{"id":"https://openalex.org/W199847150","doi":null,"title":"Myeloid derived suppressor cells in patients with Pancreatic Adenocarcinoma","display_name":"Myeloid derived suppressor cells in patients with Pancreatic Adenocarcinoma","publication_year":2014,"publication_date":"2014-12-07","ids":{"openalex":"https://openalex.org/W199847150","mag":"199847150"},"language":"en","primary_location":{"id":"mag:199847150","doi":null,"is_oa":false,"landing_page_url":"https://www.escholar.manchester.ac.uk/uk-ac-man-scw:242425","pdf_url":null,"source":{"id":"https://openalex.org/S4306532719","display_name":"[Thesis]. Manchester, UK: The University of                    Manchester; 2014.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"[Thesis]. Manchester, UK: The University of Manchester; 2014.","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026544086","display_name":"Yazan S. Khaled","orcid":"https://orcid.org/0000-0001-6571-3579","observed_orcids":["https://orcid.org/0000-0001-6571-3579"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yazan S. Khaled","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6571-3579","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026544086"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01092055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/granulocytic-mdscs","display_name":"granulocytic MDSCs","score":0.8799999952316284},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.7710000276565552},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7419999837875366},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.5440000295639038},{"id":"https://openalex.org/keywords/immunotherapy-targets","display_name":"immunotherapy targets","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.7871278524398804},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6823912262916565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6449947953224182},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6397791504859924},{"id":"https://openalex.org/C176290653","wikidata":"https://www.wikidata.org/wiki/Q21114013","display_name":"CD33","level":4,"score":0.5541170239448547},{"id":"https://openalex.org/C2776804306","wikidata":"https://www.wikidata.org/wiki/Q3959958","display_name":"CD15","level":4,"score":0.4996347427368164},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.49318093061447144},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.48411595821380615},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.465562105178833},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.42666682600975037},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3860616087913513},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37530773878097534},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27197468280792236},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.21141570806503296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.208804190158844},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.12832367420196533},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:199847150","doi":null,"is_oa":false,"landing_page_url":"https://www.escholar.manchester.ac.uk/uk-ac-man-scw:242425","pdf_url":null,"source":{"id":"https://openalex.org/S4306532719","display_name":"[Thesis]. Manchester, UK: The University of                    Manchester; 2014.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"[Thesis]. Manchester, UK: The University of Manchester; 2014.","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W193748226","https://openalex.org/W1500831029","https://openalex.org/W1522526271","https://openalex.org/W1531663900","https://openalex.org/W1562210554","https://openalex.org/W1574072808","https://openalex.org/W1574172480","https://openalex.org/W1580678794","https://openalex.org/W1585754595","https://openalex.org/W1598162705","https://openalex.org/W1612749618","https://openalex.org/W1695158112","https://openalex.org/W1838939739","https://openalex.org/W1875254393","https://openalex.org/W1877245175","https://openalex.org/W1913322240","https://openalex.org/W1960585934","https://openalex.org/W1965037168","https://openalex.org/W1965794095","https://openalex.org/W1966052610","https://openalex.org/W1966577330","https://openalex.org/W1972274031","https://openalex.org/W1974219858","https://openalex.org/W1975191869","https://openalex.org/W1978346387","https://openalex.org/W1981488923","https://openalex.org/W1984225796","https://openalex.org/W1984700615","https://openalex.org/W1985105495","https://openalex.org/W1986354204","https://openalex.org/W1990381878","https://openalex.org/W1990792892","https://openalex.org/W1993381640","https://openalex.org/W1993442154","https://openalex.org/W1995232616","https://openalex.org/W2002801575","https://openalex.org/W2004316987","https://openalex.org/W2006896453","https://openalex.org/W2012405690","https://openalex.org/W2015620306","https://openalex.org/W2016400954","https://openalex.org/W2016466834","https://openalex.org/W2021268612","https://openalex.org/W2022391569","https://openalex.org/W2023917164","https://openalex.org/W2030753263","https://openalex.org/W2031626045","https://openalex.org/W2038918212","https://openalex.org/W2039183048","https://openalex.org/W2043610206","https://openalex.org/W2046768931","https://openalex.org/W2048983733","https://openalex.org/W2050923400","https://openalex.org/W2054246680","https://openalex.org/W2055965331","https://openalex.org/W2060443633","https://openalex.org/W2062721793","https://openalex.org/W2062873927","https://openalex.org/W2064625349","https://openalex.org/W2065809741","https://openalex.org/W2068994108","https://openalex.org/W2073327302","https://openalex.org/W2075860675","https://openalex.org/W2077775081","https://openalex.org/W2079357192","https://openalex.org/W2082626794","https://openalex.org/W2093504658","https://openalex.org/W2099363671","https://openalex.org/W2100519108","https://openalex.org/W2107130188","https://openalex.org/W2109978756","https://openalex.org/W2111463022","https://openalex.org/W2114200189","https://openalex.org/W2114262474","https://openalex.org/W2115048931","https://openalex.org/W2115674896","https://openalex.org/W2117576368","https://openalex.org/W2119077297","https://openalex.org/W2120233660","https://openalex.org/W2124303254","https://openalex.org/W2127107746","https://openalex.org/W2127853804","https://openalex.org/W2127982431","https://openalex.org/W2128957395","https://openalex.org/W2130870648","https://openalex.org/W2132132140","https://openalex.org/W2134401635","https://openalex.org/W2134653497","https://openalex.org/W2138326965","https://openalex.org/W2140109386","https://openalex.org/W2140368744","https://openalex.org/W2146437446","https://openalex.org/W2149142217","https://openalex.org/W2150678612","https://openalex.org/W2151666328","https://openalex.org/W2153243639","https://openalex.org/W2157962067","https://openalex.org/W2159623950","https://openalex.org/W2160229573","https://openalex.org/W2161332805","https://openalex.org/W2163825883","https://openalex.org/W2165028688","https://openalex.org/W2168200596","https://openalex.org/W2168669893","https://openalex.org/W2169088092","https://openalex.org/W2171503626","https://openalex.org/W2266876831","https://openalex.org/W2275872217","https://openalex.org/W2469287579","https://openalex.org/W2595333609"],"related_works":["https://openalex.org/W2062721793","https://openalex.org/W7095196327","https://openalex.org/W2038988394","https://openalex.org/W4230179562","https://openalex.org/W2272124863","https://openalex.org/W2168259432","https://openalex.org/W7166836957","https://openalex.org/W2077775081","https://openalex.org/W1977103256","https://openalex.org/W3206243836"],"abstract_inverted_index":{"Background:":[0],"Pancreatic":[1],"cancer":[2],"(PC)":[3],"often":[4],"presents":[5],"late":[6],"with":[7,97,137,141,147,175],"poor":[8],"survival.":[9],"While":[10],"the":[11,44,62,74,192,208,235],"role":[12,225],"of":[13,56,65,78,91,170,181,191,194,197,212,237],"immune":[14,45],"suppressive":[15],"cells":[16,25,34,40,214],"in":[17,29,73,122,135,202,226,246],"pre-clinical":[18],"studies":[19,232],"has":[20],"generated":[21],"immunotherapeutic":[22,239],"agents,":[23],"these":[24,213],"remain":[26],"under":[27],"investigated":[28],"PC.":[30,247],"Myeloid":[31],"derived":[32],"suppressor":[33],"(MDSC)":[35],"are":[36,215],"heterogeneous":[37],"immature":[38],"myeloid":[39],"that":[41,207,221],"negatively":[42],"regulate":[43],"responses":[46],"during":[47],"tumour":[48,182],"progression,":[49],"inflammation,":[50],"and":[51,67,71,76,101,107,124,144,199,205,210,243],"infection.":[52],"Aim:":[53],"The":[54,152],"aim":[55],"this":[57],"study":[58],"was":[59,85],"to":[60,241],"characterise":[61],"different":[63,195],"subsets":[64,196],"MDSCs":[66,154,201,222,245],"evaluate":[68],"their":[69,165],"levels":[70,169,180],"functions":[72],"circulation":[75],"tissue":[77,111],"PC":[79,93,138,156,176,203],"patients.":[80],"Methods:":[81],"Flow":[82],"cytometric":[83],"staining":[84],"performed":[86],"on":[87],"peripheral":[88,198],"blood":[89],"samples":[90,112],"24":[92],"patients,":[94],"12":[95],"patients":[96,136,146,157,204],"chronic":[98],"pancreatitis":[99],"(CP)":[100],"16":[102],"healthy":[103,142],"donors.":[104],"Tumour":[105],"(n=7)":[106,109],"benign":[108,148],"pancreatic":[110,149,227],"were":[113,133],"also":[114],"examined":[115],"for":[116],"comparative":[117],"analysis.":[118],"Results:":[119],"Significant":[120],"increases":[121],"circulating":[123,153],"tumour-infiltrating":[125],"granulocytic":[126],"(Lin-HLA-DR-CD33+CD11b+CD15+),":[127],"but":[128],"not":[129],"monocytic":[130],"(Lin-HLA-DR-CD14+),":[131],"MDSC":[132,171],"observed":[134],"when":[139],"compared":[140],"donors":[143],"age-matched":[145],"disease":[150],"(CP).":[151],"from":[155],"expressed":[158],"arginase":[159],"1":[160],"(ARG":[161],"1),":[162],"which":[163],"represents":[164],"functional":[166],"state.":[167],"Blood":[168],"showed":[172],"no":[173],"association":[174],"stage":[177],"or":[178],"preoperative":[179],"markers.":[183],"Conclusions:":[184],"Our":[185],"findings":[186,219],"provide":[187],"a":[188,224],"first":[189],"characterisation":[190],"phenotype":[193],"local":[200],"suggest":[206,220],"frequency":[209],"contribution":[211],"predominantly":[216],"granulocytic.":[217],"These":[218],"have":[223],"cancer.":[228],"Future":[229],"large":[230],"validation":[231],"may":[233],"help":[234],"development":[236],"new":[238],"strategies":[240],"inhibit":[242],"eliminate":[244]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}