{"id":"https://openalex.org/W1998450246","doi":"https://doi.org/10.1086/506005","title":"Metabolic Adjustments to Varying Protein Intake in Harbor Seals (Phoca vitulina): Evidence from Serum Free Amino Acids","display_name":"Metabolic Adjustments to Varying Protein Intake in Harbor Seals (Phoca vitulina): Evidence from Serum Free Amino Acids","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W1998450246","doi":"https://doi.org/10.1086/506005","mag":"1998450246","pmid":"https://pubmed.ncbi.nlm.nih.gov/16927243"},"language":"en","primary_location":{"id":"doi:10.1086/506005","doi":"https://doi.org/10.1086/506005","is_oa":false,"landing_page_url":"https://doi.org/10.1086/506005","pdf_url":null,"source":{"id":"https://openalex.org/S127706618","display_name":"Physiological and Biochemical Zoology","issn_l":"1522-2152","issn":["1522-2152","1537-5293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310315672","host_organization_name":"University of Chicago Press","host_organization_lineage":["https://openalex.org/P4310315672","https://openalex.org/P4310315690"],"host_organization_lineage_names":["University of Chicago Press","University of Chicago"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological and Biochemical Zoology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101872719","display_name":"Liying Zhao","orcid":"https://orcid.org/0000-0003-0402-5048","observed_orcids":["https://orcid.org/0000-0003-0402-5048"]},"institutions":[{"id":"https://openalex.org/I141472210","display_name":"University of Alaska Fairbanks","ror":"https://ror.org/01j7nq853","country_code":"US","type":"education","lineage":["https://openalex.org/I141472210"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Liying Zhao","raw_affiliation_strings":["Institute of Marine Science, School of Fisheries and Ocean Sciences, University of Alaska, Fairbanks, Alaska 99775-7220, USA. lyzhao@uiuc.edu","Institute of Marine Science, School of Fisheries and Ocean Sciences, University of Alaska, Fairbanks, Alaska 99775\u20107220"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Marine Science, School of Fisheries and Ocean Sciences, University of Alaska, Fairbanks, Alaska 99775-7220, USA. lyzhao@uiuc.edu","institution_ids":["https://openalex.org/I141472210"]},{"raw_affiliation_string":"Institute of Marine Science, School of Fisheries and Ocean Sciences, University of Alaska, Fairbanks, Alaska 99775\u20107220","institution_ids":["https://openalex.org/I141472210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072300922","display_name":"Michael A. Castellini","orcid":"https://orcid.org/0000-0003-0396-1045","observed_orcids":["https://orcid.org/0000-0003-0396-1045"]},"institutions":[{"id":"https://openalex.org/I141472210","display_name":"University of Alaska Fairbanks","ror":"https://ror.org/01j7nq853","country_code":"US","type":"education","lineage":["https://openalex.org/I141472210"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael\u00a0A. Castellini","raw_affiliation_strings":["Institute of Marine Science, School of Fisheries and Ocean Sciences, University of Alaska, Fairbanks, Alaska 99775\u20107220"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Marine Science, School of Fisheries and Ocean Sciences, University of Alaska, Fairbanks, Alaska 99775\u20107220","institution_ids":["https://openalex.org/I141472210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113605159","display_name":"D. M. Schell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141472210","display_name":"University of Alaska Fairbanks","ror":"https://ror.org/01j7nq853","country_code":"US","type":"education","lineage":["https://openalex.org/I141472210"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donald\u00a0M. Schell","raw_affiliation_strings":["Institute of Marine Science, School of Fisheries and Ocean Sciences, University of Alaska, Fairbanks, Alaska 99775\u20107220"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Marine Science, School of Fisheries and Ocean Sciences, University of Alaska, Fairbanks, Alaska 99775\u20107220","institution_ids":["https://openalex.org/I141472210"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072300922","https://openalex.org/A5101872719","https://openalex.org/A5113605159"],"corresponding_institution_ids":["https://openalex.org/I141472210"],"apc_list":null,"apc_paid":null,"fwci":1.5504,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.79235647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"79","issue":"5","first_page":"965","last_page":"976"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10659","display_name":"Marine animal studies overview","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10659","display_name":"Marine animal studies overview","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12073","display_name":"Isotope Analysis in Ecology","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10450","display_name":"Aquaculture Nutrition and Growth","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/harbor-seal","display_name":"Phoca vitulina","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-intake","display_name":"protein intake","score":0.8970000147819519},{"id":"https://openalex.org/keywords/serum-free-amino-acids","display_name":"serum free amino acids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/essential-amino-acids","display_name":"essential amino acids","score":0.9369999766349792},{"id":"https://openalex.org/keywords/non-essential-amino-acids","display_name":"non-essential amino acids","score":0.9829999804496765},{"id":"https://openalex.org/keywords/protein-metabolism","display_name":"protein metabolism","score":0.8240000009536743},{"id":"https://openalex.org/keywords/walleye-pollock","display_name":"walleye pollock","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pacific-herring","display_name":"Pacific herring","score":0.9800000190734863},{"id":"https://openalex.org/keywords/macronutrient-composition","display_name":"macronutrient composition","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.703644335269928},{"id":"https://openalex.org/C2779290800","wikidata":"https://www.wikidata.org/wiki/Q3127419","display_name":"Herring","level":3,"score":0.6739253997802734},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.6582051515579224},{"id":"https://openalex.org/C2780457584","wikidata":"https://www.wikidata.org/wiki/Q878742","display_name":"Phoca","level":2,"score":0.6546616554260254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5890114903450012},{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.5341808795928955},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5006589889526367},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.4973783791065216},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4443250596523285},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.4407814145088196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4117186963558197},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3181745409965515},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.1765064299106598},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.15984269976615906},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.10126113891601562},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06899717450141907}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004044","descriptor_name":"Dietary Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046049","descriptor_name":"Phoca","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D046049","descriptor_name":"Phoca","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1086/506005","doi":"https://doi.org/10.1086/506005","is_oa":false,"landing_page_url":"https://doi.org/10.1086/506005","pdf_url":null,"source":{"id":"https://openalex.org/S127706618","display_name":"Physiological and Biochemical Zoology","issn_l":"1522-2152","issn":["1522-2152","1537-5293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310315672","host_organization_name":"University of Chicago Press","host_organization_lineage":["https://openalex.org/P4310315672","https://openalex.org/P4310315690"],"host_organization_lineage_names":["University of Chicago Press","University of Chicago"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological and Biochemical Zoology","raw_type":"journal-article"},{"id":"pmid:16927243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16927243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological and biochemical zoology : PBZ","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.6735000014305115,"display_name":"Zero hunger"},{"id":"https://metadata.un.org/sdg/14","score":0.5769000053405762,"display_name":"Life below water"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W85681050","https://openalex.org/W224354273","https://openalex.org/W1489310106","https://openalex.org/W1558235660","https://openalex.org/W1830769757","https://openalex.org/W1855176222","https://openalex.org/W1918271356","https://openalex.org/W1969671278","https://openalex.org/W1979591475","https://openalex.org/W1983843279","https://openalex.org/W2042043994","https://openalex.org/W2058805531","https://openalex.org/W2064140562","https://openalex.org/W2075097011","https://openalex.org/W2106999300","https://openalex.org/W2113780901","https://openalex.org/W2115438532","https://openalex.org/W2117657582","https://openalex.org/W2130772012","https://openalex.org/W2131926214","https://openalex.org/W2168208734","https://openalex.org/W2412858245","https://openalex.org/W2895791735"],"related_works":["https://openalex.org/W148982114","https://openalex.org/W58318372","https://openalex.org/W1983261100","https://openalex.org/W2124588807","https://openalex.org/W3177073104","https://openalex.org/W2152270667","https://openalex.org/W2087241713","https://openalex.org/W224354273","https://openalex.org/W2337797266","https://openalex.org/W2153327612"],"abstract_inverted_index":{"Effects":[0],"of":[1,106,136,160,174],"varying":[2],"dietary":[3,119,127],"protein":[4,103,120,128,146,171],"intake":[5,104,121],"on":[6,85],"serum":[7],"free":[8],"amino":[9,57,67,153,161],"acid":[10,162],"(FAA)":[11],"concentrations":[12,46,93,117],"were":[13,49],"studied":[14],"in":[15,44,133,145,151],"harbor":[16,175],"seals":[17],"(Phoca":[18],"vitulina)":[19],"fed":[20],"two":[21,53,65,138],"different":[22],"prey":[23,139],"fish":[24,140],"diets:":[25],"either":[26],"exclusively":[27],"low-fat,":[28],"high-protein":[29],"walleye":[30],"pollock":[31,82,109],"(Theragra":[32],"chalcogramma)":[33],"or":[34],"high-fat,":[35],"relatively":[36],"high-energy-density":[37],"Pacific":[38],"herring":[39,80],"(Clupea":[40],"pallasi).":[41],"Significant":[42],"differences":[43,132],"FAA":[45],"and":[47,62,64,71,83,94,118],"patterns":[48],"observed":[50],"between":[51,115],"the":[52,75,101,137,170],"diets.":[54],"All":[55],"essential":[56],"acids":[58,68],"(EAA),":[59],"except":[60],"methionine":[61],"phenylalanine,":[63],"nonessential":[66],"(NEAA),":[69],"glycine":[70],"tyrosine,":[72],"decreased":[73,99],"when":[74],"diet":[76],"was":[77,149],"switched":[78],"from":[79],"to":[81,88,167],"increased":[84],"switching":[86],"back":[87],"herring.":[89],"Both":[90],"total":[91],"EAA":[92,95,116],":":[96],"NEAA":[97],"ratios":[98],"with":[100],"elevated":[102],"typical":[105],"a":[107,143],"low-fat":[108],"diet,":[110],"indicating":[111],"an":[112],"inverse":[113],"correlation":[114],"levels.":[122],"We":[123],"propose":[124],"that":[125,148,158],"differing":[126],"intake,":[129],"caused":[130],"by":[131],"macronutrient":[134],"composition":[135],"species,":[141],"induced":[142],"change":[144],"metabolism":[147],"reflected":[150],"blood-circulating":[152],"acids.":[154],"These":[155],"findings":[156],"suggest":[157],"surveys":[159],"profiles":[163],"may":[164],"be":[165],"useful":[166],"partially":[168],"determine":[169],"metabolic":[172],"status":[173],"seals.":[176]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}