{"id":"https://openalex.org/W1998604377","doi":"https://doi.org/10.1073/pnas.1116397109","title":"Molecular actions of smoking cessation drugs at \u03b14\u03b22 nicotinic receptors defined in crystal structures of a homologous binding protein","display_name":"Molecular actions of smoking cessation drugs at \u03b14\u03b22 nicotinic receptors defined in crystal structures of a homologous binding protein","publication_year":2012,"publication_date":"2012-05-22","ids":{"openalex":"https://openalex.org/W1998604377","doi":"https://doi.org/10.1073/pnas.1116397109","mag":"1998604377","pmid":"https://pubmed.ncbi.nlm.nih.gov/22619328","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3384148"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1116397109","doi":"https://doi.org/10.1073/pnas.1116397109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1116397109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3384148","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048344574","display_name":"Bert Billen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bert Billen","raw_affiliation_strings":["Laboratory of Structural Neurobiology, KU Leuven, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Neurobiology, KU Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065580868","display_name":"Radovan Spurn\u00fd","orcid":"https://orcid.org/0000-0003-4617-130X","observed_orcids":["https://orcid.org/0000-0003-4617-130X"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Radovan Spurny","raw_affiliation_strings":["Laboratory of Structural Neurobiology, KU Leuven, 3000 Leuven, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Neurobiology, KU Leuven, 3000 Leuven, Belgium;","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041531714","display_name":"Marijke Brams","orcid":"https://orcid.org/0000-0002-1830-7620","observed_orcids":["https://orcid.org/0000-0002-1830-7620"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marijke Brams","raw_affiliation_strings":["Laboratory of Structural Neurobiology, KU Leuven, 3000 Leuven, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Neurobiology, KU Leuven, 3000 Leuven, Belgium;","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110888183","display_name":"Ren\u00e9 van Elk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108594","display_name":"Amsterdam Neuroscience","ror":"https://ror.org/01x2d9f70","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210108594"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 van Elk","raw_affiliation_strings":["Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV, Amsterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV, Amsterdam, The Netherlands;","institution_ids":["https://openalex.org/I4210108594","https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027299788","display_name":"Soledad Valera-Kummer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130222","display_name":"HiQScreen (Switzerland)","ror":"https://ror.org/02qjgmm73","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210130222"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Soledad Valera-Kummer","raw_affiliation_strings":["HiQScreen, 1211 Geneva, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HiQScreen, 1211 Geneva, Switzerland;","institution_ids":["https://openalex.org/I4210130222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005034885","display_name":"Jerrel L. Yakel","orcid":"https://orcid.org/0000-0001-5463-674X","observed_orcids":["https://orcid.org/0000-0001-5463-674X"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerrel L. Yakel","raw_affiliation_strings":["Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 22709; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 22709; and","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021952303","display_name":"Thomas Voets","orcid":"https://orcid.org/0000-0001-5526-5821","observed_orcids":["https://orcid.org/0000-0001-5526-5821"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Thomas Voets","raw_affiliation_strings":["Laboratory of Ion Channel Research, KU Leuven, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Ion Channel Research, KU Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106084698","display_name":"Daniel Bertrand","orcid":"https://orcid.org/0000-0003-2057-7133","observed_orcids":["https://orcid.org/0000-0003-2057-7133"]},"institutions":[{"id":"https://openalex.org/I4210130222","display_name":"HiQScreen (Switzerland)","ror":"https://ror.org/02qjgmm73","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210130222"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel Bertrand","raw_affiliation_strings":["HiQScreen, 1211 Geneva, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HiQScreen, 1211 Geneva, Switzerland;","institution_ids":["https://openalex.org/I4210130222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046661343","display_name":"August Benjamin Smit","orcid":"https://orcid.org/0000-0002-2286-1587","observed_orcids":["https://orcid.org/0000-0002-2286-1587"]},"institutions":[{"id":"https://openalex.org/I4210108594","display_name":"Amsterdam Neuroscience","ror":"https://ror.org/01x2d9f70","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210108594"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"August B. Smit","raw_affiliation_strings":["Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV, Amsterdam, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV, Amsterdam, The Netherlands;","institution_ids":["https://openalex.org/I4210108594","https://openalex.org/I865915315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050669467","display_name":"Chris Ulens","orcid":"https://orcid.org/0000-0002-8202-5281","observed_orcids":["https://orcid.org/0000-0002-8202-5281"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Chris Ulens","raw_affiliation_strings":["Laboratory of Structural Neurobiology, KU Leuven, 3000 Leuven, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Neurobiology, KU Leuven, 3000 Leuven, Belgium;","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5050669467"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":null,"apc_paid":null,"fwci":4.1983,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.95908097,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"109","issue":"23","first_page":"9173","last_page":"9178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/varenicline","display_name":"varenicline","score":0.8190000057220459},{"id":"https://openalex.org/keywords/lobeline","display_name":"lobeline","score":0.9700000286102295},{"id":"https://openalex.org/keywords/alpha4beta2-nicotinic-acetylcholine-receptor","display_name":"\u03b14\u03b22 nicotinic acetylcholine receptor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/smoking-cessation-drugs","display_name":"smoking cessation drugs","score":0.8259999752044678},{"id":"https://openalex.org/keywords/partial-agonists","display_name":"partial agonists","score":0.8799999952316284},{"id":"https://openalex.org/keywords/acetylcholine-binding-protein","display_name":"acetylcholine binding protein","score":0.9539999961853027},{"id":"https://openalex.org/keywords/capitella-teleta","display_name":"Capitella teleta","score":0.9900000095367432},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.8460000157356262},{"id":"https://openalex.org/keywords/channel-opening","display_name":"channel opening","score":0.6850000023841858},{"id":"https://openalex.org/keywords/binding-site-residues","display_name":"binding site residues","score":0.6499999761581421},{"id":"https://openalex.org/keywords/structure-based-mutagenesis","display_name":"structure-guided mutagenesis","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C2777053506","wikidata":"https://www.wikidata.org/wiki/Q411330","display_name":"Varenicline","level":3,"score":0.9169406890869141},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.7734024524688721},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.7450563311576843},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6144077777862549},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5882154703140259},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5775770545005798},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.5723752379417419},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.5009217262268066},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.499891996383667},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41911154985427856},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.26886847615242004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26874011754989624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2331623136997223},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18804118037223816},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068580","descriptor_name":"Varenicline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074606","descriptor_name":"Smoking Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011077","descriptor_name":"Polychaeta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D061485","descriptor_name":"Tobacco Use Cessation Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1073/pnas.1116397109","doi":"https://doi.org/10.1073/pnas.1116397109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1116397109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2387545","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3384148","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22619328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22619328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3384148","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3384148/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:research.vu.nl:openaire_cris_publications/5231df96-5022-40d7-b932-34e14b157a59","doi":null,"is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/5231df96-5022-40d7-b932-34e14b157a59","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Billen, B, Spurny, R, Brams, M, van Elk, R, Valera-Kummer, S, Yakel, J L, Voets, T, Bertrand, D, Smit, A B & Ulens, C 2012, 'Molecular actions of smoking cessation drugs at \u03b14\u03b22 nicotinic receptors defined in crystal structures of a homologous binding protein', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 23, pp. 9173-9178. https://doi.org/10.1073/pnas.1116397109","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/348910","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/348910","pdf_url":"https://lirias.kuleuven.be/retrieve/1a1af672-e17a-450f-8f47-5c0ec98fd417","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, vol. 109 (23), (9173-9178)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dora:psi_12160","doi":null,"is_oa":false,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:12160","pdf_url":null,"source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America PNAS","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu:oai:research.vu.nl:publications/5231df96-5022-40d7-b932-34e14b157a59","doi":null,"is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/5231df96-5022-40d7-b932-34e14b157a59","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 109(23), 9173 - 9178. National Acad Sciences","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2387545","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3384148","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1167558415","display_name":"Neurotransmitter Cys-loop receptors: structure, function and disease","funder_award_id":"202088","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998604377.pdf","grobid_xml":"https://content.openalex.org/works/W1998604377.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1503600024","https://openalex.org/W1530038052","https://openalex.org/W1563648214","https://openalex.org/W1571140265","https://openalex.org/W1588036538","https://openalex.org/W1635375164","https://openalex.org/W1908222510","https://openalex.org/W1919867164","https://openalex.org/W1966099771","https://openalex.org/W1974510063","https://openalex.org/W1975154104","https://openalex.org/W1975239375","https://openalex.org/W1986084361","https://openalex.org/W1993112595","https://openalex.org/W2003468829","https://openalex.org/W2005829345","https://openalex.org/W2010752451","https://openalex.org/W2011202557","https://openalex.org/W2050347178","https://openalex.org/W2054525948","https://openalex.org/W2059230624","https://openalex.org/W2073905010","https://openalex.org/W2085913208","https://openalex.org/W2088025163","https://openalex.org/W2097345469","https://openalex.org/W2099277573","https://openalex.org/W2101370257","https://openalex.org/W2106950438","https://openalex.org/W2141246891","https://openalex.org/W2141456252","https://openalex.org/W2143014450","https://openalex.org/W2147835957","https://openalex.org/W2148168931","https://openalex.org/W2152418590","https://openalex.org/W2157325884","https://openalex.org/W2165094621","https://openalex.org/W2165501997","https://openalex.org/W2169051367","https://openalex.org/W2337946333"],"related_works":["https://openalex.org/W2091109046","https://openalex.org/W2101520329","https://openalex.org/W2059181730","https://openalex.org/W2946623164","https://openalex.org/W1993112595","https://openalex.org/W2141246891","https://openalex.org/W2193877390","https://openalex.org/W2165094621","https://openalex.org/W2356317465","https://openalex.org/W2070026700"],"abstract_inverted_index":{"Partial":[0],"agonists":[1],"of":[2,59,91,119,127,146,165],"the":[3,67,86,95,124,128,155],"\u03b14\u03b22":[4,33,105,132],"nicotinic":[5],"acetylcholine":[6,62],"receptor":[7,51],"(nAChR),":[8],"such":[9],"as":[10],"varenicline,":[11],"are":[12,30,79,143],"therapeutically":[13],"used":[14,109],"in":[15,72,104,131,138,171],"smoking":[16,166],"cessation":[17,167],"treatment.":[18],"These":[19,83],"drugs":[20,168],"derive":[21],"their":[22,101],"therapeutic":[23],"effect":[24],"from":[25,66],"fundamental":[26],"molecular":[27,89,102,144,163],"actions,":[28],"which":[29,78],"to":[31,115],"desensitize":[32],"nAChRs":[34,170],"and":[35,112,141,148],"induce":[36],"channel":[37,149],"opening":[38,150],"with":[39,74,121,151],"higher":[40],"affinity,":[41],"but":[42],"lower":[43],"efficacy":[44,153],"than":[45],"a":[46,60,172],"full":[47],"agonist":[48,157],"at":[49],"equal":[50],"occupancy.":[52],"Here,":[53],"we":[54],"report":[55],"X-ray":[56],"crystal":[57],"structures":[58,84],"unique":[61],"binding":[63,129],"protein":[64],"(AChBP)":[65],"annelid":[68],"Capitella":[69],"teleta,":[70],"Ct-AChBP,":[71],"complex":[73],"varenicline":[75,120],"or":[76],"lobeline,":[77],"both":[80],"partial":[81,156],"agonists.":[82],"highlight":[85],"architecture":[87],"for":[88],"recognition":[90,164],"these":[92],"ligands,":[93],"indicating":[94],"contact":[96],"residues":[97,122,137],"that":[98,136],"potentially":[99],"mediate":[100],"actions":[103],"nAChRs.":[106,133],"We":[107,134],"then":[108],"structure-guided":[110],"mutagenesis":[111],"electrophysiological":[113],"recordings":[114],"pinpoint":[116],"crucial":[117],"interactions":[118],"on":[123],"complementary":[125],"face":[126],"site":[130],"observe":[135],"loops":[139],"D":[140],"E":[142],"determinants":[145],"desensitization":[147],"limited":[152],"by":[154,169],"varenicline.":[158],"Together,":[159],"this":[160],"study":[161],"analyzes":[162],"structural":[173],"context.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}