{"id":"https://openalex.org/W1998538046","doi":"https://doi.org/10.1158/1538-7445.tumimm2012-pr1","title":"Abstract PR1: Oncogenic driver mutations shape the nature of immune responses in tumors.","display_name":"Abstract PR1: Oncogenic driver mutations shape the nature of immune responses in tumors.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1998538046","doi":"https://doi.org/10.1158/1538-7445.tumimm2012-pr1","mag":"1998538046"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.tumimm2012-pr1","doi":"https://doi.org/10.1158/1538-7445.tumimm2012-pr1","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.tumimm2012-pr1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004143067","display_name":"Vladislava Juric","orcid":"https://orcid.org/0000-0003-3324-0847","observed_orcids":["https://orcid.org/0000-0003-3324-0847"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladislava Juric","raw_affiliation_strings":["1University of California, San Francisco, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco, CA,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021009961","display_name":"Brian Ruffell","orcid":"https://orcid.org/0000-0002-3846-6872","observed_orcids":["https://orcid.org/0000-0002-3846-6872"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Ruffell","raw_affiliation_strings":["2Oregon Health and Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Oregon Health and Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089138950","display_name":"J. Michael Bishop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Michael Bishop","raw_affiliation_strings":["1University of California, San Francisco, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco, CA,","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"1_Supplement","first_page":"PR1","last_page":"PR1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.06019999831914902,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.871999979019165},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.6359999775886536},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hepatoblastoma","display_name":"hepatoblastoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/neutrophil-polarization","display_name":"neutrophil polarization","score":0.4650000035762787},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.6290000081062317},{"id":"https://openalex.org/keywords/tumor-associated-lymphocytes","display_name":"tumor-associated lymphocytes","score":0.4779999852180481},{"id":"https://openalex.org/keywords/tumor-associated-dendritic-cells","display_name":"tumor-associated dendritic cells","score":0.492000013589859},{"id":"https://openalex.org/keywords/tumor-associated-b-cells","display_name":"tumor-associated B cells","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7612883448600769},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.68260657787323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6434264183044434},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6278536319732666},{"id":"https://openalex.org/C2776304256","wikidata":"https://www.wikidata.org/wiki/Q1607658","display_name":"Hepatoblastoma","level":2,"score":0.4871789813041687},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4701659381389618},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4701526165008545},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4520447850227356},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4034401476383209},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.31390267610549927},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3007592260837555},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24410969018936157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1803615689277649},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13529041409492493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11007755994796753},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.tumimm2012-pr1","doi":"https://doi.org/10.1158/1538-7445.tumimm2012-pr1","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.tumimm2012-pr1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1999533042","https://openalex.org/W178208372","https://openalex.org/W4365504079","https://openalex.org/W2535182413","https://openalex.org/W7171557022","https://openalex.org/W3035547287","https://openalex.org/W2275276837","https://openalex.org/W4280515355","https://openalex.org/W1982711335","https://openalex.org/W3004964052"],"abstract_inverted_index":{"Abstract":[0],"The":[1,115],"composition":[2,89,395],"of":[3,22,30,46,54,72,82,90,108,122,132,168,205,232,263,368,382,399,455,463],"tumor-associated":[4],"leukocytes":[5,142,170],"and":[6,57,74,119,134,201,223,251,315,370,396,430,475],"their":[7],"pro-":[8],"or":[9,111,124,424],"anti-tumor":[10],"polarization":[11],"are":[12,404,414],"heterogeneous":[13],"among":[14,28],"different":[15],"tumor":[16,274,322,372],"types.":[17],"In":[18,342,387],"addition,":[19],"the":[20,31,42,80,87,97,127,165,174,179,184,227,237,255,269,289,313,321,362,375,393,397,417,453,464],"abundance":[21],"leukocyte":[23,154,195],"subtypes":[24],"can":[25,48],"vary":[26],"even":[27],"tumors":[29,47,253],"same":[32,363],"type.":[33],"Understanding":[34],"what":[35],"determines":[36],"this":[37,194],"heterogeneity":[38],"is":[39,65,434],"important":[40],"since":[41],"immune":[43,400,456],"cell":[44],"contexture":[45],"serve":[49],"as":[50,437],"a":[51,190,260,281,317,379],"strong":[52],"predictor":[53],"clinical":[55],"outcomes":[56],"response":[58,217],"to":[59,130,183,294,319,338],"anti-cancer":[60],"therapy.":[61],"Given":[62],"that":[63,79,215,331,392],"tumorigenesis":[64,103,403,426],"driven":[66,427],"by":[67,105,147,157,410,419,428],"mutations":[68,451],"in":[69,126,143,164,173,178,193,198,202,248,252,254,283,324,335,374,384,408,458],"various":[70],"types":[71],"proto-oncogenes":[73],"tumor-suppressor":[75],"genes,":[76],"we":[77,95,285],"postulated":[78],"identity":[81],"driver":[83,450],"mutation":[84],"could":[85],"shape":[86,452],"leukocytic":[88,394],"tumors.":[91,203,459],"To":[92,276],"test":[93],"this,":[94],"used":[96],"established":[98],"mouse":[99],"models":[100,146],"for":[101,327],"liver":[102,128,149,233],"induced":[104],"hydrodynamic":[106],"transfection":[107,308,352],"c-MYC":[109],"(MYC)":[110],"myr-AKT1+N-RasV12":[112],"(AKT+RAS)":[113],"oncogenes.":[114],"resulting":[116],"somatic":[117],"integration":[118],"long-term":[120],"overexpression":[121],"MYC":[123,180,270,376,429],"AKT+RAS":[125,187,256,325],"leads":[129],"development":[131],"hepatoblastoma":[133],"hepatocellular":[135],"carcinoma,":[136],"respectively.":[137],"We":[138,413],"profiled":[139],"liver-infiltrated":[140],"CD45+":[141,169],"these":[144,332],"two":[145],"staining":[148,231,246],"single-cell":[150],"suspensions":[151],"with":[152,226,236,288,300],"lineage-specific":[153],"markers,":[155],"followed":[156],"polychromatic":[158],"FACS":[159,228],"analysis.":[160],"A":[161],"massive":[162],"increase":[163,192,320],"CD11b+/F4/80-/Ly6Ghi/Ly6Cmed":[166,216,279,310,383,421],"fraction":[167],"was":[171,267],"detected":[172],"AKT+RAS,":[175],"but":[176],"not":[177,210],"model.":[181],"Compared":[182],"vehicle-injected":[185],"controls,":[186],"livers":[188,250,314],"exhibited":[189],"3-fold":[191],"population":[196],"both":[197,247],"pre-neoplastic":[199,249],"stages":[200,337],"Overexpression":[204],"either":[206],"oncogenes":[207],"alone":[208],"did":[209],"trigger":[211],"such":[212],"increase,":[213],"suggesting":[214,330,378],"resulted":[218],"from":[219,312],"cooperation":[220],"between":[221],"AKT":[222],"RAS.":[224],"Consistent":[225],"results,":[229],"IHC":[230],"tissue":[234],"sections":[235],"neutrophil":[238],"marker":[239],"7/4":[240,264],"antigen":[241],"revealed":[242],"an":[243,356],"abundant":[244],"positive":[245],"model,":[257,377],"while":[258],"only":[259,272],"small":[261],"infiltration":[262],"antigen-positive":[265],"cells":[266,311,333,422],"observed":[268],"model":[271],"at":[273,406],"stage.":[275],"address":[277],"if":[278],"play":[280],"role":[282,381],"tumorigenesis,":[284],"treated":[286],"mice":[287,326,369],"rat":[290],"monoclonal":[291],"Gr-1":[292,301,344],"antibody":[293],"systemically":[295],"deplete":[296],"Ly6G/Ly6C-expressing":[297],"cells.":[298],"Treatment":[299],"starting":[302,346],"on":[303,347,358,468],"day":[304,348],"-1":[305],"before":[306],"oncogene":[307,351],"ablated":[309],"showed":[316],"tendency":[318],"burden":[323,373],"nearly":[328],"50%,":[329],"act":[334],"early":[336],"suppress":[339,425],"AKT+RAS-induced":[340,359],"tumorigenesis.":[341,360,386],"contrast,":[343],"treatment":[345],"4":[349],"after":[350],"no":[353],"longer":[354],"had":[355],"effect":[357],"Nevertheless,":[361],"protocol":[364],"significantly":[365],"extended":[366],"survival":[367],"reduced":[371],"tumor-promoting":[380],"MYC-induced":[385],"conclusion,":[388],"our":[389],"results":[390],"demonstrate":[391],"nature":[398,454],"responses":[401,457],"during":[402],"shaped,":[405],"least":[407],"part,":[409],"tumor-driving":[411],"mutations.":[412],"currently":[415],"elucidating":[416],"mechanism":[418],"which":[420],"promote":[423],"AKT+RAS.":[431],"This":[432],"abstract":[433],"also":[435],"presented":[436],"Poster":[438],"A46.":[439],"Citation":[440],"Format:":[441],"Vladislava":[442],"Juric,":[443],"Brian":[444],"Ruffell,":[445],"J.":[446],"Michael":[447],"Bishop.":[448],"Oncogenic":[449],"[abstract].":[460],"In:":[461],"Proceedings":[462],"AACR":[465],"Special":[466],"Conference":[467],"Tumor":[469],"Immunology:":[470],"Multidisciplinary":[471],"Science":[472],"Driving":[473],"Basic":[474],"Clinical":[476],"Advances;":[477],"Dec":[478],"2-5,":[479],"2012;":[480],"Miami,":[481],"FL.":[482],"Philadelphia":[483],"(PA):":[484],"AACR;":[485],"Cancer":[486],"Res":[487],"2013;73(1":[488],"Suppl):Abstract":[489],"nr":[490],"PR1.":[491]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}