{"id":"https://openalex.org/W1998553342","doi":"https://doi.org/10.4161/cc.10.20.17842","title":"Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders","display_name":"Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders","publication_year":2011,"publication_date":"2011-10-15","ids":{"openalex":"https://openalex.org/W1998553342","doi":"https://doi.org/10.4161/cc.10.20.17842","mag":"1998553342","pmid":"https://pubmed.ncbi.nlm.nih.gov/22067658","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3266183"},"language":"en","primary_location":{"id":"doi:10.4161/cc.10.20.17842","doi":"https://doi.org/10.4161/cc.10.20.17842","is_oa":false,"landing_page_url":"https://doi.org/10.4161/cc.10.20.17842","pdf_url":null,"source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3266183","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049335284","display_name":"Anna B. Glinskii","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna B. Glinskii","raw_affiliation_strings":["Translational and Functional Genomics Laboratory, Genlighttechnology Corporation, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational and Functional Genomics Laboratory, Genlighttechnology Corporation, La Jolla, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101717949","display_name":"Shuang Ma","orcid":"https://orcid.org/0000-0002-3646-1461","observed_orcids":["https://orcid.org/0000-0002-3646-1461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuang Ma","raw_affiliation_strings":["Ordway Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ordway Research Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101706879","display_name":"Jun Ma","orcid":"https://orcid.org/0000-0003-2024-9471","observed_orcids":["https://orcid.org/0000-0003-2024-9471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Ma","raw_affiliation_strings":["Ordway Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ordway Research Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014610282","display_name":"Denise Grant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denise Grant","raw_affiliation_strings":["Ordway Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ordway Research Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047629165","display_name":"Chang\u2010Uk Lim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chang-Uk Lim","raw_affiliation_strings":["Ordway Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ordway Research Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053448908","display_name":"Ian Guest","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian Guest","raw_affiliation_strings":["Ordway Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ordway Research Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090632544","display_name":"Stewart Sell","orcid":"https://orcid.org/0000-0002-3703-789X","observed_orcids":["https://orcid.org/0000-0002-3703-789X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stewart Sell","raw_affiliation_strings":["Ordway Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ordway Research Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088350338","display_name":"Ralph Buttyan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph Buttyan","raw_affiliation_strings":["Ordway Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ordway Research Institute,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083792252","display_name":"Gennadi V. Glinsky","orcid":"https://orcid.org/0000-0002-2523-8264","observed_orcids":["https://orcid.org/0000-0002-2523-8264","https://orcid.org/0000-0002-8551-9914"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gennadi V. Glinsky","raw_affiliation_strings":["Ordway Research Institute; Albany Medical College; Genlighttechnologies Corporation; Sanford-Burnham Institute for Medical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ordway Research Institute; Albany Medical College; Genlighttechnologies Corporation; Sanford-Burnham Institute for Medical Research","institution_ids":["https://openalex.org/I188891513","https://openalex.org/I4405260259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7822,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.60154905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"20","first_page":"3571","last_page":"3597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.21310000121593475,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-range-enhancers","display_name":"long-range enhancers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.8330000042915344},{"id":"https://openalex.org/keywords/allele-specific-gene-regulation","display_name":"allele-specific gene regulation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.4729999899864197},{"id":"https://openalex.org/keywords/transcriptional-regulatory-networks","display_name":"transcriptional regulatory networks","score":0.36500000953674316},{"id":"https://openalex.org/keywords/prostate-cancer-susceptibility","display_name":"prostate cancer susceptibility","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8936692476272583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5562430620193481},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.49365076422691345},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.46664145588874817},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.45959410071372986},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.43699437379837036},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.43537724018096924},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.43457329273223877},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3335089683532715},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31871497631073},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2837352752685547}],"mesh":[{"descriptor_ui":"D000070576","descriptor_name":"NLR Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002886","descriptor_name":"Chromosomes, Human, Pair 17","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002898","descriptor_name":"Chromosomes, Human, Pair 8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021901","descriptor_name":"DNA, Intergenic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038621","descriptor_name":"Regulatory Sequences, Ribonucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4161/cc.10.20.17842","doi":"https://doi.org/10.4161/cc.10.20.17842","is_oa":false,"landing_page_url":"https://doi.org/10.4161/cc.10.20.17842","pdf_url":null,"source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3266183","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3266183","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"Text"},{"id":"pmid:22067658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22067658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:nature.com:10101/npre.2011.6069.1","doi":null,"is_oa":true,"landing_page_url":"http://precedings.nature.com/documents/6069/version/1","pdf_url":null,"source":{"id":"https://openalex.org/S48744551","display_name":"Nature Precedings","issn_l":"1756-0357","issn":["1756-0357"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Precedings","raw_type":"Manuscript"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3266183","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3266183","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W125239468","https://openalex.org/W247898098","https://openalex.org/W1595665778","https://openalex.org/W1966778525","https://openalex.org/W1975701871","https://openalex.org/W1981834161","https://openalex.org/W1987248329","https://openalex.org/W1991460649","https://openalex.org/W1992980220","https://openalex.org/W1995404520","https://openalex.org/W2004097837","https://openalex.org/W2005930015","https://openalex.org/W2010723194","https://openalex.org/W2011181841","https://openalex.org/W2014787267","https://openalex.org/W2017538897","https://openalex.org/W2019612289","https://openalex.org/W2021654829","https://openalex.org/W2021986944","https://openalex.org/W2022110934","https://openalex.org/W2033510780","https://openalex.org/W2037686178","https://openalex.org/W2041233550","https://openalex.org/W2044916117","https://openalex.org/W2051816266","https://openalex.org/W2056741637","https://openalex.org/W2057629607","https://openalex.org/W2057857079","https://openalex.org/W2059478037","https://openalex.org/W2060390444","https://openalex.org/W2065218625","https://openalex.org/W2074718000","https://openalex.org/W2075145482","https://openalex.org/W2098891062","https://openalex.org/W2102304447","https://openalex.org/W2104518333","https://openalex.org/W2106554405","https://openalex.org/W2108527275","https://openalex.org/W2111619522","https://openalex.org/W2112001233","https://openalex.org/W2117446594","https://openalex.org/W2126079508","https://openalex.org/W2132024988","https://openalex.org/W2135000328","https://openalex.org/W2135082819","https://openalex.org/W2138020005","https://openalex.org/W2149548305","https://openalex.org/W2157043398","https://openalex.org/W2164716330","https://openalex.org/W2166537866","https://openalex.org/W2166666333","https://openalex.org/W2167133159","https://openalex.org/W2168272873","https://openalex.org/W2168458391","https://openalex.org/W2168602111","https://openalex.org/W2172042768","https://openalex.org/W2187181884","https://openalex.org/W2408089991"],"related_works":["https://openalex.org/W2041233550","https://openalex.org/W2132556073","https://openalex.org/W2884490195","https://openalex.org/W186791440","https://openalex.org/W2082375541","https://openalex.org/W2511381148","https://openalex.org/W2460679135","https://openalex.org/W2006358633","https://openalex.org/W2093110325","https://openalex.org/W4226070127"],"abstract_inverted_index":{"The":[0],"mechanistic":[1],"relevance":[2],"of":[3,27,30,42,59,75,80,91,117,176,184,209,226,230,291,313,330,335,349,365,375],"intergenic":[4,212,305],"disease-associated":[5],"genetic":[6,357],"loci":[7,329],"(IDAGL)":[8],"containing":[9,64],"highly":[10,158,237,369],"statistically":[11],"significant":[12],"disease-linked":[13],"SNPs":[14,65],"remains":[15],"unknown.":[16],"Here,":[17],"we":[18],"present":[19],"experimental":[20,76],"and":[21,52,88,95,104,121,128,150,164,187,203,236,258,268,279,288,309,324,332,347,352,356,361],"clinical":[22,231,373],"evidence":[23,77],"supporting":[24],"the":[25,28,253,303,314,320,343],"importantance":[26],"role":[29],"IDAGL":[31,51,111,321],"in":[32,62,119,201,207,248,260,270],"human":[33,120,154,292],"diseases.":[34],"A":[35],"targeted":[36],"RT-PCR":[37],"screen":[38],"coupled":[39],"with":[40,68,223,252,359],"sequencing":[41],"purified":[43],"PCR":[44],"products":[45],"detects":[46],"widespread":[47],"transcription":[48],"at":[49,307,322],"multiple":[50],"identifies":[53],"96":[54],"small":[55],"noncoding":[56],"trans-regulatory":[57],"RNAs":[58],"~100-300":[60],"nt":[61],"length":[63],"(snpRNAs)":[66],"associated":[67],"21":[69],"common":[70],"disorders.":[71],"Multiple":[72],"independent":[73],"lines":[74],"support":[78],"functionality":[79],"snpRNAs":[81,118,136,149],"by":[82,298,310],"documenting":[83],"their":[84],"cell":[85],"type-specific":[86],"expression":[87,101,186,246],"evolutionary":[89],"conservation":[90],"sequences,":[92],"genomic":[93],"coordinates":[94],"biological":[96],"effects.":[97],"Chromatin":[98],"state":[99],"signatures,":[100],"profiling":[102],"experiments":[103,284],"luciferase":[105,165],"reporter":[106,166],"assays":[107,167],"demonstrate":[108,168,190],"that":[109,169,178,191,219,286],"many":[110],"are":[112],"Polycomb-regulated":[113],"long-range":[114],"enhancers.":[115],"Expression":[116],"mouse":[122],"cells":[123,156,294],"markedly":[124,234],"affects":[125],"cellular":[126],"behavior":[127],"induces":[129],"allele-specific":[130,173,182],"clinically":[131],"relevant":[132],"phenotypic":[133],"changes:":[134],"NLRP1-locus":[135,278,304],"rs2670660":[137],"exert":[138],"regulatory":[139,328],"effects":[140],"on":[141],"monocyte/macrophage":[142],"transdifferentiation,":[143],"induce":[144],"prostate":[145,256],"cancer":[146],"(PC)":[147],"susceptibility":[148],"transform":[151],"low-malignancy":[152],"hormone-dependent":[153],"PC":[155,210,293,351],"into":[157],"malignant":[159],"androgen-independent":[160],"PC.":[161,227,376],"Q-PCR":[162,228],"analysis":[163,229],"snpRNA":[170,245],"sequences":[171],"represent":[172],"\"decoy\"":[174],"targets":[175,358],"microRNAs":[177],"function":[179],"as":[180,326],"SNP":[181,214],"modifiers":[183],"microRNA":[185],"activity.":[188],"We":[189],"trans-acting":[192],"RNA":[193],"molecules":[194,300],"facilitating":[195],"resistance":[196],"to":[197],"androgen":[198],"depletion":[199],"(RAD)":[200],"vitro":[202],"castration-resistant":[204],"phenotype":[205,290],"(CRP)":[206],"vivo":[208],"contain":[211],"8q24-locus":[213,280,315],"variants":[215],"(rs1447295;":[216],"rs16901979;":[217],"rs6983267)":[218],"were":[220],"recently":[221],"linked":[222],"increased":[224,235],"risk":[225],"samples":[232],"reveals":[233],"concordant":[238],"(r":[239],"=":[240,265,275],"0.896;":[241],"p":[242],"<":[243],"0.0001)":[244,276],"levels":[247],"tumor":[249],"tissues":[250],"compared":[251],"adjacent":[254],"normal":[255],"[122-fold":[257],"45-fold":[259],"Gleason":[261,271],"7":[262],"tumors":[263,273],"(p":[264,274],"0.03);":[266],"370-fold":[267],"127-fold":[269],"8":[272],"for":[277,371],"snpRNAs,":[281],"respectively].":[282],"Our":[283,317],"indicate":[285],"RAD":[287,331],"CR":[289,333],"can":[295],"be":[296,368],"triggered":[297],"ncRNA":[299],"transcribed":[301],"from":[302],"enhancer":[306],"17p13":[308,323],"downstream":[311],"activation":[312],"snpRNAs.":[316],"results":[318],"define":[319],"8q24":[325],"candidate":[327],"phenotypes":[334],"PC,":[336],"reveal":[337],"previously":[338],"unknown":[339],"molecular":[340,355],"links":[341],"between":[342],"innate":[344],"immunity/inflammasome":[345],"system":[346],"development":[348],"hormone-independent":[350],"identify":[353],"novel":[354],"diagnostic":[360],"therapeutic":[362],"potentials,":[363],"exploration":[364],"which":[366],"should":[367],"beneficial":[370],"personalized":[372],"management":[374]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}