{"id":"https://openalex.org/W1998577031","doi":"https://doi.org/10.1074/jbc.m609001200","title":"FBXO11 Promotes the Neddylation of p53 and Inhibits Its Transcriptional Activity","display_name":"FBXO11 Promotes the Neddylation of p53 and Inhibits Its Transcriptional Activity","publication_year":2006,"publication_date":"2006-11-14","ids":{"openalex":"https://openalex.org/W1998577031","doi":"https://doi.org/10.1074/jbc.m609001200","mag":"1998577031","pmid":"https://pubmed.ncbi.nlm.nih.gov/17098746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3690493"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m609001200","doi":"https://doi.org/10.1074/jbc.m609001200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609001200","pdf_url":"http://www.jbc.org/article/S0021925820721794/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820721794/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062426672","display_name":"Wassim M. Abida","orcid":"https://orcid.org/0000-0002-9006-7043","observed_orcids":["https://orcid.org/0000-0002-9006-7043"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wassim M. Abida","raw_affiliation_strings":["Institute for Cancer Genetics and the Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics and the Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059235641","display_name":"Anatoly Y. Nikolaev","orcid":"https://orcid.org/0000-0003-2818-5839","observed_orcids":["https://orcid.org/0000-0003-2818-5839"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anatoly Nikolaev","raw_affiliation_strings":["Institute for Cancer Genetics and the Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics and the Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086522493","display_name":"Wenhui Zhao","orcid":"https://orcid.org/0000-0002-7703-7106","observed_orcids":["https://orcid.org/0000-0002-7703-7106"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenhui Zhao","raw_affiliation_strings":["Institute for Cancer Genetics and the Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics and the Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009775477","display_name":"Wenzhu Zhang","orcid":"https://orcid.org/0000-0002-1353-340X","observed_orcids":["https://orcid.org/0000-0002-1353-340X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenzhu Zhang","raw_affiliation_strings":["Institute for Cancer Genetics and the Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics and the Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015664805","display_name":"Wei Jun Gu","orcid":"https://orcid.org/0000-0002-1480-2368","observed_orcids":["https://orcid.org/0000-0002-1480-2368"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Gu","raw_affiliation_strings":["Institute for Cancer Genetics and the Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics and the Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015664805"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.4036,"has_fulltext":true,"cited_by_count":201,"citation_normalized_percentile":{"value":0.95051322,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"282","issue":"3","first_page":"1797","last_page":"1804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.5679000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.5679000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.42289999127388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fbxo11","display_name":"FBXO11","score":1.0},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neddylation","display_name":"neddylation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nedd8","display_name":"NEDD8","score":0.9039999842643738},{"id":"https://openalex.org/keywords/scf-ubiquitin-ligase","display_name":"SCF ubiquitin ligase","score":0.6690000295639038},{"id":"https://openalex.org/keywords/f-box-protein","display_name":"F-box protein","score":0.8849999904632568},{"id":"https://openalex.org/keywords/p53-transcriptional-activity","display_name":"p53 transcriptional activity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/p53-acetylation","display_name":"p53 acetylation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/p53-tumor-suppressor","display_name":"p53 tumor suppressor","score":0.6019999980926514},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.6949999928474426},{"id":"https://openalex.org/keywords/adaptor-proteins","display_name":"adaptor proteins","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C45005369","wikidata":"https://www.wikidata.org/wiki/Q21115705","display_name":"Neddylation","level":5,"score":0.9898276329040527},{"id":"https://openalex.org/C2779231659","wikidata":"https://www.wikidata.org/wiki/Q6953444","display_name":"NEDD8","level":5,"score":0.9422088861465454},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.7346387505531311},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6733787655830383},{"id":"https://openalex.org/C2778567606","wikidata":"https://www.wikidata.org/wiki/Q41797435","display_name":"Cullin","level":5,"score":0.6631587147712708},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.6121122241020203},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.6059622764587402},{"id":"https://openalex.org/C107793267","wikidata":"https://www.wikidata.org/wiki/Q14908260","display_name":"PCAF","level":4,"score":0.6046832203865051},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5600689053535461},{"id":"https://openalex.org/C2775868145","wikidata":"https://www.wikidata.org/wiki/Q18031515","display_name":"Skp1","level":5,"score":0.5427761673927307},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5186321139335632},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47107210755348206},{"id":"https://openalex.org/C131312102","wikidata":"https://www.wikidata.org/wiki/Q5423632","display_name":"F-box protein","level":5,"score":0.421773225069046},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.41471827030181885},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.413186252117157},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33682236075401306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26072901487350464},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.13848772644996643},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000075687","descriptor_name":"NEDD8 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099224","descriptor_name":"p300-CBP-Associated Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011484","descriptor_name":"Protein-Arginine N-Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044783","descriptor_name":"F-Box Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044842","descriptor_name":"Cullin Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044843","descriptor_name":"SKP Cullin F-Box Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050880","descriptor_name":"p300-CBP Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051548","descriptor_name":"Histone Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m609001200","doi":"https://doi.org/10.1074/jbc.m609001200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609001200","pdf_url":"http://www.jbc.org/article/S0021925820721794/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17098746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17098746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2684697","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3690493","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3690493","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3690493","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m609001200","doi":"https://doi.org/10.1074/jbc.m609001200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609001200","pdf_url":"http://www.jbc.org/article/S0021925820721794/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1370126020","display_name":null,"funder_award_id":"R01-CA085533","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3294924082","display_name":"Mechanisms of Mdm2/Mdmx in repressing p53","funder_award_id":"R01CA131439","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5041840061","display_name":"The role of ARF-BP1 in tumorigenesis","funder_award_id":"R01CA118561","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6844883839","display_name":"Regulation of p53 acetylation and deacetylation in tumorigenesis.","funder_award_id":"2r01ca085533-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7503782845","display_name":"Role of Parc in the p53 Pathway","funder_award_id":"R01CA104843","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7692078529","display_name":"Mechanisms of p53 activation in tumorsuppression","funder_award_id":"R01CA098821","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8386454437","display_name":"Dynamic roles of HAUSP in p53/Mdm2 regulation","funder_award_id":"R01CA129627","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998577031.pdf","grobid_xml":"https://content.openalex.org/works/W1998577031.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W100225602","https://openalex.org/W1493846190","https://openalex.org/W1558846872","https://openalex.org/W1590759479","https://openalex.org/W1650797637","https://openalex.org/W1769736739","https://openalex.org/W1852163795","https://openalex.org/W1958512987","https://openalex.org/W1969044026","https://openalex.org/W1980755687","https://openalex.org/W1981045929","https://openalex.org/W1984103033","https://openalex.org/W1986068161","https://openalex.org/W1991494214","https://openalex.org/W1993864973","https://openalex.org/W2005973634","https://openalex.org/W2006313701","https://openalex.org/W2007658328","https://openalex.org/W2011991138","https://openalex.org/W2013317474","https://openalex.org/W2028044172","https://openalex.org/W2035065476","https://openalex.org/W2044724807","https://openalex.org/W2050745715","https://openalex.org/W2055892514","https://openalex.org/W2060853377","https://openalex.org/W2060972565","https://openalex.org/W2061156149","https://openalex.org/W2075124527","https://openalex.org/W2076411120","https://openalex.org/W2079238991","https://openalex.org/W2082541302","https://openalex.org/W2094866737","https://openalex.org/W2095899172","https://openalex.org/W2097350262","https://openalex.org/W2098817749","https://openalex.org/W2116755440","https://openalex.org/W2119363024","https://openalex.org/W2120921507","https://openalex.org/W2121077625","https://openalex.org/W2126344344","https://openalex.org/W2126863927","https://openalex.org/W2131833681","https://openalex.org/W2138822307","https://openalex.org/W2141957886","https://openalex.org/W2144919418","https://openalex.org/W2150621953","https://openalex.org/W2168852880","https://openalex.org/W2168933043","https://openalex.org/W2168979257","https://openalex.org/W2169281107","https://openalex.org/W2171186199"],"related_works":["https://openalex.org/W7172543822","https://openalex.org/W2168979257","https://openalex.org/W2052022561","https://openalex.org/W177274740","https://openalex.org/W2733529598","https://openalex.org/W2002466777","https://openalex.org/W2141387804","https://openalex.org/W4404444726","https://openalex.org/W2695347159","https://openalex.org/W2988041907"],"abstract_inverted_index":{"The":[0],"p53":[1,73,100,105,124],"tumor":[2],"suppressor":[3],"is":[4,108],"regulated":[5],"by":[6],"post-translational":[7],"modification,":[8],"including":[9],"ubiquitination,":[10],"phosphorylation":[11],"and":[12,52,77,95,97],"acetylation.":[13],"It":[14],"has":[15],"previously":[16],"been":[17],"shown":[18],"that":[19,67,114,154],"the":[20,26,41,48,56,70,83,157],"ubiquitin":[21],"ligase":[22],"Mdm2":[23],"also":[24,89],"promotes":[25,69],"conjugation":[27,92],"of":[28,43,47,55,72,99,104,138,145,159],"Nedd8,":[29],"a":[30,45,53,61,115,160],"ubiquitin-like":[31],"protein,":[32],"to":[33,82,93,102,117],"p53,":[34],"inhibiting":[35],"its":[36],"transcriptional":[37],"activity.":[38],"We":[39,65],"report":[40],"identification":[42],"FBXO11,":[44],"member":[46],"F-box":[49,147],"protein":[50,148,153],"family":[51],"component":[54],"Skp1.Cullin1.F-box":[57],"(SCF)":[58],"complex,":[59],"as":[60,131,150],"new":[62],"p53-interacting":[63],"protein.":[64],"show":[66],"FBXO11":[68,87],"neddylation":[71,98,158],"both":[74],"in":[75,78],"vitro":[76],"vivo.":[79],"In":[80],"addition":[81],"C-terminal":[84],"lysine":[85,116],"residues,":[86],"can":[88,155],"promote":[90],"Nedd8":[91],"Lys-320":[94,121,127],"Lys-321,":[96],"leads":[101],"suppression":[103],"function.":[106],"This":[107],"consistent":[109],"with":[110],"recent":[111],"studies":[112],"showing":[113],"arginine":[118],"mutation":[119],"at":[120],"significantly":[122],"enhances":[123],"function,":[125],"although":[126],"was":[128],"originally":[129],"identified":[130],"an":[132,143,146,151],"acetylation":[133],"site":[134],"involving":[135],"PCAF-mediated":[136],"activation":[137],"p53.":[139],"Our":[140],"study":[141],"provides":[142],"example":[144],"acting":[149],"adaptor":[152],"mediate":[156],"non-cullin":[161],"substrate.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
