{"id":"https://openalex.org/W1998483336","doi":"https://doi.org/10.3389/fphar.2014.00114","title":"The role of TMPRSS6/matriptase-2 in iron regulation and anemia","display_name":"The role of TMPRSS6/matriptase-2 in iron regulation and anemia","publication_year":2014,"publication_date":"2014-05-19","ids":{"openalex":"https://openalex.org/W1998483336","doi":"https://doi.org/10.3389/fphar.2014.00114","mag":"1998483336","pmid":"https://pubmed.ncbi.nlm.nih.gov/24966834","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4053654"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2014.00114","doi":"https://doi.org/10.3389/fphar.2014.00114","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2014.00114","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2014.00114/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2014.00114/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103161606","display_name":"Chia\u2010Yu Wang","orcid":"https://orcid.org/0000-0003-3679-6453","observed_orcids":["https://orcid.org/0000-0003-3679-6453","https://orcid.org/0000-0002-4850-3470"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-Yu Wang","raw_affiliation_strings":["Program in Anemia Signaling Research, Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Anemia Signaling Research, Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002713704","display_name":"Delphine Meynard","orcid":"https://orcid.org/0000-0002-9927-5535","observed_orcids":["https://orcid.org/0000-0002-9927-5535"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210113758","display_name":"Centre de Physiopathologie de Toulouse-Purpan","ror":"https://ror.org/02c1tv516","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210113758","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Delphine Meynard","raw_affiliation_strings":["INSERM, U1043, CNRS, U5282, Universit\u00e9 Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U1043, CNRS, U5282, Universit\u00e9 Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210113758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105935846","display_name":"Herbert Yih-Fuu Lin","orcid":"https://orcid.org/0009-0008-4774-0627","observed_orcids":["https://orcid.org/0009-0008-4774-0627"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Herbert Y. Lin","raw_affiliation_strings":["Program in Anemia Signaling Research, Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Anemia Signaling Research, Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5105935846"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.0323,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.67894447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"5","issue":null,"first_page":"114","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tmprss6","display_name":"TMPRSS6","score":0.9470000267028809},{"id":"https://openalex.org/keywords/matriptase-2","display_name":"matriptase-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/iron-refractory-iron-deficiency-anemia","display_name":"iron-refractory iron deficiency anemia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hepcidin-regulation","display_name":"hepcidin regulation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/type-ii-transmembrane-serine-protease","display_name":"type II transmembrane serine protease","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8190000057220459},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.4620000123977661},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C173188278","wikidata":"https://www.wikidata.org/wiki/Q18052595","display_name":"TMPRSS6","level":5,"score":0.9748044610023499},{"id":"https://openalex.org/C2776768029","wikidata":"https://www.wikidata.org/wiki/Q14882371","display_name":"Hepcidin","level":3,"score":0.8803431391716003},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.5870128273963928},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.45502880215644836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4183506369590759},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36734187602996826},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32270440459251404},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.3138221502304077},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31205278635025024},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2541474401950836},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24717554450035095},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.2323734164237976},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16756486892700195}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fphar.2014.00114","doi":"https://doi.org/10.3389/fphar.2014.00114","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2014.00114","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2014.00114/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3041532","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4053654","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24966834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24966834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4053654","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4053654/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/12406685","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406685","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f80231637a634d2cbff7616582fa6bb0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f80231637a634d2cbff7616582fa6bb0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 5 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2014.00114","doi":"https://doi.org/10.3389/fphar.2014.00114","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2014.00114","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2014.00114/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4537218895","display_name":"Mechanisms of action of hemojuvelin","funder_award_id":"R01DK071837","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7836824667","display_name":"Regulation of BMP signaling in kidney","funder_award_id":"R01DK069533","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998483336.pdf","grobid_xml":"https://content.openalex.org/works/W1998483336.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1550867738","https://openalex.org/W1588675203","https://openalex.org/W1885241490","https://openalex.org/W1963860082","https://openalex.org/W1967998795","https://openalex.org/W1973282765","https://openalex.org/W1974266372","https://openalex.org/W1975590431","https://openalex.org/W1977767277","https://openalex.org/W1979307757","https://openalex.org/W1980042430","https://openalex.org/W1984773555","https://openalex.org/W1985099261","https://openalex.org/W1987961752","https://openalex.org/W1995768948","https://openalex.org/W1999467702","https://openalex.org/W2003255834","https://openalex.org/W2004724037","https://openalex.org/W2005389846","https://openalex.org/W2009542872","https://openalex.org/W2009988274","https://openalex.org/W2012956876","https://openalex.org/W2013673267","https://openalex.org/W2020150065","https://openalex.org/W2021552825","https://openalex.org/W2033458525","https://openalex.org/W2043349967","https://openalex.org/W2045010179","https://openalex.org/W2045705582","https://openalex.org/W2046891044","https://openalex.org/W2048448975","https://openalex.org/W2049917711","https://openalex.org/W2050833520","https://openalex.org/W2051875442","https://openalex.org/W2052311092","https://openalex.org/W2054149566","https://openalex.org/W2067747556","https://openalex.org/W2068382047","https://openalex.org/W2069594569","https://openalex.org/W2070165530","https://openalex.org/W2080200109","https://openalex.org/W2082855795","https://openalex.org/W2083359289","https://openalex.org/W2087744489","https://openalex.org/W2090165219","https://openalex.org/W2101543922","https://openalex.org/W2108843246","https://openalex.org/W2109406699","https://openalex.org/W2110999561","https://openalex.org/W2113642938","https://openalex.org/W2114716461","https://openalex.org/W2115311848","https://openalex.org/W2117133328","https://openalex.org/W2124303634","https://openalex.org/W2130423953","https://openalex.org/W2135159262","https://openalex.org/W2135937876","https://openalex.org/W2142833570","https://openalex.org/W2144801974","https://openalex.org/W2146966692","https://openalex.org/W2148914218","https://openalex.org/W2152815385","https://openalex.org/W2152855697","https://openalex.org/W2154484742","https://openalex.org/W2155487325","https://openalex.org/W2163438420","https://openalex.org/W2163487646","https://openalex.org/W2164451457","https://openalex.org/W2167117158","https://openalex.org/W2167910235","https://openalex.org/W2168209462","https://openalex.org/W2170731566","https://openalex.org/W2183118348","https://openalex.org/W2330680246","https://openalex.org/W2332998067","https://openalex.org/W6641369547","https://openalex.org/W6663850360","https://openalex.org/W6679929862"],"related_works":["https://openalex.org/W2164451457","https://openalex.org/W7098659202","https://openalex.org/W2088531477","https://openalex.org/W7099181705","https://openalex.org/W2068382047","https://openalex.org/W4386567042","https://openalex.org/W2168209462","https://openalex.org/W2539356519","https://openalex.org/W3093181580","https://openalex.org/W7217790146"],"abstract_inverted_index":{"Matriptase-2,":[0],"encoded":[1],"by":[2],"the":[3,10,44,69,74,78,87,107,122],"TMPRSS6":[4,62,64],"gene,":[5],"is":[6,65,116],"a":[7],"member":[8],"of":[9,46,76,90,104,109,125],"type":[11],"II":[12],"transmembrane":[13],"serine":[14],"protease":[15],"family.":[16],"Matriptase-2":[17,32],"has":[18,26],"structural":[19],"and":[20,71,93,99],"enzymatic":[21],"similarities":[22],"to":[23,36],"matriptase-1,":[24],"which":[25],"been":[27],"implicated":[28],"in":[29,39,52,58,68,96,111],"cancer":[30,100],"progression.":[31,101],"was":[33],"later":[34],"established":[35],"be":[37],"essential":[38],"iron":[40,48,80,97],"homeostasis":[41],"based":[42],"on":[43,86],"phenotypes":[45],"iron-refractory":[47],"deficiency":[49],"anemia":[50],"identified":[51],"mouse":[53],"models":[54],"as":[55,57,119,121],"well":[56,120],"human":[59],"patients":[60],"with":[61],"mutations.":[63],"expressed":[66],"mainly":[67],"liver":[70],"negatively":[72],"regulates":[73],"production":[75],"hepcidin,":[77],"systemic":[79],"regulatory":[81],"hormone.":[82],"This":[83],"review":[84],"focuses":[85],"current":[88],"understanding":[89],"matriptase-2":[91,110,126],"biochemistry,":[92],"its":[94],"role":[95],"metabolism":[98],"In":[102],"light":[103],"recent":[105],"investigations,":[106],"function":[108],"hepcidin":[112],"regulation,":[113],"how":[114],"it":[115],"being":[117],"regulated,":[118],"therapeutic":[123],"potential":[124],"are":[127],"also":[128],"discussed.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}