{"id":"https://openalex.org/W1998537177","doi":"https://doi.org/10.1007/s00294-014-0432-3","title":"Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones","display_name":"Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones","publication_year":2014,"publication_date":"2014-06-12","ids":{"openalex":"https://openalex.org/W1998537177","doi":"https://doi.org/10.1007/s00294-014-0432-3","mag":"1998537177","pmid":"https://pubmed.ncbi.nlm.nih.gov/24923785"},"language":"en","primary_location":{"id":"doi:10.1007/s00294-014-0432-3","doi":"https://doi.org/10.1007/s00294-014-0432-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00294-014-0432-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00294-014-0432-3.pdf","source":{"id":"https://openalex.org/S56878690","display_name":"Current Genetics","issn_l":"0172-8083","issn":["0172-8083","1432-0983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/s00294-014-0432-3.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006104220","display_name":"Jill L. Johnson","orcid":"https://orcid.org/0000-0003-3881-722X","observed_orcids":["https://orcid.org/0000-0003-3881-722X"]},"institutions":[{"id":"https://openalex.org/I155093810","display_name":"University of Idaho","ror":"https://ror.org/03hbp5t65","country_code":"US","type":"education","lineage":["https://openalex.org/I155093810"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jill L. Johnson","raw_affiliation_strings":["Department of Biological Sciences, University of Idaho, P.O. Box 443051, Moscow, ID, 83844-3051, USA, jilljohn@uidaho.edu","University of Idaho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Idaho, P.O. Box 443051, Moscow, ID, 83844-3051, USA, jilljohn@uidaho.edu","institution_ids":["https://openalex.org/I155093810"]},{"raw_affiliation_string":"University of Idaho","institution_ids":["https://openalex.org/I155093810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077052833","display_name":"Abbey D. Zuehlke","orcid":"https://orcid.org/0000-0003-0432-8823","observed_orcids":["https://orcid.org/0000-0003-0432-8823"]},"institutions":[{"id":"https://openalex.org/I155093810","display_name":"University of Idaho","ror":"https://ror.org/03hbp5t65","country_code":"US","type":"education","lineage":["https://openalex.org/I155093810"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abbey D. Zuehlke","raw_affiliation_strings":["Department of Biological Sciences, University of Idaho, P.O. Box 443051, Moscow, ID, 83844-3051, USA","National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Idaho, P.O. Box 443051, Moscow, ID, 83844-3051, USA","institution_ids":["https://openalex.org/I155093810"]},{"raw_affiliation_string":"National Cancer Institute","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017040151","display_name":"Victoria R. Tenge","orcid":"https://orcid.org/0000-0002-9429-7161","observed_orcids":["https://orcid.org/0000-0002-9429-7161"]},"institutions":[{"id":"https://openalex.org/I155093810","display_name":"University of Idaho","ror":"https://ror.org/03hbp5t65","country_code":"US","type":"education","lineage":["https://openalex.org/I155093810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria R. Tenge","raw_affiliation_strings":["Department of Biological Sciences, University of Idaho, P.O. Box 443051, Moscow, ID, 83844-3051, USA","University of Idaho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Idaho, P.O. Box 443051, Moscow, ID, 83844-3051, USA","institution_ids":["https://openalex.org/I155093810"]},{"raw_affiliation_string":"University of Idaho","institution_ids":["https://openalex.org/I155093810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023275793","display_name":"Jordan C. Langworthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155093810","display_name":"University of Idaho","ror":"https://ror.org/03hbp5t65","country_code":"US","type":"education","lineage":["https://openalex.org/I155093810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan C. Langworthy","raw_affiliation_strings":["Department of Biological Sciences, University of Idaho, P.O. Box 443051, Moscow, ID, 83844-3051, USA","University of Idaho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Idaho, P.O. Box 443051, Moscow, ID, 83844-3051, USA","institution_ids":["https://openalex.org/I155093810"]},{"raw_affiliation_string":"University of Idaho","institution_ids":["https://openalex.org/I155093810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006104220"],"corresponding_institution_ids":["https://openalex.org/I155093810"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":1.2292,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.770446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"60","issue":"4","first_page":"265","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.968999981880188},{"id":"https://openalex.org/keywords/co-chaperones","display_name":"co-chaperones","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sgt1","display_name":"SGT1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cdc37","display_name":"Cdc37","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ppt1","display_name":"PPT1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/aha1","display_name":"Aha1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hsp90-client-proteins","display_name":"Hsp90 client proteins","score":0.656000018119812},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8230000138282776},{"id":"https://openalex.org/keywords/temperature-sensitive-mutants","display_name":"temperature-sensitive mutants","score":0.4970000088214874},{"id":"https://openalex.org/keywords/chaperone-activity","display_name":"chaperone activity","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.8088524341583252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7242669463157654},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6822690963745117},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.6714438199996948},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5531220436096191},{"id":"https://openalex.org/C141109615","wikidata":"https://www.wikidata.org/wiki/Q5137430","display_name":"Co-chaperone","level":5,"score":0.4262343645095825},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.36290043592453003},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.35005852580070496},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2676851749420166},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16861310601234436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0698913037776947},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00294-014-0432-3","doi":"https://doi.org/10.1007/s00294-014-0432-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00294-014-0432-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00294-014-0432-3.pdf","source":{"id":"https://openalex.org/S56878690","display_name":"Current Genetics","issn_l":"0172-8083","issn":["0172-8083","1432-0983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Genetics","raw_type":"journal-article"},{"id":"pmid:24923785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24923785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00294-014-0432-3","doi":"https://doi.org/10.1007/s00294-014-0432-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00294-014-0432-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00294-014-0432-3.pdf","source":{"id":"https://openalex.org/S56878690","display_name":"Current Genetics","issn_l":"0172-8083","issn":["0172-8083","1432-0983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.8199999928474426,"display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2644246380","display_name":"Folding and Activation of Client Proteins by the Hsp90 Molecular Chaperone Machine","funder_award_id":"0744522","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998537177.pdf","grobid_xml":"https://content.openalex.org/works/W1998537177.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1601258312","https://openalex.org/W1607384859","https://openalex.org/W1849202109","https://openalex.org/W1955276614","https://openalex.org/W1965060663","https://openalex.org/W1971063516","https://openalex.org/W1974206962","https://openalex.org/W1983211885","https://openalex.org/W1987329471","https://openalex.org/W1991582269","https://openalex.org/W1993525477","https://openalex.org/W1994133544","https://openalex.org/W1998425418","https://openalex.org/W2001462925","https://openalex.org/W2003299656","https://openalex.org/W2007996847","https://openalex.org/W2013947447","https://openalex.org/W2022531767","https://openalex.org/W2023493483","https://openalex.org/W2041894424","https://openalex.org/W2042809289","https://openalex.org/W2043244176","https://openalex.org/W2049058792","https://openalex.org/W2049659699","https://openalex.org/W2052599054","https://openalex.org/W2052639102","https://openalex.org/W2053738827","https://openalex.org/W2054368237","https://openalex.org/W2055304293","https://openalex.org/W2055582545","https://openalex.org/W2055811175","https://openalex.org/W2056939106","https://openalex.org/W2057074443","https://openalex.org/W2057464403","https://openalex.org/W2059433050","https://openalex.org/W2069816360","https://openalex.org/W2070535450","https://openalex.org/W2072870287","https://openalex.org/W2074297938","https://openalex.org/W2074807756","https://openalex.org/W2077496193","https://openalex.org/W2079096997","https://openalex.org/W2088377890","https://openalex.org/W2092266686","https://openalex.org/W2093169681","https://openalex.org/W2093857293","https://openalex.org/W2095099777","https://openalex.org/W2095686344","https://openalex.org/W2096237314","https://openalex.org/W2097666362","https://openalex.org/W2103854266","https://openalex.org/W2107263572","https://openalex.org/W2108255072","https://openalex.org/W2109982971","https://openalex.org/W2112338871","https://openalex.org/W2112586165","https://openalex.org/W2113659644","https://openalex.org/W2123398918","https://openalex.org/W2125774147","https://openalex.org/W2127692414","https://openalex.org/W2131573148","https://openalex.org/W2140457152","https://openalex.org/W2140518858","https://openalex.org/W2140702339","https://openalex.org/W2142951552","https://openalex.org/W2144741305","https://openalex.org/W2147891181","https://openalex.org/W2152226677","https://openalex.org/W2154574591","https://openalex.org/W2159443208","https://openalex.org/W2164836215","https://openalex.org/W2169923882","https://openalex.org/W4254510769"],"related_works":["https://openalex.org/W1987329471","https://openalex.org/W7116741831","https://openalex.org/W1994133544","https://openalex.org/W1980748104","https://openalex.org/W7036749511","https://openalex.org/W2077496193","https://openalex.org/W2023439480","https://openalex.org/W2802759152","https://openalex.org/W2123398918","https://openalex.org/W2790861867"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}