{"id":"https://openalex.org/W1998496550","doi":"https://doi.org/10.1155/s0962935194000281","title":"Changes and Relationship of PAF and TNF in Rats with Myocardial Ischaemia and Reperfusion Injury","display_name":"Changes and Relationship of PAF and TNF in Rats with Myocardial Ischaemia and Reperfusion Injury","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W1998496550","doi":"https://doi.org/10.1155/s0962935194000281","mag":"1998496550","pmid":"https://pubmed.ncbi.nlm.nih.gov/18472943","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2367036"},"language":"en","primary_location":{"id":"doi:10.1155/s0962935194000281","doi":"https://doi.org/10.1155/s0962935194000281","is_oa":true,"landing_page_url":"https://doi.org/10.1155/s0962935194000281","pdf_url":"https://downloads.hindawi.com/journals/mi/1994/698059.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/mi/1994/698059.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100394738","display_name":"Yaling Han","orcid":"https://orcid.org/0000-0003-4569-6737","observed_orcids":["https://orcid.org/0000-0003-4569-6737","https://orcid.org/0000-0002-6545-8632"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ya-Ling Han","raw_affiliation_strings":["Department of Cardiology Chang Zheng Hospital Shanghai China","Department of Cardiology, Chang Zheng Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology Chang Zheng Hospital Shanghai China","institution_ids":["https://openalex.org/I4210099558"]},{"raw_affiliation_string":"Department of Cardiology, Chang Zheng Hospital","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003073663","display_name":"S L Li","orcid":"https://orcid.org/0000-0003-1528-0298","observed_orcids":["https://orcid.org/0000-0003-1528-0298"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shao-Ha Li","raw_affiliation_strings":["Department of Pathophysiology, Second Military Medical Universit,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Second Military Medical Universit,","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110103238","display_name":"Qin-Yue Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin-Yue Zheng","raw_affiliation_strings":["Department of Pharmacology (School of Pharmacy), Second Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (School of Pharmacy), Second Military Medical University","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong-Bin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Bin Wang","raw_affiliation_strings":["Department of Pharmacology (School of Pharmacy), Second Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (School of Pharmacy), Second Military Medical University","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003842684","display_name":"Guo\u2010Yan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guo-Yan Zhang","raw_affiliation_strings":["Department of Cardiology, Chang Zheng Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Chang Zheng Hospital","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109109132","display_name":"Zhong-Gui Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhong-Gui Wu","raw_affiliation_strings":["Department of Cardiology, Chang Zheng Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Chang Zheng Hospital","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005234163","display_name":"Si\u2010Cong Chen","orcid":"https://orcid.org/0000-0003-0764-7918","observed_orcids":["https://orcid.org/0000-0003-0764-7918"]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Cong Chen","raw_affiliation_strings":["Department of Cardiology, Chang Zheng Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Chang Zheng Hospital","institution_ids":["https://openalex.org/I4210099558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100394738"],"corresponding_institution_ids":["https://openalex.org/I4210099558"],"apc_list":{"value":3040,"currency":"USD","value_usd":3040},"apc_paid":{"value":3040,"currency":"USD","value_usd":3040},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.15035417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"3","issue":"3","first_page":"205","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9570000171661377},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.824999988079071},{"id":"https://openalex.org/keywords/paf-antagonists","display_name":"PAF antagonists","score":0.6389999985694885},{"id":"https://openalex.org/keywords/coronary-artery-ligation","display_name":"coronary artery ligation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8820000290870667},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2779020240","wikidata":"https://www.wikidata.org/wiki/Q420577","display_name":"Platelet-activating factor","level":2,"score":0.8954250812530518},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.6980125308036804},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6958820223808289},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6437331438064575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6206240653991699},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6055920124053955},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6010249257087708},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5744858980178833},{"id":"https://openalex.org/C2780955469","wikidata":"https://www.wikidata.org/wiki/Q15320063","display_name":"Platelet-activating factor receptor","level":4,"score":0.5271555781364441},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5066198110580444},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43313995003700256},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4149143695831299},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36978280544281006},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33173277974128723},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28319501876831055}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/s0962935194000281","doi":"https://doi.org/10.1155/s0962935194000281","is_oa":true,"landing_page_url":"https://doi.org/10.1155/s0962935194000281","pdf_url":"https://downloads.hindawi.com/journals/mi/1994/698059.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2367036","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2367036","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators Inflamm","raw_type":"Text"},{"id":"pmid:18472943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18472943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of inflammation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:62417ba53f794dc396c7a1afa7890f34","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/62417ba53f794dc396c7a1afa7890f34","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mediators of Inflammation, Vol 3, Iss 3, Pp 205-209 (1994)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/s0962935194000281","doi":"https://doi.org/10.1155/s0962935194000281","is_oa":true,"landing_page_url":"https://doi.org/10.1155/s0962935194000281","pdf_url":"https://downloads.hindawi.com/journals/mi/1994/698059.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998496550.pdf","grobid_xml":"https://content.openalex.org/works/W1998496550.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W172831766","https://openalex.org/W1529157409","https://openalex.org/W1989452382","https://openalex.org/W2004497243","https://openalex.org/W2035834604","https://openalex.org/W2040693761","https://openalex.org/W2070857612","https://openalex.org/W2127539832","https://openalex.org/W2190771080","https://openalex.org/W2259287221","https://openalex.org/W2408459536","https://openalex.org/W2411506366"],"related_works":["https://openalex.org/W2461143907","https://openalex.org/W2475435189","https://openalex.org/W2141745947","https://openalex.org/W4242397787","https://openalex.org/W1966185899","https://openalex.org/W2473512047","https://openalex.org/W2344354945","https://openalex.org/W1997577779","https://openalex.org/W2000660906","https://openalex.org/W4240814936"],"abstract_inverted_index":{"IN":[0],"THIS":[1],"STUDY":[2],"IT":[3],"IS":[4],"REPORTED":[5],"THAT:":[6],"(1)":[7],"the":[8,42,88,115,161],"levels":[9],"of":[10,90,117,163],"blood":[11,118],"platelet-activating":[12],"factor":[13,18],"and":[14,24,71,87,106,123,132,142,145,165],"serum":[15,91,121],"tumour":[16],"necrosis":[17],"significantly":[19],"increased":[20],"after":[21,67,83],"coronary":[22],"ligation":[23],"reperfusion,":[25],"compared":[26,36],"with":[27,37,41],"sham-ligated":[28],"controls,":[29,39],"in":[30,53,139],"an":[31],"anaesthetized":[32],"rat":[33],"model;":[34],"(2)":[35],"vehicle":[38],"pretreatment":[40],"PAF":[43,119,131,147,164],"antagonist":[44],"BN":[45],"50739":[46],"(10":[47],"mg/kg,":[48],"i.v.)":[49],"produced":[50],"significant":[51],"decreases":[52],"infarct":[54,124],"size":[55],"(from":[56,93],"29.6":[57],"+/-":[58,62,74,78,95,100],"4.0%":[59],"to":[60,76,98],"22.4":[61],"2.1%,":[63],"p":[64,80,103],"<":[65,81,104],"0.05":[66],"3":[68],"h":[69,85],"ligation,":[70],"from":[72],"28.5":[73],"9.5%":[75],"10.5":[77],"4.5%,":[79],"0.01":[82],"4":[84],"reperfusion)":[86],"level":[89,116],"TNF":[92,122,133],"10.4":[94],"7.7":[96],"U/ml":[97],"3.9":[99],"4.8":[101],"U/ml,":[102],"0.05);":[105],"(3)":[107],"a":[108,151],"significan":[109],"positive":[110],"correlation":[111],"was":[112],"found":[113],"between":[114],"or":[120,156],"size.":[125],"The":[126],"present":[127],"results":[128],"indicate":[129],"that":[130,146],"may":[134,149],"be":[135],"important":[136],"mediators":[137],"involved":[138],"myocardial":[140],"ischaemia":[141],"reperfusion":[143],"injury,":[144],"antagonists":[148],"exert":[150],"protective":[152],"effect":[153],"on":[154],"ischaemic":[155],"reperfused":[157],"myocardium":[158],"by":[159],"inhibiting":[160],"interaction":[162],"TNF.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}