{"id":"https://openalex.org/W1998484940","doi":"https://doi.org/10.1093/nar/gks538","title":"Prioritizing cancer-related key miRNA\u2013target interactions by integrative genomics","display_name":"Prioritizing cancer-related key miRNA\u2013target interactions by integrative genomics","publication_year":2012,"publication_date":"2012-06-16","ids":{"openalex":"https://openalex.org/W1998484940","doi":"https://doi.org/10.1093/nar/gks538","mag":"1998484940","pmid":"https://pubmed.ncbi.nlm.nih.gov/22705797","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3439920"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gks538","doi":"https://doi.org/10.1093/nar/gks538","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gks538","pdf_url":"https://academic.oup.com/nar/article-pdf/40/16/7653/16966952/gks538.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/40/16/7653/16966952/gks538.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003301022","display_name":"Yun Xiao","orcid":"https://orcid.org/0000-0003-0785-3957","observed_orcids":["https://orcid.org/0000-0003-0785-3957"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Xiao","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Department of Neurology, The Affiliated Hospital and Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Department of Neurology, The Affiliated Hospital and Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110395657","display_name":"Jinxia Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinxia Guan","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003264203","display_name":"Yanyan Ping","orcid":"https://orcid.org/0000-0002-1810-1200","observed_orcids":["https://orcid.org/0000-0002-1810-1200"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyan Ping","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036602641","display_name":"Chaohan Xu","orcid":"https://orcid.org/0000-0001-5145-8757","observed_orcids":["https://orcid.org/0000-0001-5145-8757"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaohan Xu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112129005","display_name":"Teng Huang","orcid":"https://orcid.org/0000-0001-8323-6163","observed_orcids":["https://orcid.org/0000-0001-8323-6163"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Teng Huang","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103210049","display_name":"Hongying Zhao","orcid":"https://orcid.org/0000-0003-4191-4805","observed_orcids":["https://orcid.org/0000-0003-4191-4805"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongying Zhao","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049857586","display_name":"Huihui Fan","orcid":"https://orcid.org/0000-0003-4233-5389","observed_orcids":["https://orcid.org/0000-0003-4233-5389"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huihui Fan","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100604268","display_name":"Yiqun Li","orcid":"https://orcid.org/0000-0001-7402-5081","observed_orcids":["https://orcid.org/0000-0001-7402-5081"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiqun Li","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054150007","display_name":"Yanling Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanling Lv","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101981901","display_name":"Tingting Zhao","orcid":"https://orcid.org/0000-0002-1820-7072","observed_orcids":["https://orcid.org/0000-0002-1820-7072"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Zhao","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062768118","display_name":"Yucui Dong","orcid":"https://orcid.org/0000-0001-5261-4125","observed_orcids":["https://orcid.org/0000-0001-5261-4125"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yucui Dong","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022476919","display_name":"Huan Ren","orcid":"https://orcid.org/0000-0001-7114-2012","observed_orcids":["https://orcid.org/0000-0001-7114-2012"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Ren","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100445596","display_name":"Xia Li","orcid":"https://orcid.org/0000-0002-9794-2648","observed_orcids":["https://orcid.org/0000-0002-9794-2648","https://orcid.org/0000-0002-4691-4348","https://orcid.org/0000-0002-2991-6544"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xia Li","raw_affiliation_strings":["College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, 2 Department of Neurology, The Affiliated Hospital and 3 Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"1College of Bioinformatics Science and Technology, 2Department of Neurology, The Affiliated Hospital and 3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100445596"],"corresponding_institution_ids":["https://openalex.org/I156144747"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":1.8284,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.84736622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"40","issue":"16","first_page":"7653","last_page":"7665"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6890000104904175},{"id":"https://openalex.org/keywords/mirna-target-interactions","display_name":"miRNA-target interactions","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.8560000061988831},{"id":"https://openalex.org/keywords/microrna-binding-sites","display_name":"microRNA binding sites","score":0.8840000033378601},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6200000047683716},{"id":"https://openalex.org/keywords/microrna-function","display_name":"microRNA function","score":0.699999988079071},{"id":"https://openalex.org/keywords/mir-155","display_name":"miR-155","score":0.921999990940094},{"id":"https://openalex.org/keywords/integrative-genomics","display_name":"integrative genomics","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7998253703117371},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7820936441421509},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7692035436630249},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6427031755447388},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5966594219207764},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.5800454020500183},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5382511615753174},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5059718489646912},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.44106775522232056},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4114637076854706},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37578117847442627},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3492567837238312},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2871585488319397},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/nar/gks538","doi":"https://doi.org/10.1093/nar/gks538","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gks538","pdf_url":"https://academic.oup.com/nar/article-pdf/40/16/7653/16966952/gks538.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2443093","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3439920","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3439920","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3439920","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:22705797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22705797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.782.8743","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.782.8743","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/34/ee/gks538.PMC3439920.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:nar:40/16/7653","doi":null,"is_oa":false,"landing_page_url":"http://nar.oxfordjournals.org/cgi/content/short/40/16/7653","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/nar/gks538","doi":"https://doi.org/10.1093/nar/gks538","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gks538","pdf_url":"https://academic.oup.com/nar/article-pdf/40/16/7653/16966952/gks538.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1250959053","display_name":"\u5c0f\u5206\u5b50\u4e0e\u5176\u8c03\u63a7\u7684\u590d\u6742\u75be\u75c5\u76f8\u5173\u9776\u901a\u8def\u8bc6\u522b\u53ca\u529f\u80fd\u7814\u7a76","funder_award_id":"61170154","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1347416899","display_name":null,"funder_award_id":"61073136","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7520990219","display_name":null,"funder_award_id":"20102307110022","funder_id":"https://openalex.org/F4320336024","funder_display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336024","display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998484940.pdf","grobid_xml":"https://content.openalex.org/works/W1998484940.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1969504027","https://openalex.org/W1971460830","https://openalex.org/W1971645224","https://openalex.org/W1971759686","https://openalex.org/W1977838165","https://openalex.org/W1981889510","https://openalex.org/W1985563073","https://openalex.org/W1990933893","https://openalex.org/W1993370700","https://openalex.org/W1993469143","https://openalex.org/W1998498286","https://openalex.org/W2000491596","https://openalex.org/W2006797972","https://openalex.org/W2007794074","https://openalex.org/W2008945738","https://openalex.org/W2014946489","https://openalex.org/W2017426710","https://openalex.org/W2019009111","https://openalex.org/W2024704386","https://openalex.org/W2025183726","https://openalex.org/W2026051181","https://openalex.org/W2026570544","https://openalex.org/W2028994878","https://openalex.org/W2030166934","https://openalex.org/W2037275886","https://openalex.org/W2039342473","https://openalex.org/W2045234988","https://openalex.org/W2047967134","https://openalex.org/W2048296798","https://openalex.org/W2049344510","https://openalex.org/W2053835153","https://openalex.org/W2059073003","https://openalex.org/W2061638986","https://openalex.org/W2070412833","https://openalex.org/W2078388350","https://openalex.org/W2080407932","https://openalex.org/W2080800490","https://openalex.org/W2089001345","https://openalex.org/W2089274312","https://openalex.org/W2094082417","https://openalex.org/W2102140136","https://openalex.org/W2102427034","https://openalex.org/W2103017472","https://openalex.org/W2105274319","https://openalex.org/W2107769103","https://openalex.org/W2109555487","https://openalex.org/W2119157844","https://openalex.org/W2119412782","https://openalex.org/W2122863289","https://openalex.org/W2128016314","https://openalex.org/W2128768066","https://openalex.org/W2133226725","https://openalex.org/W2133814931","https://openalex.org/W2133968430","https://openalex.org/W2135810600","https://openalex.org/W2136010280","https://openalex.org/W2138664009","https://openalex.org/W2144014661","https://openalex.org/W2146292498","https://openalex.org/W2146518187","https://openalex.org/W2148203455","https://openalex.org/W2155699197","https://openalex.org/W2159482845","https://openalex.org/W2159857693","https://openalex.org/W2160467221","https://openalex.org/W2162674813","https://openalex.org/W2164683872","https://openalex.org/W2166240615","https://openalex.org/W2168290712","https://openalex.org/W2168494970","https://openalex.org/W2216554257","https://openalex.org/W4238545515","https://openalex.org/W4248234957","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2531260467","https://openalex.org/W2740159514","https://openalex.org/W2110234420","https://openalex.org/W1990933893","https://openalex.org/W2105136962","https://openalex.org/W2604737133","https://openalex.org/W4411603978","https://openalex.org/W261377557","https://openalex.org/W2077539934","https://openalex.org/W2113088268"],"abstract_inverted_index":{"Accumulating":[0],"evidence":[1],"indicates":[2],"that":[3,123,154],"microRNAs":[4],"(miRNAs)":[5],"can":[6,125,159],"function":[7,103],"as":[8,149],"oncogenes":[9],"or":[10],"tumor":[11],"suppressor":[12],"genes":[13],"by":[14,176],"controlling":[15],"few":[16],"key":[17,32,46,64,115,181,197],"targets,":[18],"which":[19],"in":[20],"turn":[21],"contribute":[22],"to":[23,81,94,112],"the":[24,82,130,142,155,171,192],"pathogenesis":[25],"of":[26,30,43,79,119,135,144,164,173,194],"cancer.":[27],"The":[28,183],"identification":[29],"cancer-related":[31,45,63,114,180,196],"miRNA-target":[33,198],"interactions":[34,47,65,158],"remains":[35],"a":[36,40,107,150,188],"challenge.":[37],"We":[38],"performed":[39],"systematic":[41],"analysis":[42],"known":[44],"manually":[48],"curated":[49],"from":[50],"published":[51],"papers":[52],"based":[53],"on":[54],"different":[55],"aspects":[56],"including":[57],"sequence,":[58,100],"expression":[59,86,101],"and":[60,88,102],"function.":[61],"Known":[62],"show":[66],"more":[67,76],"miRNA":[68,80],"binding":[69,74,78],"sites":[70],"(especially":[71],"for":[72,161,191],"8mer":[73],"sites),":[75],"reliable":[77],"target":[83],"region,":[84],"higher":[85],"associations":[87],"broader":[89],"functional":[90],"coverage":[91],"when":[92],"compared":[93],"non-disease-related":[95],"interactions.":[96,116,182,199],"Through":[97],"integrating":[98],"these":[99],"features,":[104],"we":[105,152,168],"proposed":[106],"bioinformatics":[108],"approach":[109,121,175,184],"termed":[110],"PCmtI":[111],"prioritize":[113],"Ten-fold":[117],"cross-validation":[118,139],"our":[120,145,174],"revealed":[122],"it":[124],"achieve":[126],"an":[127],"area":[128],"under":[129],"receiver":[131],"operating":[132],"characteristic":[133],"curve":[134],"93.9%.":[136],"Subsequent":[137],"leave-one-miRNA-out":[138],"also":[140],"demonstrated":[141,170],"performance":[143],"approach.":[146],"Using":[147],"miR-155":[148],"case,":[151],"found":[153],"top":[156],"ranked":[157],"account":[160],"most":[162],"functions":[163],"miR-155.":[165],"In":[166],"addition,":[167],"further":[169],"power":[172],"23":[177],"recently":[178],"identified":[179],"described":[185],"here":[186],"offers":[187],"new":[189],"way":[190],"discovery":[193],"novel":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}