{"id":"https://openalex.org/W1998487776","doi":"https://doi.org/10.1126/science.7839144","title":"Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms","display_name":"Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms","publication_year":1995,"publication_date":"1995-02-03","ids":{"openalex":"https://openalex.org/W1998487776","doi":"https://doi.org/10.1126/science.7839144","mag":"1998487776","pmid":"https://pubmed.ncbi.nlm.nih.gov/7839144"},"language":"en","primary_location":{"id":"doi:10.1126/science.7839144","doi":"https://doi.org/10.1126/science.7839144","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.7839144","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024093558","display_name":"Beno\u0131\u0302t D\u00e9rijard","orcid":"https://orcid.org/0000-0002-1104-8267","observed_orcids":["https://orcid.org/0000-0002-1104-8267"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benoit D\u00e9rijard","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075758610","display_name":"Jo\u00ebl Raingeaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jo\u00ebl Raingeaud","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081735713","display_name":"Tamera Barrett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamera Barrett","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088743420","display_name":"I\u2010Huan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I-Huan Wu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069188763","display_name":"Jiahuai Han","orcid":"https://orcid.org/0000-0001-5592-4487","observed_orcids":["https://orcid.org/0000-0001-5592-4487"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiahuai Han","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103117461","display_name":"Richard J. Ulevitch","orcid":"https://orcid.org/0000-0003-0308-2964","observed_orcids":["https://orcid.org/0000-0003-0308-2964"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Ulevitch","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028742170","display_name":"Roger J. Davis","orcid":"https://orcid.org/0000-0002-0130-1652","observed_orcids":["https://orcid.org/0000-0002-0130-1652"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger J. Davis","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":null,"apc_paid":null,"fwci":44.1967,"has_fulltext":false,"cited_by_count":1566,"citation_normalized_percentile":{"value":0.99969507,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"267","issue":"5198","first_page":"682","last_page":"685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.38769999146461487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.652999997138977},{"id":"https://openalex.org/keywords/mkk3","display_name":"MKK3","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mkk4","display_name":"MKK4","score":1.0},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8600000143051147},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.6079999804496765},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.8989999890327454},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.8379999995231628},{"id":"https://openalex.org/keywords/dual-phosphorylation","display_name":"dual phosphorylation","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.7798863649368286},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.7591249942779541},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.7464185357093811},{"id":"https://openalex.org/C138227536","wikidata":"https://www.wikidata.org/wiki/Q18030789","display_name":"MAPK7","level":5,"score":0.7285467386245728},{"id":"https://openalex.org/C91734924","wikidata":"https://www.wikidata.org/wiki/Q18033952","display_name":"MAPKAPK2","level":5,"score":0.7100969552993774},{"id":"https://openalex.org/C163035849","wikidata":"https://www.wikidata.org/wiki/Q15326910","display_name":"MAPK14","level":5,"score":0.6947354078292847},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.6680314540863037},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.6574394106864929},{"id":"https://openalex.org/C59143045","wikidata":"https://www.wikidata.org/wiki/Q15314942","display_name":"Cyclin-dependent kinase 9","level":5,"score":0.6381896734237671},{"id":"https://openalex.org/C99405784","wikidata":"https://www.wikidata.org/wiki/Q410434","display_name":"c-Raf","level":5,"score":0.6132596135139465},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5146223306655884},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.504909336566925},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49300333857536316},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.4826527237892151},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.447922021150589},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3816286325454712},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.370887815952301},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3617936074733734},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3394862413406372}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048371","descriptor_name":"MAP Kinase Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.7839144","doi":"https://doi.org/10.1126/science.7839144","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.7839144","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:7839144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7839144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2911965758","display_name":"SIGNAL TRANSDUCTION BY THE EGF RECEPTOR","funder_award_id":"R01CA058396","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5175297616","display_name":"MOLECULAR PATHOLOGY OF LPS-INDUCED INJURY","funder_award_id":"R01AI015136","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G727105485","display_name":"BIOCHEMICAL MECHANISMS OF CELLULAR INJURY IN TRAUMA","funder_award_id":"P01GM037696","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W137936598","https://openalex.org/W138153588","https://openalex.org/W1482432683","https://openalex.org/W1486631729","https://openalex.org/W1572416479","https://openalex.org/W1573821584","https://openalex.org/W1577992990","https://openalex.org/W1581952739","https://openalex.org/W1848239201","https://openalex.org/W1888645976","https://openalex.org/W1965833684","https://openalex.org/W1968590447","https://openalex.org/W1976462601","https://openalex.org/W1982390204","https://openalex.org/W1984665850","https://openalex.org/W1984903682","https://openalex.org/W1988604934","https://openalex.org/W1992494265","https://openalex.org/W1993657069","https://openalex.org/W2001399809","https://openalex.org/W2005900169","https://openalex.org/W2007186796","https://openalex.org/W2025548430","https://openalex.org/W2026951979","https://openalex.org/W2031610264","https://openalex.org/W2038087154","https://openalex.org/W2060913542","https://openalex.org/W2068446924","https://openalex.org/W2079588007"],"related_works":["https://openalex.org/W2042216100","https://openalex.org/W2030900078","https://openalex.org/W2013044374","https://openalex.org/W2063501226","https://openalex.org/W1967683406","https://openalex.org/W2487749306","https://openalex.org/W2054363543","https://openalex.org/W1560294775","https://openalex.org/W2004141049","https://openalex.org/W2009667315"],"abstract_inverted_index":{"Mammalian":[0],"mitogen-activated":[1],"protein":[2,8],"(MAP)":[3],"kinases":[4,35],"include":[5],"extracellular":[6],"signal-regulated":[7],"kinase":[9,13,20,34,86],"(ERK),":[10],"c-Jun":[11],"amino-terminal":[12],"(JNK),":[14],"and":[15,29,37,43,74,78,81],"p38":[16,45,72],"subgroups.":[17],"These":[18,48,65],"MAP":[19,33,46,58,85],"isoforms":[21,50],"are":[22],"activated":[23],"by":[24],"dual":[25],"phosphorylation":[26],"on":[27],"threonine":[28],"tyrosine.":[30],"Two":[31],"human":[32],"(MKK3":[36,73],"MKK4)":[38],"were":[39],"cloned":[40],"that":[41,68],"phosphorylate":[42],"activate":[44,53,63],"kinase.":[47],"MKK":[49],"did":[51,62],"not":[52],"the":[54,69],"ERK":[55,79],"subgroup":[56],"of":[57,71],"kinases,":[59],"but":[60],"MKK4":[61],"JNK.":[64],"data":[66],"demonstrate":[67],"activators":[70],"MKK4),":[75],"JNK":[76],"(MKK4),":[77],"(MEK1":[80],"MEK2)":[82],"define":[83],"independent":[84],"signal":[87],"transduction":[88],"pathways.":[89]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":28}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}