{"id":"https://openalex.org/W1998452058","doi":"https://doi.org/10.1111/febs.12779","title":"Structural and functional analysis of a FeoB A143S G5 loop mutant explains the accelerated GDP release rate","display_name":"Structural and functional analysis of a FeoB A143S G5 loop mutant explains the accelerated GDP release rate","publication_year":2014,"publication_date":"2014-03-20","ids":{"openalex":"https://openalex.org/W1998452058","doi":"https://doi.org/10.1111/febs.12779","mag":"1998452058","pmid":"https://pubmed.ncbi.nlm.nih.gov/24649829"},"language":"en","primary_location":{"id":"doi:10.1111/febs.12779","doi":"https://doi.org/10.1111/febs.12779","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.12779","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020939590","display_name":"Amy\u00a0P. Guilfoyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800664540","display_name":"Centenary Institute","ror":"https://ror.org/05gvja138","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2800664540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Amy P. Guilfoyle","raw_affiliation_strings":["Faculty of Medicine Central Clinical School University of Sydney New South Wales Australia","Structural Biology Program Centenary Institute Sydney New South Wales Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine Central Clinical School University of Sydney New South Wales Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Structural Biology Program Centenary Institute Sydney New South Wales Australia","institution_ids":["https://openalex.org/I2800664540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068961165","display_name":"Chandrika N. Deshpande","orcid":"https://orcid.org/0000-0002-5557-519X","observed_orcids":["https://orcid.org/0000-0002-5557-519X"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800664540","display_name":"Centenary Institute","ror":"https://ror.org/05gvja138","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2800664540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chandrika N. Deshpande","raw_affiliation_strings":["Faculty of Medicine Central Clinical School University of Sydney New South Wales Australia","Structural Biology Program Centenary Institute Sydney New South Wales Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine Central Clinical School University of Sydney New South Wales Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Structural Biology Program Centenary Institute Sydney New South Wales Australia","institution_ids":["https://openalex.org/I2800664540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019370014","display_name":"Kimberley Vincent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800664540","display_name":"Centenary Institute","ror":"https://ror.org/05gvja138","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2800664540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kimberley Vincent","raw_affiliation_strings":["Faculty of Medicine Central Clinical School University of Sydney New South Wales Australia","Structural Biology Program Centenary Institute Sydney New South Wales Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine Central Clinical School University of Sydney New South Wales Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Structural Biology Program Centenary Institute Sydney New South Wales Australia","institution_ids":["https://openalex.org/I2800664540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102803489","display_name":"Marcelo Monteiro Pedroso","orcid":"https://orcid.org/0000-0002-4769-384X","observed_orcids":["https://orcid.org/0000-0002-4769-384X"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Marcelo M. Pedroso","raw_affiliation_strings":["School of Chemistry and Molecular Biosciences The University of Queensland St Lucia Queensland Australia","School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences The University of Queensland St Lucia Queensland Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026257435","display_name":"Gerhard Schenk","orcid":"https://orcid.org/0000-0001-8619-0631","observed_orcids":["https://orcid.org/0000-0001-8619-0631"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gerhard Schenk","raw_affiliation_strings":["School of Chemistry and Molecular Biosciences The University of Queensland St Lucia Queensland Australia","School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences The University of Queensland St Lucia Queensland Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025793442","display_name":"Megan J. Maher","orcid":"https://orcid.org/0000-0003-0848-9640","observed_orcids":["https://orcid.org/0000-0003-0848-9640"]},"institutions":[{"id":"https://openalex.org/I196829312","display_name":"La Trobe University","ror":"https://ror.org/01rxfrp27","country_code":"AU","type":"education","lineage":["https://openalex.org/I196829312"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Megan J. Maher","raw_affiliation_strings":["La Trobe Institute for Molecular Science, La Trobe University Melbourne Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Trobe Institute for Molecular Science, La Trobe University Melbourne Victoria Australia","institution_ids":["https://openalex.org/I196829312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047281297","display_name":"Mika Jormakka","orcid":"https://orcid.org/0000-0002-2326-1735","observed_orcids":["https://orcid.org/0000-0002-2326-1735"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800664540","display_name":"Centenary Institute","ror":"https://ror.org/05gvja138","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2800664540"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Mika Jormakka","raw_affiliation_strings":["Faculty of Medicine Central Clinical School University of Sydney New South Wales Australia","Structural Biology Program Centenary Institute Sydney New South Wales Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine Central Clinical School University of Sydney New South Wales Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Structural Biology Program Centenary Institute Sydney New South Wales Australia","institution_ids":["https://openalex.org/I2800664540"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5047281297"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800664540"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.8197,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.69434791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"281","issue":"9","first_page":"2254","last_page":"2265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feob","display_name":"FeoB","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gdp-release","display_name":"GDP release","score":0.5740000009536743},{"id":"https://openalex.org/keywords/gtpase","display_name":"GTPase","score":0.7139999866485596},{"id":"https://openalex.org/keywords/nucleotide-binding-domain","display_name":"nucleotide-binding domain","score":0.5889999866485596},{"id":"https://openalex.org/keywords/streptococcus-thermophilus","display_name":"Streptococcus thermophilus","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.796999990940094},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.593999981880188},{"id":"https://openalex.org/keywords/membrane-proteins","display_name":"membrane proteins","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2779817904","wikidata":"https://www.wikidata.org/wiki/Q422582","display_name":"Guanosine diphosphate","level":5,"score":0.6240127682685852},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.62100750207901},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.5508138537406921},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5450130701065063},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.48069554567337036},{"id":"https://openalex.org/C139407321","wikidata":"https://www.wikidata.org/wiki/Q408561","display_name":"Heterotrimeric G protein","level":4,"score":0.48023372888565063},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4311954081058502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4266586899757385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3524542450904846},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3285679519176483},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2600577473640442},{"id":"https://openalex.org/C2776638253","wikidata":"https://www.wikidata.org/wiki/Q392227","display_name":"Guanosine triphosphate","level":4,"score":0.2438119351863861},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12515828013420105}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048249","descriptor_name":"Streptococcus thermophilus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/febs.12779","doi":"https://doi.org/10.1111/febs.12779","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.12779","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:24649829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24649829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3213747236","display_name":"A targeted nutrient-depletion approach to tackle prostate cancer","funder_award_id":"1035693","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G5995251891","display_name":"The molecular basis of G protein coupled transport","funder_award_id":"632703","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320540","display_name":"Australian Synchrotron","ror":"https://ror.org/03vk18a84"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1512001995","https://openalex.org/W1835109348","https://openalex.org/W1964201498","https://openalex.org/W1974286739","https://openalex.org/W1982553648","https://openalex.org/W1983474162","https://openalex.org/W1989971979","https://openalex.org/W1994953274","https://openalex.org/W2005189737","https://openalex.org/W2008922681","https://openalex.org/W2029260500","https://openalex.org/W2038840577","https://openalex.org/W2040261982","https://openalex.org/W2041756859","https://openalex.org/W2042352993","https://openalex.org/W2044775506","https://openalex.org/W2047063931","https://openalex.org/W2056493923","https://openalex.org/W2059222613","https://openalex.org/W2064664612","https://openalex.org/W2070407927","https://openalex.org/W2073439477","https://openalex.org/W2074592237","https://openalex.org/W2076444265","https://openalex.org/W2108921801","https://openalex.org/W2110035145","https://openalex.org/W2114460420","https://openalex.org/W2122339645","https://openalex.org/W2127957332","https://openalex.org/W2137015675","https://openalex.org/W2144081223","https://openalex.org/W2150252959","https://openalex.org/W2154714625","https://openalex.org/W2163341755","https://openalex.org/W2164749403","https://openalex.org/W2167857702","https://openalex.org/W2180229411"],"related_works":["https://openalex.org/W1983398113","https://openalex.org/W1965489120","https://openalex.org/W2074592237","https://openalex.org/W2056261267","https://openalex.org/W3118972601","https://openalex.org/W291002743","https://openalex.org/W2062602712","https://openalex.org/W1969731657","https://openalex.org/W7100279976","https://openalex.org/W2950449510"],"abstract_inverted_index":{"GTPases":[0],"(G":[1],"proteins)":[2],"hydrolyze":[3],"the":[4,47,63,72,77,88,93,129,134,137,141,147,173,180,191,222,225,231,239,245,252],"conversion":[5],"of":[6,17,49,74,87,136,165,182,224,251],"GTP":[7,43],"to":[8,39,113,199,206],"GDP":[9,50,75,117,214],"and":[10,19,24,45,81,175,178,202,216,248],"free":[11],"phosphate,":[12],"comprising":[13],"an":[14,98,115,157],"integral":[15,99],"part":[16,100],"prokaryotic":[18,148],"eukaryotic":[20,59],"signaling,":[21],"protein":[22,35,150,161],"biosynthesis":[23],"cell":[25],"division,":[26],"as":[27,29,96],"well":[28],"membrane":[30,149],"transport":[31],"processes.":[32],"The":[33,163,194],"G":[34,68,122,160],"cycle":[36,54],"is":[37],"brought":[38],"a":[40,52,66,106,121,183,200,235],"halt":[41],"after":[42],"hydrolysis,":[44],"requires":[46],"release":[48,73,103,118,126,212,241],"before":[51],"new":[53],"can":[55],"be":[56],"initiated.":[57],"For":[58],"heterotrimeric":[60],"G\u03b1\u03b2\u03b3":[61],"proteins,":[62],"interaction":[64],"with":[65,204],"membrane-bound":[67],"protein-coupled":[69,123],"receptor":[70,124],"catalyzes":[71],"from":[76,152],"G\u03b1":[78],"subunit.":[79],"Structural":[80],"functional":[82],"studies":[83],"have":[84,114],"implicated":[85],"one":[86],"nucleotide":[89,211,240,253],"binding":[90],"sequence":[91],"motifs,":[92],"G5":[94,108,142,192,232],"motif,":[95],"playing":[97],"in":[101,140,146,172,179,190,208,230,238],"this":[102,166,228],"mechanism.":[104],"Indeed,":[105],"G\u03b1s":[107],"mutant":[109],"(A366S)":[110],"was":[111,197],"shown":[112],"accelerated":[116],"rate,":[119,213],"mimicking":[120],"catalyzed":[125],"state.":[127],"In":[128],"present":[130],"study,":[131],"we":[132],"investigate":[133],"role":[135,237],"equivalent":[138],"residue":[139,196,226],"motif":[143],"(residue":[144],"A143)":[145],"FeoB":[151],"Streptococcus":[153],"thermophilus,":[154],"which":[155],"includes":[156],"N-terminal":[158],"soluble":[159],"domain.":[162],"structure":[164],"domain":[167],"has":[168],"previously":[169],"been":[170],"determined":[171],"apo":[174],"GDP-bound":[176],"states":[177],"presence":[181],"transition":[184],"state":[185],"analogue,":[186],"revealing":[187],"conformational":[188],"changes":[189,207],"motif.":[193],"A143":[195],"mutated":[198],"serine":[201],"analyzed":[203],"respect":[205],"GTPase":[209],"activity,":[210],"affinity":[215],"structural":[217],"alterations.":[218],"We":[219],"conclude":[220],"that":[221],"identity":[223],"at":[227],"position":[229],"loop":[233],"plays":[234],"key":[236],"rate":[242],"by":[243],"allowing":[244],"correct":[246],"positioning":[247],"hydrogen":[249],"bonding":[250],"base.":[254]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}