{"id":"https://openalex.org/W1998520449","doi":"https://doi.org/10.1053/spid.2001.19240","title":"Modulation of the complement system in the prevention and treatment of sepsis","display_name":"Modulation of the complement system in the prevention and treatment of sepsis","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W1998520449","doi":"https://doi.org/10.1053/spid.2001.19240","mag":"1998520449"},"language":"en","primary_location":{"id":"doi:10.1053/spid.2001.19240","doi":"https://doi.org/10.1053/spid.2001.19240","is_oa":false,"landing_page_url":"https://doi.org/10.1053/spid.2001.19240","pdf_url":null,"source":{"id":"https://openalex.org/S108600424","display_name":"Seminars in Pediatric Infectious Diseases","issn_l":"1045-1870","issn":["1045-1870","1557-9387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Pediatric Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065244390","display_name":"Ellen Andrews","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Andrews","raw_affiliation_strings":["Division of Neonatal Medicine, Department of Pediatrics, and the Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neonatal Medicine, Department of Pediatrics, and the Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078531250","display_name":"Pamela A. Feldhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela A. Feldhoff","raw_affiliation_strings":["Division of Neonatal Medicine, Department of Pediatrics, and the Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neonatal Medicine, Department of Pediatrics, and the Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001608293","display_name":"Herbert A. Lassiter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert A. Lassiter","raw_affiliation_strings":["Division of Neonatal Medicine, Department of Pediatrics, and the Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neonatal Medicine, Department of Pediatrics, and the Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.10175392,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"12","issue":"1","first_page":"54","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":1.0},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/bacterial-sepsis","display_name":"bacterial sepsis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.906000018119812},{"id":"https://openalex.org/keywords/complement-inhibitors","display_name":"complement inhibitors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pediatric-sepsis","display_name":"pediatric sepsis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/vaccines","display_name":"vaccines","score":0.47200000286102295},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9610000252723694},{"id":"https://openalex.org/keywords/sepsis-treatment","display_name":"sepsis treatment","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.7961060404777527},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7254616022109985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7234012484550476},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.7111454010009766},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6347257494926453},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5688247084617615},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.4586693048477173},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.42159461975097656},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33053094148635864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15568047761917114},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.08200681209564209},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1053/spid.2001.19240","doi":"https://doi.org/10.1053/spid.2001.19240","is_oa":false,"landing_page_url":"https://doi.org/10.1053/spid.2001.19240","pdf_url":null,"source":{"id":"https://openalex.org/S108600424","display_name":"Seminars in Pediatric Infectious Diseases","issn_l":"1045-1870","issn":["1045-1870","1557-9387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Pediatric Infectious Diseases","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7300000190734863}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W33303977","https://openalex.org/W75705058","https://openalex.org/W78319224","https://openalex.org/W79238399","https://openalex.org/W204547449","https://openalex.org/W596751443","https://openalex.org/W621010499","https://openalex.org/W637492389","https://openalex.org/W879069745","https://openalex.org/W1482527259","https://openalex.org/W1500664838","https://openalex.org/W1512215317","https://openalex.org/W1513100518","https://openalex.org/W1513577262","https://openalex.org/W1533555489","https://openalex.org/W1574909924","https://openalex.org/W1592616574","https://openalex.org/W1927393010","https://openalex.org/W1961339089","https://openalex.org/W1966301103","https://openalex.org/W1971115464","https://openalex.org/W1972420743","https://openalex.org/W1973253168","https://openalex.org/W1973928480","https://openalex.org/W1975838930","https://openalex.org/W1981462405","https://openalex.org/W1985081223","https://openalex.org/W1988699127","https://openalex.org/W1990463170","https://openalex.org/W1990593946","https://openalex.org/W1991392777","https://openalex.org/W1994517200","https://openalex.org/W1997978259","https://openalex.org/W2003334412","https://openalex.org/W2003882961","https://openalex.org/W2004594321","https://openalex.org/W2006293608","https://openalex.org/W2013537752","https://openalex.org/W2017520388","https://openalex.org/W2019497257","https://openalex.org/W2022321254","https://openalex.org/W2023205018","https://openalex.org/W2031190324","https://openalex.org/W2031842509","https://openalex.org/W2033102468","https://openalex.org/W2036836556","https://openalex.org/W2047057483","https://openalex.org/W2048395992","https://openalex.org/W2049255819","https://openalex.org/W2064088579","https://openalex.org/W2070485926","https://openalex.org/W2079811464","https://openalex.org/W2080135373","https://openalex.org/W2082062394","https://openalex.org/W2083192361","https://openalex.org/W2084248058","https://openalex.org/W2085277293","https://openalex.org/W2089346130","https://openalex.org/W2092042753","https://openalex.org/W2098504065","https://openalex.org/W2104429032","https://openalex.org/W2112249032","https://openalex.org/W2113719877","https://openalex.org/W2121290135","https://openalex.org/W2122555521","https://openalex.org/W2132003425","https://openalex.org/W2133008646","https://openalex.org/W2151092999","https://openalex.org/W2155314299","https://openalex.org/W2174380698","https://openalex.org/W2189625031","https://openalex.org/W2321425062","https://openalex.org/W2322178002","https://openalex.org/W2331901704","https://openalex.org/W2399998500","https://openalex.org/W2469651797","https://openalex.org/W2490425947","https://openalex.org/W2494046793","https://openalex.org/W2500283871","https://openalex.org/W2568596784","https://openalex.org/W4254710724","https://openalex.org/W4296380130","https://openalex.org/W4390928064","https://openalex.org/W6628713428","https://openalex.org/W6640933908","https://openalex.org/W6700846602","https://openalex.org/W6719830151"],"related_works":["https://openalex.org/W2151092999","https://openalex.org/W7167045629","https://openalex.org/W2034554356","https://openalex.org/W2803562764","https://openalex.org/W579282277","https://openalex.org/W2025150816","https://openalex.org/W7135025878","https://openalex.org/W2053753605","https://openalex.org/W2889232296","https://openalex.org/W3039359075"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}