{"id":"https://openalex.org/W1998557621","doi":null,"title":"Replacement of the p16/CDKN2 gene suppresses human glioma cell growth.","display_name":"Replacement of the p16/CDKN2 gene suppresses human glioma cell growth.","publication_year":1995,"publication_date":"1995-03-15","ids":{"openalex":"https://openalex.org/W1998557621","mag":"1998557621","pmid":"https://pubmed.ncbi.nlm.nih.gov/7882335"},"language":"en","primary_location":{"id":"pmid:7882335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7882335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042976999","display_name":"Wadih Arap","orcid":"https://orcid.org/0000-0002-8686-4584","observed_orcids":["https://orcid.org/0000-0002-8686-4584"]},"institutions":[{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Arap","raw_affiliation_strings":["Ludwig Institute for Cancer Research, La Jolla, CA 92093-0660"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, La Jolla, CA 92093-0660","institution_ids":["https://openalex.org/I4210150094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051066157","display_name":"Ryo Nishikawa","orcid":"https://orcid.org/0000-0002-3725-7489","observed_orcids":["https://orcid.org/0000-0002-3725-7489"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Nishikawa","raw_affiliation_strings":["University of California at San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036985768","display_name":"Frank B. Furnari","orcid":"https://orcid.org/0000-0003-1909-4361","observed_orcids":["https://orcid.org/0000-0003-1909-4361"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F B Furnari","raw_affiliation_strings":["University of California at San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072507966","display_name":"Webster K. Cavenee","orcid":"https://orcid.org/0000-0003-3804-9179","observed_orcids":["https://orcid.org/0000-0003-3804-9179"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W K Cavenee","raw_affiliation_strings":["University of California at San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106223125","display_name":"H-J. Su Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H J Huang","raw_affiliation_strings":["University of California at San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.572,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.98387991,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"55","issue":"6","first_page":"1351","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.7269999980926514},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8679999709129333},{"id":"https://openalex.org/keywords/gene-transfer","display_name":"gene transfer","score":0.6570000052452087},{"id":"https://openalex.org/keywords/9p21","display_name":"9p21","score":0.7770000100135803},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9679999947547913},{"id":"https://openalex.org/keywords/homozygous-deletion","display_name":"homozygous deletion","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.843999981880188},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7473909854888916},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.6417835354804993},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6405667066574097},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5611260533332825},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5000407695770264},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.42434537410736084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25348836183547974},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.18582308292388916}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7882335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7882335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1998557621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7882335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1485772597","https://openalex.org/W1498486272","https://openalex.org/W1501631032","https://openalex.org/W1529548059","https://openalex.org/W1548870826","https://openalex.org/W1590316048","https://openalex.org/W1799814822","https://openalex.org/W1967304777","https://openalex.org/W1983348452","https://openalex.org/W1997073961","https://openalex.org/W2046577405","https://openalex.org/W2048672429","https://openalex.org/W2066848701","https://openalex.org/W2074067954","https://openalex.org/W2076273397","https://openalex.org/W2137189485","https://openalex.org/W2137273750"],"related_works":["https://openalex.org/W7099522595","https://openalex.org/W2313440299","https://openalex.org/W2084617510","https://openalex.org/W2341469193","https://openalex.org/W2027317872","https://openalex.org/W2399118059","https://openalex.org/W1979228279","https://openalex.org/W7097145443","https://openalex.org/W322502563","https://openalex.org/W2087102089"],"abstract_inverted_index":{"The":[0,85],"p16/CDKN2":[1,81,89,111,125],"gene":[2,54,83,126],"has":[3,67],"many":[4],"features":[5],"of":[6,18,20,25,32,50,52,80,87,120],"a":[7,15,23,128],"growth":[8,77,93,130],"suppressor":[9,131],"gene:":[10],"it":[11,28],"maps":[12],"to":[13,61],"9p21,":[14],"frequent":[16],"region":[17],"loss":[19],"heterozygozity":[21],"in":[22,42,55,95,105,118,135],"variety":[24],"tumor":[26,57,64],"types;":[27],"encodes":[29],"an":[30],"inhibitor":[31],"cyclin-dependent":[33],"kinase":[34],"4;":[35],"and":[36],"its":[37],"homozygous":[38],"deletion":[39],"is":[40,127],"common":[41],"tumor-derived":[43],"cell":[44,65],"lines.":[45],"However,":[46],"the":[47,53,62,76,121,124],"lower":[48],"frequency":[49],"alteration":[51],"primary":[56],"tissue":[58],"as":[59],"compared":[60],"cognate":[63],"lines":[66],"brought":[68],"this":[69],"interpretation":[70],"into":[71],"question.":[72],"We":[73],"have":[74],"assessed":[75],"suppressive":[78],"function":[79],"by":[82],"transfer.":[84],"introduction":[86],"full-length":[88],"cDNA":[90],"caused":[91],"marked":[92],"suppression":[94],"p16/CDKN2-null":[96],"human":[97],"glioma":[98],"cells,":[99],"but":[100],"was":[101],"without":[102],"significant":[103],"effect":[104],"those":[106],"cells":[107],"with":[108],"endogenous":[109],"wild-type":[110],"alleles.":[112],"These":[113],"results":[114],"provide":[115],"functional":[116,129],"evidence":[117],"support":[119],"hypothesis":[122],"that":[123],"gene,":[132],"at":[133],"least":[134],"gliomas.":[136]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}