{"id":"https://openalex.org/W1998507595","doi":"https://doi.org/10.1111/j.1574-6968.2002.tb11432.x","title":"Regulation of icaR gene expression in Staphylococcus epidermidis","display_name":"Regulation of icaR gene expression in Staphylococcus epidermidis","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W1998507595","doi":"https://doi.org/10.1111/j.1574-6968.2002.tb11432.x","mag":"1998507595","pmid":"https://pubmed.ncbi.nlm.nih.gov/12435499"},"language":"en","primary_location":{"id":"doi:10.1111/j.1574-6968.2002.tb11432.x","doi":"https://doi.org/10.1111/j.1574-6968.2002.tb11432.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1574-6968.2002.tb11432.x","pdf_url":null,"source":{"id":"https://openalex.org/S34954451","display_name":"FEMS Microbiology Letters","issn_l":"0378-1097","issn":["0378-1097","1574-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111922455","display_name":"Kevin M. Conlon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I2801846703","display_name":"Beaumont Hospital","ror":"https://ror.org/043mzjj67","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2801846703"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Kevin M Conlon","raw_affiliation_strings":["Department of Microbiology, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Royal College of Surgeons in Ireland, 9, Dublin, Ireland","Department of Microbiology, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Royal College of Surgeons in Ireland, 9, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I2801846703"]},{"raw_affiliation_string":"Department of Microbiology, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I2801846703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081903810","display_name":"H. Humphreys","orcid":"https://orcid.org/0000-0002-9646-2183","observed_orcids":["https://orcid.org/0000-0002-9646-2183"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I2801846703","display_name":"Beaumont Hospital","ror":"https://ror.org/043mzjj67","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2801846703"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Hilary Humphreys","raw_affiliation_strings":["Department of Microbiology, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I2801846703"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019032222","display_name":"James P. O\u2019Gara","orcid":"https://orcid.org/0000-0003-3866-7161","observed_orcids":["https://orcid.org/0000-0003-3866-7161"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I2801846703","display_name":"Beaumont Hospital","ror":"https://ror.org/043mzjj67","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2801846703"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"James P O'Gara","raw_affiliation_strings":["Department of Microbiology, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I2801846703"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019032222"],"corresponding_institution_ids":["https://openalex.org/I142762351","https://openalex.org/I2801846703"],"apc_list":{"value":2500,"currency":"GBP","value_usd":3297},"apc_paid":null,"fwci":3.3078,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.91786174,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"216","issue":"2","first_page":"171","last_page":"177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.10440000146627426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-epidermidis","display_name":"Staphylococcus epidermidis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ica-operon","display_name":"ica operon","score":0.949999988079071},{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.4970000088214874},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.9890000224113464},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.7922054529190063},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.7771172523498535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6270450353622437},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.5904201865196228},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5853192210197449},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.546903133392334},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4941449463367462},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.49088650941848755},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4882362186908722},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.463181734085083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4625840187072754},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.45303356647491455},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27247709035873413},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013212","descriptor_name":"Staphylococcus epidermidis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013212","descriptor_name":"Staphylococcus epidermidis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013212","descriptor_name":"Staphylococcus epidermidis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1574-6968.2002.tb11432.x","doi":"https://doi.org/10.1111/j.1574-6968.2002.tb11432.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1574-6968.2002.tb11432.x","pdf_url":null,"source":{"id":"https://openalex.org/S34954451","display_name":"FEMS Microbiology Letters","issn_l":"0378-1097","issn":["0378-1097","1574-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Letters","raw_type":"journal-article"},{"id":"doi:10.1016/s0378-1097(02)01031-5","doi":"https://doi.org/10.1016/s0378-1097(02)01031-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0378-1097(02)01031-5","pdf_url":null,"source":{"id":"https://openalex.org/S34954451","display_name":"FEMS Microbiology Letters","issn_l":"0378-1097","issn":["0378-1097","1574-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Letters","raw_type":"journal-article"},{"id":"pmid:12435499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12435499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS microbiology letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313911","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878"},{"id":"https://openalex.org/F4320320769","display_name":"Indian Council of Agricultural Research","ror":"https://ror.org/04fw54a43"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1716781317","https://openalex.org/W1838684040","https://openalex.org/W1969585273","https://openalex.org/W2015509108","https://openalex.org/W2035776733","https://openalex.org/W2049426021","https://openalex.org/W2050738002","https://openalex.org/W2058357139","https://openalex.org/W2100092533","https://openalex.org/W2103020587","https://openalex.org/W2107827960","https://openalex.org/W2110895299","https://openalex.org/W2111154143","https://openalex.org/W2112461089","https://openalex.org/W2118021257","https://openalex.org/W2130493239","https://openalex.org/W2131237419","https://openalex.org/W2132114933","https://openalex.org/W2135736506","https://openalex.org/W2139191979","https://openalex.org/W2154384223","https://openalex.org/W2164527823"],"related_works":["https://openalex.org/W2154384223","https://openalex.org/W4299167211","https://openalex.org/W7062424704","https://openalex.org/W2129157869","https://openalex.org/W2922700395","https://openalex.org/W2085292867","https://openalex.org/W2518170535","https://openalex.org/W2921896641","https://openalex.org/W2055989417","https://openalex.org/W1982366830"],"abstract_inverted_index":{"LightCycler":[0],"and":[1,29,95,101],"conventional":[2],"reverse":[3],"transcription-polymerase":[4],"chain":[5],"reaction":[6],"(RT-PCR)":[7],"were":[8],"used":[9],"to":[10,92],"examine":[11],"regulation":[12,79],"of":[13,19,27,37,44,49,80],"icaR,":[14],"which":[15,51],"encodes":[16],"a":[17],"repressor":[18],"the":[20,81,99],"Staphylococcus":[21],"epidermidis":[22],"ica":[23,32,45,69,94,114],"operon.":[24],"Varying":[25],"concentrations":[26,48],"NaCl":[28,64,104],"ethanol":[30,67,87],"activated":[31,68],"but":[33,65,109],"only":[34],"high":[35],"levels":[36],"both":[38,71],"compounds":[39,72],"repressed":[40,73],"icaR":[41,58,74,82,107],"transcription.":[42],"Activation":[43],"by":[46],"subinhibitory":[47],"tetracycline,":[50],"was":[52,54],"strain-dependent,":[53],"also":[55,105],"associated":[56],"with":[57],"repression.":[59],"In":[60],"an":[61,116],"ICAR::Em":[62],"mutant,":[63],"not":[66],"whereas":[70],"expression":[75,108],"indicating":[76],"that":[77],"environmental":[78],"gene":[83],"is":[84],"IcaR-independent.":[85],"Apparently":[86],"signals":[88],"exclusively":[89],"through":[90],"IcaR":[91,97],"activate":[93,113],"regulates":[96,106],"at":[98],"transcriptional":[100],"posttranscriptional":[102],"levels.":[103],"in":[110],"addition":[111],"can":[112],"via":[115],"icaR-independent":[117],"pathway.":[118]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}