_id":"R01GM050875","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7727289013","display_name":"Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts","funder_award_id":"P01AI089556","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998624792.pdf","grobid_xml":"https://content.openalex.org/works/W1998624792.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1582333999","https://openalex.org/W1588670395","https://openalex.org/W1599241152","https://openalex.org/W1600258010","https://openalex.org/W1830142691","https://openalex.org/W1920534265","https://openalex.org/W1968107592","https://openalex.org/W1968483413","https://openalex.org/W1970676273","https://openalex.org/W1977167871","https://openalex.org/W1979992854","https://openalex.org/W1988560283","https://openalex.org/W1989811385","https://openalex.org/W1990118856","https://openalex.org/W1999340607","https://openalex.org/W2005943573","https://openalex.org/W2006499389","https://openalex.org/W2007722358","https://openalex.org/W2015214016","https://openalex.org/W2022016766","https://openalex.org/W2029412037","https://openalex.org/W2030855575","https://openalex.org/W2031407394","https://openalex.org/W2033012796","https://openalex.org/W2033597878","https://openalex.org/W2039436354","https://openalex.org/W2041111328","https://openalex.org/W2043509877","https://openalex.org/W2045114099","https://openalex.org/W2049655446","https://openalex.org/W2059331690","https://openalex.org/W2060437379","https://openalex.org/W2060640813","https://openalex.org/W2062178705","https://openalex.org/W2065891017","https://openalex.org/W2067126118","https://openalex.org/W2067418704","https://openalex.org/W2068205868","https://openalex.org/W2075288731","https://openalex.org/W2078752247","https://openalex.org/W2084565323","https://openalex.org/W2087519572","https://openalex.org/W2091514522","https://openalex.org/W2094362725","https://openalex.org/W2095666785","https://openalex.org/W2105151699","https://openalex.org/W2112563960","https://openalex.org/W2123753106","https://openalex.org/W2130835454","https://openalex.org/W2131719935","https://openalex.org/W2131755176","https://openalex.org/W2134176933","https://openalex.org/W2136586552","https://openalex.org/W2138831748","https://openalex.org/W2155041363","https://openalex.org/W2167376210","https://openalex.org/W2168768770","https://openalex.org/W2275549384","https://openalex.org/W2316035406","https://openalex.org/W2320430410","https://openalex.org/W2321409795","https://openalex.org/W2325727928","https://openalex.org/W2734881742","https://openalex.org/W2995642382","https://openalex.org/W4250587277","https://openalex.org/W4253296098","https://openalex.org/W4294349031"],"related_works":["https://openalex.org/W7096537173","https://openalex.org/W2091909636","https://openalex.org/W2511330110","https://openalex.org/W2148720330","https://openalex.org/W2416260546","https://openalex.org/W4240405172","https://openalex.org/W942241117","https://openalex.org/W2043699510","https://openalex.org/W2091514522","https://openalex.org/W2043563180"],"abstract_inverted_index":{"Vascularized":[0],"composite":[1,117,131,150,185,220],"tissue":[2,29,118,151,173,189,221],"allotransplantation":[3],"is":[4],"a":[5,81,122],"rapidly":[6],"evolving":[7],"area":[8],"that":[9],"has":[10],"brought":[11],"to":[12,53,129],"the":[13,18,43,50,114,217],"forefront":[14],"technological":[15],"advances":[16,187],"in":[17,76,112,147,171,188,192],"areas":[19],"of":[20,45,83,89,104,116,203,208,219],"plastic":[21],"surgery,":[22],"hand":[23],"surgery":[24],"and":[25,36,49,55,67,102,120,168],"transplant":[26],"biology.":[27],"Composite":[28],"allografts":[30,119],"may":[31,59,108,143,157,210],"have":[32],"profound":[33],"functional,":[34],"aesthetic":[35],"psychological":[37],"benefits,":[38],"but":[39],"carry":[40],"with":[41,87,97,140,180],"them":[42],"risks":[44],"lifelong":[46],"immune":[47],"suppression":[48],"inadequate":[51],"abilities":[52],"monitor":[54],"prevent":[56,65],"rejection.":[57],"Allografts":[58],"suffer":[60],"from":[61,177],"additional":[62,204],"insults":[63],"which":[64,162],"regenerative":[66,100,213],"reparative":[68],"activities,":[69],"further":[70],"weakening":[71],"their":[72],"overall":[73],"benefits.":[74],"Changes":[75],"local":[77],"blood":[78],"flow":[79],"as":[80,121,125,199,201],"consequence":[82],"endothelial":[84],"injury,":[85],"neuropathy":[86],"lack":[88],"completely":[90],"restored":[91],"neurologic":[92],"function,":[93],"infection,":[94],"inappropriate":[95],"inflammation":[96],"subsequent":[98],"dysregulated":[99],"activity,":[101],"paucity":[103],"appropriate":[105],"growth":[106],"factors":[107],"all":[109],"be":[110],"involved":[111],"reducing":[113],"potential":[115],"consequence,":[123],"serve":[124],"new":[126,178,212],"therapeutic":[127],"targets":[128],"improve":[130],"allograft":[132,152],"outcomes.":[133],"New":[134],"strategies":[135,215],"involving":[136],"minimized":[137],"immunosuppression":[138],"combined":[139],"pro-regenerative":[141,169],"therapeutics":[142],"provide":[144,164,211],"greater":[145],"inroads":[146],"optimizing":[148],"long-term":[149],"function.":[153],"One":[154],"such":[155],"strategy":[156],"include":[158],"mesenchymal":[159,181],"stem":[160,182],"cells,":[161],"can":[163],"both":[165],"unique":[166],"anti-inflammatory":[167],"effects":[170],"many":[172],"types.":[174],"Insights":[175],"gained":[176],"studies":[179],"cells":[183],"on":[184],"allografts,":[186],"regeneration":[190],"reported":[191],"other":[193],"mesenchymal-stem":[194],"cell":[195],"based":[196,214],"clinical":[197],"studies,":[198],"well":[200],"consideration":[202],"newly":[205],"described":[206],"capacities":[207],"MSC,":[209],"for":[216],"care":[218],"allografts.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
