{"id":"https://openalex.org/W1998512967","doi":"https://doi.org/10.3892/ijmm.11.3.287","title":"Spatial distribution of liposome encapsulated tin etiopurpurin dichloride (SnET2) in the canine prostate: Implications for computer simulation of photodynamic therapy","display_name":"Spatial distribution of liposome encapsulated tin etiopurpurin dichloride (SnET2) in the canine prostate: Implications for computer simulation of photodynamic therapy","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W1998512967","doi":"https://doi.org/10.3892/ijmm.11.3.287","mag":"1998512967","pmid":"https://pubmed.ncbi.nlm.nih.gov/12579328"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.11.3.287","doi":"https://doi.org/10.3892/ijmm.11.3.287","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.11.3.287","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034719878","display_name":"Jacek Anio\u0142a","orcid":"https://orcid.org/0000-0002-3105-607X","observed_orcids":["https://orcid.org/0000-0002-3105-607X"]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacek Aniola","raw_affiliation_strings":["Urology Research Center, Medical College of Ohio, Toledo, OH 43614-5807, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology Research Center, Medical College of Ohio, Toledo, OH 43614-5807, USA","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081142231","display_name":"Steven H. Selman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Selman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014618519","display_name":"Lothar D. Lilge","orcid":"https://orcid.org/0000-0001-5533-0005","observed_orcids":["https://orcid.org/0000-0001-5533-0005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lothar Lilge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111452586","display_name":"Rick W. Keck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rick Keck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079636370","display_name":"Jerzy Jankun","orcid":"https://orcid.org/0000-0003-2354-4046","observed_orcids":["https://orcid.org/0000-0003-2354-4046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerzy Jankun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2902,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80133738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"11","issue":"3","first_page":"287","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8379999995231628},{"id":"https://openalex.org/keywords/photosensitizer-distribution","display_name":"photosensitizer distribution","score":0.800000011920929},{"id":"https://openalex.org/keywords/liposome-encapsulation","display_name":"liposome encapsulation","score":0.781000018119812},{"id":"https://openalex.org/keywords/light-diffuser","display_name":"light diffuser","score":0.8529999852180481},{"id":"https://openalex.org/keywords/light-attenuation-coefficient","display_name":"light attenuation coefficient","score":0.6830000281333923},{"id":"https://openalex.org/keywords/critical-fluence","display_name":"critical fluence","score":0.9789999723434448},{"id":"https://openalex.org/keywords/canine-prostate","display_name":"canine prostate","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.8767901659011841},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.7422945499420166},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.713919997215271},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6593314409255981},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.46462494134902954},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.4131113290786743},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38574090600013733},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3532063961029053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3234180808067322},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32128238677978516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24331921339035034},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2426123023033142},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1833360493183136},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07862672209739685},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijmm.11.3.287","doi":"https://doi.org/10.3892/ijmm.11.3.287","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.11.3.287","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:12579328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12579328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6901862125","display_name":"Computer Directed Photodynamic Therapy of Prostate Ca","funder_award_id":"R01CA090524","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1964562243","https://openalex.org/W1982137727","https://openalex.org/W1983744700","https://openalex.org/W2000035753","https://openalex.org/W2030935998","https://openalex.org/W2036288932","https://openalex.org/W2048117661","https://openalex.org/W2053133275","https://openalex.org/W2056040379","https://openalex.org/W2057003107","https://openalex.org/W2075738006","https://openalex.org/W2084073906","https://openalex.org/W2085894430","https://openalex.org/W2088044717","https://openalex.org/W2093529591","https://openalex.org/W2166426919","https://openalex.org/W2212588018","https://openalex.org/W2409848348","https://openalex.org/W2415811532","https://openalex.org/W2571408655"],"related_works":["https://openalex.org/W2085894430","https://openalex.org/W2022339623","https://openalex.org/W2133549869","https://openalex.org/W1992004443","https://openalex.org/W2075236275","https://openalex.org/W2077243114","https://openalex.org/W1492884456","https://openalex.org/W2064208376","https://openalex.org/W2094192722","https://openalex.org/W1620448903"],"abstract_inverted_index":{"Photodynamic":[0],"therapy":[1],"(PDT)":[2],"is":[3,37,55,122,234,265,270,280],"a":[4,28,44,56,82,138,167,201],"minimally":[5],"invasive":[6],"treatment":[7,173],"that":[8,170,260,283],"can":[9,110,171],"be":[10,99,111],"employed":[11],"in":[12,76,189,194,197,211,267,272],"many":[13],"human":[14],"diseases":[15],"including":[16],"prostate":[17,21,53,64,78,132,163,231,248],"cancer.":[18],"PDT":[19,59,254],"for":[20],"cancer":[22,54],"depends":[23],"on":[24,69,223],"the":[25,32,47,62,70,77,87,120,128,131,135,150,157,162,178,184,212,224,230,238,241,247,261,273,276,297,303,308],"sequestration":[26,299],"of":[27,73,81,92,130,145,181,186,208,226,240,244,253,263,275,287,290,300,307],"photosensitizing":[29],"drug":[30,49,228],"within":[31,127,229,246],"glandular":[33,63,277],"tissue.":[34,51],"The":[35,105,175,205],"photosensitizer":[36,245,301],"subsequently":[38],"activated":[39],"by":[40,113,124],"light":[41,74,84,93,108,115,121,146,159,187],"(usually":[42],"from":[43],"laser)":[45],"and":[46,79,94,147,183,191,218,269,302],"active":[48,227],"destroys":[50],"Since":[52],"multifocal":[57],"disease,":[58],"must":[60,98,293],"ablate":[61],"completely.":[65],"This":[66],"will":[67],"depend":[68,222],"precise":[71],"placement":[72],"sources":[75,91],"delivery":[80],"therapeutic":[83,107],"dose":[85],"to":[86,101,134,141,148,236,249],"entire":[88],"gland.":[89,232],"Also,":[90],"their":[95],"spatial":[96,242],"distribution":[97,109,160,243],"tailored":[100],"each":[102],"individual":[103],"patient.":[104],"uniform,":[106],"achieved":[112],"interstitial":[114],"irradiation.":[116],"In":[117],"this":[118,291],"case,":[119],"delivered":[123],"diffusers":[125,188],"placed":[126],"substance":[129],"parallel":[133],"urethra":[136],"at":[137],"distance":[139],"optimized":[140],"deliver":[142],"adequate":[143],"levels":[144],"create":[149],"desired":[151],"photodynamic":[152],"effect.":[153],"To":[154],"help":[155],"achieve":[156],"uniform":[158],"throughout":[161],"we":[164],"have":[165],"developed":[166],"computer":[168,213,251],"program":[169,176],"determine":[172],"effects.":[174],"predicts":[177],"best":[179],"set":[180],"parameters":[182,207],"position":[185],"space,":[190],"displays":[192],"them":[193],"graphical":[195],"or":[196],"numerical":[198],"form":[199],"assuming":[200],"fixed":[202],"attenuation":[203,216],"coefficient.":[204],"two":[206],"greatest":[209],"importance":[210],"simulation":[214],"are":[215],"coefficient":[217],"critical":[219],"fluence.":[220],"Both":[221],"concentration":[225,262],"It":[233,279],"necessary":[235],"know":[237],"nature":[239],"execute":[250],"modeling":[252,289],"with":[255],"high":[256],"precision.":[257],"We":[258],"found":[259],"SnET2":[264],"heterogeneous":[266],"nature,":[268],"higher":[271],"proximity":[274],"capsule.":[278],"clear":[281],"therefore":[282],"any":[284],"future":[285],"attempts":[286],"computerized":[288],"procedure":[292],"take":[294],"into":[295],"consideration":[296],"uneven":[298],"consequential":[304],"asymmetrical":[305],"necrosis":[306],"prostate.":[309]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}