{"id":"https://openalex.org/W1998440809","doi":"https://doi.org/10.1016/j.lfs.2005.08.009","title":"The presence of high concentrations of free d-amino acids in human saliva","display_name":"The presence of high concentrations of free d-amino acids in human saliva","publication_year":2006,"publication_date":"2006-02-10","ids":{"openalex":"https://openalex.org/W1998440809","doi":"https://doi.org/10.1016/j.lfs.2005.08.009","mag":"1998440809","pmid":"https://pubmed.ncbi.nlm.nih.gov/16480744"},"language":"en","primary_location":{"id":"doi:10.1016/j.lfs.2005.08.009","doi":"https://doi.org/10.1016/j.lfs.2005.08.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2005.08.009","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1998440809"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112516276","display_name":"Yoko Nagata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoko Nagata","raw_affiliation_strings":["Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101-8308, Japan. nagata@chem.cst.nihon-u.ac.jp","Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8308, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101-8308, Japan. nagata@chem.cst.nihon-u.ac.jp","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8308, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091561390","display_name":"Masatoshi Higashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatoshi Higashi","raw_affiliation_strings":["Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101-8308, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101-8308, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108498365","display_name":"Yutaka Ishii","orcid":"https://orcid.org/0000-0002-8880-5975","observed_orcids":["https://orcid.org/0000-0002-8880-5975"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Ishii","raw_affiliation_strings":["Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101-8308, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101-8308, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017900980","display_name":"Hiroaki Sano","orcid":"https://orcid.org/0000-0001-8325-4820","observed_orcids":["https://orcid.org/0000-0001-8325-4820"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Sano","raw_affiliation_strings":["Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101-8308, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101-8308, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009465067","display_name":"Minoru Tanigawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Tanigawa","raw_affiliation_strings":["Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101-8308, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda-Surugadai, Chiyoda-Ku, Tokyo 101-8308, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002160227","display_name":"Kumiko Nagata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kumiko Nagata","raw_affiliation_strings":["Department of Bacteriology, Hyogo College of Medicine, Hyogo 663-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, Hyogo College of Medicine, Hyogo 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112065480","display_name":"Kazuma Noguchi","orcid":"https://orcid.org/0000-0001-5307-161X","observed_orcids":["https://orcid.org/0000-0001-5307-161X"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuma Noguchi","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Hyogo 663-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Hyogo 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024134718","display_name":"Masahiro Urade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Urade","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Hyogo 663-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Hyogo 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112516276"],"corresponding_institution_ids":["https://openalex.org/I104946051"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":1.0894,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.68663175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"78","issue":"15","first_page":"1677","last_page":"1681"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d-amino-acids","display_name":"D-amino acids","score":0.8989999890327454},{"id":"https://openalex.org/keywords/free-amino-acids","display_name":"free amino acids","score":0.7009999752044678},{"id":"https://openalex.org/keywords/saliva","display_name":"saliva","score":0.9539999961853027},{"id":"https://openalex.org/keywords/d-alanine","display_name":"D-alanine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/d-aspartate","display_name":"D-aspartate","score":0.9279999732971191},{"id":"https://openalex.org/keywords/d-proline","display_name":"D-proline","score":0.9900000095367432},{"id":"https://openalex.org/keywords/d-serine","display_name":"D-serine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/submandibular-gland","display_name":"submandibular gland","score":0.9869999885559082},{"id":"https://openalex.org/keywords/oral-epithelial-cells","display_name":"oral epithelial cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/non-essential-amino-acids","display_name":"non-essential amino acids","score":0.8190000057220459},{"id":"https://openalex.org/keywords/oral-bacteria","display_name":"oral bacteria","score":0.5730000138282776},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.7700413465499878},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6468104124069214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5398904085159302},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42501527070999146},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.33923351764678955}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003605","descriptor_name":"D-Amino-Acid Oxidase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013363","descriptor_name":"Submandibular Gland","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lfs.2005.08.009","doi":"https://doi.org/10.1016/j.lfs.2005.08.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2005.08.009","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:16480744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16480744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W191877742","https://openalex.org/W1965228219","https://openalex.org/W1977187301","https://openalex.org/W1985332974","https://openalex.org/W1994320858","https://openalex.org/W2001590934","https://openalex.org/W2002552484","https://openalex.org/W2010158663","https://openalex.org/W2012898922","https://openalex.org/W2018697556","https://openalex.org/W2019617917","https://openalex.org/W2032224482","https://openalex.org/W2032718719","https://openalex.org/W2033469593","https://openalex.org/W2048174020","https://openalex.org/W2048587986","https://openalex.org/W2064126736","https://openalex.org/W2091866321","https://openalex.org/W2147157843","https://openalex.org/W2220591145","https://openalex.org/W2298924071","https://openalex.org/W2326842020","https://openalex.org/W2406280528"],"related_works":["https://openalex.org/W4214925625","https://openalex.org/W2052805043","https://openalex.org/W2002552484","https://openalex.org/W1997924973","https://openalex.org/W2134014044","https://openalex.org/W2019617917","https://openalex.org/W2032718719","https://openalex.org/W634465165","https://openalex.org/W7145772086","https://openalex.org/W4313198509"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}