{"id":"https://openalex.org/W1998475835","doi":"https://doi.org/10.1016/j.ntt.2009.01.010","title":"GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity","display_name":"GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity","publication_year":2009,"publication_date":"2009-02-11","ids":{"openalex":"https://openalex.org/W1998475835","doi":"https://doi.org/10.1016/j.ntt.2009.01.010","mag":"1998475835","pmid":"https://pubmed.ncbi.nlm.nih.gov/19602384"},"language":"en","primary_location":{"id":"doi:10.1016/j.ntt.2009.01.010","doi":"https://doi.org/10.1016/j.ntt.2009.01.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ntt.2009.01.010","pdf_url":null,"source":{"id":"https://openalex.org/S149459226","display_name":"Neurotoxicology and Teratology","issn_l":"0892-0362","issn":["0892-0362","1872-9738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotoxicology and Teratology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10261/37324","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112028274","display_name":"Mireia Galofr\u00e9","orcid":"https://orcid.org/0000-0003-1863-619X","observed_orcids":["https://orcid.org/0000-0003-1863-619X"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210154894","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica","ror":"https://ror.org/050q0kv47","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210154894","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mireia Galofr\u00e9","raw_affiliation_strings":["Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona, Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain","CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Spain","Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona, Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]},{"raw_affiliation_string":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Spain","institution_ids":["https://openalex.org/I4210154894"]},{"raw_affiliation_string":"Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008463597","display_name":"Zoila Babot","orcid":"https://orcid.org/0000-0003-4551-0189","observed_orcids":["https://orcid.org/0000-0003-4551-0189"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210154894","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica","ror":"https://ror.org/050q0kv47","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210154894","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Zoila Babot","raw_affiliation_strings":["CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Spain","Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Spain","institution_ids":["https://openalex.org/I4210154894"]},{"raw_affiliation_string":"Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058487325","display_name":"Daniel A. Garc\u00eda","orcid":"https://orcid.org/0000-0001-5282-2557","observed_orcids":["https://orcid.org/0000-0001-5282-2557"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Daniel A. Garc\u00eda","raw_affiliation_strings":["Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026234677","display_name":"Susana Iraola\u2010Guzm\u00e1n","orcid":"https://orcid.org/0000-0003-3359-1241","observed_orcids":["https://orcid.org/0000-0003-3359-1241"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Susana Iraola","raw_affiliation_strings":["Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091545327","display_name":"Eduard Rodr\u00edguez-Farr\u00e9","orcid":"https://orcid.org/0000-0001-9305-3168","observed_orcids":["https://orcid.org/0000-0001-9305-3168"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210154894","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica","ror":"https://ror.org/050q0kv47","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210154894","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduard Rodr\u00edguez-Farr\u00e9","raw_affiliation_strings":["CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Spain","Department of Brain Ischemia and Neurodegeneration, IIBB, CSIC-IDIBAPS, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Spain","institution_ids":["https://openalex.org/I4210154894"]},{"raw_affiliation_string":"Department of Brain Ischemia and Neurodegeneration, IIBB, CSIC-IDIBAPS, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074620462","display_name":"Anna Forsby","orcid":"https://orcid.org/0000-0001-6298-201X","observed_orcids":["https://orcid.org/0000-0001-6298-201X"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Forsby","raw_affiliation_strings":["Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040496201","display_name":"Cristina E. Sunol","orcid":"https://orcid.org/0000-0001-9367-8483","observed_orcids":["https://orcid.org/0000-0001-9367-8483"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210154894","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica","ror":"https://ror.org/050q0kv47","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210154894","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Cristina Su\u00f1ol","raw_affiliation_strings":["CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Spain","Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Spain","institution_ids":["https://openalex.org/I4210154894"]},{"raw_affiliation_string":"Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas, CSIC-IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5040496201"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210154894","https://openalex.org/I4210160192"],"apc_list":{"value":3850,"currency":"USD","value_usd":3850},"apc_paid":null,"fwci":5.2041,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.94643365,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"32","issue":"1","first_page":"52","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.9620000123977661},{"id":"https://openalex.org/keywords/acute-neurotoxicity","display_name":"acute neurotoxicity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/primary-neuronal-cultures","display_name":"primary neuronal cultures","score":0.7239999771118164},{"id":"https://openalex.org/keywords/gaba-uptake","display_name":"GABA uptake","score":0.8610000014305115},{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.9860000014305115},{"id":"https://openalex.org/keywords/in-vitro-toxicity-testing","display_name":"in vitro toxicity testing","score":0.6880000233650208},{"id":"https://openalex.org/keywords/drug-abuse","display_name":"drug abuse","score":0.6899999976158142},{"id":"https://openalex.org/keywords/biocide-toxicity","display_name":"biocide toxicity","score":0.5180000066757202},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6790000200271606},{"id":"https://openalex.org/keywords/gabaergic-transmission","display_name":"GABAergic neurotransmission","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.847299337387085},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7105314135551453},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5217815041542053},{"id":"https://openalex.org/C2993684226","wikidata":"https://www.wikidata.org/wiki/Q2662727","display_name":"Human cell","level":3,"score":0.4841773808002472},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48402139544487},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4823150634765625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45968908071517944},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41245341300964355},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40212109684944153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3324206471443176},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24698889255523682},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2307296097278595},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ntt.2009.01.010","doi":"https://doi.org/10.1016/j.ntt.2009.01.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ntt.2009.01.010","pdf_url":null,"source":{"id":"https://openalex.org/S149459226","display_name":"Neurotoxicology and Teratology","issn_l":"0892-0362","issn":["0892-0362","1872-9738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotoxicology and Teratology","raw_type":"journal-article"},{"id":"pmid:19602384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19602384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotoxicology and teratology","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/37324","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/37324","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo"},{"id":"pmh:oai:digital.csic.es:10261/83392","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/83392","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Comunicaci\u00f3n de congreso"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/64566","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/64566","pdf_url":null,"source":{"id":"https://openalex.org/S4306402455","display_name":"CONICET Digital (CONICET)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148385","host_organization_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","host_organization_lineage":["https://openalex.org/I4210148385"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:digital.csic.es:10261/37324","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/37324","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W235103770","https://openalex.org/W1546622988","https://openalex.org/W1602139259","https://openalex.org/W1867863455","https://openalex.org/W1891840621","https://openalex.org/W1964964443","https://openalex.org/W1969683921","https://openalex.org/W1973198505","https://openalex.org/W1978450544","https://openalex.org/W1989778572","https://openalex.org/W1989975164","https://openalex.org/W1994277171","https://openalex.org/W1995019025","https://openalex.org/W1996033662","https://openalex.org/W1997843854","https://openalex.org/W2004281743","https://openalex.org/W2021112410","https://openalex.org/W2023205553","https://openalex.org/W2027127607","https://openalex.org/W2034635044","https://openalex.org/W2036854292","https://openalex.org/W2039923977","https://openalex.org/W2042021237","https://openalex.org/W2044694660","https://openalex.org/W2048265745","https://openalex.org/W2050171502","https://openalex.org/W2050827945","https://openalex.org/W2055874486","https://openalex.org/W2056188359","https://openalex.org/W2058825628","https://openalex.org/W2059707255","https://openalex.org/W2064674367","https://openalex.org/W2068096393","https://openalex.org/W2068630344","https://openalex.org/W2068961101","https://openalex.org/W2072050520","https://openalex.org/W2078659300","https://openalex.org/W2081900803","https://openalex.org/W2083546894","https://openalex.org/W2087566897","https://openalex.org/W2104783190","https://openalex.org/W2111671651","https://openalex.org/W2121429522","https://openalex.org/W2143958525","https://openalex.org/W2173525109","https://openalex.org/W2253893947","https://openalex.org/W2410518776","https://openalex.org/W3194190452","https://openalex.org/W4297692515"],"related_works":["https://openalex.org/W2042021237","https://openalex.org/W2007541245","https://openalex.org/W7204796230","https://openalex.org/W1003941037","https://openalex.org/W2069960646","https://openalex.org/W1968049236","https://openalex.org/W2013494027","https://openalex.org/W4410223032","https://openalex.org/W67570079","https://openalex.org/W2413571168"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}