{"id":"https://openalex.org/W1998466116","doi":"https://doi.org/10.1016/s0003-9861(03)00213-3","title":"Mechanism of simvastatin on induction of heat shock protein in osteoblasts","display_name":"Mechanism of simvastatin on induction of heat shock protein in osteoblasts","publication_year":2003,"publication_date":"2003-06-02","ids":{"openalex":"https://openalex.org/W1998466116","doi":"https://doi.org/10.1016/s0003-9861(03)00213-3","mag":"1998466116","pmid":"https://pubmed.ncbi.nlm.nih.gov/12801507"},"language":"en","primary_location":{"id":"doi:10.1016/s0003-9861(03)00213-3","doi":"https://doi.org/10.1016/s0003-9861(03)00213-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0003-9861(03)00213-3","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039472836","display_name":"Xiaodan Wang","orcid":"https://orcid.org/0000-0002-5387-2748","observed_orcids":["https://orcid.org/0000-0002-5387-2748"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Xiaodan Wang","raw_affiliation_strings":["Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi, Gifu-ken 500-8705, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi, Gifu-ken 500-8705, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025863828","display_name":"Haruhiko Tokuda","orcid":"https://orcid.org/0000-0001-7552-9003","observed_orcids":["https://orcid.org/0000-0001-7552-9003"]},"institutions":[{"id":"https://openalex.org/I4210157504","display_name":"Chubu National Hospital","ror":"https://ror.org/0032p1p15","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210157504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruhiko Tokuda","raw_affiliation_strings":["Department of Internal Medicine, Chubu National Hospital, National Institute for Longevity Sciences, Obu 474-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chubu National Hospital, National Institute for Longevity Sciences, Obu 474-8511, Japan","institution_ids":["https://openalex.org/I4210157504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111548299","display_name":"Daijiro Hatakeyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daijiro Hatakeyama","raw_affiliation_strings":["Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi, Gifu-ken 500-8705, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi, Gifu-ken 500-8705, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087841061","display_name":"Kouseki Hirade","orcid":"https://orcid.org/0000-0001-8367-602X","observed_orcids":["https://orcid.org/0000-0001-8367-602X"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouseki Hirade","raw_affiliation_strings":["Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi, Gifu-ken 500-8705, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi, Gifu-ken 500-8705, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086083838","display_name":"Masayuki Niwa","orcid":"https://orcid.org/0000-0003-2746-2486","observed_orcids":["https://orcid.org/0000-0003-2746-2486"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Niwa","raw_affiliation_strings":["Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi, Gifu-ken 500-8705, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi, Gifu-ken 500-8705, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041999667","display_name":"Hidenori Ito","orcid":"https://orcid.org/0000-0002-6527-477X","observed_orcids":["https://orcid.org/0000-0002-6527-477X","https://orcid.org/0000-0003-4186-406X"]},"institutions":[{"id":"https://openalex.org/I4210160234","display_name":"Aichi Human Service Center","ror":"https://ror.org/00c4ncp37","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210160234"]},{"id":"https://openalex.org/I4405287295","display_name":"Institute for Developmental Research","ror":"https://ror.org/04qywsk58","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210166504","https://openalex.org/I4405287295"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Ito","raw_affiliation_strings":["Department of Biochemistry, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-03, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-03, Japan","institution_ids":["https://openalex.org/I4210160234","https://openalex.org/I4405287295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108801450","display_name":"Kanefusa Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160234","display_name":"Aichi Human Service Center","ror":"https://ror.org/00c4ncp37","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210160234"]},{"id":"https://openalex.org/I4405287295","display_name":"Institute for Developmental Research","ror":"https://ror.org/04qywsk58","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210166504","https://openalex.org/I4405287295"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kanefusa Kato","raw_affiliation_strings":["Department of Biochemistry, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-03, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-03, Japan","institution_ids":["https://openalex.org/I4210160234","https://openalex.org/I4405287295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083502334","display_name":"Osamu Kozawa","orcid":"https://orcid.org/0000-0002-4834-6073","observed_orcids":["https://orcid.org/0000-0002-4834-6073"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Osamu Kozawa","raw_affiliation_strings":["Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi, Gifu-ken 500-8705, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi, Gifu-ken 500-8705, Japan","institution_ids":["https://openalex.org/I42405503"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5083502334"],"corresponding_institution_ids":["https://openalex.org/I42405503"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":null,"fwci":0.9428,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.69114837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"415","issue":"1","first_page":"6","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":1.0},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hsp27","display_name":"HSP27","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.847000002861023},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":1.0},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mc3t3-e1-cells","display_name":"MC3T3-E1 cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9359999895095825},{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.9425273537635803},{"id":"https://openalex.org/C2779559962","wikidata":"https://www.wikidata.org/wiki/Q14905263","display_name":"Hsp27","level":5,"score":0.7502934336662292},{"id":"https://openalex.org/C2780940807","wikidata":"https://www.wikidata.org/wiki/Q417740","display_name":"Lovastatin","level":3,"score":0.6080120801925659},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5878090858459473},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5841356515884399},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.5486831665039062},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.48375558853149414},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.47969505190849304},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4418070614337921},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.43537843227386475},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3509669005870819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29128414392471313},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2785326838493347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26412510871887207},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.04926380515098572},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0003-9861(03)00213-3","doi":"https://doi.org/10.1016/s0003-9861(03)00213-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0003-9861(03)00213-3","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:12801507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12801507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W596330948","https://openalex.org/W1491060698","https://openalex.org/W1537398036","https://openalex.org/W1557998083","https://openalex.org/W1573694004","https://openalex.org/W1582859718","https://openalex.org/W1980930563","https://openalex.org/W1987247016","https://openalex.org/W1987805481","https://openalex.org/W1989528832","https://openalex.org/W1998899866","https://openalex.org/W2007762330","https://openalex.org/W2007986629","https://openalex.org/W2012459203","https://openalex.org/W2020364703","https://openalex.org/W2022914311","https://openalex.org/W2027819282","https://openalex.org/W2032731042","https://openalex.org/W2035936653","https://openalex.org/W2051793369","https://openalex.org/W2052082098","https://openalex.org/W2054918960","https://openalex.org/W2070044720","https://openalex.org/W2071124826","https://openalex.org/W2084152511","https://openalex.org/W2098719212","https://openalex.org/W2098946775","https://openalex.org/W2100837269","https://openalex.org/W2104161119","https://openalex.org/W2140150136","https://openalex.org/W2142848667","https://openalex.org/W2990963811"],"related_works":["https://openalex.org/W2021438186","https://openalex.org/W2971862726","https://openalex.org/W2012459203","https://openalex.org/W2096738462","https://openalex.org/W7144583295","https://openalex.org/W2009709078","https://openalex.org/W2018834971","https://openalex.org/W3142584362","https://openalex.org/W1997644808","https://openalex.org/W2049855386"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
