{"id":"https://openalex.org/W1998618966","doi":"https://doi.org/10.1371/journal.pone.0034112","title":"Hormone Treatment, Estrogen Receptor Polymorphisms and Mortality: A Prospective Cohort Study","display_name":"Hormone Treatment, Estrogen Receptor Polymorphisms and Mortality: A Prospective Cohort Study","publication_year":2012,"publication_date":"2012-03-23","ids":{"openalex":"https://openalex.org/W1998618966","doi":"https://doi.org/10.1371/journal.pone.0034112","mag":"1998618966","pmid":"https://pubmed.ncbi.nlm.nih.gov/22457817","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3311587"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0034112","doi":"https://doi.org/10.1371/journal.pone.0034112","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0034112","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0034112&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0034112&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081383005","display_name":"Joanne L. Ryan","orcid":"https://orcid.org/0000-0002-7039-6325","observed_orcids":["https://orcid.org/0000-0002-7039-6325"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4387153574","display_name":"Universit\u00e9 Montpellier 1","ror":"https://ror.org/0227fbx80","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Joanne Ryan","raw_affiliation_strings":["Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France. joanne.ryan@inserm.fr","Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France. joanne.ryan@inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153574"]},{"raw_affiliation_string":"Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4387153574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030503819","display_name":"Marianne Canonico","orcid":"https://orcid.org/0000-0002-2843-8640","observed_orcids":["https://orcid.org/0000-0002-2843-8640"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marianne Canonico","raw_affiliation_strings":["Inserm U1018, Universit\u00e9 Paris Sud 11, UMRS 1018, F-94807, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1018, Universit\u00e9 Paris Sud 11, UMRS 1018, F-94807, Villejuif, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025485223","display_name":"Laure Carcaillon\u2010Bentata","orcid":"https://orcid.org/0000-0003-1556-8590","observed_orcids":["https://orcid.org/0000-0003-1556-8590"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laure Carcaillon","raw_affiliation_strings":["Inserm U1018, Universit\u00e9 Paris Sud 11, UMRS 1018, F-94807, Villejuif, France","Inserm U897, Universit\u00e9 Bordeaux 2, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1018, Universit\u00e9 Paris Sud 11, UMRS 1018, F-94807, Villejuif, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Inserm U897, Universit\u00e9 Bordeaux 2, Bordeaux, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068708409","display_name":"Isabelle Carri\u00e8re","orcid":"https://orcid.org/0000-0002-3617-0752","observed_orcids":["https://orcid.org/0000-0002-3617-0752"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4387153574","display_name":"Universit\u00e9 Montpellier 1","ror":"https://ror.org/0227fbx80","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Carri\u00e8re","raw_affiliation_strings":["Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4387153574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044152303","display_name":"Jacqueline Scali","orcid":"https://orcid.org/0000-0003-2844-7499","observed_orcids":["https://orcid.org/0000-0003-2844-7499"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4387153574","display_name":"Universit\u00e9 Montpellier 1","ror":"https://ror.org/0227fbx80","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacqueline Scali","raw_affiliation_strings":["Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4387153574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048761069","display_name":"Jean\u2010Fran\u00e7ois Dartigues","orcid":"https://orcid.org/0000-0001-9482-5529","observed_orcids":["https://orcid.org/0000-0001-9482-5529"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Francois Dartigues","raw_affiliation_strings":["Inserm U897, Universit\u00e9 Bordeaux 2, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U897, Universit\u00e9 Bordeaux 2, Bordeaux, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059582687","display_name":"Carole Dufouil","orcid":"https://orcid.org/0000-0003-2442-4476","observed_orcids":["https://orcid.org/0000-0003-2442-4476"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carole Dufouil","raw_affiliation_strings":["Inserm U708, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U708, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075011135","display_name":"Karen A. Ritchie","orcid":"https://orcid.org/0000-0002-0688-8982","observed_orcids":["https://orcid.org/0000-0002-0688-8982"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4387153574","display_name":"Universit\u00e9 Montpellier 1","ror":"https://ror.org/0227fbx80","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["FR","GB"],"is_corresponding":false,"raw_author_name":"Karen Ritchie","raw_affiliation_strings":["Faculty of Medicine, Imperial College, London, United Kingdom","Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Imperial College, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4387153574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079978234","display_name":"Pierre\u2010Yves Scarabin","orcid":"https://orcid.org/0000-0001-7266-3696","observed_orcids":["https://orcid.org/0000-0001-7266-3696"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre-Yves Scarabin","raw_affiliation_strings":["Inserm U1018, Universit\u00e9 Paris Sud 11, UMRS 1018, F-94807, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1018, Universit\u00e9 Paris Sud 11, UMRS 1018, F-94807, Villejuif, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009296549","display_name":"Marie\u2010Laure Ancelin","orcid":"https://orcid.org/0000-0002-1149-4320","observed_orcids":["https://orcid.org/0000-0002-1149-4320"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4387153574","display_name":"Universit\u00e9 Montpellier 1","ror":"https://ror.org/0227fbx80","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Laure Ancelin","raw_affiliation_strings":["Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1061, Universit\u00e9 Montpellier 1, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4387153574"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5081383005"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4387153574"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.0783,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.91321395,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"3","first_page":"e34112","last_page":"e34112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/estrogen-receptor-polymorphisms","display_name":"estrogen receptor polymorphisms","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cancer-mortality","display_name":"cancer mortality","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.890999972820282},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.699999988079071},{"id":"https://openalex.org/keywords/older-women","display_name":"older women","score":0.8199999928474426},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.5149999856948853},{"id":"https://openalex.org/keywords/age-at-initiation","display_name":"age at initiation","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6803733706474304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6464983224868774},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.6106756925582886},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5223428010940552},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5054309368133545},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4766726791858673},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4724861979484558},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45073947310447693},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.44831186532974243},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4376488924026489},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4181011915206909},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4101417660713196},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38464170694351196},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.36528974771499634},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020249","descriptor_name":"Hormone Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0034112","doi":"https://doi.org/10.1371/journal.pone.0034112","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0034112","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0034112&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3311587","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3311587","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22457817","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22457817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/262716","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/262716","pdf_url":"http://hdl.handle.net/11343/262716","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.411.2397","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.411.2397","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hal.inria.fr/docs/00/85/68/72/PDF/journal.pone.0034112.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.816.4430","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.816.4430","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/10/3b/pone.0034112.PMC3311587.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:inserm-00856872v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00856872v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 2012, 7 (3), pp.e34112. ⟨10.1371/journal.pone.0034112⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pone00:0034112","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034112","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4796f24d8e6e4869b4f36871ac089cae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4796f24d8e6e4869b4f36871ac089cae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 3, p e34112 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0034112","doi":"https://doi.org/10.1371/journal.pone.0034112","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0034112","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0034112&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322646","display_name":"Fondation de France","ror":"https://ror.org/02zkxjz73"},{"id":"https://openalex.org/F4320324827","display_name":"Mutuelle G\u00e9n\u00e9rale de l'Education Nationale","ror":"https://ror.org/029vj4k86"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998618966.pdf","grobid_xml":"https://content.openalex.org/works/W1998618966.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W38490725","https://openalex.org/W1586699954","https://openalex.org/W1593442063","https://openalex.org/W1838292546","https://openalex.org/W1847168837","https://openalex.org/W1892432125","https://openalex.org/W1968661022","https://openalex.org/W1974355951","https://openalex.org/W1985109518","https://openalex.org/W1986731085","https://openalex.org/W1991285369","https://openalex.org/W1994349098","https://openalex.org/W1996731323","https://openalex.org/W1999691424","https://openalex.org/W2000836832","https://openalex.org/W2008854521","https://openalex.org/W2022916509","https://openalex.org/W2027765842","https://openalex.org/W2035153654","https://openalex.org/W2054313225","https://openalex.org/W2055622376","https://openalex.org/W2057914123","https://openalex.org/W2070660975","https://openalex.org/W2074423736","https://openalex.org/W2095807163","https://openalex.org/W2101037478","https://openalex.org/W2105612963","https://openalex.org/W2108415399","https://openalex.org/W2108588412","https://openalex.org/W2109376303","https://openalex.org/W2112044919","https://openalex.org/W2112442316","https://openalex.org/W2112778345","https://openalex.org/W2113264115","https://openalex.org/W2121398847","https://openalex.org/W2128529067","https://openalex.org/W2137615802","https://openalex.org/W2143152245","https://openalex.org/W2146136609","https://openalex.org/W2148080316","https://openalex.org/W2156945727","https://openalex.org/W2160639597","https://openalex.org/W2167311298","https://openalex.org/W2168328801","https://openalex.org/W2168512925","https://openalex.org/W2183788149","https://openalex.org/W2313401542","https://openalex.org/W2317012058","https://openalex.org/W2352579400","https://openalex.org/W2399172003","https://openalex.org/W2473060236","https://openalex.org/W2602374858","https://openalex.org/W2611478076","https://openalex.org/W4254094697","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3155890179","https://openalex.org/W6902196063","https://openalex.org/W7171964383","https://openalex.org/W2611478076","https://openalex.org/W3212512357","https://openalex.org/W2050681327","https://openalex.org/W2887549503","https://openalex.org/W1967838625","https://openalex.org/W2109616203","https://openalex.org/W7098870996"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,84,222,233],"association":[2,129,149],"between":[3,130,150],"hormone":[4],"treatment":[5,32],"(HT)":[6],"and":[7,33,54,64,77,90,99,123,132,152,229],"mortality":[8,20,156,191,216,236],"remains":[9],"controversial.":[10],"This":[11],"study":[12,47],"aimed":[13],"to":[14,72,172,263,291],"determine":[15],"whether":[16],"the":[17,28,39,104,136,143,148,179,206,264,286,292],"risk":[18,188,213,234],"of":[19,31,38,48,107,135,140,182,189,214,235,266,270,289,297],"associated":[21,239],"with":[22,160,164,192,240,256],"HT":[23,73,131,151,193,241,267],"use":[24,74],"varies":[25],"depending":[26],"on":[27],"specific":[29],"characteristics":[30],"genetic":[34],"variability":[35],"in":[36,62,174,200,268,279],"terms":[37,269],"estrogen":[40,79,166,272],"receptor.":[41],"METHODOLOGY/PRINCIPAL":[42],"FINDINGS:":[43],"A":[44],"prospective,":[45],"population-based":[46],"5135":[49],"women":[50,95,258,290],"aged":[51],"65":[52],"years":[53],"older":[55],"who":[56],"were":[57,82,103,224],"recruited":[58],"from":[59],"three":[60,165],"cities":[61],"France":[63],"followed":[65],"over":[66],"six":[67],"years.":[68],"Detailed":[69],"information":[70],"related":[71],"was":[75,87,237,249],"obtained":[76],"five":[78],"receptor":[80,167,273],"polymorphisms":[81,168],"genotyped.":[83],"total":[85],"follow-up":[86],"25,436":[88],"person-years":[89],"during":[91],"this":[92],"time":[93],"352":[94],"died.":[96],"Cancer":[97],"(36.4%)":[98],"cardiovascular":[100],"disease":[101],"(19.3%)":[102],"major":[105],"causes":[106],"death.":[108],"Cox":[109],"proportional":[110],"hazards":[111],"models":[112],"adjusted":[113,175],"for":[114,205,226],"age,":[115],"education,":[116],"centre,":[117],"living":[118],"situation,":[119],"comorbidity,":[120],"depression,":[121],"physical":[122],"mental":[124],"incapacities,":[125],"indicated":[126],"no":[127],"significant":[128,161],"mortality,":[133],"regardless":[134],"type":[137,243],"or":[138,142,154,244,294],"duration":[139],"treatment,":[141],"age":[144,245],"at":[145,246],"initiation.":[146,247],"However,":[147],"all-cause":[153,190],"cancer-related":[155,215],"varied":[157],"across":[158,253],"women,":[159,255],"interactions":[162],"identified":[163],"(p-values":[169],"=":[170],"0.004":[171],"0.03)":[173],"analyses.":[176],"Women":[177],"carrying":[178],"C":[180],"allele":[181,208],"ESR1":[183,227],"rs2234693":[184],"had":[185,209],"a":[186,210],"decreased":[187],"(HR:":[194,217],"0.42,":[195],"95%":[196,219],"CI:":[197,220],"0.18-0.97),":[198],"while":[199],"stark":[201],"contrast,":[202],"those":[203],"homozygous":[204],"T":[207],"significantly":[211],"increased":[212],"3.18,":[218],"1.23-8.20).":[221],"findings":[223],"similar":[225],"rs9340799":[228],"ESR2":[230],"rs1271572.":[231],"CONCLUSIONS/SIGNIFICANCE:":[232],"not":[238,251],"duration,":[242],"It":[248],"however":[250],"equal":[252],"all":[254],"some":[257],"appearing":[259],"genetically":[260],"more":[261],"vulnerable":[262],"effects":[265,296],"their":[271],"genotype.":[274],"These":[275],"findings,":[276],"if":[277],"confirmed":[278],"another":[280],"independent":[281],"study,":[282],"may":[283],"help":[284],"explain":[285],"differential":[287],"susceptibility":[288],"beneficial":[293],"adverse":[295],"HT.":[298]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}